| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/49806720 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Alectinib relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| C4BPA | complement component 4 binding protein, alpha | 1.76 |
| HMOX1 | heme oxygenase 1 | 1.7 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | 1.54 |
| CLK1 | CDC-like kinase 1 | 1.45 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 1.45 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 1.4 |
| CLK4 | CDC-like kinase 4 | 1.21 |
| TIGD1 | tigger transposable element derived 1 | 1.18 |
| SQSTM1 | sequestosome 1 | 1.15 |
| TSPAN3 | tetraspanin 3 | 1.14 |
| F5 | coagulation factor V (proaccelerin, labile factor) | 1.11 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 1.02 |
| NCOA4 | nuclear receptor coactivator 4 | 1.01 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 1.0 |
| ABHD2 | abhydrolase domain containing 2 | 0.96 |
| TOR1AIP2 | torsin A interacting protein 2 | 0.92 |
| FBXO44 | F-box protein 44 | 0.92 |
| ABHD4 | abhydrolase domain containing 4 | 0.9 |
| LZTS1 | leucine zipper, putative tumor suppressor 1 | 0.9 |
| CCDC158 | coiled-coil domain containing 158 | 0.89 |
| XBP1 | X-box binding protein 1 | 0.88 |
| MAP2 | microtubule-associated protein 2 | 0.88 |
| SRXN1 | sulfiredoxin 1 | 0.87 |
| AEN | apoptosis enhancing nuclease | 0.86 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | 0.85 |
| SLC49A4 | solute carrier family 49 member 4 | 0.84 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.84 |
| GEM | GTP binding protein overexpressed in skeletal muscle | 0.82 |
| JUN | jun proto-oncogene | 0.8 |
| ARG2 | arginase 2 | 0.78 |
| NAV3 | neuron navigator 3 | 0.77 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.77 |
| ITPRIPL2 | inositol 1,4,5-trisphosphate receptor interacting protein-like 2 | 0.76 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.76 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 0.76 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.75 |
| BAG3 | BCL2-associated athanogene 3 | 0.75 |
| NBR1 | neighbor of BRCA1 gene 1 | 0.75 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.74 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.74 |
| CYP4F11 | cytochrome P450, family 4, subfamily F, polypeptide 11 | 0.74 |
| TRIB1 | tribbles pseudokinase 1 | 0.73 |
| EID2 | EP300 interacting inhibitor of differentiation 2 | 0.73 |
| RNF115 | ring finger protein 115 | 0.73 |
| FBXW8 | F-box and WD repeat domain containing 8 | 0.73 |
| TRAF3 | TNF receptor-associated factor 3 | 0.72 |
| ZSWIM1 | zinc finger, SWIM-type containing 1 | 0.71 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 0.71 |
| SLC35B1 | solute carrier family 35, member B1 | 0.71 |
| CREBZF | CREB/ATF bZIP transcription factor | 0.71 |
| PLPP3 | phospholipid phosphatase 3 | 0.7 |
| STC2 | stanniocalcin 2 | 0.7 |
| KLHL21 | kelch-like family member 21 | 0.69 |
| GRAMD2B | GRAM domain containing 2B | 0.69 |
| CC2D2A | coiled-coil and C2 domain containing 2A | 0.68 |
| CPA4 | carboxypeptidase A4 | 0.68 |
| APOL2 | apolipoprotein L, 2 | 0.68 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.66 |
| NDFIP1 | Nedd4 family interacting protein 1 | 0.65 |
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 0.65 |
| LAMC2 | laminin, gamma 2 | 0.63 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.63 |
| FNBP4 | formin binding protein 4 | 0.62 |
| IQCB1 | IQ motif containing B1 | 0.62 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.62 |
| CLDN3 | claudin 3 | 0.62 |
| MAGEF1 | melanoma antigen family F1 | 0.61 |
| RNF26 | ring finger protein 26 | 0.61 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.61 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | 0.6 |
| RAB40C | RAB40C, member RAS oncogene family | 0.6 |
| APOB | apolipoprotein B | 0.59 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.59 |
| PREX1 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | 0.58 |
| LAMB3 | laminin, beta 3 | 0.58 |
| LYPD3 | LY6/PLAUR domain containing 3 | 0.58 |
| MYO15A | myosin XVA | 0.57 |
| TRIML2 | tripartite motif family-like 2 | 0.57 |
| ZSCAN25 | zinc finger and SCAN domain containing 25 | 0.57 |
| C12ORF66 | chromosome 12 open reading frame 66 | 0.57 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.57 |
| SQLE | squalene epoxidase | 0.56 |
| SAYSD1 | SAYSVFN motif domain containing 1 | 0.56 |
| UBQLN2 | ubiquilin 2 | 0.56 |
| VIM | vimentin | 0.56 |
| FOSL1 | FOS-like antigen 1 | 0.56 |
| LPIN1 | lipin 1 | 0.56 |
| ZBED8 | zinc finger, BED-type containing 8 | 0.55 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.55 |
| ATF3 | activating transcription factor 3 | 0.55 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.55 |
| MSMO1 | methylsterol monooxygenase 1 | 0.55 |
| ADM | adrenomedullin | 0.54 |
| ZFP36 | ZFP36 ring finger protein | 0.54 |
| BRF2 | BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit | 0.54 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.54 |
| CD63 | CD63 molecule | 0.54 |
| PLA2G6 | phospholipase A2, group VI (cytosolic, calcium-independent) | 0.54 |
| APOE | apolipoprotein E | 0.53 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | -2.92 |
| SON | SON DNA binding protein | -1.49 |
| ARL6IP4 | ADP-ribosylation factor-like 6 interacting protein 4 | -1.18 |
| EPN3 | epsin 3 | -0.92 |
| LRRC45 | leucine rich repeat containing 45 | -0.89 |
| SFSWAP | splicing factor, suppressor of white-apricot family | -0.88 |
| PRIMPOL | primase and polymerase (DNA-directed) | -0.84 |
| KIF20B | kinesin family member 20B | -0.82 |
| SEMA3F | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F | -0.81 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | -0.81 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.81 |
| SIX5 | SIX homeobox 5 | -0.8 |
| ZKSCAN2 | zinc finger with KRAB and SCAN domains 2 | -0.79 |
| ICK | intestinal cell (MAK-like) kinase | -0.78 |
| CUL9 | cullin 9 | -0.77 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | -0.76 |
| FURIN | furin (paired basic amino acid cleaving enzyme) | -0.73 |
| BAIAP2 | BAI1-associated protein 2 | -0.71 |
| NADK | NAD kinase | -0.69 |
| SP140 | SP140 nuclear body protein | -0.69 |
| FBXW5 | F-box and WD repeat domain containing 5 | -0.68 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | -0.68 |
| POF1B | premature ovarian failure, 1B | -0.68 |
| ODF2L | outer dense fiber of sperm tails 2-like | -0.67 |
| FBXL6 | F-box and leucine-rich repeat protein 6 | -0.66 |
| SYTL1 | synaptotagmin-like 1 | -0.66 |
| BCL2L12 | BCL2-like 12 (proline rich) | -0.66 |
| MUTYH | mutY homolog | -0.66 |
| PCNX3 | pecanex 3 | -0.65 |
| RMDN3 | regulator of microtubule dynamics 3 | -0.64 |
| KRTCAP3 | keratinocyte associated protein 3 | -0.64 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | -0.63 |
| CDCA3 | cell division cycle associated 3 | -0.63 |
| TEDC2 | tubulin epsilon and delta complex 2 | -0.62 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | -0.61 |
| SORT1 | sortilin 1 | -0.61 |
| MYRF | myelin regulatory factor | -0.61 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.61 |
| SLC6A9 | solute carrier family 6 (neurotransmitter transporter, glycine), member 9 | -0.61 |
| BCLAF1 | BCL2-associated transcription factor 1 | -0.6 |
| PKN3 | protein kinase N3 | -0.6 |
| TEX30 | testis expressed 30 | -0.6 |
| MT2A | metallothionein 2A | -0.6 |
| TMEM129 | transmembrane protein 129, E3 ubiquitin protein ligase | -0.59 |
| PKMYT1 | protein kinase, membrane associated tyrosine/threonine 1 | -0.59 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.58 |
| RASAL1 | RAS protein activator like 1 (GAP1 like) | -0.58 |
| ZNF483 | zinc finger protein 483 | -0.58 |
| TONSL | tonsoku-like, DNA repair protein | -0.57 |
| TRPT1 | tRNA phosphotransferase 1 | -0.57 |
| TMEM248 | transmembrane protein 248 | -0.56 |
| CCDC34 | coiled-coil domain containing 34 | -0.55 |
| ATP2A1 | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 | -0.54 |
| NAT14 | N-acetyltransferase 14 (GCN5-related, putative) | -0.54 |
| GRID1 | glutamate receptor, ionotropic, delta 1 | -0.54 |
| MAP3K6 | mitogen-activated protein kinase kinase kinase 6 | -0.54 |
| EGFL7 | EGF-like-domain, multiple 7 | -0.53 |
| ZNF280D | zinc finger protein 280D | -0.53 |
| MRM1 | mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) | -0.53 |
| ACD | adrenocortical dysplasia homolog (mouse) | -0.53 |
| OBSL1 | obscurin-like 1 | -0.53 |
| CYBC1 | cytochrome b-245 chaperone 1 | -0.53 |
| OSBPL7 | oxysterol binding protein-like 7 | -0.52 |
| PDSS1 | prenyl (decaprenyl) diphosphate synthase, subunit 1 | -0.52 |
| UNC13D | unc-13 homolog D (C. elegans) | -0.52 |
| MLXIPL | MLX interacting protein-like | -0.51 |
| PLXNA3 | plexin A3 | -0.51 |
| RETSAT | retinol saturase (all-trans-retinol 13,14-reductase) | -0.51 |
| NEIL1 | nei endonuclease VIII-like 1 (E. coli) | -0.51 |
| TMEM189 | transmembrane protein 189 | -0.51 |
| USP53 | ubiquitin specific peptidase 53 | -0.5 |
| DGKQ | diacylglycerol kinase, theta 110kDa | -0.5 |
| KSR2 | kinase suppressor of ras 2 | -0.5 |
| WDR24 | WD repeat domain 24 | -0.5 |
| TTC31 | tetratricopeptide repeat domain 31 | -0.5 |
| AXL | AXL receptor tyrosine kinase | -0.5 |
| NAGS | N-acetylglutamate synthase | -0.49 |
| TIMM10B | translocase of inner mitochondrial membrane 10 homolog B (yeast) | -0.49 |
| ARHGEF40 | Rho guanine nucleotide exchange factor (GEF) 40 | -0.49 |
| SSNA1 | Sjogren syndrome nuclear autoantigen 1 | -0.49 |
| RMDN2 | regulator of microtubule dynamics 2 | -0.49 |
| RPL22L1 | ribosomal protein L22-like 1 | -0.49 |
| YDJC | YdjC homolog (bacterial) | -0.48 |
| GAS2L1 | growth arrest-specific 2 like 1 | -0.48 |
| CLCN5 | chloride channel, voltage-sensitive 5 | -0.48 |
| EFCAB14 | EF-hand calcium binding domain 14 | -0.47 |
| AP5B1 | adaptor-related protein complex 5, beta 1 subunit | -0.47 |
| XYLT2 | xylosyltransferase II | -0.47 |
| GALT | galactose-1-phosphate uridylyltransferase | -0.47 |
| MRC2 | mannose receptor, C type 2 | -0.47 |
| GLI4 | GLI family zinc finger 4 | -0.47 |
| SLC38A10 | solute carrier family 38, member 10 | -0.47 |
| TRIM65 | tripartite motif containing 65 | -0.47 |
| SLX4 | SLX4 structure-specific endonuclease subunit | -0.47 |
| CCDC14 | coiled-coil domain containing 14 | -0.47 |
| GPSM1 | G-protein signaling modulator 1 | -0.46 |
| ARRDC1 | arrestin domain containing 1 | -0.46 |
| ARHGEF19 | Rho guanine nucleotide exchange factor (GEF) 19 | -0.46 |
| NR2C2AP | nuclear receptor 2C2-associated protein | -0.46 |
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | -0.46 |
