| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5493444 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Aliskiren relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CD63 | CD63 molecule | 0.93 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.76 |
| ENO1 | enolase 1, (alpha) | 0.59 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | 0.56 |
| RAD9A | RAD9 homolog A (S. pombe) | 0.54 |
| MID1IP1 | MID1 interacting protein 1 | 0.5 |
| SLC17A5 | solute carrier family 17 (acidic sugar transporter), member 5 | 0.49 |
| SETD5 | SET domain containing 5 | 0.46 |
| EPDR1 | ependymin related 1 | 0.43 |
| ZNF646 | zinc finger protein 646 | 0.42 |
| FAM161A | family with sequence similarity 161, member A | 0.4 |
| CYB5A | cytochrome b5 type A (microsomal) | 0.4 |
| CC2D2A | coiled-coil and C2 domain containing 2A | 0.39 |
| TATDN2 | TatD DNase domain containing 2 | 0.39 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.38 |
| ATP6V0D1 | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 | 0.37 |
| KIF21B | kinesin family member 21B | 0.37 |
| KLF13 | Kruppel-like factor 13 | 0.37 |
| ZNF483 | zinc finger protein 483 | 0.37 |
| DUSP5 | dual specificity phosphatase 5 | 0.36 |
| PGLS | 6-phosphogluconolactonase | 0.35 |
| ARHGEF37 | Rho guanine nucleotide exchange factor (GEF) 37 | 0.35 |
| SELENBP1 | selenium binding protein 1 | 0.33 |
| RPE | ribulose-5-phosphate-3-epimerase | 0.33 |
| PLA2G6 | phospholipase A2, group VI (cytosolic, calcium-independent) | 0.32 |
| LIPH | lipase, member H | 0.32 |
| COPS4 | COP9 signalosome subunit 4 | 0.32 |
| TIMM23 | translocase of inner mitochondrial membrane 23 homolog (yeast) | 0.32 |
| COX10 | COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor | 0.31 |
| MMACHC | methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria | 0.3 |
| COPZ1 | coatomer protein complex, subunit zeta 1 | 0.3 |
| COMMD3 | COMM domain containing 3 | 0.3 |
| FKBP7 | FK506 binding protein 7 | 0.3 |
| KCTD17 | potassium channel tetramerization domain containing 17 | 0.3 |
| FBXO41 | F-box protein 41 | 0.3 |
| ANAPC10 | anaphase promoting complex subunit 10 | 0.3 |
| SH2B1 | SH2B adaptor protein 1 | 0.3 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | 0.29 |
| RBX1 | ring-box 1, E3 ubiquitin protein ligase | 0.29 |
| ASNSD1 | asparagine synthetase domain containing 1 | 0.29 |
| LYPLA2 | lysophospholipase II | 0.29 |
| UNC13D | unc-13 homolog D (C. elegans) | 0.28 |
| BLOC1S2 | biogenesis of lysosomal organelles complex-1, subunit 2 | 0.28 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | 0.28 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.27 |
| ENTR1 | endosome associated trafficking regulator 1 | 0.27 |
| COPE | coatomer protein complex, subunit epsilon | 0.27 |
| TCEAL4 | transcription elongation factor A (SII)-like 4 | 0.27 |
| BLOC1S1 | biogenesis of lysosomal organelles complex-1, subunit 1 | 0.26 |
| BRK1 | BRICK1, SCAR/WAVE actin-nucleating complex subunit | 0.26 |
| B4GALT3 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 | 0.26 |
| ELOB | elongin B | 0.25 |
| ZNF691 | zinc finger protein 691 | 0.25 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.25 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.25 |
| CTSA | cathepsin A | 0.25 |
| ZNF511 | zinc finger protein 511 | 0.25 |
| MUS81 | MUS81 structure-specific endonuclease subunit | 0.24 |
| CCNE2 | cyclin E2 | 0.23 |
| TMEM135 | transmembrane protein 135 | 0.23 |
| IFI35 | interferon-induced protein 35 | 0.23 |
| KDM8 | lysine (K)-specific demethylase 8 | 0.23 |
| ABCD1 | ATP-binding cassette, sub-family D (ALD), member 1 | 0.23 |
| PLPP2 | phospholipid phosphatase 2 | 0.23 |
| RARA | retinoic acid receptor, alpha | 0.23 |
| PPT2 | palmitoyl-protein thioesterase 2 | 0.23 |
| TMEM104 | transmembrane protein 104 | 0.22 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.22 |
| PGRMC1 | progesterone receptor membrane component 1 | 0.22 |
| ATL1 | atlastin GTPase 1 | 0.22 |
| PIMREG | PICALM interacting mitotic regulator | 0.22 |
| C1ORF226 | chromosome 1 open reading frame 226 | 0.22 |
| DGAT1 | diacylglycerol O-acyltransferase 1 | 0.22 |
| GRAMD1A | GRAM domain containing 1A | 0.22 |
| MMAA | methylmalonic aciduria (cobalamin deficiency) cblA type | 0.22 |
| ARL13B | ADP-ribosylation factor-like 13B | 0.21 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.21 |
| SIDT2 | SID1 transmembrane family, member 2 | 0.21 |
| ANAPC11 | anaphase promoting complex subunit 11 | 0.21 |
| TM7SF3 | transmembrane 7 superfamily member 3 | 0.21 |
| VPS37C | vacuolar protein sorting 37 homolog C (S. cerevisiae) | 0.21 |
| POLQ | polymerase (DNA directed), theta | 0.21 |
| THAP1 | THAP domain containing, apoptosis associated protein 1 | 0.21 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.21 |
| ROGDI | rogdi homolog (Drosophila) | 0.21 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | 0.21 |
| TIMM8A | translocase of inner mitochondrial membrane 8 homolog A (yeast) | 0.2 |
| RPGR | retinitis pigmentosa GTPase regulator | 0.2 |
| POLR1D | polymerase (RNA) I polypeptide D, 16kDa | 0.2 |
| SLC25A21 | solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 | 0.2 |
| CERS5 | ceramide synthase 5 | 0.2 |
| MAN2B2 | mannosidase, alpha, class 2B, member 2 | 0.2 |
| CLPP | caseinolytic mitochondrial matrix peptidase proteolytic subunit | 0.2 |
| YDJC | YdjC homolog (bacterial) | 0.2 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 0.2 |
| SLC12A5 | solute carrier family 12 (potassium/chloride transporter), member 5 | 0.2 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.2 |
| PRDM2 | PR domain containing 2, with ZNF domain | 0.2 |
| CDC37L1 | cell division cycle 37-like 1 | 0.19 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ABCA13 | ATP-binding cassette, sub-family A (ABC1), member 13 | -2.83 |
| ALPK3 | alpha-kinase 3 | -1.41 |
| UBE2G2 | ubiquitin-conjugating enzyme E2G 2 | -1.2 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.98 |
| DTNA | dystrobrevin, alpha | -0.9 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -0.83 |
| UNC80 | unc-80 homolog (C. elegans) | -0.73 |
| FAR2 | fatty acyl CoA reductase 2 | -0.7 |
| MYO3A | myosin IIIA | -0.54 |
| BRD8 | bromodomain containing 8 | -0.53 |
| RIN3 | Ras and Rab interactor 3 | -0.53 |
| ZRSR2 | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 | -0.49 |
| TJP1 | tight junction protein 1 | -0.48 |
| FAM89A | family with sequence similarity 89, member A | -0.47 |
| DIPK1A | divergent protein kinase domain 1A | -0.44 |
| RGL3 | ral guanine nucleotide dissociation stimulator-like 3 | -0.44 |
| SNX10 | sorting nexin 10 | -0.43 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.43 |
| RMND5B | required for meiotic nuclear division 5 homolog B (S. cerevisiae) | -0.43 |
| ZBTB39 | zinc finger and BTB domain containing 39 | -0.42 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.41 |
| ELL3 | elongation factor RNA polymerase II-like 3 | -0.4 |
| HSPA1L | heat shock 70kDa protein 1-like | -0.4 |
| FAM122A | family with sequence similarity 122A | -0.39 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.38 |
| METTL25 | methyltransferase like 25 | -0.38 |
| CCDC127 | coiled-coil domain containing 127 | -0.38 |
| GATA6 | GATA binding protein 6 | -0.38 |
| RBPJL | recombination signal binding protein for immunoglobulin kappa J region-like | -0.37 |
| ATXN1L | ataxin 1-like | -0.37 |
| FAM13A | family with sequence similarity 13, member A | -0.37 |
| TMEM185B | transmembrane protein 185B | -0.36 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.36 |
| MLST8 | MTOR associated protein, LST8 homolog (S. cerevisiae) | -0.36 |
| DENND1A | DENN/MADD domain containing 1A | -0.35 |
| DOLPP1 | dolichyldiphosphatase 1 | -0.34 |
| HECA | headcase homolog (Drosophila) | -0.34 |
| CRTC3 | CREB regulated transcription coactivator 3 | -0.34 |
| PACC1 | proton activated chloride channel 1 | -0.34 |
| AURKAIP1 | aurora kinase A interacting protein 1 | -0.34 |
| FKBP1A | FK506 binding protein 1A, 12kDa | -0.33 |
| CCNE1 | cyclin E1 | -0.33 |
| SETD6 | SET domain containing 6 | -0.33 |
| NAT14 | N-acetyltransferase 14 (GCN5-related, putative) | -0.33 |
| PLCD1 | phospholipase C, delta 1 | -0.32 |
| SSH2 | slingshot protein phosphatase 2 | -0.32 |
| NFKBIL1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 | -0.32 |
| ANKRD13B | ankyrin repeat domain 13B | -0.32 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.32 |
| ABCD4 | ATP-binding cassette, sub-family D (ALD), member 4 | -0.31 |
| RHOB | ras homolog family member B | -0.31 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | -0.31 |
| USP48 | ubiquitin specific peptidase 48 | -0.31 |
| SLC38A9 | solute carrier family 38, member 9 | -0.31 |
| DIABLO | diablo, IAP-binding mitochondrial protein | -0.3 |
| METTL7A | methyltransferase like 7A | -0.3 |
| CRYM | crystallin, mu | -0.3 |
| BAIAP2 | BAI1-associated protein 2 | -0.3 |
| DCAF4 | DDB1 and CUL4 associated factor 4 | -0.3 |
| TMEM200A | transmembrane protein 200A | -0.3 |
| FAAH | fatty acid amide hydrolase | -0.3 |
| FBRSL1 | fibrosin-like 1 | -0.3 |
| LPIN1 | lipin 1 | -0.3 |
| ZNF267 | zinc finger protein 267 | -0.29 |
| TRIM13 | tripartite motif containing 13 | -0.29 |
| SPRYD3 | SPRY domain containing 3 | -0.29 |
| AMN1 | antagonist of mitotic exit network 1 homolog (S. cerevisiae) | -0.29 |
| RMI2 | RecQ mediated genome instability 2 | -0.29 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.29 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.29 |
| ELK1 | ELK1, member of ETS oncogene family | -0.29 |
| AMDHD1 | amidohydrolase domain containing 1 | -0.29 |
| SUCO | SUN domain containing ossification factor | -0.28 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.28 |
| VMP1 | vacuole membrane protein 1 | -0.28 |
| UPF3A | UPF3 regulator of nonsense transcripts homolog A (yeast) | -0.28 |
| NUDT18 | nudix (nucleoside diphosphate linked moiety X)-type motif 18 | -0.27 |
| C20ORF194 | chromosome 20 open reading frame 194 | -0.27 |
| CEP120 | centrosomal protein 120kDa | -0.27 |
| GNPTG | N-acetylglucosamine-1-phosphate transferase, gamma subunit | -0.27 |
| FAM199X | family with sequence similarity 199, X-linked | -0.27 |
| SLC25A28 | solute carrier family 25 (mitochondrial iron transporter), member 28 | -0.27 |
| PLEC | plectin | -0.27 |
| TBC1D17 | TBC1 domain family, member 17 | -0.27 |
| TSSC4 | tumor suppressing subtransferable candidate 4 | -0.26 |
| RCN2 | reticulocalbin 2, EF-hand calcium binding domain | -0.26 |
| PMS1 | PMS1 postmeiotic segregation increased 1 (S. cerevisiae) | -0.26 |
| TAF1L | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like | -0.26 |
| ROR1 | receptor tyrosine kinase-like orphan receptor 1 | -0.26 |
| PRSS8 | protease, serine, 8 | -0.26 |
| PRG4 | proteoglycan 4 | -0.25 |
| CENPH | centromere protein H | -0.25 |
| DNPH1 | 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | -0.25 |
| TEN1 | TEN1 CST complex subunit | -0.25 |
| ATP7A | ATPase, Cu++ transporting, alpha polypeptide | -0.25 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.25 |
| LIN7A | lin-7 homolog A (C. elegans) | -0.25 |
| ETNK2 | ethanolamine kinase 2 | -0.25 |
| CBR3 | carbonyl reductase 3 | -0.25 |
| EPHB3 | EPH receptor B3 | -0.25 |
