Aggressive Periodontitis Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A periodontitis that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as dental plaque and dental calculus resulting in inflammation and a loss of periodontium. (Human Disease Ontology, DOID_1474)
External Link https://www.disgenet.org/browser/0/1/0/C0031106
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Genes

177 genes associated with the disease Aggressive Periodontitis in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ADAM23 ADAM metallopeptidase domain 23
ADGRG6 adhesion G protein-coupled receptor G6
AIM2 absent in melanoma 2
ALOX5 arachidonate 5-lipoxygenase
AP1S3 adaptor-related protein complex 1, sigma 3 subunit
APOH apolipoprotein H (beta-2-glycoprotein I)
ATN1 atrophin 1
BAD BCL2-associated agonist of cell death
BEGAIN brain-enriched guanylate kinase-associated
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
CAMP cathelicidin antimicrobial peptide
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCL2 chemokine (C-C motif) ligand 2
CCL3 chemokine (C-C motif) ligand 3
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CD14 CD14 molecule
CD28 CD28 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDX2 caudal type homeobox 2
CFB complement factor B
CIR1 corepressor interacting with RBPJ, 1
CKAP2L cytoskeleton associated protein 2-like
CLU clusterin
CNOT8 CCR4-NOT transcription complex, subunit 8
COX2
CSF1 colony stimulating factor 1 (macrophage)
CSF3 colony stimulating factor 3 (granulocyte)
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTSC cathepsin C
CTSD cathepsin D
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR3 chemokine (C-X-C motif) receptor 3
CYBA cytochrome b-245, alpha polypeptide
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DEFA1 defensin, alpha 1
DEFA1B defensin, alpha 1B
DEFB1 defensin, beta 1
DEFB4A defensin, beta 4A
DEFB4B defensin, beta 4B
DGKA diacylglycerol kinase, alpha 80kDa
EEFSEC eukaryotic elongation factor, selenocysteine-tRNA-specific
ELN elastin
ESR2 estrogen receptor 2 (ER beta)
FCAR Fc fragment of IgA receptor
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FPR1 formyl peptide receptor 1
GATA3 GATA binding protein 3
GC group-specific component (vitamin D binding protein)
GLT6D1 glycosyltransferase 6 domain containing 1
GNAS GNAS complex locus
GPRC6A G protein-coupled receptor, class C, group 6, member A
GPRIN1 G protein regulated inducer of neurite outgrowth 1
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HSPA14 heat shock 70kDa protein 14
HSPB1 heat shock 27kDa protein 1
HSPB2 heat shock 27kDa protein 2
HSPB3 heat shock 27kDa protein 3
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HTRA1 HtrA serine peptidase 1
IFNG interferon, gamma
IFNL1 interferon, lambda 1
IFNL2 interferon, lambda 2
IFNL3 interferon, lambda 3
IGF1R insulin-like growth factor 1 receptor
IL10 interleukin 10
IL12RB2 interleukin 12 receptor, beta 2
IL13 interleukin 13
IL17A interleukin 17A
IL17C interleukin 17C
IL17RA interleukin 17 receptor A
IL18 interleukin 18
IL19 interleukin 19
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL1R2 interleukin 1 receptor, type II
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL20 interleukin 20
IL23A interleukin 23, alpha subunit p19
IL24 interleukin 24
IL2RA interleukin 2 receptor, alpha
IL36RN interleukin 36 receptor antagonist
IL37 interleukin 37
IL4 interleukin 4
IL6 interleukin 6
INHA inhibin, alpha
IRF5 interferon regulatory factor 5
ISG20 interferon stimulated exonuclease gene 20kDa
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KLF6 Kruppel-like factor 6
KRT23 keratin 23, type I
KRT25 keratin 25, type I
LCN2 lipocalin 2
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LTA lymphotoxin alpha
LTF lactotransferrin
MBL2 mannose-binding lectin (protein C) 2, soluble
MKLN1 muskelin 1, intracellular mediator containing kelch motifs
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP25 matrix metallopeptidase 25
MMP28 matrix metallopeptidase 28
MMP3 matrix metallopeptidase 3
MMP8 matrix metallopeptidase 8
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MUC2 mucin 2, oligomeric mucus/gel-forming
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC6 mucin 6, oligomeric mucus/gel-forming
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOS2 nitric oxide synthase 2, inducible
NOTCH1 notch 1
OSTCP2 oligosaccharyltransferase complex subunit pseudogene 2
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PES1 pescadillo ribosomal biogenesis factor 1
PI3 peptidase inhibitor 3, skin-derived
PLG plasminogen
PON1 paraoxonase 1
POPDC2 popeye domain containing 2
POSTN periostin, osteoblast specific factor
PRDM1 PR domain containing 1, with ZNF domain
PRTN3 proteinase 3
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYDC2 pyrin domain containing 2
RBM45 RNA binding motif protein 45
S100A8 S100 calcium binding protein A8
SCN4A sodium channel, voltage gated, type IV alpha subunit
SELE selectin E
SELENOS selenoprotein S
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFXN1 sideroflexin 1
SIGLEC5 sialic acid binding Ig-like lectin 5
SLAMF7 SLAM family member 7
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SMAD4 SMAD family member 4
SMAD7 SMAD family member 7
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
STAT1 signal transducer and activator of transcription 1, 91kDa
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TIMP2 TIMP metallopeptidase inhibitor 2
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TP53 tumor protein p53
TPO thyroid peroxidase
TREM1 triggering receptor expressed on myeloid cells 1
TYK2 tyrosine kinase 2
UBE3D ubiquitin protein ligase E3D
UCN2 urocortin 2
VCAM1 vascular cell adhesion molecule 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WNT5A wingless-type MMTV integration site family, member 5A
ZNF136 zinc finger protein 136