| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Aliskiren perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Aliskiren_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.126681 |
| KRT8 | keratin 8, type II | 0.107532 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.101046 |
| FAT1 | FAT atypical cadherin 1 | 0.0977175 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0764621 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0756386 |
| VCL | vinculin | 0.0723802 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0700892 |
| POTEF | POTE ankyrin domain family, member F | 0.0668407 |
| RPS12 | ribosomal protein S12 | 0.0575283 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0489924 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0485862 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0483901 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0472599 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.044749 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0442652 |
| CADPS | Ca++-dependent secretion activator | 0.0440475 |
| RPL3 | ribosomal protein L3 | 0.0429929 |
| VEGFA | vascular endothelial growth factor A | 0.0419027 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0416834 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0408876 |
| CENPF | centromere protein F, 350/400kDa | 0.0397658 |
| RPS2 | ribosomal protein S2 | 0.0386358 |
| VMP1 | vacuole membrane protein 1 | 0.0384125 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0381614 |
| FHIT | fragile histidine triad | 0.0376906 |
| MYO1E | myosin IE | 0.0374225 |
| ASPH | aspartate beta-hydroxylase | 0.0368917 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0350646 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | 0.0339145 |
| TNS4 | tensin 4 | 0.033759 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.033702 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0336818 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0335659 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0326293 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0325135 |
| GPHN | gephyrin | 0.0321638 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0320018 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0311475 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.0308124 |
| B4GALNT3 | beta-1,4-N-acetyl-galactosaminyl transferase 3 | 0.0305679 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0297718 |
| PDE10A | phosphodiesterase 10A | 0.0294987 |
| MCL1 | myeloid cell leukemia 1 | 0.0288997 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0286286 |
| MUC13 | mucin 13, cell surface associated | 0.028522 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0283619 |
| LAMA4 | laminin, alpha 4 | 0.0282327 |
| USP53 | ubiquitin specific peptidase 53 | 0.0277391 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.02765 |
| RPS8 | ribosomal protein S8 | 0.0273492 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0270234 |
| SAMD5 | sterile alpha motif domain containing 5 | 0.0266489 |
| RCOR1 | REST corepressor 1 | 0.026251 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0261662 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0261037 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | 0.026052 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0256756 |
| DIAPH3 | diaphanous-related formin 3 | 0.0254719 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0251683 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0251108 |
| CMIP | c-Maf inducing protein | 0.0249776 |
| EGFR | epidermal growth factor receptor | 0.0247337 |
| ECT2 | epithelial cell transforming 2 | 0.0233095 |
| RPL23 | ribosomal protein L23 | 0.0232019 |
| RPL37A | ribosomal protein L37a | 0.0230724 |
| PNN | pinin, desmosome associated protein | 0.0226241 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0224761 |
| ETV6 | ets variant 6 | 0.0222803 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0221943 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0221879 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0221258 |
| NRXN3 | neurexin 3 | 0.022033 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0218487 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0218184 |
| TPM1 | tropomyosin 1 (alpha) | 0.0215994 |
| ITGA6 | integrin, alpha 6 | 0.0213989 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0212793 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0210799 |
| AREG | amphiregulin | 0.0210537 |
| PCBP2 | poly(rC) binding protein 2 | 0.0208743 |
| RAD51B | RAD51 paralog B | 0.0205933 |
| NPSR1 | neuropeptide S receptor 1 | 0.0205749 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0201945 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | 0.0200662 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0200357 |
| EXOC6B | exocyst complex component 6B | 0.0199018 |
| NOSTRIN | nitric oxide synthase trafficking | 0.0195381 |
| AHCYL2 | adenosylhomocysteinase-like 2 | 0.019062 |
| TPM3 | tropomyosin 3 | 0.018944 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0189277 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0189033 |
| WWOX | WW domain containing oxidoreductase | 0.0188074 |
| FOCAD | focadhesin | 0.0187746 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0187279 |
| SIK3 | SIK family kinase 3 | 0.0186253 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | 0.0183897 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0182068 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | 0.0181373 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0179937 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.29713 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.193097 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.13418 |
| PTMA | prothymosin, alpha | -0.1195 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0836447 |
| ANXA2 | annexin A2 | -0.0808713 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.076474 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0740823 |
| CANX | calnexin | -0.0729363 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.070138 |
| FAM13A | family with sequence similarity 13, member A | -0.0680359 |
| WDR45B | WD repeat domain 45B | -0.0670416 |
| EZR | ezrin | -0.0665273 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.06639 |
| S100A6 | S100 calcium binding protein A6 | -0.0629425 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0628082 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.055038 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0546027 |
| AHNAK | AHNAK nucleoprotein | -0.0544967 |
| AGR2 | anterior gradient 2 | -0.0541486 |
| HDLBP | high density lipoprotein binding protein | -0.0536227 |
| ARF1 | ADP-ribosylation factor 1 | -0.0531572 |
| PGK1 | phosphoglycerate kinase 1 | -0.0531481 |
| KRT18 | keratin 18, type I | -0.0525533 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0520701 |
| LDHA | lactate dehydrogenase A | -0.0503912 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0503407 |
| KIF5B | kinesin family member 5B | -0.0502366 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0502335 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0499619 |
| GOLGA4 | golgin A4 | -0.0485659 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0472577 |
| ONECUT3 | one cut homeobox 3 | -0.0471116 |
| H1-0 | H1.0 linker histone | -0.0468515 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0463944 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0461286 |
| EPCAM | epithelial cell adhesion molecule | -0.0460414 |
| RBM39 | RNA binding motif protein 39 | -0.0457545 |
| TPM4 | tropomyosin 4 | -0.0453501 |
| NFIA | nuclear factor I/A | -0.044695 |
| GDF15 | growth differentiation factor 15 | -0.0445977 |
| TMSB10 | thymosin beta 10 | -0.0432023 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.042937 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.042068 |
| TMEM123 | transmembrane protein 123 | -0.041589 |
| TXNIP | thioredoxin interacting protein | -0.0415493 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0414207 |
| EREG | epiregulin | -0.0413763 |
| LMO7 | LIM domain 7 | -0.0408743 |
| EMP1 | epithelial membrane protein 1 | -0.0406676 |
| SHROOM3 | shroom family member 3 | -0.0404373 |
| RRBP1 | ribosome binding protein 1 | -0.040428 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0402883 |
| OGA | O-GlcNAcase | -0.0401944 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0400246 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0396688 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0396634 |
| RPLP0 | ribosomal protein, large, P0 | -0.0395199 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0394452 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0391941 |
| PIGR | polymeric immunoglobulin receptor | -0.0383166 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0381524 |
| ANXA1 | annexin A1 | -0.037872 |
| EXOC1 | exocyst complex component 1 | -0.0377925 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0375485 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0375206 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0361338 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.035806 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0355219 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0355127 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0354446 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0351015 |
| RLF | rearranged L-myc fusion | -0.0350166 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0350144 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0349047 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0348268 |
| RPS6 | ribosomal protein S6 | -0.0344785 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0343296 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0342091 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0341747 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0340461 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | -0.0338251 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0337411 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0337323 |
| FERMT1 | fermitin family member 1 | -0.0335455 |
| PHKB | phosphorylase kinase, beta | -0.0321588 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0319051 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0318122 |
| SBF2 | SET binding factor 2 | -0.0314991 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0311755 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0310813 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0310127 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0308333 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0306749 |
| UBC | ubiquitin C | -0.0304754 |
| ZNF292 | zinc finger protein 292 | -0.030338 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0301592 |
| CCNI | cyclin I | -0.0299062 |
| KLF6 | Kruppel-like factor 6 | -0.0298391 |
| ACTN4 | actinin, alpha 4 | -0.0298029 |
