| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Aliskiren perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Aliskiren_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.128751 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0760676 |
| POTEF | POTE ankyrin domain family, member F | 0.0755635 |
| TP63 | tumor protein p63 | 0.0529234 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0478586 |
| CAPRIN2 | caprin family member 2 | 0.0475067 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0470177 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0419214 |
| MT1X | metallothionein 1X | 0.0401204 |
| RPS12 | ribosomal protein S12 | 0.0379526 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0371755 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.0365872 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0352846 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0332441 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0324987 |
| FMNL2 | formin-like 2 | 0.0302526 |
| DST | dystonin | 0.0295468 |
| RPL23 | ribosomal protein L23 | 0.0294512 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0271661 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0268858 |
| VMP1 | vacuole membrane protein 1 | 0.0264872 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0261694 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0259922 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0249541 |
| TSC22D1 | TSC22 domain family, member 1 | 0.023293 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0232081 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0231677 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0229713 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0227114 |
| RPS3 | ribosomal protein S3 | 0.0217886 |
| TNFRSF6B | tumor necrosis factor receptor superfamily, member 6b, decoy | 0.0216414 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0213809 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0209572 |
| CDK6 | cyclin-dependent kinase 6 | 0.0202319 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0201547 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0196175 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0196077 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0194269 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0193596 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0190837 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0190391 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.019007 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 0.0189215 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0187073 |
| RTTN | rotatin | 0.0186436 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0181989 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0177088 |
| RPL26 | ribosomal protein L26 | 0.0175857 |
| DIAPH3 | diaphanous-related formin 3 | 0.0170757 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0170599 |
| RPS19 | ribosomal protein S19 | 0.0168409 |
| PDE10A | phosphodiesterase 10A | 0.016656 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0165371 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0163584 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0159802 |
| YAP1 | Yes-associated protein 1 | 0.0155262 |
| SON | SON DNA binding protein | 0.0155129 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0150766 |
| RPL11 | ribosomal protein L11 | 0.0150328 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0149887 |
| CEP128 | centrosomal protein 128kDa | 0.0148839 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0148592 |
| NEK10 | NIMA-related kinase 10 | 0.0147793 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | 0.0147629 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0147254 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0146814 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0146118 |
| PTK2 | protein tyrosine kinase 2 | 0.0146117 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | 0.014551 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0144737 |
| CFAP299 | cilia and flagella associated protein 299 | 0.0143402 |
| PRIM2 | primase, DNA, polypeptide 2 (58kDa) | 0.0140934 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0138688 |
| DIS3L2 | DIS3 like 3'-5' exoribonuclease 2 | 0.013786 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0137466 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0137097 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0136762 |
| WDR27 | WD repeat domain 27 | 0.0136653 |
| FGGY | FGGY carbohydrate kinase domain containing | 0.0136066 |
| DNER | delta/notch-like EGF repeat containing | 0.0135485 |
| DNAJB6 | DnaJ (Hsp40) homolog, subfamily B, member 6 | 0.0135107 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0134364 |
| RPL9 | ribosomal protein L9 | 0.0133175 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0132684 |
| CMIP | c-Maf inducing protein | 0.0132431 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0132035 |
| VEGFC | vascular endothelial growth factor C | 0.013131 |
| DPH6 | diphthamine biosynthesis 6 | 0.0130879 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0130498 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0130135 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0129324 |
| PCBP2 | poly(rC) binding protein 2 | 0.0129286 |
| YBX3 | Y box binding protein 3 | 0.0129272 |
| BCL2L1 | BCL2-like 1 | 0.0128933 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0128408 |
| SGMS2 | sphingomyelin synthase 2 | 0.0128374 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0127821 |
| CCDC88A | coiled-coil domain containing 88A | 0.0126725 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.01262 |
| RPS17 | ribosomal protein S17 | 0.0125826 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.17648 |
| VIM | vimentin | -0.161677 |
| PTMA | prothymosin, alpha | -0.142983 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.110709 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0826347 |
| TMSB4X | thymosin beta 4, X-linked | -0.0806672 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.077639 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0765692 |
| CANX | calnexin | -0.0731763 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0682471 |
| PGK1 | phosphoglycerate kinase 1 | -0.0626875 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0592598 |
| EHBP1 | EH domain binding protein 1 | -0.0567713 |
| RAI1 | retinoic acid induced 1 | -0.0539739 |
| APP | amyloid beta (A4) precursor protein | -0.0532248 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0475828 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0463736 |
| TNS3 | tensin 3 | -0.0434586 |
| LOXL2 | lysyl oxidase-like 2 | -0.042417 |
| EFNA5 | ephrin-A5 | -0.0412414 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.041208 |
| EZR | ezrin | -0.0397595 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0391407 |
| TMEM123 | transmembrane protein 123 | -0.0388171 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0386968 |
| HDLBP | high density lipoprotein binding protein | -0.0385884 |
| GLG1 | golgi glycoprotein 1 | -0.038059 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0373061 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.036383 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0361699 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.03596 |
| MYOF | myoferlin | -0.0353465 |
| TPM4 | tropomyosin 4 | -0.0347631 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0344361 |
| YEATS2 | YEATS domain containing 2 | -0.0330885 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0330314 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0319438 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0318151 |
| ENO1 | enolase 1, (alpha) | -0.0311357 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0309821 |
| EPHA4 | EPH receptor A4 | -0.0303799 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0302202 |
| AHNAK | AHNAK nucleoprotein | -0.029883 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0295359 |
| CALR | calreticulin | -0.0294598 |
| ZNF217 | zinc finger protein 217 | -0.0294257 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.029248 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0291453 |
| CD44 | CD44 molecule (Indian blood group) | -0.0290327 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0283369 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0282368 |
| TXNIP | thioredoxin interacting protein | -0.0281191 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0279747 |
| NDRG1 | N-myc downstream regulated 1 | -0.0278072 |
| DOCK11 | dedicator of cytokinesis 11 | -0.0274961 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0274561 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0274133 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0270518 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0270054 |
| CADM2 | cell adhesion molecule 2 | -0.0268108 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0268041 |
| HLA-B | major histocompatibility complex, class I, B | -0.0267785 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0264676 |
| SQSTM1 | sequestosome 1 | -0.0264128 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0262695 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0261836 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0261237 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0261154 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0261154 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.025936 |
| ANXA1 | annexin A1 | -0.025611 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0255413 |
| PKM | pyruvate kinase, muscle | -0.0255082 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0252775 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0252721 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0250565 |
| RPS8 | ribosomal protein S8 | -0.0249778 |
| WDR45B | WD repeat domain 45B | -0.024894 |
| CAVIN1 | caveolae associated protein 1 | -0.0236858 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0235961 |
| SPAG9 | sperm associated antigen 9 | -0.0234254 |
| RPL38 | ribosomal protein L38 | -0.0232029 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0228791 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0227971 |
| PLIN2 | perilipin 2 | -0.0225217 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.022348 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0219856 |
| RLF | rearranged L-myc fusion | -0.0219718 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0216769 |
| ACTG1 | actin gamma 1 | -0.021455 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | -0.0213119 |
| CENPF | centromere protein F, 350/400kDa | -0.0211154 |
| RAP2B | RAP2B, member of RAS oncogene family | -0.0210048 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0209012 |
| KRT18 | keratin 18, type I | -0.0208161 |
| UBC | ubiquitin C | -0.0207185 |
| CEP350 | centrosomal protein 350kDa | -0.0205437 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0201618 |
| OGA | O-GlcNAcase | -0.0200749 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0198864 |
