| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Aliskiren perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Aliskiren_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.173899 |
| LMO7 | LIM domain 7 | 0.166524 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.145401 |
| SMAD3 | SMAD family member 3 | 0.127838 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.111498 |
| INTS6 | integrator complex subunit 6 | 0.0973425 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0906573 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0866598 |
| EFNB2 | ephrin-B2 | 0.0673522 |
| VMP1 | vacuole membrane protein 1 | 0.0642741 |
| DST | dystonin | 0.0525207 |
| VCL | vinculin | 0.0513183 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0511568 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0503257 |
| ERBIN | erbb2 interacting protein | 0.0495551 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0481487 |
| YAP1 | Yes-associated protein 1 | 0.0448431 |
| ASPH | aspartate beta-hydroxylase | 0.0440216 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0435265 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0429712 |
| BCL2L1 | BCL2-like 1 | 0.0426426 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0401086 |
| TOX3 | TOX high mobility group box family member 3 | 0.0394037 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0381102 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.038072 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0378823 |
| KYNU | kynureninase | 0.0360689 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0357997 |
| ANXA2 | annexin A2 | 0.0356646 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0351947 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0350938 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0335834 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0335746 |
| CTBP2 | C-terminal binding protein 2 | 0.033528 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0334499 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0319784 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0311846 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.030846 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0291606 |
| PDZD8 | PDZ domain containing 8 | 0.0285618 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0278931 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0275297 |
| ETV6 | ets variant 6 | 0.0272519 |
| PADI1 | peptidyl arginine deiminase, type I | 0.0268862 |
| FAT1 | FAT atypical cadherin 1 | 0.0264839 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0264066 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0260858 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0259511 |
| POF1B | premature ovarian failure, 1B | 0.0250844 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.024827 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0247927 |
| AREG | amphiregulin | 0.0246936 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0240563 |
| MCU | mitochondrial calcium uniporter | 0.0240277 |
| EREG | epiregulin | 0.0232432 |
| PLSCR2 | phospholipid scramblase 2 | 0.0230949 |
| DIAPH1 | diaphanous-related formin 1 | 0.0230464 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0230101 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0229962 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0227486 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0227162 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0224509 |
| PRSS22 | protease, serine, 22 | 0.0223532 |
| FNIP2 | folliculin interacting protein 2 | 0.0218254 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0214985 |
| HKDC1 | hexokinase domain containing 1 | 0.0212009 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0211936 |
| MYO5B | myosin VB | 0.0210899 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0208899 |
| KIAA1217 | KIAA1217 | 0.0206371 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0205841 |
| AFAP1L2 | actin filament associated protein 1-like 2 | 0.02055 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.0204129 |
| TNS4 | tensin 4 | 0.0198363 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0197615 |
| TM4SF19 | transmembrane 4 L six family member 19 | 0.0193702 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.019333 |
| SETX | senataxin | 0.0190353 |
| USP53 | ubiquitin specific peptidase 53 | 0.0189201 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.018671 |
| TRIM2 | tripartite motif containing 2 | 0.0186473 |
| IFNGR1 | interferon gamma receptor 1 | 0.0182977 |
| UTRN | utrophin | 0.0181263 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.018074 |
| WWOX | WW domain containing oxidoreductase | 0.0180652 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.017929 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0175391 |
| NABP1 | nucleic acid binding protein 1 | 0.0173543 |
| MED13 | mediator complex subunit 13 | 0.0173367 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0173094 |
| FNIP1 | folliculin interacting protein 1 | 0.0171542 |
| CAPN8 | calpain 8 | 0.0170851 |
| HPCAL1 | hippocalcin-like 1 | 0.0170699 |
| UBAP2 | ubiquitin associated protein 2 | 0.0168324 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0166524 |
| KIF16B | kinesin family member 16B | 0.0165099 |
| NTN4 | netrin 4 | 0.0164718 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0164428 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0163635 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0163091 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.179954 |
| B2M | beta-2-microglobulin | -0.150091 |
| HLA-B | major histocompatibility complex, class I, B | -0.110393 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.108467 |
| PTMA | prothymosin, alpha | -0.100409 |
| LYZ | lysozyme | -0.0967436 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0955276 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.084305 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0740359 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0656748 |
| EZR | ezrin | -0.0606934 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0599536 |
| HLA-E | major histocompatibility complex, class I, E | -0.0594075 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0542313 |
| RPL35A | ribosomal protein L35a | -0.05353 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0514537 |
| FTL | ferritin, light polypeptide | -0.0492625 |
| RPLP1 | ribosomal protein, large, P1 | -0.048664 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0484957 |
| RPS6 | ribosomal protein S6 | -0.0447135 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0446842 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0439161 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0430393 |
| SQSTM1 | sequestosome 1 | -0.043004 |
| WDR45B | WD repeat domain 45B | -0.0421964 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0420925 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0420424 |
| JUN | jun proto-oncogene | -0.0416005 |
| EPCAM | epithelial cell adhesion molecule | -0.0411221 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | -0.0404624 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0401437 |
| RPL34 | ribosomal protein L34 | -0.040031 |
| UBC | ubiquitin C | -0.0395109 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.039101 |
| PGK1 | phosphoglycerate kinase 1 | -0.0390459 |
| TMC5 | transmembrane channel-like 5 | -0.0387568 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0387147 |
| XAF1 | XIAP associated factor 1 | -0.0386406 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0384253 |
| HLA-C | major histocompatibility complex, class I, C | -0.0384191 |
| IRF1 | interferon regulatory factor 1 | -0.038066 |
| S100A6 | S100 calcium binding protein A6 | -0.0379333 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0379075 |
| AHI1 | Abelson helper integration site 1 | -0.0369723 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0367035 |
| NPSR1 | neuropeptide S receptor 1 | -0.0366719 |
| RRBP1 | ribosome binding protein 1 | -0.0366322 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0366118 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0363577 |
| MUC20 | mucin 20, cell surface associated | -0.0362624 |
| H1-0 | H1.0 linker histone | -0.0361617 |
| PHF3 | PHD finger protein 3 | -0.0360611 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.035736 |
| TPM4 | tropomyosin 4 | -0.0356588 |
| RPL19 | ribosomal protein L19 | -0.0355478 |
| EGR1 | early growth response 1 | -0.0354428 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.034236 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0336771 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0321927 |
| CMPK1 | cytidine monophosphate (UMP-CMP) kinase 1, cytosolic | -0.0321556 |
| RPS24 | ribosomal protein S24 | -0.0321421 |
| TMSB10 | thymosin beta 10 | -0.0317349 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0316804 |
| LOC112694756 | uncharaterized LOC112694756 | -0.031523 |
| RPL23 | ribosomal protein L23 | -0.0313741 |
| NDRG1 | N-myc downstream regulated 1 | -0.031178 |
| RAB1A | RAB1A, member RAS oncogene family | -0.031095 |
| RPL26 | ribosomal protein L26 | -0.0310352 |
| RPS8 | ribosomal protein S8 | -0.0308695 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0306894 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0303279 |
| CSTB | cystatin B (stefin B) | -0.0303145 |
| RBM39 | RNA binding motif protein 39 | -0.0301135 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.029943 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0296039 |
| RNF149 | ring finger protein 149 | -0.0278829 |
| TFRC | transferrin receptor | -0.0276798 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | -0.0276788 |
| LCN2 | lipocalin 2 | -0.0275876 |
| ARF1 | ADP-ribosylation factor 1 | -0.0275465 |
| PERP | PERP, TP53 apoptosis effector | -0.0274932 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0274769 |
| SPATA13 | spermatogenesis associated 13 | -0.0271287 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0269515 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0267798 |
| RPL37 | ribosomal protein L37 | -0.0267396 |
| H3-3B | H3.3 histone B | -0.0267228 |
| YBX3 | Y box binding protein 3 | -0.0266848 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0265596 |
| GNAS | GNAS complex locus | -0.0265165 |
| DSTN | destrin (actin depolymerizing factor) | -0.0261717 |
| MT2A | metallothionein 2A | -0.0259796 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0258205 |
| CALR | calreticulin | -0.0257697 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0256969 |
| TPI1 | triosephosphate isomerase 1 | -0.0254452 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0251751 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.0250655 |
| RPL7L1 | ribosomal protein L7-like 1 | -0.0250573 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0250437 |
