Aliskiren_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aliskiren perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Aliskiren_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.114254
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0952692
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0919339
NLGN1 neuroligin 1 0.0811854
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.078614
VIM vimentin 0.0674253
YAP1 Yes-associated protein 1 0.0634918
DST dystonin 0.0561387
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0542935
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0542223
ANXA1 annexin A1 0.0528559
MBNL1 muscleblind-like splicing regulator 1 0.0511688
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0469616
HMGA2 high mobility group AT-hook 2 0.0468885
MMP12 matrix metallopeptidase 12 0.0466407
XPO1 exportin 1 0.0461801
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.046133
ERRFI1 ERBB receptor feedback inhibitor 1 0.0449518
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0437958
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0435283
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0434172
NIPBL Nipped-B homolog (Drosophila) 0.0433804
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0433749
RBM39 RNA binding motif protein 39 0.0433471
NHSL1 NHS-like 1 0.0427441
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0406456
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0390188
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0390184
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0385528
ZNF638 zinc finger protein 638 0.0384726
USP34 ubiquitin specific peptidase 34 0.0382494
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0378757
FXR1 fragile X mental retardation, autosomal homolog 1 0.0377316
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0367933
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0366141
MACF1 microtubule-actin crosslinking factor 1 0.0363773
TBC1D5 TBC1 domain family, member 5 0.0363047
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.035855
PCBP2 poly(rC) binding protein 2 0.0358443
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0356786
PCDH9 protocadherin 9 0.0335785
KIF5B kinesin family member 5B 0.0335375
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0333228
PEG10 paternally expressed 10 0.0327436
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0322982
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.031457
KMT2E lysine (K)-specific methyltransferase 2E 0.0313004
MKI67 marker of proliferation Ki-67 0.0311628
SSH2 slingshot protein phosphatase 2 0.0308149
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0305926
GSK3B glycogen synthase kinase 3 beta 0.0302104
PRELID2 PRELI domain containing 2 0.0301537
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.029667
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0294831
EIF4A2 eukaryotic translation initiation factor 4A2 0.0294036
KTN1 kinectin 1 (kinesin receptor) 0.0293621
SPATS2 spermatogenesis associated, serine-rich 2 0.0292257
SPAG9 sperm associated antigen 9 0.0291123
WWOX WW domain containing oxidoreductase 0.028898
H1-0 H1.0 linker histone 0.0288804
VMP1 vacuole membrane protein 1 0.0288779
PUM2 pumilio RNA-binding family member 2 0.0288196
CSNK1A1 casein kinase 1, alpha 1 0.0284083
SPTBN1 spectrin, beta, non-erythrocytic 1 0.028336
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0281561
ZNF148 zinc finger protein 148 0.0280431
ZSWIM6 zinc finger, SWIM-type containing 6 0.027849
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0277526
CANX calnexin 0.0275632
TRIO trio Rho guanine nucleotide exchange factor 0.0275205
RAB1A RAB1A, member RAS oncogene family 0.0273557
MED13L mediator complex subunit 13-like 0.0271426
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0270331
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0268703
MGAT4C MGAT4 family, member C 0.0268265
USP9X ubiquitin specific peptidase 9, X-linked 0.0265754
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0262772
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0259662
TNRC6B trinucleotide repeat containing 6B 0.0258433
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0255379
SLC38A1 solute carrier family 38, member 1 0.0253932
HSPH1 heat shock 105kDa/110kDa protein 1 0.025282
BRD2 bromodomain containing 2 0.0251218
JMJD1C jumonji domain containing 1C 0.024997
PHACTR4 phosphatase and actin regulator 4 0.0249334
BIRC6 baculoviral IAP repeat containing 6 0.0247478
AFF4 AF4/FMR2 family, member 4 0.0247266
NRDC nardilysin convertase 0.0246029
HSPB1 heat shock 27kDa protein 1 0.0244375
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) 0.0244348
FUS FUS RNA binding protein 0.0243995
AHNAK AHNAK nucleoprotein 0.0243681
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0243653
GNAS GNAS complex locus 0.0243573
ADIPOR2 adiponectin receptor 2 0.0243545
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0241998
INTS6 integrator complex subunit 6 0.0240199
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0239401
HSPA8 heat shock 70kDa protein 8 0.0237468
PAPOLA poly(A) polymerase alpha 0.0235959

decreased expression

Symbol Name Standardized Value
AREG amphiregulin -0.108503
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0906334
SLC38A2 solute carrier family 38, member 2 -0.0491412
DPYD dihydropyrimidine dehydrogenase -0.0382829
RPL11 ribosomal protein L11 -0.0378108
TMSB10 thymosin beta 10 -0.0353779
RPS12 ribosomal protein S12 -0.0350198
RPL37 ribosomal protein L37 -0.0348144
RPS2 ribosomal protein S2 -0.0333324
RPL26 ribosomal protein L26 -0.0310108
ZBTB20 zinc finger and BTB domain containing 20 -0.0290709
RPS27A ribosomal protein S27a -0.0281551
RPL37A ribosomal protein L37a -0.0274385
EGR1 early growth response 1 -0.0247584
RPS3 ribosomal protein S3 -0.0247044
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0231217
TPT1 tumor protein, translationally-controlled 1 -0.0224587
RPL12 ribosomal protein L12 -0.0221161
RPS13 ribosomal protein S13 -0.0206688
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0197006
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0195259
RPS21 ribosomal protein S21 -0.0194655
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0191046
RPL23 ribosomal protein L23 -0.0187812
RPL27 ribosomal protein L27 -0.0187415
RPS6 ribosomal protein S6 -0.0182115
RPLP2 ribosomal protein, large, P2 -0.0179366
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0178877
RPS24 ribosomal protein S24 -0.0178638
SBF2 SET binding factor 2 -0.0177466
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 -0.0174764
RPL34 ribosomal protein L34 -0.0172204
NABP1 nucleic acid binding protein 1 -0.0171324
EHBP1 EH domain binding protein 1 -0.0169799
RPL9 ribosomal protein L9 -0.0169019
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -0.016742
RPS23 ribosomal protein S23 -0.0157651
PHF14 PHD finger protein 14 -0.015729
CCN2 cellular communication network factor 2 -0.0156713
CMIP c-Maf inducing protein -0.0151922
MTAP methylthioadenosine phosphorylase -0.0151875
PDCD5 programmed cell death 5 -0.014375
BCHE butyrylcholinesterase -0.014075
RPS17 ribosomal protein S17 -0.0140574
ZNF804A zinc finger protein 804A -0.0137748
RPL5 ribosomal protein L5 -0.0133553
MYL12B myosin, light chain 12B, regulatory -0.0131109
RTN4 reticulon 4 -0.0130156
RABGAP1L RAB GTPase activating protein 1-like -0.0130154
NLN neurolysin (metallopeptidase M3 family) -0.0129275
RACK1 receptor for activated C kinase 1 -0.0127973
RPLP0 ribosomal protein, large, P0 -0.0125076
ANKRD12 ankyrin repeat domain 12 -0.0124133
RPS19 ribosomal protein S19 -0.0123993
NCEH1 neutral cholesterol ester hydrolase 1 -0.0122847
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0121766
RPS27 ribosomal protein S27 -0.0121541
PRR16 proline rich 16 -0.0118232
RPS14 ribosomal protein S14 -0.0117649
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0114754
SFPQ splicing factor proline/glutamine-rich -0.0113977
CALD1 caldesmon 1 -0.0113826
MARCHF4 membrane associated ring-CH-type finger 4 -0.0113671
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0109402
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0108773
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0108174
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0106959
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0105177
EIF3M eukaryotic translation initiation factor 3, subunit M -0.0103879
RASAL2 RAS protein activator like 2 -0.0102978
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0102113
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0101762
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.010167
RPS7 ribosomal protein S7 -0.0101471
RPL36A ribosomal protein L36a -0.0101334
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0101334
GCG glucagon -0.0100268
UQCRB ubiquinol-cytochrome c reductase binding protein -0.00987615
FOXK2 forkhead box K2 -0.00982588
RIMKLB ribosomal modification protein rimK-like family member B -0.00951597
WWC2 WW and C2 domain containing 2 -0.00949918
MRPL3 mitochondrial ribosomal protein L3 -0.00949321
VCL vinculin -0.00945481
EPB41L5 erythrocyte membrane protein band 4.1 like 5 -0.00941018
RPL7A ribosomal protein L7a -0.00933948
RPL35A ribosomal protein L35a -0.00917531
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.00913718
NKTR natural killer cell triggering receptor -0.00912422
WDR33 WD repeat domain 33 -0.00912038
EIF1 eukaryotic translation initiation factor 1 -0.00910939
BIRC2 baculoviral IAP repeat containing 2 -0.00906238
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.00898474
SS18 synovial sarcoma translocation, chromosome 18 -0.00896934
ARL5B ADP-ribosylation factor-like 5B -0.00893476
SUB1 SUB1 homolog (S. cerevisiae) -0.00893011
DACH1 dachshund family transcription factor 1 -0.0089036
PCNX4 pecanex 4 -0.00885391
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.00874883
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme -0.00861082
SEH1L SEH1-like (S. cerevisiae) -0.00860974