| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Aliskiren perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Aliskiren_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.181593 |
| PODXL | podocalyxin-like | 0.0793488 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0604616 |
| POTEF | POTE ankyrin domain family, member F | 0.0581592 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0523848 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0506944 |
| CENPF | centromere protein F, 350/400kDa | 0.050036 |
| CD44 | CD44 molecule (Indian blood group) | 0.0484211 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0483984 |
| TPM3 | tropomyosin 3 | 0.0482949 |
| MSN | moesin | 0.0463023 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0463014 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0459476 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.044628 |
| EFNA5 | ephrin-A5 | 0.0442239 |
| RUNX1 | runt-related transcription factor 1 | 0.0438652 |
| NAV1 | neuron navigator 1 | 0.0437573 |
| ASPH | aspartate beta-hydroxylase | 0.0432949 |
| EGFR | epidermal growth factor receptor | 0.0432041 |
| MAP1B | microtubule-associated protein 1B | 0.0431938 |
| CDH13 | cadherin 13 | 0.0427975 |
| HDAC9 | histone deacetylase 9 | 0.0422773 |
| GLIS3 | GLIS family zinc finger 3 | 0.0389998 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0372598 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0358814 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0349855 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0343846 |
| FLNA | filamin A, alpha | 0.0342907 |
| CDK6 | cyclin-dependent kinase 6 | 0.0328253 |
| DCLK2 | doublecortin-like kinase 2 | 0.032676 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0317428 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0315732 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0308 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0306431 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0274034 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | 0.0272513 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0271799 |
| PLXNA2 | plexin A2 | 0.0266478 |
| PKM | pyruvate kinase, muscle | 0.0266472 |
| SMAD3 | SMAD family member 3 | 0.0264993 |
| MCL1 | myeloid cell leukemia 1 | 0.0250827 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0248739 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0241124 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0239691 |
| FLNB | filamin B, beta | 0.0235841 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0232246 |
| VEGFC | vascular endothelial growth factor C | 0.022549 |
| DST | dystonin | 0.0222608 |
| NEK7 | NIMA-related kinase 7 | 0.0217291 |
| PTK2 | protein tyrosine kinase 2 | 0.0215124 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0212644 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0211874 |
| SON | SON DNA binding protein | 0.0211401 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0209204 |
| KIAA1549L | KIAA1549-like | 0.0207968 |
| SET | SET nuclear proto-oncogene | 0.0206832 |
| XKR6 | XK, Kell blood group complex subunit-related family, member 6 | 0.0205098 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0203284 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0201925 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0201908 |
| DIAPH3 | diaphanous-related formin 3 | 0.0201415 |
| RNF144A | ring finger protein 144A | 0.0199723 |
| PFN1 | profilin 1 | 0.0199539 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0199489 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0199241 |
| SUCNR1 | succinate receptor 1 | 0.0199178 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0196352 |
| RRM2 | ribonucleotide reductase M2 | 0.0195613 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0195457 |
| FAT1 | FAT atypical cadherin 1 | 0.0195149 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0192847 |
| DGKG | diacylglycerol kinase, gamma 90kDa | 0.0191465 |
| NOTCH2 | notch 2 | 0.0189729 |
| BAZ1B | bromodomain adjacent to zinc finger domain, 1B | 0.0189446 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0188257 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0186729 |
| TPM1 | tropomyosin 1 (alpha) | 0.0182749 |
| INTS6 | integrator complex subunit 6 | 0.0180633 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0180074 |
| PRKCA | protein kinase C, alpha | 0.0178436 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0178262 |
| LAMB1 | laminin, beta 1 | 0.0177294 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0176629 |
| VCL | vinculin | 0.0176355 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.0174556 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.017367 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0173174 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.017233 |
| PCBP2 | poly(rC) binding protein 2 | 0.017001 |
| L1CAM | L1 cell adhesion molecule | 0.016911 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0167099 |
| FNIP2 | folliculin interacting protein 2 | 0.0166331 |
| IFI44L | interferon-induced protein 44-like | 0.0165742 |
| RAD51B | RAD51 paralog B | 0.0165209 |
| FOSL1 | FOS-like antigen 1 | 0.0165201 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0164488 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0164062 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0163613 |
| ANO6 | anoctamin 6 | 0.0161925 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0161243 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.41302 |
| VIM | vimentin | -0.205993 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.153172 |
| TMSB10 | thymosin beta 10 | -0.146523 |
| PTMA | prothymosin, alpha | -0.11035 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.110063 |
| S100A6 | S100 calcium binding protein A6 | -0.0868907 |
| AHNAK | AHNAK nucleoprotein | -0.0829749 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.081145 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0802693 |
| CANX | calnexin | -0.0781805 |
| THBS2 | thrombospondin 2 | -0.0737532 |
| CSTB | cystatin B (stefin B) | -0.0725158 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.069341 |
| LOX | lysyl oxidase | -0.0672822 |
| HLA-B | major histocompatibility complex, class I, B | -0.0654767 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0632894 |
| LOXL2 | lysyl oxidase-like 2 | -0.0623632 |
| FBN1 | fibrillin 1 | -0.0605038 |
| LMNA | lamin A/C | -0.0600591 |
| CAVIN1 | caveolae associated protein 1 | -0.0600233 |
| S100A10 | S100 calcium binding protein A10 | -0.0555538 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0542792 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0538869 |
| COL3A1 | collagen, type III, alpha 1 | -0.0523264 |
| COL1A2 | collagen, type I, alpha 2 | -0.051765 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0516669 |
| UBC | ubiquitin C | -0.0490138 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0458994 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0456042 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0454422 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0443389 |
| SQSTM1 | sequestosome 1 | -0.0434132 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | -0.0426919 |
| INSIG1 | insulin induced gene 1 | -0.0424549 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0422461 |
| CALR | calreticulin | -0.0418316 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0399106 |
| HLA-E | major histocompatibility complex, class I, E | -0.038997 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0370179 |
| OGA | O-GlcNAcase | -0.0369056 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0354747 |
| FTL | ferritin, light polypeptide | -0.0342738 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0338489 |
| TMSB4X | thymosin beta 4, X-linked | -0.0327232 |
| MT2A | metallothionein 2A | -0.0326741 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0326639 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0310208 |
| GOLGA2 | golgin A2 | -0.0308356 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0307042 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0301307 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0299802 |
| S100A4 | S100 calcium binding protein A4 | -0.0299275 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0298818 |
| CCND1 | cyclin D1 | -0.0296825 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0288247 |
| RRBP1 | ribosome binding protein 1 | -0.0283343 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0277331 |
| GNAS | GNAS complex locus | -0.0277284 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0275062 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.027444 |
| SLC38A1 | solute carrier family 38, member 1 | -0.027371 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0267176 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.02669 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0265752 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0264769 |
| GOLGA4 | golgin A4 | -0.0263469 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.026315 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.026279 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0260519 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0257253 |
| ANXA2 | annexin A2 | -0.025548 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0254381 |
| HLA-C | major histocompatibility complex, class I, C | -0.0252586 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0252372 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0249241 |
| CD99 | CD99 molecule | -0.0247971 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0247584 |
| SPAG9 | sperm associated antigen 9 | -0.023874 |
| ARF1 | ADP-ribosylation factor 1 | -0.023707 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.023593 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.023492 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0231984 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0230662 |
| HIP1 | huntingtin interacting protein 1 | -0.0220683 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0220399 |
| WDFY1 | WD repeat and FYVE domain containing 1 | -0.022033 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0218009 |
| CYLD | cylindromatosis (turban tumor syndrome) | -0.0215263 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0215249 |
| HDLBP | high density lipoprotein binding protein | -0.0214068 |
| TPM4 | tropomyosin 4 | -0.0211708 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0210998 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0210121 |
| COL5A2 | collagen, type V, alpha 2 | -0.0206831 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0205348 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0204079 |
| CD63 | CD63 molecule | -0.0203599 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0203509 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.020301 |
