| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Aliskiren perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Aliskiren_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.107489 |
| GRAMD1B | GRAM domain containing 1B | 0.0967669 |
| POTEF | POTE ankyrin domain family, member F | 0.0860738 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0841215 |
| PFN1 | profilin 1 | 0.0792298 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0776262 |
| WWOX | WW domain containing oxidoreductase | 0.0638079 |
| VIM | vimentin | 0.0626552 |
| IGF2 | insulin-like growth factor 2 | 0.0590218 |
| MCL1 | myeloid cell leukemia 1 | 0.0590003 |
| TMSB10 | thymosin beta 10 | 0.0581821 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0489393 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0483837 |
| HMGA1 | high mobility group AT-hook 1 | 0.0464452 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0446989 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0446888 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0398708 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0383663 |
| MAP1B | microtubule-associated protein 1B | 0.0382052 |
| PKM | pyruvate kinase, muscle | 0.0378382 |
| PDE8A | phosphodiesterase 8A | 0.0351959 |
| MSN | moesin | 0.0348913 |
| CMIP | c-Maf inducing protein | 0.0346065 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0341073 |
| PLS3 | plastin 3 | 0.0314239 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.031192 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0311164 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0310141 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0308272 |
| AXL | AXL receptor tyrosine kinase | 0.030751 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0307312 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0306767 |
| CENPF | centromere protein F, 350/400kDa | 0.030611 |
| TGM2 | transglutaminase 2 | 0.0305402 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0303864 |
| ACTN1 | actinin, alpha 1 | 0.0301588 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0294859 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0290679 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.0287578 |
| FHIT | fragile histidine triad | 0.0284097 |
| EGR1 | early growth response 1 | 0.0283673 |
| RTN4 | reticulon 4 | 0.0280019 |
| HDGF | hepatoma-derived growth factor | 0.0278183 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0275719 |
| TAGLN2 | transgelin 2 | 0.0274091 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0273624 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0272251 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.02704 |
| FAM107B | family with sequence similarity 107, member B | 0.0265849 |
| RBM25 | RNA binding motif protein 25 | 0.0265138 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0264729 |
| CCNY | cyclin Y | 0.0259621 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.0253672 |
| FAT1 | FAT atypical cadherin 1 | 0.0252608 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0251031 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.02496 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0249557 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0249117 |
| CBX3 | chromobox homolog 3 | 0.0247978 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0247517 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0244619 |
| MYADM | myeloid-associated differentiation marker | 0.0244059 |
| PCBP2 | poly(rC) binding protein 2 | 0.0242632 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0241409 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0240352 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0239751 |
| PDE10A | phosphodiesterase 10A | 0.0239736 |
| SETD5 | SET domain containing 5 | 0.0238003 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0237362 |
| FLNB | filamin B, beta | 0.0229914 |
| FOXP1 | forkhead box P1 | 0.0228713 |
| TMOD3 | tropomodulin 3 (ubiquitous) | 0.0227695 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0226856 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0226503 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0225976 |
| ZNF277 | zinc finger protein 277 | 0.0223452 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0223388 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0222595 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.022224 |
| IGFBP4 | insulin-like growth factor binding protein 4 | 0.0221159 |
| RFWD3 | ring finger and WD repeat domain 3 | 0.0217298 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0216976 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0216525 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0209411 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0206562 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0205527 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0205089 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.020456 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0200723 |
| EPAS1 | endothelial PAS domain protein 1 | 0.019955 |
| NRG1 | neuregulin 1 | 0.0199388 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0199089 |
| TMEM245 | transmembrane protein 245 | 0.0198564 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0196989 |
| CALD1 | caldesmon 1 | 0.019487 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0193019 |
| JMJD1C | jumonji domain containing 1C | 0.0191993 |
| MEF2D | myocyte enhancer factor 2D | 0.0191968 |
| PTEN | phosphatase and tensin homolog | 0.0191231 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0191055 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.157667 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.15376 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.141313 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.139984 |
| IER3 | immediate early response 3 | -0.0944394 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0917419 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0898335 |
| CAVIN1 | caveolae associated protein 1 | -0.0870946 |
| MT2A | metallothionein 2A | -0.0860042 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0844934 |
| AHNAK | AHNAK nucleoprotein | -0.0731292 |
| FTL | ferritin, light polypeptide | -0.0730203 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0713925 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0712273 |
| APP | amyloid beta (A4) precursor protein | -0.0704579 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0656143 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.05722 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0525289 |
| RPL19 | ribosomal protein L19 | -0.0513069 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0505645 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0501516 |
| HLA-E | major histocompatibility complex, class I, E | -0.0490855 |
| RPS12 | ribosomal protein S12 | -0.0460733 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0458758 |
| RPL4 | ribosomal protein L4 | -0.0455493 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0448911 |
| RPL23 | ribosomal protein L23 | -0.0446194 |
| RBM39 | RNA binding motif protein 39 | -0.0428196 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0427077 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0409951 |
| HLA-B | major histocompatibility complex, class I, B | -0.0401861 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0390159 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0387031 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0386812 |
| RPS8 | ribosomal protein S8 | -0.0382024 |
| STC1 | stanniocalcin 1 | -0.0377692 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0375091 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0372244 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0371609 |
| CANX | calnexin | -0.0369385 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0369167 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0368078 |
| SQSTM1 | sequestosome 1 | -0.0360018 |
| S100A10 | S100 calcium binding protein A10 | -0.035883 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0357114 |
| RPL37 | ribosomal protein L37 | -0.0352615 |
| RPL26 | ribosomal protein L26 | -0.0342055 |
| HDAC9 | histone deacetylase 9 | -0.0341716 |
| PYGL | phosphorylase, glycogen, liver | -0.0340898 |
| KIF5B | kinesin family member 5B | -0.0339347 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0335931 |
| ARF1 | ADP-ribosylation factor 1 | -0.0335107 |
| RPS27A | ribosomal protein S27a | -0.0325177 |
| RPLP1 | ribosomal protein, large, P1 | -0.032363 |
| RPS3 | ribosomal protein S3 | -0.032105 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0318158 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0316748 |
| DYNC1LI2 | dynein, cytoplasmic 1, light intermediate chain 2 | -0.031535 |
| RPL34 | ribosomal protein L34 | -0.0314614 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0311525 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0305796 |
| RPL31 | ribosomal protein L31 | -0.0300315 |
| HLA-C | major histocompatibility complex, class I, C | -0.0298476 |
| CALR | calreticulin | -0.0297269 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0293548 |
| RPS2 | ribosomal protein S2 | -0.0293206 |
| AHR | aryl hydrocarbon receptor | -0.029308 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0292093 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0290112 |
| GLG1 | golgi glycoprotein 1 | -0.0289362 |
| OGFRL1 | opioid growth factor receptor-like 1 | -0.027991 |
| RPS25 | ribosomal protein S25 | -0.0278414 |
| OSMR | oncostatin M receptor | -0.027667 |
| HDLBP | high density lipoprotein binding protein | -0.0276172 |
| ATG7 | autophagy related 7 | -0.0276123 |
| RACK1 | receptor for activated C kinase 1 | -0.0274909 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0269149 |
| TXNRD1 | thioredoxin reductase 1 | -0.0268995 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0268147 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0268001 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0263522 |
| YME1L1 | YME1-like 1 ATPase | -0.0262927 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0259584 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.0259551 |
| PHF3 | PHD finger protein 3 | -0.0259029 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0257945 |
| SERINC1 | serine incorporator 1 | -0.0254649 |
| FAM110C | family with sequence similarity 110, member C | -0.0251235 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.025061 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0249876 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0248859 |
| CFDP1 | craniofacial development protein 1 | -0.0246775 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0246267 |
| RPL30 | ribosomal protein L30 | -0.0246231 |
| CDK13 | cyclin-dependent kinase 13 | -0.0243251 |
| RHOA | ras homolog family member A | -0.0240771 |
| GOLT1B | golgi transport 1B | -0.0238852 |
| VCL | vinculin | -0.0237632 |
| MORF4L2 | mortality factor 4 like 2 | -0.0234573 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0233621 |
