Aliskiren_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aliskiren perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Aliskiren_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.273409
COL6A3 collagen, type VI, alpha 3 0.0979853
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0812508
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.059524
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0585185
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0521353
FNDC3B fibronectin type III domain containing 3B 0.0429299
MYH9 myosin, heavy chain 9, non-muscle 0.0413219
TRIO trio Rho guanine nucleotide exchange factor 0.0381342
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0365614
CD44 CD44 molecule (Indian blood group) 0.034477
DST dystonin 0.033812
IL6ST interleukin 6 signal transducer 0.033009
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0311166
WWTR1 WW domain containing transcription regulator 1 0.0305547
ASPH aspartate beta-hydroxylase 0.02947
STAT1 signal transducer and activator of transcription 1, 91kDa 0.028101
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0267588
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.026565
LDHA lactate dehydrogenase A 0.0262964
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0262678
ZBTB38 zinc finger and BTB domain containing 38 0.0257922
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0253118
MACF1 microtubule-actin crosslinking factor 1 0.0244399
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0244238
RIGI RNA sensor RIG-I 0.0241187
ENO1 enolase 1, (alpha) 0.0234136
AHNAK AHNAK nucleoprotein 0.0226878
NAV2 neuron navigator 2 0.0221915
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0217687
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0195861
ALCAM activated leukocyte cell adhesion molecule 0.0192776
HSPA8 heat shock 70kDa protein 8 0.018246
SPAG9 sperm associated antigen 9 0.0171956
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0170263
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.016837
COL4A1 collagen, type IV, alpha 1 0.0166487
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0166105
HDAC9 histone deacetylase 9 0.0164964
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0163304
JAK1 Janus kinase 1 0.0163209
PRELID2 PRELI domain containing 2 0.0162704
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0161742
RPL3 ribosomal protein L3 0.0156496
FAT1 FAT atypical cadherin 1 0.0155069
HIPK2 homeodomain interacting protein kinase 2 0.0154143
TNIP1 TNFAIP3 interacting protein 1 0.0152105
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0151557
CANX calnexin 0.0149328
YBX1 Y box binding protein 1 0.0147864
SAMD9 sterile alpha motif domain containing 9 0.0145422
SOD2 superoxide dismutase 2, mitochondrial 0.0140658
ADAM9 ADAM metallopeptidase domain 9 0.0140463
EEF2 eukaryotic translation elongation factor 2 0.0139572
TLN1 talin 1 0.0138708
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.013569
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0134513
MAP1B microtubule-associated protein 1B 0.0134286
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.013356
JAG1 jagged 1 0.0133515
MYO10 myosin X 0.0132606
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0131476
ANXA2 annexin A2 0.013061
SDC2 syndecan 2 0.0129579
FTH1 ferritin, heavy polypeptide 1 0.0125949
AHR aryl hydrocarbon receptor 0.0125546
ARHGAP29 Rho GTPase activating protein 29 0.0124718
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.012428
PLEC plectin 0.01242
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0124188
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0123812
DSPP dentin sialophosphoprotein 0.0123544
HYOU1 hypoxia up-regulated 1 0.0122542
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0122526
CSF1 colony stimulating factor 1 (macrophage) 0.0122512
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0122402
H1-0 H1.0 linker histone 0.0121203
ARRDC3 arrestin domain containing 3 0.0120077
CADM1 cell adhesion molecule 1 0.0119423
SMAD3 SMAD family member 3 0.0118307
ECE1 endothelin converting enzyme 1 0.011672
B2M beta-2-microglobulin 0.0114777
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0114401
FLNA filamin A, alpha 0.011375
SP100 SP100 nuclear antigen 0.011374
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0113501
MBNL1 muscleblind-like splicing regulator 1 0.0113053
NRIP1 nuclear receptor interacting protein 1 0.0112774
ANO6 anoctamin 6 0.0111105
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0107935
BIRC3 baculoviral IAP repeat containing 3 0.0107357
FXR1 fragile X mental retardation, autosomal homolog 1 0.0106853
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.010465
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0102232
RNF145 ring finger protein 145 0.0101944
OSBPL9 oxysterol binding protein-like 9 0.0101398
HAS2 hyaluronan synthase 2 0.0101335
GRB10 growth factor receptor-bound protein 10 0.0100598
PICALM phosphatidylinositol binding clathrin assembly protein 0.00989798
TSC22D2 TSC22 domain family, member 2 0.00986655

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.199933
IGFBP3 insulin-like growth factor binding protein 3 -0.141788
COL1A1 collagen, type I, alpha 1 -0.135897
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0926445
COL1A2 collagen, type I, alpha 2 -0.0897828
TMSB10 thymosin beta 10 -0.0873046
NDRG1 N-myc downstream regulated 1 -0.0646185
TPM4 tropomyosin 4 -0.0603719
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0528554
RPL35A ribosomal protein L35a -0.0507893
F3 coagulation factor III (thromboplastin, tissue factor) -0.0503773
PTMA prothymosin, alpha -0.0498019
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0489702
TGFBI transforming growth factor, beta-induced, 68kDa -0.0472003
IER3 immediate early response 3 -0.043726
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0427633
FTL ferritin, light polypeptide -0.0405495
CDH13 cadherin 13 -0.0377684
RPS8 ribosomal protein S8 -0.037499
EIF1 eukaryotic translation initiation factor 1 -0.0328899
ACTG1 actin gamma 1 -0.0297694
HLA-B major histocompatibility complex, class I, B -0.0295203
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0290229
RPS6 ribosomal protein S6 -0.0288131
STC1 stanniocalcin 1 -0.0271352
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0270887
TPT1 tumor protein, translationally-controlled 1 -0.0270416
S100A9 S100 calcium binding protein A9 -0.0267242
S100A6 S100 calcium binding protein A6 -0.0256599
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0255208
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0236684
MTDH metadherin -0.023309
RPL37A ribosomal protein L37a -0.022524
PDE10A phosphodiesterase 10A -0.0221234
LOXL2 lysyl oxidase-like 2 -0.020816
DPYD dihydropyrimidine dehydrogenase -0.0207723
ARL4C ADP-ribosylation factor-like 4C -0.0203567
CLMP CXADR-like membrane protein -0.0201169
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0190704
RPS25 ribosomal protein S25 -0.0184599
TMEM165 transmembrane protein 165 -0.018398
RPL37 ribosomal protein L37 -0.0175757
MRPS6 mitochondrial ribosomal protein S6 -0.0171666
RPS13 ribosomal protein S13 -0.0171595
RRBP1 ribosome binding protein 1 -0.0170087
PSD3 pleckstrin and Sec7 domain containing 3 -0.0169886
RPL9 ribosomal protein L9 -0.0169807
HM13 histocompatibility (minor) 13 -0.0168108
IL6 interleukin 6 -0.0167553
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0166161
GNAS GNAS complex locus -0.0165946
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0159343
CALD1 caldesmon 1 -0.0158249
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0158171
SLC38A2 solute carrier family 38, member 2 -0.0157519
RPLP2 ribosomal protein, large, P2 -0.0156934
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0156634
RPL36 ribosomal protein L36 -0.0155248
RPS16 ribosomal protein S16 -0.0154434
KPNB1 karyopherin (importin) beta 1 -0.0153586
RPL31 ribosomal protein L31 -0.0153561
CMIP c-Maf inducing protein -0.0152997
TRPS1 trichorhinophalangeal syndrome I -0.0152519
ADM adrenomedullin -0.0150784
RPL34 ribosomal protein L34 -0.0150001
RPLP1 ribosomal protein, large, P1 -0.0148256
GOLGA4 golgin A4 -0.01466
CALU calumenin -0.0145949
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0144794
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0143838
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0140706
ENO2 enolase 2 (gamma, neuronal) -0.0140482
RPL28 ribosomal protein L28 -0.0138452
RPL30 ribosomal protein L30 -0.0137847
COL5A1 collagen, type V, alpha 1 -0.0136804
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0136802
RPS19 ribosomal protein S19 -0.013605
RPS24 ribosomal protein S24 -0.0135861
CD63 CD63 molecule -0.0135407
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0131514
MYDGF myeloid-derived growth factor -0.0130817
VDAC1 voltage-dependent anion channel 1 -0.0130777
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0130322
COL3A1 collagen, type III, alpha 1 -0.0129698
ATF4 activating transcription factor 4 -0.012869
RAB2A RAB2A, member RAS oncogene family -0.0128549
CAVIN1 caveolae associated protein 1 -0.0126536
RPS14 ribosomal protein S14 -0.0124502
RPS29 ribosomal protein S29 -0.0124419
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0124312
GGNBP2 gametogenetin binding protein 2 -0.0123547
FKBP10 FK506 binding protein 10, 65 kDa -0.0123425
BNC2 basonuclin 2 -0.0122199
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0121785
RPS20 ribosomal protein S20 -0.0121038
ZMYND8 zinc finger, MYND-type containing 8 -0.0120307
LMO4 LIM domain only 4 -0.0118974
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0117002
CALR calreticulin -0.0116637
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0115633