Alcohol Abuse Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences. (Human Disease Ontology, DOID_1574)
External Link https://www.disgenet.org/browser/0/1/0/C0085762
Similar Terms
Downloads & Tools

Genes

154 genes associated with the disease Alcohol Abuse in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACE angiotensin I converting enzyme
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AFP alpha-fetoprotein
AGRP agouti related neuropeptide
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase)
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANKK1 ankyrin repeat and kinase domain containing 1
ANXA4 annexin A4
APOE apolipoprotein E
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ARTN artemin
AVP arginine vasopressin
BDNF brain-derived neurotrophic factor
BMP2 bone morphogenetic protein 2
C9ORF9 chromosome 9 open reading frame 9
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CCHCR1 coiled-coil alpha-helical rod protein 1
CCK cholecystokinin
CCKAR cholecystokinin A receptor
CCND1 cyclin D1
CD14 CD14 molecule
CD81 CD81 molecule
CDK20 cyclin-dependent kinase 20
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CLOCK clock circadian regulator
CNR1 cannabinoid receptor 1 (brain)
CNR2 cannabinoid receptor 2 (macrophage)
COMT catechol-O-methyltransferase
CRH corticotropin releasing hormone
CRHR1 corticotropin releasing hormone receptor 1
CRP C-reactive protein, pentraxin-related
CTRC chymotrypsin C (caldecrin)
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
DAPK1 death-associated protein kinase 1
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53
DRD2 dopamine receptor D2
DRD3 dopamine receptor D3
DRD4 dopamine receptor D4
EGFR epidermal growth factor receptor
ENG endoglin
ERCC1 excision repair cross-complementation group 1
F2 coagulation factor II (thrombin)
FAAH fatty acid amide hydrolase
FKBP5 FK506 binding protein 5
FN1 fibronectin 1
FSHB follicle stimulating hormone, beta polypeptide
FTO fat mass and obesity associated
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD4 frizzled class receptor 4
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2
GAL galanin/GMAP prepropeptide
GALR1 galanin receptor 1
GALR2 galanin receptor 2
GALR3 galanin receptor 3
GATA4 GATA binding protein 4
GGT1 gamma-glutamyltransferase 1
GHSR growth hormone secretagogue receptor
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPHN gephyrin
GPR151 G protein-coupled receptor 151
GPRC6A G protein-coupled receptor, class C, group 6, member A
HAMP hepcidin antimicrobial peptide
HCRTR1 hypocretin (orexin) receptor 1
HDAC2 histone deacetylase 2
HFE hemochromatosis
HPX hemopexin
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled
IFNL3 interferon, lambda 3
IGF1 insulin-like growth factor 1 (somatomedin C)
IL10 interleukin 10
IL17A interleukin 17A
IL6 interleukin 6
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6
LDLR low density lipoprotein receptor
LEP leptin
LGR6 leucine-rich repeat containing G protein-coupled receptor 6
LHB luteinizing hormone beta polypeptide
LPAR3 lysophosphatidic acid receptor 3
MAOA monoamine oxidase A
MARCH11 membrane-associated ring finger (C3HC4) 11
MCM5 minichromosome maintenance complex component 5
MGMT O-6-methylguanine-DNA methyltransferase
MMP1 matrix metallopeptidase 1
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MPDZ multiple PDZ domain protein
MRGPRX1 MAS-related GPR, member X1
MRGPRX3 MAS-related GPR, member X3
MRGPRX4 MAS-related GPR, member X4
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAN neurocan
NFE2L2 nuclear factor, erythroid 2-like 2
NPC1L1 NPC1-like 1
NPY neuropeptide Y
NPY2R neuropeptide Y receptor Y2
NPY5R neuropeptide Y receptor Y5
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
OPRL1 opiate receptor-like 1
OPRM1 opioid receptor, mu 1
OXER1 oxoeicosanoid (OXE) receptor 1
OXTR oxytocin receptor
PCSK9 proprotein convertase subtilisin/kexin type 9
PDE4A phosphodiesterase 4A, cAMP-specific
PDE4B phosphodiesterase 4B, cAMP-specific
PDYN prodynorphin
PENK proenkephalin
PHGDH phosphoglycerate dehydrogenase
PITX2 paired-like homeodomain 2
POMC proopiomelanocortin
RPL18A ribosomal protein L18a
SELENBP1 selenium binding protein 1
SHBG sex hormone-binding globulin
SIRT1 sirtuin 1
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SMAD2 SMAD family member 2
SMS spermine synthase
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SPG21 spastic paraplegia 21 (autosomal recessive, Mast syndrome)
SPI1 Spi-1 proto-oncogene
TACR1 tachykinin receptor 1
TACR3 tachykinin receptor 3
TAS2R16 taste receptor, type 2, member 16
TAS2R38 taste receptor, type 2, member 38
TBX19 T-box 19
TF transferrin
TFRC transferrin receptor
TGFB1 transforming growth factor, beta 1
TKT transketolase
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TPH2 tryptophan hydroxylase 2
UROD uroporphyrinogen decarboxylase
XDH xanthine dehydrogenase