| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Aliskiren perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Aliskiren_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0770372 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0636747 |
| MCL1 | myeloid cell leukemia 1 | 0.0604741 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0553767 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0469519 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0459595 |
| SLTM | SAFB-like, transcription modulator | 0.0458606 |
| CES1 | carboxylesterase 1 | 0.0443894 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0423416 |
| FAM13A | family with sequence similarity 13, member A | 0.0409327 |
| VMP1 | vacuole membrane protein 1 | 0.0396688 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0391372 |
| INTS6 | integrator complex subunit 6 | 0.0371557 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.036734 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0355326 |
| PM20D1 | peptidase M20 domain containing 1 | 0.034003 |
| PKM | pyruvate kinase, muscle | 0.0337458 |
| RUNX1 | runt-related transcription factor 1 | 0.0335295 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0317258 |
| TOP1 | topoisomerase (DNA) I | 0.0311768 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0311093 |
| MAP7 | microtubule-associated protein 7 | 0.0309306 |
| BRD2 | bromodomain containing 2 | 0.0308702 |
| PCBP2 | poly(rC) binding protein 2 | 0.0306414 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0303365 |
| MKI67 | marker of proliferation Ki-67 | 0.0303338 |
| GRAMD1B | GRAM domain containing 1B | 0.0284373 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0281636 |
| SPAG9 | sperm associated antigen 9 | 0.0279143 |
| HOMER1 | homer scaffolding protein 1 | 0.0270839 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0264831 |
| SIK3 | SIK family kinase 3 | 0.026059 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | 0.0260259 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0256161 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0255685 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0252172 |
| DTNA | dystrobrevin, alpha | 0.0251362 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0245252 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | 0.0242935 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0242534 |
| LRP12 | low density lipoprotein receptor-related protein 12 | 0.0236689 |
| RPL3 | ribosomal protein L3 | 0.0227599 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0226711 |
| MSN | moesin | 0.0224171 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0223917 |
| ARRDC3 | arrestin domain containing 3 | 0.022272 |
| POTEF | POTE ankyrin domain family, member F | 0.0221509 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0214895 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0208724 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0207887 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0207606 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0205451 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0200668 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0200565 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0199377 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0197813 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0197498 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0195917 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0193014 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0189957 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0184345 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0183582 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0181199 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0177908 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0177174 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0176605 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.017422 |
| TES | testin LIM domain protein | 0.0174175 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0171981 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0166691 |
| BMP6 | bone morphogenetic protein 6 | 0.0166645 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0163132 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0161278 |
| HELZ | helicase with zinc finger | 0.0161166 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0158026 |
| HYOU1 | hypoxia up-regulated 1 | 0.0156941 |
| RPS2 | ribosomal protein S2 | 0.0154236 |
| GPATCH2L | G patch domain containing 2-like | 0.0153704 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0153316 |
| MYO1E | myosin IE | 0.0152375 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0152 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0151517 |
| AREG | amphiregulin | 0.0151407 |
| NPTN | neuroplastin | 0.0150253 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0148413 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0147671 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0146093 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0144803 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0144436 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0144078 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0142925 |
| NABP1 | nucleic acid binding protein 1 | 0.0142659 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0140921 |
| SPCS2 | signal peptidase complex subunit 2 homolog (S. cerevisiae) | 0.0140839 |
| PYGL | phosphorylase, glycogen, liver | 0.0140431 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0140298 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0138301 |
| KANSL1L | KAT8 regulatory NSL complex subunit 1-like | 0.0137568 |
| TPM3 | tropomyosin 3 | 0.0137046 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0136735 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.153462 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.137653 |
| LAMC2 | laminin, gamma 2 | -0.114262 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.107298 |
| LMO7 | LIM domain 7 | -0.104289 |
| ACTG1 | actin gamma 1 | -0.073656 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0705931 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0703208 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0679807 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0663757 |
| ASPH | aspartate beta-hydroxylase | -0.064701 |
| OSMR | oncostatin M receptor | -0.0612427 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0609579 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0608428 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0582841 |
| KRT18 | keratin 18, type I | -0.0554774 |
| AHNAK | AHNAK nucleoprotein | -0.0516343 |
| CCND1 | cyclin D1 | -0.0514439 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0503051 |
| S100A10 | S100 calcium binding protein A10 | -0.049853 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0492826 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.04703 |
| HLA-B | major histocompatibility complex, class I, B | -0.0446083 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0425315 |
| TRIM56 | tripartite motif containing 56 | -0.0421808 |
| KRT7 | keratin 7, type II | -0.0417018 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0400059 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0395484 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0375697 |
| CST3 | cystatin C | -0.0366716 |
| PATJ | PATJ crumbs cell polarity complex component | -0.036097 |
| S100A6 | S100 calcium binding protein A6 | -0.0350373 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0340944 |
| HDLBP | high density lipoprotein binding protein | -0.0337502 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.033583 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0335139 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0335093 |
| GNAS | GNAS complex locus | -0.0334805 |
| EFNA5 | ephrin-A5 | -0.0334729 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0334502 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0328525 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0325338 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0324587 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0323023 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0322962 |
| RNF213 | ring finger protein 213 | -0.0313447 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.03113 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0307323 |
| LDHA | lactate dehydrogenase A | -0.0304351 |
| PTMA | prothymosin, alpha | -0.029943 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0292922 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0292573 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0287729 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0286627 |
| GM2A | GM2 ganglioside activator | -0.0282804 |
| H1-0 | H1.0 linker histone | -0.0282683 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0280486 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0279242 |
| ANXA2 | annexin A2 | -0.0277844 |
| RPL34 | ribosomal protein L34 | -0.0277784 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0275451 |
| KRT19 | keratin 19, type I | -0.0261166 |
| LAMB3 | laminin, beta 3 | -0.0260446 |
| SCEL | sciellin | -0.0258758 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0256803 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.025523 |
| IER3 | immediate early response 3 | -0.0253359 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.024822 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0243273 |
| PGK1 | phosphoglycerate kinase 1 | -0.0242709 |
| B2M | beta-2-microglobulin | -0.0240268 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0239893 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0238864 |
| TNS3 | tensin 3 | -0.0238632 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.023625 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0235295 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0235244 |
| RPL35A | ribosomal protein L35a | -0.0232808 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0231026 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0225933 |
| NCOA3 | nuclear receptor coactivator 3 | -0.022323 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0222813 |
| EGFR | epidermal growth factor receptor | -0.0222197 |
| GOLGA3 | golgin A3 | -0.0218676 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0217222 |
| ARF1 | ADP-ribosylation factor 1 | -0.0213727 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0210194 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0207443 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.020626 |
| SHTN1 | shootin 1 | -0.0203886 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0200102 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | -0.0198136 |
| ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | -0.0196939 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0196756 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0195748 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0195535 |
| TPM4 | tropomyosin 4 | -0.0195051 |
| FOXP1 | forkhead box P1 | -0.0193935 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0193235 |
| DSG2 | desmoglein 2 | -0.0191717 |
