| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Aliskiren perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Aliskiren_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.182561 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.158706 |
| GLCCI1 | glucocorticoid induced 1 | 0.151651 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.123257 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.120771 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.108121 |
| CD44 | CD44 molecule (Indian blood group) | 0.092294 |
| NTN4 | netrin 4 | 0.088323 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0815655 |
| HMGA2 | high mobility group AT-hook 2 | 0.0762366 |
| NRP1 | neuropilin 1 | 0.0735374 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0692561 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0687324 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.066891 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0638931 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0619251 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0618985 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0605295 |
| KYNU | kynureninase | 0.0598902 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0539599 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0535755 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0527232 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0515219 |
| NAV2 | neuron navigator 2 | 0.0510051 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0509127 |
| NUMB | numb homolog (Drosophila) | 0.0508812 |
| VRK2 | vaccinia related kinase 2 | 0.0483082 |
| EHBP1 | EH domain binding protein 1 | 0.0481657 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0465888 |
| PID1 | phosphotyrosine interaction domain containing 1 | 0.0456764 |
| TPST1 | tyrosylprotein sulfotransferase 1 | 0.0456133 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0452573 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0444628 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0433036 |
| VIM | vimentin | 0.0423652 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0423611 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.0416564 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0408513 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0397555 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0397336 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0394756 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0394514 |
| S100A6 | S100 calcium binding protein A6 | 0.0385769 |
| SNX9 | sorting nexin 9 | 0.0376936 |
| VMP1 | vacuole membrane protein 1 | 0.0376814 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0372594 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0365543 |
| RNF24 | ring finger protein 24 | 0.0365157 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0364832 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0359591 |
| MYO10 | myosin X | 0.0356211 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0351148 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0349629 |
| TMEM131 | transmembrane protein 131 | 0.0349328 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0346119 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0345197 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0341036 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0339385 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0337194 |
| STK38L | serine/threonine kinase 38 like | 0.0336691 |
| CLMP | CXADR-like membrane protein | 0.0336621 |
| ARHGAP42 | Rho GTPase activating protein 42 | 0.0334163 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0333601 |
| TGM2 | transglutaminase 2 | 0.0331503 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0328427 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.032071 |
| OXSR1 | oxidative stress responsive 1 | 0.0314822 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0310486 |
| ARID3B | AT rich interactive domain 3B (BRIGHT-like) | 0.030789 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0306815 |
| MAPK8 | mitogen-activated protein kinase 8 | 0.0305549 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0305381 |
| OSMR | oncostatin M receptor | 0.0305097 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0304119 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0301952 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.029937 |
| KSR1 | kinase suppressor of ras 1 | 0.0298987 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | 0.0296803 |
| IL6ST | interleukin 6 signal transducer | 0.0296722 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0292848 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0292668 |
| ITGAV | integrin, alpha V | 0.0292364 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0290296 |
| ADD3 | adducin 3 (gamma) | 0.0286414 |
| HIP1 | huntingtin interacting protein 1 | 0.0275215 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.027515 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0274981 |
| AHI1 | Abelson helper integration site 1 | 0.027334 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0273004 |
| FNIP1 | folliculin interacting protein 1 | 0.027247 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0270932 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0269938 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0269349 |
| MED13 | mediator complex subunit 13 | 0.0268733 |
| GALNT1 | polypeptide N-acetylgalactosaminyltransferase 1 | 0.0267634 |
| RGS17 | regulator of G-protein signaling 17 | 0.0264414 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0263935 |
| TMSB10 | thymosin beta 10 | 0.0263848 |
| TMEM87A | transmembrane protein 87A | 0.026292 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0262052 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.178074 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.170197 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.159728 |
| CDH13 | cadherin 13 | -0.0948214 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0790257 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0767812 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0718208 |
| GPC6 | glypican 6 | -0.0688336 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0686865 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0598797 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0596911 |
| FN1 | fibronectin 1 | -0.0584636 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.054883 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0501275 |
| RPS12 | ribosomal protein S12 | -0.048876 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | -0.0482201 |
| UBC | ubiquitin C | -0.0480527 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.045921 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0452249 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0447064 |
| PCBP2 | poly(rC) binding protein 2 | -0.0433364 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0425265 |
| FAM13A | family with sequence similarity 13, member A | -0.0422832 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0401296 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0396205 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0395734 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.039278 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0385292 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0384778 |
| PRELID2 | PRELI domain containing 2 | -0.0376781 |
| MTSS1 | metastasis suppressor 1 | -0.0376132 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0374841 |
| HDAC4 | histone deacetylase 4 | -0.0368194 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0363024 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0361001 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0358571 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.034844 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0341035 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0331972 |
| CANX | calnexin | -0.0323139 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0322135 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0319341 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0316026 |
| EFCAB13 | EF-hand calcium binding domain 13 | -0.031459 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0310901 |
| MECOM | MDS1 and EVI1 complex locus | -0.0305743 |
| CFAP20DC | CFAP20 domain containing | -0.0301141 |
| ATG7 | autophagy related 7 | -0.0298505 |
| PKM | pyruvate kinase, muscle | -0.0297657 |
| MCL1 | myeloid cell leukemia 1 | -0.0293209 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0290119 |
| CDK14 | cyclin-dependent kinase 14 | -0.028906 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0285301 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0277295 |
| FAM107B | family with sequence similarity 107, member B | -0.0277008 |
| HDLBP | high density lipoprotein binding protein | -0.0275828 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0275315 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0274782 |
| RPL12 | ribosomal protein L12 | -0.0273889 |
| CA12 | carbonic anhydrase XII | -0.0258061 |
| ENO1 | enolase 1, (alpha) | -0.0257845 |
| MT2A | metallothionein 2A | -0.025337 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0250098 |
| RPL23 | ribosomal protein L23 | -0.0245667 |
| FAM20C | family with sequence similarity 20, member C | -0.0244023 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0241274 |
| SCAPER | S-phase cyclin A-associated protein in the ER | -0.0234516 |
| SYT1 | synaptotagmin I | -0.0232065 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0229589 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0227223 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0226973 |
| MYOF | myoferlin | -0.0223649 |
| FBN1 | fibrillin 1 | -0.0221326 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | -0.0221227 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0220815 |
| OGA | O-GlcNAcase | -0.0220307 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0217901 |
| FAM162A | family with sequence similarity 162, member A | -0.02172 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0216922 |
| DST | dystonin | -0.0213741 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0213589 |
| OXR1 | oxidation resistance 1 | -0.021309 |
| ZNF804A | zinc finger protein 804A | -0.0212112 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | -0.0211909 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0210519 |
| RSF1 | remodeling and spacing factor 1 | -0.0208883 |
| RPL31 | ribosomal protein L31 | -0.0206983 |
| LDHA | lactate dehydrogenase A | -0.0206777 |
| MEF2A | myocyte enhancer factor 2A | -0.0204727 |
| LOX | lysyl oxidase | -0.0203161 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0202966 |
| TSPAN5 | tetraspanin 5 | -0.0201731 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0193298 |
| FRMPD4 | FERM and PDZ domain containing 4 | -0.0192685 |
| SLC44A5 | solute carrier family 44, member 5 | -0.0192166 |
| PHF21A | PHD finger protein 21A | -0.0191707 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0188336 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0187456 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0186803 |
| RPS2 | ribosomal protein S2 | -0.0186417 |
