Alexander Disease_CNS - Brain - Olfactory Bulb (MMHCC)_GSE977 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Diseases
Category transcriptomics
Type disease perturbation
Description disease perturbation identified as [disease]_[tissue]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE977
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Genes

600 genes differentially expressed during Alexander Disease_CNS - Brain - Olfactory Bulb (MMHCC)_GSE977 disease perturbation from the GEO Signatures of Differentially Expressed Genes for Diseases dataset.

increased expression

Symbol Name Standardized Value
SMC4 structural maintenance of chromosomes 4 3.49369
TPT1 tumor protein, translationally-controlled 1 3.47176
PLXNB2 plexin B2 3.32554
MCL1 myeloid cell leukemia 1 3.1821
PNCK pregnancy up-regulated nonubiquitous CaM kinase 3.16304
SLC39A4 solute carrier family 39 (zinc transporter), member 4 3.13085
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 3.10095
KDM3B lysine (K)-specific demethylase 3B 3.08147
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 3.06302
ANXA3 annexin A3 2.97948
EIF1B eukaryotic translation initiation factor 1B 2.94442
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 2.9045
GSTM5 glutathione S-transferase mu 5 2.84402
TXNRD1 thioredoxin reductase 1 2.82508
GSTP1 glutathione S-transferase pi 1 2.78853
TBRG1 transforming growth factor beta regulator 1 2.73792
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 2.73201
H2AFV H2A histone family, member V 2.72843
FTH1 ferritin, heavy polypeptide 1 2.6951
GCLC glutamate-cysteine ligase, catalytic subunit 2.68236
PRDX6 peroxiredoxin 6 2.64294
RPL7 ribosomal protein L7 2.62879
VMP1 vacuole membrane protein 1 2.61451
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit 2.58332
RPL7A ribosomal protein L7a 2.56505
DDR1 discoidin domain receptor tyrosine kinase 1 2.56256
BAX BCL2-associated X protein 2.45372
LXN latexin 2.44373
TMEM43 transmembrane protein 43 2.44008
RAB23 RAB23, member RAS oncogene family 2.43697
RPL10A ribosomal protein L10a 2.4364
RPS7 ribosomal protein S7 2.43179
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 2.42188
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 2.4036
PTGR1 prostaglandin reductase 1 2.39826
SFR1 SWI5-dependent recombination repair 1 2.39576
ILK integrin-linked kinase 2.37166
VASP vasodilator-stimulated phosphoprotein 2.35932
DEF8 differentially expressed in FDCP 8 homolog (mouse) 2.3341
GPX1 glutathione peroxidase 1 2.27978
DDT D-dopachrome tautomerase 2.27444
CARHSP1 calcium regulated heat stable protein 1, 24kDa 2.2616
HLTF helicase-like transcription factor 2.25688
NPHP1 nephronophthisis 1 (juvenile) 2.22846
SHROOM3 shroom family member 3 2.21193
TALDO1 transaldolase 1 2.2015
REXO2 RNA exonuclease 2 2.19843
ZZZ3 zinc finger, ZZ-type containing 3 2.19705
CHUK conserved helix-loop-helix ubiquitous kinase 2.19666
TRIP6 thyroid hormone receptor interactor 6 2.18932
RPS5 ribosomal protein S5 2.18724
RNF19B ring finger protein 19B 2.16249
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 2.13891
CNN3 calponin 3, acidic 2.12472
TXNIP thioredoxin interacting protein 2.12265
PRDX1 peroxiredoxin 1 2.12203
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.11865
GOLPH3 golgi phosphoprotein 3 (coat-protein) 2.11438
HIST1H1C histone cluster 1, H1c 2.11426
BAG3 BCL2-associated athanogene 3 2.04284
PON2 paraoxonase 2 2.02403
TWF1 twinfilin actin binding protein 1 2.01454
JUND jun D proto-oncogene 2.00116
CLTB clathrin, light chain B 1.99161
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 1.98598
PTOV1 prostate tumor overexpressed 1 1.97652
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 1.96866
RPS26 ribosomal protein S26 1.95768
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 1.95701
CDC42SE1 CDC42 small effector 1 1.95677
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 1.95462
TBC1D23 TBC1 domain family, member 23 1.95214
TFCP2L1 transcription factor CP2-like 1 1.93551
CTGF connective tissue growth factor 1.92733
EPB41L4A erythrocyte membrane protein band 4.1 like 4A 1.92194
ACTG1 actin gamma 1 1.90205
HOPX HOP homeobox 1.89987
TMTC2 transmembrane and tetratricopeptide repeat containing 2 1.8898
DSCR3 Down syndrome critical region 3 1.88934
CBFB core-binding factor, beta subunit 1.88838
UBC ubiquitin C 1.88741
NTPCR nucleoside-triphosphatase, cancer-related 1.88035
BBS9 Bardet-Biedl syndrome 9 1.87114
UBR4 ubiquitin protein ligase E3 component n-recognin 4 1.86662
HMOX1 heme oxygenase 1 1.84964
CCND3 cyclin D3 1.84512
CP ceruloplasmin (ferroxidase) 1.84197
FOXJ1 forkhead box J1 1.84162
FABP7 fatty acid binding protein 7, brain 1.83201
ZNF207 zinc finger protein 207 1.82883
FIBP fibroblast growth factor (acidic) intracellular binding protein 1.827
PXMP2 peroxisomal membrane protein 2, 22kDa 1.81845
ADM adrenomedullin 1.817
PCID2 PCI domain containing 2 1.80939
CAT catalase 1.80823
TMED2 transmembrane emp24 domain trafficking protein 2 1.80261
C8ORF33 chromosome 8 open reading frame 33 1.80068
RIT1 Ras-like without CAAX 1 1.79581
TBCK TBC1 domain containing kinase 1.79545
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa 1.79434
RAE1 ribonucleic acid export 1 1.79225
RIC8A RIC8 guanine nucleotide exchange factor A 1.79111
GNA13 guanine nucleotide binding protein (G protein), alpha 13 1.78074
MCM3 minichromosome maintenance complex component 3 1.77626
PDLIM7 PDZ and LIM domain 7 (enigma) 1.77586
XIRP1 xin actin binding repeat containing 1 1.77415
TP53 tumor protein p53 1.77399
PKIB protein kinase (cAMP-dependent, catalytic) inhibitor beta 1.77327
SKI SKI proto-oncogene 1.76884
LRP1 low density lipoprotein receptor-related protein 1 1.76793
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 1.76688
TXNDC9 thioredoxin domain containing 9 1.76645
BMP1 bone morphogenetic protein 1 1.76557
SERINC3 serine incorporator 3 1.76485
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 1.75797
GPC4 glypican 4 1.75138
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 1.7308
ZNF362 zinc finger protein 362 1.73022
EEF2 eukaryotic translation elongation factor 2 1.72709
ADAM9 ADAM metallopeptidase domain 9 1.71113
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 1.71109
TARS threonyl-tRNA synthetase 1.70774
GTF2H1 general transcription factor IIH, polypeptide 1, 62kDa 1.70053
ADAM10 ADAM metallopeptidase domain 10 1.69938
ZMAT3 zinc finger, matrin-type 3 1.69849
SBF2 SET binding factor 2 1.69462
SGK1 serum/glucocorticoid regulated kinase 1 1.6869
GLRX3 glutaredoxin 3 1.68602
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.67415
CAPNS1 calpain, small subunit 1 1.67289
SORBS1 sorbin and SH3 domain containing 1 1.66497
BRI3 brain protein I3 1.6635
KLF6 Kruppel-like factor 6 1.65712
TXNDC12 thioredoxin domain containing 12 (endoplasmic reticulum) 1.654
AMOTL2 angiomotin like 2 1.64268
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 1.64239
RPL6 ribosomal protein L6 1.63987
IGFBP3 insulin-like growth factor binding protein 3 1.62769
AK3 adenylate kinase 3 1.62741
LZTFL1 leucine zipper transcription factor-like 1 1.6272
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 1.62198
CXCL2 chemokine (C-X-C motif) ligand 2 1.6171
EIF1AX eukaryotic translation initiation factor 1A, X-linked 1.61556
RPLP0 ribosomal protein, large, P0 1.61534
UNG uracil-DNA glycosylase 1.61074
FTO fat mass and obesity associated 1.61065
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 1.60914
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A 1.60858
TBC1D14 TBC1 domain family, member 14 1.60732
FXYD1 FXYD domain containing ion transport regulator 1 1.60635
UBXN4 UBX domain protein 4 1.60488
TM7SF3 transmembrane 7 superfamily member 3 1.60392
SRM spermidine synthase 1.60256
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 1.59956
MRPS17 mitochondrial ribosomal protein S17 1.59534
FSTL1 follistatin-like 1 1.59272
SYS1 Sys1 golgi trafficking protein 1.59212
PEA15 phosphoprotein enriched in astrocytes 15 1.58987
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.58883
LATS2 large tumor suppressor kinase 2 1.58715
INPP5B inositol polyphosphate-5-phosphatase, 75kDa 1.58655
SQSTM1 sequestosome 1 1.582
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 1.57841
SLC44A2 solute carrier family 44 (choline transporter), member 2 1.57622
RAB8A RAB8A, member RAS oncogene family 1.57438
NKAIN1 Na+/K+ transporting ATPase interacting 1 1.56573
HEBP1 heme binding protein 1 1.55843
CDT1 chromatin licensing and DNA replication factor 1 1.55819
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 1.55098
KIF22 kinesin family member 22 1.54517
HINT1 histidine triad nucleotide binding protein 1 1.53462
PLXND1 plexin D1 1.53392
STK40 serine/threonine kinase 40 1.53196
UFD1L ubiquitin fusion degradation 1 like (yeast) 1.53127
MED12 mediator complex subunit 12 1.53025
KIF1C kinesin family member 1C 1.5261
NUP62 nucleoporin 62kDa 1.52373
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 1.5225
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 1.51698
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 1.51188
CDK5RAP3 CDK5 regulatory subunit associated protein 3 1.50683
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 1.50643
NFE2L2 nuclear factor, erythroid 2-like 2 1.49289
NCL nucleolin 1.4865
PRPF31 pre-mRNA processing factor 31 1.48649
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 1.48242
IARS isoleucyl-tRNA synthetase 1.48053
MAEA macrophage erythroblast attacher 1.47627
GSR glutathione reductase 1.4754
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 1.47397
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 1.46893
TAGLN2 transgelin 2 1.46855
CACUL1 CDK2-associated, cullin domain 1 1.46693
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 1.46294
AP1M1 adaptor-related protein complex 1, mu 1 subunit 1.46257
ITGB5 integrin, beta 5 1.45746
CHD1L chromodomain helicase DNA binding protein 1-like 1.43826
ESD esterase D 1.43796
OSTC oligosaccharyltransferase complex subunit (non-catalytic) 1.43679
DPF2 D4, zinc and double PHD fingers family 2 1.43464
CEL carboxyl ester lipase 1.43032
GPX3 glutathione peroxidase 3 1.42569
NOP58 NOP58 ribonucleoprotein 1.42254
GAS1 growth arrest-specific 1 1.41826
ASRGL1 asparaginase like 1 1.41767
CHD4 chromodomain helicase DNA binding protein 4 1.41669
FAM107B family with sequence similarity 107, member B 1.41664
ZDHHC6 zinc finger, DHHC-type containing 6 1.41435
SAP30L SAP30-like 1.40818
CAPZB capping protein (actin filament) muscle Z-line, beta 1.40775
IGF1R insulin-like growth factor 1 receptor 1.40546
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 1.40509
FN1 fibronectin 1 1.40263
ERP44 endoplasmic reticulum protein 44 1.40238
ABHD5 abhydrolase domain containing 5 1.40204
RASSF5 Ras association (RalGDS/AF-6) domain family member 5 1.40143
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 1.4008
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 1.39871
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 1.39537
RBM38 RNA binding motif protein 38 1.39184
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 1.39068
NRIP1 nuclear receptor interacting protein 1 1.38625
MRPL45 mitochondrial ribosomal protein L45 1.38293
MRPL48 mitochondrial ribosomal protein L48 1.38076
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase) 1.37848
RPL18 ribosomal protein L18 1.37838
SOAT1 sterol O-acyltransferase 1 1.37704
WDR7 WD repeat domain 7 1.37536
CORO1A coronin, actin binding protein, 1A 1.37519
GNG5 guanine nucleotide binding protein (G protein), gamma 5 1.36852
LBR lamin B receptor 1.36205
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 1.36195
CCNB2 cyclin B2 1.35988
MAPRE1 microtubule-associated protein, RP/EB family, member 1 1.35663
METTL8 methyltransferase like 8 1.35651
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 1.35617
WDR74 WD repeat domain 74 1.35421
SURF4 surfeit 4 1.35217
PTPN1 protein tyrosine phosphatase, non-receptor type 1 1.34706
ENO3 enolase 3 (beta, muscle) 1.34621
ACSS1 acyl-CoA synthetase short-chain family member 1 1.34549
SRXN1 sulfiredoxin 1 1.34501
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A 1.33918
IMP3 IMP3, U3 small nucleolar ribonucleoprotein 1.33835
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 1.33758
RPS2 ribosomal protein S2 1.33585
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.33531
DCUN1D5 DCN1, defective in cullin neddylation 1, domain containing 5 1.33423
ATG4B autophagy related 4B, cysteine peptidase 1.33168
CIRH1A cirrhosis, autosomal recessive 1A (cirhin) 1.33034
EIF4A3 eukaryotic translation initiation factor 4A3 1.31892
TMOD3 tropomodulin 3 (ubiquitous) 1.31367
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 1.31005
FAM102A family with sequence similarity 102, member A 1.30877
USP19 ubiquitin specific peptidase 19 1.30796
NANS N-acetylneuraminic acid synthase 1.30566
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.30371
NOP16 NOP16 nucleolar protein 1.30321
STK19 serine/threonine kinase 19 1.29979
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 1.2982
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) 1.29263
EMC8 ER membrane protein complex subunit 8 1.29005
WWC1 WW and C2 domain containing 1 1.2843
EXOC7 exocyst complex component 7 1.28428
RHOU ras homolog family member U 1.2833
LGALS9B lectin, galactoside-binding, soluble, 9B 1.28294
CDCA7L cell division cycle associated 7-like 1.28151
IL4R interleukin 4 receptor 1.27959
TOP3A topoisomerase (DNA) III alpha 1.2789
SMAD2 SMAD family member 2 1.27749
MOB1A MOB kinase activator 1A 1.27395
EMP3 epithelial membrane protein 3 1.27395
CYP4A22 cytochrome P450, family 4, subfamily A, polypeptide 22 1.27066
CD2 CD2 molecule 1.2686
HBEGF heparin-binding EGF-like growth factor 1.25935
SIX6 SIX homeobox 6 1.2538
GTPBP4 GTP binding protein 4 1.25201
MRPL30 mitochondrial ribosomal protein L30 1.24873
FAM60A family with sequence similarity 60, member A 1.24822
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 1.24621
HSPB8 heat shock 22kDa protein 8 1.24291
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 1.23987
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 1.23964
TMEM165 transmembrane protein 165 1.23802
UGDH UDP-glucose 6-dehydrogenase 1.23755
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.23745
ODC1 ornithine decarboxylase 1 1.23648
KIF1A kinesin family member 1A 1.23266
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 1.23077
ADRB2 adrenoceptor beta 2, surface 1.23031
USP24 ubiquitin specific peptidase 24 1.22906
GPN3 GPN-loop GTPase 3 1.22803
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 1.22746
ZNF688 zinc finger protein 688 1.22623
SARDH sarcosine dehydrogenase 1.22401
GDF15 growth differentiation factor 15 1.21694
EMP1 epithelial membrane protein 1 1.21595
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 1.20857
MIDN midnolin 1.20802
SNX6 sorting nexin 6 1.20728

decreased expression

Symbol Name Standardized Value
TPI1 triosephosphate isomerase 1 -4.07171
ITM2C integral membrane protein 2C -3.79426
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa -3.59657
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa -3.44272
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -3.41341
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial) -3.30578
CCT7 chaperonin containing TCP1, subunit 7 (eta) -3.17587
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -3.13786
SNX3 sorting nexin 3 -3.10979
AHCYL1 adenosylhomocysteinase-like 1 -3.06598
PKM pyruvate kinase, muscle -3.0557
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 -3.04957
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 -3.03796
ABHD16A abhydrolase domain containing 16A -3.01282
PABPN1 poly(A) binding protein, nuclear 1 -2.99079
GPS1 G protein pathway suppressor 1 -2.94494
KIF3C kinesin family member 3C -2.91283
YIPF5 Yip1 domain family, member 5 -2.89646
PGM1 phosphoglucomutase 1 -2.88608
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) -2.88432
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 -2.82762
NEURL4 neuralized E3 ubiquitin protein ligase 4 -2.81081
AP4S1 adaptor-related protein complex 4, sigma 1 subunit -2.80163
TRAPPC2L trafficking protein particle complex 2-like -2.76382
SON SON DNA binding protein -2.76218
NDUFB3 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa -2.7617
OSBPL1A oxysterol binding protein-like 1A -2.73064
ACOT7 acyl-CoA thioesterase 7 -2.72421
CHCHD10 coiled-coil-helix-coiled-coil-helix domain containing 10 -2.70389
NFS1 NFS1 cysteine desulfurase -2.70099
PUM2 pumilio RNA-binding family member 2 -2.60348
CDR2L cerebellar degeneration-related protein 2-like -2.57373
TMEM97 transmembrane protein 97 -2.5733
NAMPT nicotinamide phosphoribosyltransferase -2.56538
EML5 echinoderm microtubule associated protein like 5 -2.55669
PRDX5 peroxiredoxin 5 -2.50774
CDC123 cell division cycle 123 -2.49969
NPY neuropeptide Y -2.4975
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 -2.4936
PHKG1 phosphorylase kinase, gamma 1 (muscle) -2.48775
FKBP4 FK506 binding protein 4, 59kDa -2.48165
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent) -2.45793
ASNA1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) -2.43329
USP3 ubiquitin specific peptidase 3 -2.43139
LYSMD2 LysM, putative peptidoglycan-binding, domain containing 2 -2.43129
SAMM50 SAMM50 sorting and assembly machinery component -2.42232
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) -2.41972
TUBB4A tubulin, beta 4A class IVa -2.41881
NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) -2.40659
ALDOA aldolase A, fructose-bisphosphate -2.40426
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -2.40187
GTF2I general transcription factor IIi -2.39817
HPRT1 hypoxanthine phosphoribosyltransferase 1 -2.39614
MORF4L2 mortality factor 4 like 2 -2.39609
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -2.38059
SLU7 SLU7 splicing factor homolog (S. cerevisiae) -2.37808
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa -2.37739
MTSS1L metastasis suppressor 1-like -2.36321
C7ORF55 chromosome 7 open reading frame 55 -2.35846
PGK1 phosphoglycerate kinase 1 -2.3406
EHMT2 euchromatic histone-lysine N-methyltransferase 2 -2.33943
SMYD5 SMYD family member 5 -2.32317
GJB2 gap junction protein, beta 2, 26kDa -2.31168
SRP9 signal recognition particle 9kDa -2.30854
NEFH neurofilament, heavy polypeptide -2.30441
RAB3B RAB3B, member RAS oncogene family -2.29704
PPIA peptidylprolyl isomerase A (cyclophilin A) -2.29565
SLC4A3 solute carrier family 4 (anion exchanger), member 3 -2.29186
PYGM phosphorylase, glycogen, muscle -2.28037
CERK ceramide kinase -2.27886
GUK1 guanylate kinase 1 -2.27467
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.27324
LYPLA1 lysophospholipase I -2.26213
SOD1 superoxide dismutase 1, soluble -2.25798
AARS alanyl-tRNA synthetase -2.25464
FRYL FRY-like -2.25274
UBTF upstream binding transcription factor, RNA polymerase I -2.25146
ANGEL2 angel homolog 2 (Drosophila) -2.2471
MAP2K4 mitogen-activated protein kinase kinase 4 -2.22868
GHITM growth hormone inducible transmembrane protein -2.20701
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 -2.20683
CA2 carbonic anhydrase II -2.20511
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 -2.20231
SLC22A17 solute carrier family 22, member 17 -2.20087
GOLGA4 golgin A4 -2.17366
DSTN destrin (actin depolymerizing factor) -2.17269
DENND5A DENN/MADD domain containing 5A -2.1636
MRPS21 mitochondrial ribosomal protein S21 -2.16132
ADPRH ADP-ribosylarginine hydrolase -2.15787
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -2.15689
GDI1 GDP dissociation inhibitor 1 -2.15125
AP2A2 adaptor-related protein complex 2, alpha 2 subunit -2.14958
SIN3A SIN3 transcription regulator family member A -2.13619
FAM98A family with sequence similarity 98, member A -2.11678
RNF14 ring finger protein 14 -2.1135
ATXN10 ataxin 10 -2.10381
ANKRD46 ankyrin repeat domain 46 -2.10332
WDR75 WD repeat domain 75 -2.10219
CYC1 cytochrome c-1 -2.09807
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase -2.09489
RAB7A RAB7A, member RAS oncogene family -2.09203
CTSF cathepsin F -2.08057
CA4 carbonic anhydrase IV -2.07531
CAV1 caveolin 1, caveolae protein, 22kDa -2.06786
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -2.05357
CCNDBP1 cyclin D-type binding-protein 1 -2.04968
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 -2.02561
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa -2.02299
ERGIC3 ERGIC and golgi 3 -2.01316
GRIA1 glutamate receptor, ionotropic, AMPA 1 -2.0087
PACRG PARK2 co-regulated -2.00581
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 -2.00184
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta -1.99981
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide -1.99634
RAN RAN, member RAS oncogene family -1.99314
MYLK myosin light chain kinase -1.98906
MAPK6 mitogen-activated protein kinase 6 -1.9671
ADARB1 adenosine deaminase, RNA-specific, B1 -1.95421
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 -1.95302
NPDC1 neural proliferation, differentiation and control, 1 -1.94024
TSNAX translin-associated factor X -1.93674
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase -1.93501
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9 -1.92809
BSG basigin (Ok blood group) -1.92606
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -1.92356
COA3 cytochrome c oxidase assembly factor 3 -1.91625
SEC31A SEC31 homolog A (S. cerevisiae) -1.91016
FKBP2 FK506 binding protein 2, 13kDa -1.90375
INTS3 integrator complex subunit 3 -1.90362
TUBA4A tubulin, alpha 4a -1.90174
CDC42SE2 CDC42 small effector 2 -1.90089
PRDX2 peroxiredoxin 2 -1.90084
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa -1.90057
RPUSD3 RNA pseudouridylate synthase domain containing 3 -1.89708
EGLN1 egl-9 family hypoxia-inducible factor 1 -1.89483
EIF3D eukaryotic translation initiation factor 3, subunit D -1.89213
RPN1 ribophorin I -1.89126
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -1.88798
TMUB2 transmembrane and ubiquitin-like domain containing 2 -1.87868
GRK5 G protein-coupled receptor kinase 5 -1.87205
SFXN1 sideroflexin 1 -1.86572
MRPS28 mitochondrial ribosomal protein S28 -1.858
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 -1.85654
RND2 Rho family GTPase 2 -1.85202
GABARAPL1 GABA(A) receptor-associated protein like 1 -1.85085
SUMO1 small ubiquitin-like modifier 1 -1.84768
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -1.83585
SCP2 sterol carrier protein 2 -1.83205
MDK midkine (neurite growth-promoting factor 2) -1.83191
NTSR2 neurotensin receptor 2 -1.82912
CSDE1 cold shock domain containing E1, RNA-binding -1.82527
UPP2 uridine phosphorylase 2 -1.82243
TRH thyrotropin-releasing hormone -1.81897
FH fumarate hydratase -1.8185
ADGRL2 adhesion G protein-coupled receptor L2 -1.81645
CALB2 calbindin 2 -1.8149
GARS glycyl-tRNA synthetase -1.81339
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 -1.81049
VPRBP Vpr (HIV-1) binding protein -1.80854
ATG5 autophagy related 5 -1.8004
EPN1 epsin 1 -1.79833
THOC7 THO complex 7 -1.7981
MTOR mechanistic target of rapamycin (serine/threonine kinase) -1.79129
TH tyrosine hydroxylase -1.79122
OLFM1 olfactomedin 1 -1.77885
EIF5 eukaryotic translation initiation factor 5 -1.77847
METTL18 methyltransferase like 18 -1.77652
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -1.77315
MDH2 malate dehydrogenase 2, NAD (mitochondrial) -1.77105
MRPS36 mitochondrial ribosomal protein S36 -1.76953
DAP3 death associated protein 3 -1.76413
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide -1.76391
CORO1C coronin, actin binding protein, 1C -1.76221
RAD23B RAD23 homolog B (S. cerevisiae) -1.75578
SERF2 small EDRK-rich factor 2 -1.75373
NRSN1 neurensin 1 -1.75304
MOGS mannosyl-oligosaccharide glucosidase -1.74993
ADAM11 ADAM metallopeptidase domain 11 -1.74206
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -1.74203
SUMO3 small ubiquitin-like modifier 3 -1.7387
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -1.7239
SH3GL1 SH3-domain GRB2-like 1 -1.72234
CXORF38 chromosome X open reading frame 38 -1.71539
MAPT microtubule-associated protein tau -1.71515
MGLL monoglyceride lipase -1.71259
PLD3 phospholipase D family, member 3 -1.71121
LIN7B lin-7 homolog B (C. elegans) -1.70835
ISLR immunoglobulin superfamily containing leucine-rich repeat -1.70459
UBA2 ubiquitin-like modifier activating enzyme 2 -1.70388
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) -1.70209
DIO2 deiodinase, iodothyronine, type II -1.70024
DLG1 discs, large homolog 1 (Drosophila) -1.69794
UBA5 ubiquitin-like modifier activating enzyme 5 -1.69494
REPS1 RALBP1 associated Eps domain containing 1 -1.69185
ALDOC aldolase C, fructose-bisphosphate -1.68786
CHGB chromogranin B -1.68742
THRSP thyroid hormone responsive -1.6859
CHGA chromogranin A -1.6839
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 -1.68248
KCTD12 potassium channel tetramerization domain containing 12 -1.68164
PKP4 plakophilin 4 -1.67855
COPE coatomer protein complex, subunit epsilon -1.6713
ELOVL6 ELOVL fatty acid elongase 6 -1.67129
OCIAD1 OCIA domain containing 1 -1.6654
MYH14 myosin, heavy chain 14, non-muscle -1.66389
STIM1 stromal interaction molecule 1 -1.6556
CD47 CD47 molecule -1.65541
PTPRM protein tyrosine phosphatase, receptor type, M -1.64478
FAM103A1 family with sequence similarity 103, member A1 -1.6423
NDUFV3 NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa -1.63801
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit -1.63657
RAB4B RAB4B, member RAS oncogene family -1.6363
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25 -1.6323
AIP aryl hydrocarbon receptor interacting protein -1.63156
PNKD paroxysmal nonkinesigenic dyskinesia -1.62712
RNF5 ring finger protein 5, E3 ubiquitin protein ligase -1.62541
C9ORF114 chromosome 9 open reading frame 114 -1.62484
WNK2 WNK lysine deficient protein kinase 2 -1.62064
MTX2 metaxin 2 -1.61753
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -1.61593
AK4 adenylate kinase 4 -1.61238
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa -1.61223
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H -1.61192
PCLO piccolo presynaptic cytomatrix protein -1.60997
PSAP prosaposin -1.60864
FKBP1A FK506 binding protein 1A, 12kDa -1.60744
TMEM167A transmembrane protein 167A -1.60661
RECQL RecQ helicase-like -1.60483
RAMP1 receptor (G protein-coupled) activity modifying protein 1 -1.59758
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -1.59513
INPP5J inositol polyphosphate-5-phosphatase J -1.5918
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha -1.58906
USP5 ubiquitin specific peptidase 5 (isopeptidase T) -1.58905
ORC6 origin recognition complex, subunit 6 -1.58177
STARD10 StAR-related lipid transfer (START) domain containing 10 -1.58011
PGAM1 phosphoglycerate mutase 1 (brain) -1.58007
SNAP25 synaptosomal-associated protein, 25kDa -1.57927
ARF1 ADP-ribosylation factor 1 -1.57704
UBLCP1 ubiquitin-like domain containing CTD phosphatase 1 -1.57692
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -1.57578
SCN1B sodium channel, voltage gated, type I beta subunit -1.56324
CRY2 cryptochrome circadian clock 2 -1.55968
SMAP2 small ArfGAP2 -1.55773
ABHD8 abhydrolase domain containing 8 -1.55689
RAB3IP RAB3A interacting protein -1.55591
ELMOD3 ELMO/CED-12 domain containing 3 -1.55128
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 -1.55021
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -1.55005
FADS1 fatty acid desaturase 1 -1.54793
SARNP SAP domain containing ribonucleoprotein -1.54648
NTAN1 N-terminal asparagine amidase -1.54339
MKRN2 makorin ring finger protein 2 -1.54317
ZMYM4 zinc finger, MYM-type 4 -1.5408
SUCLG1 succinate-CoA ligase, alpha subunit -1.53194
PRNP prion protein -1.53085
DGUOK deoxyguanosine kinase -1.53069
GLUL glutamate-ammonia ligase -1.52882
EIF3C eukaryotic translation initiation factor 3, subunit C -1.52758
ADGRB1 adhesion G protein-coupled receptor B1 -1.52461
STX6 syntaxin 6 -1.52427
LTBP4 latent transforming growth factor beta binding protein 4 -1.51926
CUL4A cullin 4A -1.51761
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma -1.51518
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa -1.51442
GLRX glutaredoxin (thioltransferase) -1.51415
MAP2K5 mitogen-activated protein kinase kinase 5 -1.51311
DTYMK deoxythymidylate kinase (thymidylate kinase) -1.51214
WTAP Wilms tumor 1 associated protein -1.50334
RPP21 ribonuclease P/MRP 21kDa subunit -1.50221
HSPD1 heat shock 60kDa protein 1 (chaperonin) -1.50174
ERMP1 endoplasmic reticulum metallopeptidase 1 -1.50088
CIITA class II, major histocompatibility complex, transactivator -1.49933
ACO2 aconitase 2, mitochondrial -1.49478
CDC37 cell division cycle 37 -1.4937
PREPL prolyl endopeptidase-like -1.49118
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) -1.49036
AAMP angio-associated, migratory cell protein -1.48989
WBP5 WW domain binding protein 5 -1.48602
ROGDI rogdi homolog (Drosophila) -1.48284
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -1.48244
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha -1.48174
SIPA1L2 signal-induced proliferation-associated 1 like 2 -1.47627
IGF1 insulin-like growth factor 1 (somatomedin C) -1.47369
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit -1.47355
ENSA endosulfine alpha -1.46368
NICN1 nicolin 1 -1.463
RYR3 ryanodine receptor 3 -1.45882
COX7A2 cytochrome c oxidase subunit VIIa polypeptide 2 (liver) -1.45859
HINT2 histidine triad nucleotide binding protein 2 -1.45696
CTNND1 catenin (cadherin-associated protein), delta 1 -1.45231
RAF1 Raf-1 proto-oncogene, serine/threonine kinase -1.44215
RNASEK ribonuclease, RNase K -1.43916
TMEM38B transmembrane protein 38B -1.43892
VPS25 vacuolar protein sorting 25 homolog (S. cerevisiae) -1.43889
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -1.43647
MTX1 metaxin 1 -1.43419
FGFR1OP2 FGFR1 oncogene partner 2 -1.43415
RAB5A RAB5A, member RAS oncogene family -1.43407
ATP9A ATPase, class II, type 9A -1.43298
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10 -1.43134