| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A tetrahydrofuranol that has formula C19H27N5O4. (Chemical Entities of Biological Interest Ontology, CHEBI_51141) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/2092 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Alfuzosin relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| C7 | complement component 7 | 0.87 |
| SLC16A10 | solute carrier family 16 (aromatic amino acid transporter), member 10 | 0.83 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | 0.69 |
| RWDD2B | RWD domain containing 2B | 0.56 |
| C1ORF50 | chromosome 1 open reading frame 50 | 0.54 |
| ARID3B | AT rich interactive domain 3B (BRIGHT-like) | 0.46 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.45 |
| B2M | beta-2-microglobulin | 0.43 |
| AKT1S1 | AKT1 substrate 1 (proline-rich) | 0.42 |
| EGR1 | early growth response 1 | 0.4 |
| MED29 | mediator complex subunit 29 | 0.4 |
| MED22 | mediator complex subunit 22 | 0.39 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.39 |
| KRT222 | keratin 222, type II | 0.38 |
| ACOT8 | acyl-CoA thioesterase 8 | 0.38 |
| MFAP3 | microfibrillar-associated protein 3 | 0.38 |
| EED | embryonic ectoderm development | 0.37 |
| TRAF3 | TNF receptor-associated factor 3 | 0.36 |
| TMEM64 | transmembrane protein 64 | 0.35 |
| RUFY3 | RUN and FYVE domain containing 3 | 0.35 |
| SP100 | SP100 nuclear antigen | 0.34 |
| FURIN | furin (paired basic amino acid cleaving enzyme) | 0.34 |
| STK33 | serine/threonine kinase 33 | 0.33 |
| NDEL1 | nudE neurodevelopment protein 1-like 1 | 0.33 |
| E2F8 | E2F transcription factor 8 | 0.32 |
| XBP1 | X-box binding protein 1 | 0.32 |
| HOXA10 | homeobox A10 | 0.32 |
| DNAJB5 | DnaJ (Hsp40) homolog, subfamily B, member 5 | 0.31 |
| CLN3 | ceroid-lipofuscinosis, neuronal 3 | 0.31 |
| HIST3H2BB | histone cluster 3, H2bb | 0.31 |
| UQCRH | ubiquinol-cytochrome c reductase hinge protein | 0.31 |
| SRGAP3 | SLIT-ROBO Rho GTPase activating protein 3 | 0.3 |
| NDUFB8 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa | 0.3 |
| PDZD11 | PDZ domain containing 11 | 0.3 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.29 |
| C12ORF57 | chromosome 12 open reading frame 57 | 0.29 |
| FAM171A2 | family with sequence similarity 171, member A2 | 0.29 |
| ZNF628 | zinc finger protein 628 | 0.29 |
| ENDOV | endonuclease V | 0.29 |
| ZNF623 | zinc finger protein 623 | 0.28 |
| LSM3 | LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.28 |
| ERVK3-1 | endogenous retrovirus group K3, member 1 | 0.27 |
| CENPP | centromere protein P | 0.27 |
| ESAM | endothelial cell adhesion molecule | 0.27 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.27 |
| DESI1 | desumoylating isopeptidase 1 | 0.27 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.26 |
| SCLT1 | sodium channel and clathrin linker 1 | 0.26 |
| PIM3 | Pim-3 proto-oncogene, serine/threonine kinase | 0.25 |
| GSE1 | Gse1 coiled-coil protein | 0.25 |
| NECAB3 | N-terminal EF-hand calcium binding protein 3 | 0.25 |
| CNIH4 | cornichon family AMPA receptor auxiliary protein 4 | 0.25 |
| HSPA8 | heat shock 70kDa protein 8 | 0.25 |
| USP53 | ubiquitin specific peptidase 53 | 0.25 |
| SEZ6L2 | seizure related 6 homolog (mouse)-like 2 | 0.25 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 0.25 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.25 |
| ABCA12 | ATP-binding cassette, sub-family A (ABC1), member 12 | 0.25 |
| PDE5A | phosphodiesterase 5A, cGMP-specific | 0.25 |
| POTEE | POTE ankyrin domain family, member E | 0.25 |
| BLOC1S5 | biogenesis of lysosomal organelles complex-1, subunit 5, muted | 0.24 |
| CBR3 | carbonyl reductase 3 | 0.24 |
| SGCB | sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) | 0.24 |
| ABLIM3 | actin binding LIM protein family, member 3 | 0.24 |
| FKRP | fukutin related protein | 0.24 |
| SLC16A7 | solute carrier family 16 (monocarboxylate transporter), member 7 | 0.24 |
| LAMA5 | laminin, alpha 5 | 0.24 |
| ZFP64 | ZFP64 zinc finger protein | 0.23 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | 0.23 |
| STMN2 | stathmin 2 | 0.23 |
| ENY2 | enhancer of yellow 2 homolog (Drosophila) | 0.23 |
| DST | dystonin | 0.23 |
| EFCAB7 | EF-hand calcium binding domain 7 | 0.22 |
| ZNF436 | zinc finger protein 436 | 0.22 |
| METTL22 | methyltransferase like 22 | 0.22 |
| CDC37 | cell division cycle 37 | 0.22 |
| MYOM2 | myomesin 2 | 0.22 |
| SEMA4D | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | 0.21 |
| BTBD7 | BTB (POZ) domain containing 7 | 0.21 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 0.21 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.21 |
| FAT3 | FAT atypical cadherin 3 | 0.21 |
| GLI2 | GLI family zinc finger 2 | 0.21 |
| FAM135B | family with sequence similarity 135, member B | 0.21 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.21 |
| ALKBH5 | AlkB family member 5, RNA demethylase | 0.21 |
| TM7SF3 | transmembrane 7 superfamily member 3 | 0.21 |
| TWF1 | twinfilin actin binding protein 1 | 0.21 |
| DCTD | dCMP deaminase | 0.21 |
| APBA3 | amyloid beta (A4) precursor protein-binding, family A, member 3 | 0.2 |
| MARCKSL1 | MARCKS-like 1 | 0.2 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | 0.2 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | 0.2 |
| ENTPD7 | ectonucleoside triphosphate diphosphohydrolase 7 | 0.2 |
| MTM1 | myotubularin 1 | 0.2 |
| COL2A1 | collagen, type II, alpha 1 | 0.2 |
| NOTCH3 | notch 3 | 0.2 |
| FSIP2 | fibrous sheath interacting protein 2 | 0.2 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.2 |
| C12ORF73 | chromosome 12 open reading frame 73 | 0.2 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SBSN | suprabasin | -2.5 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -2.0 |
| EPHA4 | EPH receptor A4 | -1.84 |
| CELSR3 | cadherin, EGF LAG seven-pass G-type receptor 3 | -1.49 |
| TUB | tubby bipartite transcription factor | -1.35 |
| NEIL1 | nei endonuclease VIII-like 1 (E. coli) | -1.29 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -1.04 |
| PRAME | preferentially expressed antigen in melanoma | -1.03 |
| FAM241B | family with sequence similarity 241 member B | -0.98 |
| PIP | prolactin-induced protein | -0.87 |
| ANKRD18B | ankyrin repeat domain 18B | -0.76 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.73 |
| PISD | phosphatidylserine decarboxylase | -0.71 |
| ZNF12 | zinc finger protein 12 | -0.68 |
| KMT5C | lysine methyltransferase 5C | -0.67 |
| PTPN18 | protein tyrosine phosphatase, non-receptor type 18 (brain-derived) | -0.64 |
| SLC41A3 | solute carrier family 41, member 3 | -0.64 |
| SLC6A17 | solute carrier family 6 (neutral amino acid transporter), member 17 | -0.64 |
| GPR161 | G protein-coupled receptor 161 | -0.64 |
| C5 | complement component 5 | -0.6 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.58 |
| FBXW2 | F-box and WD repeat domain containing 2 | -0.58 |
| FTL | ferritin, light polypeptide | -0.54 |
| COL6A3 | collagen, type VI, alpha 3 | -0.51 |
| INPP5J | inositol polyphosphate-5-phosphatase J | -0.51 |
| DNAJC22 | DnaJ (Hsp40) homolog, subfamily C, member 22 | -0.5 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.49 |
| ADCY6 | adenylate cyclase 6 | -0.48 |
| TPK1 | thiamin pyrophosphokinase 1 | -0.46 |
| PRELID3B | PRELI domain containing 3B | -0.46 |
| ZNF337 | zinc finger protein 337 | -0.46 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.45 |
| LRP4 | low density lipoprotein receptor-related protein 4 | -0.45 |
| SBNO2 | strawberry notch homolog 2 (Drosophila) | -0.45 |
| GJC1 | gap junction protein, gamma 1, 45kDa | -0.43 |
| LAMA2 | laminin, alpha 2 | -0.43 |
| KLHL29 | kelch-like family member 29 | -0.41 |
| GPRC5C | G protein-coupled receptor, class C, group 5, member C | -0.41 |
| CDCA4 | cell division cycle associated 4 | -0.41 |
| SPIN4 | spindlin family, member 4 | -0.4 |
| ZNF76 | zinc finger protein 76 | -0.4 |
| LYSMD3 | LysM, putative peptidoglycan-binding, domain containing 3 | -0.4 |
| CMPK2 | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial | -0.4 |
| UNC93B1 | unc-93 homolog B1 (C. elegans) | -0.4 |
| GRK3 | G protein-coupled receptor kinase 3 | -0.39 |
| ALDH8A1 | aldehyde dehydrogenase 8 family, member A1 | -0.39 |
| IL17RB | interleukin 17 receptor B | -0.39 |
| GXYLT1 | glucoside xylosyltransferase 1 | -0.39 |
| C15ORF41 | chromosome 15 open reading frame 41 | -0.38 |
| CCAR2 | cell cycle and apoptosis regulator 2 | -0.38 |
| DOLK | dolichol kinase | -0.38 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | -0.38 |
| SP140 | SP140 nuclear body protein | -0.38 |
| RNF19B | ring finger protein 19B | -0.37 |
| HTT | huntingtin | -0.36 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.36 |
| KCTD2 | potassium channel tetramerization domain containing 2 | -0.36 |
| ARL8A | ADP-ribosylation factor-like 8A | -0.36 |
| ATF1 | activating transcription factor 1 | -0.35 |
| CCDC32 | coiled-coil domain containing 32 | -0.34 |
| BCAS2 | breast carcinoma amplified sequence 2 | -0.34 |
| STARD10 | StAR-related lipid transfer (START) domain containing 10 | -0.34 |
| TASP1 | taspase, threonine aspartase, 1 | -0.34 |
| SLC35F3 | solute carrier family 35, member F3 | -0.34 |
| PDK1 | pyruvate dehydrogenase kinase, isozyme 1 | -0.34 |
| NAGS | N-acetylglutamate synthase | -0.33 |
| SLC27A6 | solute carrier family 27 (fatty acid transporter), member 6 | -0.33 |
| MYO15A | myosin XVA | -0.33 |
| TUBB4A | tubulin, beta 4A class IVa | -0.33 |
| MCOLN3 | mucolipin 3 | -0.33 |
| NSUN3 | NOP2/Sun domain family, member 3 | -0.32 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | -0.32 |
| CCDC167 | coiled-coil domain containing 167 | -0.32 |
| FKBPL | FK506 binding protein like | -0.31 |
| HTD2 | hydroxyacyl-thioester dehydratase type 2 | -0.31 |
| ABAT | 4-aminobutyrate aminotransferase | -0.31 |
| CCND3 | cyclin D3 | -0.31 |
| OIP5 | Opa interacting protein 5 | -0.31 |
| YIPF6 | Yip1 domain family, member 6 | -0.31 |
| GNAZ | guanine nucleotide binding protein (G protein), alpha z polypeptide | -0.31 |
| SLC16A6 | solute carrier family 16, member 6 | -0.31 |
| MFSD8 | major facilitator superfamily domain containing 8 | -0.3 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.3 |
| GPN3 | GPN-loop GTPase 3 | -0.3 |
| CERK | ceramide kinase | -0.3 |
| WDR7 | WD repeat domain 7 | -0.3 |
| CACNB3 | calcium channel, voltage-dependent, beta 3 subunit | -0.3 |
| STEAP2 | STEAP family member 2, metalloreductase | -0.29 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.29 |
| TCEAL8 | transcription elongation factor A (SII)-like 8 | -0.29 |
| PTGES | prostaglandin E synthase | -0.29 |
| TEX30 | testis expressed 30 | -0.29 |
| ARGLU1 | arginine and glutamate rich 1 | -0.29 |
| PLEKHG6 | pleckstrin homology domain containing, family G (with RhoGef domain) member 6 | -0.29 |
| PRG4 | proteoglycan 4 | -0.29 |
| NHP2 | NHP2 ribonucleoprotein | -0.29 |
| ZBED6 | zinc finger, BED-type containing 6 | -0.29 |
| PIK3CD | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta | -0.29 |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | -0.29 |
| C8ORF37 | chromosome 8 open reading frame 37 | -0.28 |
