| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Aliskiren perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Aliskiren_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.129703 |
| HMGA1 | high mobility group AT-hook 1 | 0.0708734 |
| VCL | vinculin | 0.0636466 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0625561 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0563457 |
| APOA2 | apolipoprotein A-II | 0.0519004 |
| TMSB10 | thymosin beta 10 | 0.0510309 |
| ASPH | aspartate beta-hydroxylase | 0.049276 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0456544 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0430846 |
| ATXN1 | ataxin 1 | 0.0387485 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.034112 |
| KYNU | kynureninase | 0.0290708 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0288566 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0283516 |
| FRMD5 | FERM domain containing 5 | 0.0276993 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0276418 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0256887 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0254985 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0254594 |
| ITGAV | integrin, alpha V | 0.0254335 |
| POTEF | POTE ankyrin domain family, member F | 0.0246407 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0239068 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.023878 |
| NABP1 | nucleic acid binding protein 1 | 0.0232434 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0230775 |
| FAM107B | family with sequence similarity 107, member B | 0.0224736 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0224353 |
| DST | dystonin | 0.0219376 |
| PTCHD4 | patched domain containing 4 | 0.021492 |
| RAD51B | RAD51 paralog B | 0.0209691 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 0.0202517 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.019988 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.0196249 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0194663 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0194088 |
| ACTN4 | actinin, alpha 4 | 0.0193296 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.0189502 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0188817 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0184328 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0184298 |
| ACTN1 | actinin, alpha 1 | 0.0184186 |
| LMO7 | LIM domain 7 | 0.0184144 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0180053 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0176805 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0170527 |
| MED13 | mediator complex subunit 13 | 0.0167636 |
| TLE4 | transducin-like enhancer of split 4 | 0.0167031 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0166971 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0166793 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0166753 |
| USP34 | ubiquitin specific peptidase 34 | 0.0163759 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0163329 |
| ZNF644 | zinc finger protein 644 | 0.0162282 |
| PCNX4 | pecanex 4 | 0.0160469 |
| EXOC4 | exocyst complex component 4 | 0.0158548 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0156465 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.0155903 |
| RASAL2 | RAS protein activator like 2 | 0.0155766 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.0154653 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.015373 |
| FKTN | fukutin | 0.0153253 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0153037 |
| FNIP1 | folliculin interacting protein 1 | 0.0150828 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0149752 |
| VCAN | versican | 0.0148798 |
| S100A9 | S100 calcium binding protein A9 | 0.0148728 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0148672 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0148605 |
| BCL2L1 | BCL2-like 1 | 0.0147985 |
| CAPRIN2 | caprin family member 2 | 0.014637 |
| STXBP4 | syntaxin binding protein 4 | 0.0143683 |
| KIAA1217 | KIAA1217 | 0.014312 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0142834 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.0142386 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0142142 |
| BRD2 | bromodomain containing 2 | 0.0140494 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | 0.013979 |
| ZNF638 | zinc finger protein 638 | 0.0139545 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0139302 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0138223 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0135997 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0135407 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.013463 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | 0.0134413 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0134283 |
| PDGFC | platelet derived growth factor C | 0.0132985 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0132894 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0132802 |
| PFN1 | profilin 1 | 0.0132298 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0132072 |
| HSPG2 | heparan sulfate proteoglycan 2 | 0.0130988 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0130558 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | 0.0130347 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0130195 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0130059 |
| PMM2 | phosphomannomutase 2 | 0.0129558 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0127869 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0127581 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0127478 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.189993 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.169295 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.141278 |
| APOB | apolipoprotein B | -0.137851 |
| GPC3 | glypican 3 | -0.133909 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.105461 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.101394 |
| ENO1 | enolase 1, (alpha) | -0.0995336 |
| TF | transferrin | -0.0953293 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0942221 |
| PEG3 | paternally expressed 3 | -0.0861588 |
| DSPP | dentin sialophosphoprotein | -0.0834332 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.082745 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0794815 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0780642 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0771497 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0726409 |
| CP | ceruloplasmin (ferroxidase) | -0.0707096 |
| AHSG | alpha-2-HS-glycoprotein | -0.068873 |
| A2M | alpha-2-macroglobulin | -0.066459 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0647728 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0641194 |
| C3 | complement component 3 | -0.059928 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0572532 |
| TRIM26 | tripartite motif containing 26 | -0.0568297 |
| CCL20 | chemokine (C-C motif) ligand 20 | -0.0560956 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.055387 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0535279 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0532064 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0510682 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0475281 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0456981 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0438459 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0436312 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0436229 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0433304 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0432064 |
| CANX | calnexin | -0.0418811 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0417771 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0416282 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.039117 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -0.038735 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.0382473 |
| SDC4 | syndecan 4 | -0.037332 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0369539 |
| WDR45B | WD repeat domain 45B | -0.0365134 |
| CFB | complement factor B | -0.0364145 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0361671 |
| RBM39 | RNA binding motif protein 39 | -0.0358597 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.0356174 |
| RPS27A | ribosomal protein S27a | -0.0350976 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0349889 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0340448 |
| RAI14 | retinoic acid induced 14 | -0.0335389 |
| JMJD1C | jumonji domain containing 1C | -0.0331791 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0329118 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0320136 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0317323 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | -0.0314578 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -0.0314123 |
| RACK1 | receptor for activated C kinase 1 | -0.0313086 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0306129 |
| RPL37A | ribosomal protein L37a | -0.0304843 |
| KIF5B | kinesin family member 5B | -0.0301987 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0301777 |
| RPS8 | ribosomal protein S8 | -0.0301767 |
| RPS6 | ribosomal protein S6 | -0.0300576 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0299186 |
| RPLP1 | ribosomal protein, large, P1 | -0.0297829 |
| RPS24 | ribosomal protein S24 | -0.0296254 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0290454 |
| UBC | ubiquitin C | -0.0283429 |
| DTNA | dystrobrevin, alpha | -0.0282652 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0281089 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0274355 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0274043 |
| RPS3 | ribosomal protein S3 | -0.027155 |
| MTSS1 | metastasis suppressor 1 | -0.0269628 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0263689 |
| KLF6 | Kruppel-like factor 6 | -0.0258444 |
| MATR3 | matrin 3 | -0.0258213 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0254412 |
| TFRC | transferrin receptor | -0.0253953 |
| GPC6 | glypican 6 | -0.025389 |
| SELENOP | selenoprotein P | -0.0253753 |
| QKI | QKI, KH domain containing, RNA binding | -0.0253749 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0252151 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0250691 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0249626 |
| RRBP1 | ribosome binding protein 1 | -0.0247816 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.024776 |
| IER3 | immediate early response 3 | -0.0243426 |
| TCIM | transcriptional and immune response regulator | -0.0241721 |
| LDHA | lactate dehydrogenase A | -0.0240325 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0239952 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0238051 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0236336 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.0234743 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0234579 |
| PTMA | prothymosin, alpha | -0.0231727 |
