Alexithymia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description An agnosia that is a deficiency in understanding, processing, or describing emotions. (Human Disease Ontology, DOID_0060131)
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Genes

122 genes co-occuring with the disease Alexithymia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
OXT oxytocin/neurophysin I prepropeptide 2.801
TMEM88B transmembrane protein 88B 2.485
OSTF1 osteoclast stimulating factor 1 2.451
OXTR oxytocin receptor 2.321
ANKK1 ankyrin repeat and kinase domain containing 1 2.235
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.225
COMT catechol-O-methyltransferase 2.096
POLI polymerase (DNA directed) iota 2.082
SRSF10 serine/arginine-rich splicing factor 10 2.062
DRD2 dopamine receptor D2 2.04
PIR pirin (iron-binding nuclear protein) 1.998
CRH corticotropin releasing hormone 1.968
BDNF brain-derived neurotrophic factor 1.933
PDYN prodynorphin 1.89
ARHGAP32 Rho GTPase activating protein 32 1.855
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 1.801
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.79
CRP C-reactive protein, pentraxin-related 1.748
POMC proopiomelanocortin 1.74
ZNF235 zinc finger protein 235 1.719
CPZ carboxypeptidase Z 1.681
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1 1.66
IL6 interleukin 6 1.625
CRHR1 corticotropin releasing hormone receptor 1 1.608
MAOA monoamine oxidase A 1.577
ACE angiotensin I converting enzyme 1.524
LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 1.52
DRD4 dopamine receptor D4 1.517
LVRN laeverin 1.498
CRHR2 corticotropin releasing hormone receptor 2 1.489
TNF tumor necrosis factor 1.481
NPY neuropeptide Y 1.478
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.474
SOS1 son of sevenless homolog 1 (Drosophila) 1.4
OPRM1 opioid receptor, mu 1 1.397
TAC1 tachykinin, precursor 1 1.384
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 1.378
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 1.375
IL1B interleukin 1, beta 1.374
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 1.366
INS insulin 1.363
HCRT hypocretin (orexin) neuropeptide precursor 1.36
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 1.358
RCC2 regulator of chromosome condensation 2 1.347
GPSM2 G-protein signaling modulator 2 1.343
NPIPA5 nuclear pore complex interacting protein family, member A5 1.327
AVPR1A arginine vasopressin receptor 1A 1.325
ARMCX3 armadillo repeat containing, X-linked 3 1.324
H1-1 H1.1 linker histone, cluster member 1.309
RTN4 reticulon 4 1.302
PNOC prepronociceptin 1.302
GHRL ghrelin/obestatin prepropeptide 1.29
HSH2D hematopoietic SH2 domain containing 1.283
CSE1L CSE1 chromosome segregation 1-like (yeast) 1.27
AFF1 AF4/FMR2 family, member 1 1.266
SHOC2 soc-2 suppressor of clear homolog (C. elegans) 1.264
ARMCX2 armadillo repeat containing, X-linked 2 1.263
CELF4 CUGBP, Elav-like family member 4 1.262
AMY1B amylase, alpha 1B (salivary) 1.261
MAOB monoamine oxidase B 1.26
NPIPB11 nuclear pore complex interacting protein family, member B11 1.253
TPH2 tryptophan hydroxylase 2 1.238
IL2 interleukin 2 1.236
CPT2 carnitine palmitoyltransferase 2 1.236
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 1.227
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 1.221
TAS2R38 taste receptor, type 2, member 38 1.218
PTPN11 protein tyrosine phosphatase, non-receptor type 11 1.218
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 1.211
IL10 interleukin 10 1.2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.195
IL4 interleukin 4 1.194
NPIPA2 nuclear pore complex interacting protein family, member A2 1.177
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 1.175
LEP leptin 1.174
CRHBP corticotropin releasing hormone binding protein 1.17
C12ORF57 chromosome 12 open reading frame 57 1.16
PTGIS prostaglandin I2 (prostacyclin) synthase 1.156
CD4 CD4 molecule 1.155
GLS2 glutaminase 2 (liver, mitochondrial) 1.149
HBA1 hemoglobin, alpha 1 1.146
LZTR1 leucine-zipper-like transcription regulator 1 1.144
ARMCX1 armadillo repeat containing, X-linked 1 1.144
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 1.135
H1-5 H1.5 linker histone, cluster member 1.134
FKBP5 FK506 binding protein 5 1.131
HBA2 hemoglobin, alpha 2 1.124
SCX scleraxis basic helix-loop-helix transcription factor 1.124
AVEN apoptosis, caspase activation inhibitor 1.117
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 1.112
PRL prolactin 1.111
OPRD1 opioid receptor, delta 1 1.11
HBD hemoglobin, delta 1.11
PRDM12 PR domain containing 12 1.108
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 1.101
SHANK3 SH3 and multiple ankyrin repeat domains 3 1.092
NELFCD negative elongation factor complex member C/D 1.083
XKR6 XK, Kell blood group complex subunit-related family, member 6 1.078
H1-2 H1.2 linker histone, cluster member 1.075
KLK4 kallikrein-related peptidase 4 1.074
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 1.074
IL18 interleukin 18 1.074
A2ML1 alpha-2-macroglobulin-like 1 1.07
SENP7 SUMO1/sentrin specific peptidase 7 1.068
CBX8 chromobox homolog 8 1.062
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 1.057
RD3 retinal degeneration 3 1.052
SOS2 son of sevenless homolog 2 (Drosophila) 1.047
GC group-specific component (vitamin D binding protein) 1.046
PRB1 proline-rich protein BstNI subfamily 1 1.042
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 1.042
AVPR1B arginine vasopressin receptor 1B 1.04
TCF20 transcription factor 20 (AR1) 1.036
FAF2 Fas associated factor family member 2 1.035
SCOC short coiled-coil protein 1.019
CXCL8 chemokine (C-X-C motif) ligand 8 1.017
TRIM25 tripartite motif containing 25 1.012
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 1.01
PLXNA2 plexin A2 1.007
AVP arginine vasopressin 1.006
H2AC20 H2A clustered histone 20 1.005
H2AC18 H2A clustered histone 18 1.004