| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Aliskiren perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Aliskiren_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0967943 |
| LMO7 | LIM domain 7 | 0.0697466 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0657396 |
| PDLIM5 | PDZ and LIM domain 5 | 0.06225 |
| HMGA2 | high mobility group AT-hook 2 | 0.0593731 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0577799 |
| RASAL2 | RAS protein activator like 2 | 0.0503873 |
| EFNA5 | ephrin-A5 | 0.0487095 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0480172 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0451693 |
| FOXO1 | forkhead box O1 | 0.0438925 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0431357 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0404029 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 0.0403654 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0399296 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0395174 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0364972 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0360742 |
| OSMR | oncostatin M receptor | 0.03601 |
| DST | dystonin | 0.0359161 |
| POTEF | POTE ankyrin domain family, member F | 0.0350719 |
| VCL | vinculin | 0.0343684 |
| ASPH | aspartate beta-hydroxylase | 0.0337545 |
| MSN | moesin | 0.0329045 |
| EGFR | epidermal growth factor receptor | 0.0317175 |
| ANKRD12 | ankyrin repeat domain 12 | 0.029959 |
| SVIL | supervillin | 0.0294776 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 0.0289285 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0288435 |
| INTS6 | integrator complex subunit 6 | 0.0285424 |
| RAD51B | RAD51 paralog B | 0.0282083 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0280198 |
| AOPEP | aminopeptidase O (putative) | 0.0280077 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0277325 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0275457 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0274426 |
| PALLD | palladin, cytoskeletal associated protein | 0.0270166 |
| RIGI | RNA sensor RIG-I | 0.0269783 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0266479 |
| RPS12 | ribosomal protein S12 | 0.0265971 |
| RPS2 | ribosomal protein S2 | 0.0264319 |
| AMOTL1 | angiomotin like 1 | 0.0261619 |
| CNTNAP3 | contactin associated protein-like 3 | 0.0260965 |
| DUSP4 | dual specificity phosphatase 4 | 0.0257031 |
| SIK3 | SIK family kinase 3 | 0.0255926 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0255395 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0248429 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0243766 |
| LAMA5 | laminin, alpha 5 | 0.0241583 |
| PLXNA2 | plexin A2 | 0.0241555 |
| RPL37 | ribosomal protein L37 | 0.0238816 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0235513 |
| HDAC9 | histone deacetylase 9 | 0.0230593 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0230448 |
| MT1E | metallothionein 1E | 0.0226231 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0224602 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0224333 |
| VEGFC | vascular endothelial growth factor C | 0.0221638 |
| GRAMD1B | GRAM domain containing 1B | 0.0220485 |
| RCOR1 | REST corepressor 1 | 0.0220423 |
| MECOM | MDS1 and EVI1 complex locus | 0.0214922 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.0213454 |
| JAG1 | jagged 1 | 0.0210901 |
| SEPTIN9 | septin 9 | 0.0209845 |
| RNF217 | ring finger protein 217 | 0.0209711 |
| EXOC4 | exocyst complex component 4 | 0.0200432 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0200393 |
| EGR1 | early growth response 1 | 0.0198375 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0195137 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0195037 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0191801 |
| CAPRIN2 | caprin family member 2 | 0.0191696 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0191571 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.018936 |
| CORO2A | coronin, actin binding protein, 2A | 0.0188932 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.0188817 |
| LUZP1 | leucine zipper protein 1 | 0.0185496 |
| GPR176 | G protein-coupled receptor 176 | 0.0185164 |
| CSMD2 | CUB and Sushi multiple domains 2 | 0.0184956 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0183889 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0181482 |
| PLS3 | plastin 3 | 0.0181262 |
| DGKH | diacylglycerol kinase, eta | 0.0180925 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.017914 |
| IFI44L | interferon-induced protein 44-like | 0.0178712 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0178256 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0177955 |
| KYNU | kynureninase | 0.0177658 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0176267 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0174622 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0174498 |
| NEK7 | NIMA-related kinase 7 | 0.0174408 |
| PCDH1 | protocadherin 1 | 0.0174267 |
| MCU | mitochondrial calcium uniporter | 0.0170522 |
| PGM3 | phosphoglucomutase 3 | 0.0170321 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0168903 |
| MCL1 | myeloid cell leukemia 1 | 0.0168083 |
| SETX | senataxin | 0.016807 |
| CDK17 | cyclin-dependent kinase 17 | 0.0166783 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0164799 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.194344 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.155762 |
| PTMA | prothymosin, alpha | -0.154082 |
| EMP1 | epithelial membrane protein 1 | -0.129601 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.113538 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.110195 |
| TMSB4X | thymosin beta 4, X-linked | -0.0971685 |
| AHNAK | AHNAK nucleoprotein | -0.0931972 |
| MEF2A | myocyte enhancer factor 2A | -0.084683 |
| FLNB | filamin B, beta | -0.0843054 |
| ANXA1 | annexin A1 | -0.0840293 |
| S100A10 | S100 calcium binding protein A10 | -0.0805287 |
| CANX | calnexin | -0.0777238 |
| PGK1 | phosphoglycerate kinase 1 | -0.0769459 |
| H1-0 | H1.0 linker histone | -0.0764479 |
| ANXA2 | annexin A2 | -0.0745892 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0721221 |
| LMNA | lamin A/C | -0.0686868 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.06819 |
| RBM39 | RNA binding motif protein 39 | -0.0678872 |
| OGA | O-GlcNAcase | -0.0672502 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0663883 |
| GNAS | GNAS complex locus | -0.0635898 |
| GOLGA4 | golgin A4 | -0.0634943 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0632984 |
| ANLN | anillin, actin binding protein | -0.0622777 |
| EZR | ezrin | -0.0622312 |
| MYOF | myoferlin | -0.0616839 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0598431 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0597341 |
| CLU | clusterin | -0.059599 |
| SPAG9 | sperm associated antigen 9 | -0.0565089 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.056323 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0562788 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0549148 |
| ITGA6 | integrin, alpha 6 | -0.0545566 |
| STC1 | stanniocalcin 1 | -0.05406 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0529754 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0523987 |
| DSTN | destrin (actin depolymerizing factor) | -0.0522196 |
| RPS6 | ribosomal protein S6 | -0.0507603 |
| IGF2 | insulin-like growth factor 2 | -0.0504469 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0499775 |
| RLF | rearranged L-myc fusion | -0.0499454 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0492671 |
| PODXL | podocalyxin-like | -0.0490392 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0489278 |
| MTSS1 | metastasis suppressor 1 | -0.0486247 |
| NDRG1 | N-myc downstream regulated 1 | -0.04837 |
| MORF4L2 | mortality factor 4 like 2 | -0.0479171 |
| TMSB10 | thymosin beta 10 | -0.0473896 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0464368 |
| KRT17 | keratin 17, type I | -0.0461969 |
| SQLE | squalene epoxidase | -0.0455208 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -0.0451883 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0448695 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0444824 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0436858 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0433991 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0421933 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0421094 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0405675 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0405229 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0402693 |
| KIAA1217 | KIAA1217 | -0.0400446 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0400327 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | -0.0395091 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0394774 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0394606 |
| ARF1 | ADP-ribosylation factor 1 | -0.0386308 |
| CD44 | CD44 molecule (Indian blood group) | -0.0385588 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0385247 |
| CAVIN1 | caveolae associated protein 1 | -0.0383277 |
| S100A6 | S100 calcium binding protein A6 | -0.0382239 |
| HLA-E | major histocompatibility complex, class I, E | -0.0363286 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | -0.0362657 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0361081 |
| CD99 | CD99 molecule | -0.0357829 |
| TKT | transketolase | -0.0356915 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.03547 |
| ENO1 | enolase 1, (alpha) | -0.0352278 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0348141 |
| YBX3 | Y box binding protein 3 | -0.0346099 |
| DENND4C | DENN/MADD domain containing 4C | -0.0345339 |
| DPM1 | dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit | -0.0345049 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0344379 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0339502 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0336114 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.033409 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0332963 |
| LDHA | lactate dehydrogenase A | -0.0330444 |
| PKM | pyruvate kinase, muscle | -0.0329481 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0324542 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0322878 |
| CUL4B | cullin 4B | -0.0321781 |
| TMEM123 | transmembrane protein 123 | -0.032084 |
| SYPL1 | synaptophysin-like 1 | -0.0319146 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0317215 |
| KRT6A | keratin 6A, type II | -0.0316967 |
| RRBP1 | ribosome binding protein 1 | -0.0315845 |
