| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Aliskiren perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Aliskiren_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| KYNU | kynureninase | 0.123987 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0989542 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0852405 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0839106 |
| LAMC2 | laminin, gamma 2 | 0.0724641 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0629548 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0523796 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0483842 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0465996 |
| IGF2 | insulin-like growth factor 2 | 0.0443656 |
| VEGFC | vascular endothelial growth factor C | 0.0435781 |
| FLNB | filamin B, beta | 0.0432167 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0431369 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0416375 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0392961 |
| PARD3 | par-3 family cell polarity regulator | 0.0386749 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.038489 |
| NAV2 | neuron navigator 2 | 0.0384466 |
| SDC4 | syndecan 4 | 0.0382106 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.037767 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.037138 |
| RIGI | RNA sensor RIG-I | 0.0362902 |
| ENKUR | enkurin, TRPC channel interacting protein | 0.0361862 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0361675 |
| NEBL | nebulette | 0.0360928 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0356775 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0347602 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0345055 |
| FTL | ferritin, light polypeptide | 0.0343997 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0333566 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0327115 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0322505 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.032143 |
| INTS6 | integrator complex subunit 6 | 0.0319602 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0314788 |
| KLF6 | Kruppel-like factor 6 | 0.0313705 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0311789 |
| MT2A | metallothionein 2A | 0.0311465 |
| TXNIP | thioredoxin interacting protein | 0.0308998 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0303558 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0291221 |
| SEPTIN9 | septin 9 | 0.029117 |
| ANO6 | anoctamin 6 | 0.0285545 |
| C1D | C1D nuclear receptor corepressor | 0.0281314 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0277321 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0275091 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.027219 |
| FN1 | fibronectin 1 | 0.0266231 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0260431 |
| VIM | vimentin | 0.0259379 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.0259229 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0258155 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0258069 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.025533 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | 0.0254073 |
| RAD51B | RAD51 paralog B | 0.0251997 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0251819 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0245852 |
| PDZD8 | PDZ domain containing 8 | 0.0245576 |
| NRG1 | neuregulin 1 | 0.0245336 |
| OLA1 | Obg-like ATPase 1 | 0.0241846 |
| TENM3 | teneurin transmembrane protein 3 | 0.0240531 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0240096 |
| SACK1A | scaffolding CK1 anchoring protein A | 0.0239216 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0238906 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0238797 |
| EFNA5 | ephrin-A5 | 0.0238373 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0236974 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | 0.0234768 |
| DUSP16 | dual specificity phosphatase 16 | 0.0232338 |
| SMYD3 | SET and MYND domain containing 3 | 0.0231877 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0231561 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0231477 |
| EGFR | epidermal growth factor receptor | 0.0231204 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.02309 |
| BPTF | bromodomain PHD finger transcription factor | 0.0229631 |
| SKIL | SKI-like proto-oncogene | 0.0227437 |
| CD109 | CD109 molecule | 0.0227354 |
| PCBP2 | poly(rC) binding protein 2 | 0.0227198 |
| DSCAM | Down syndrome cell adhesion molecule | 0.022581 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0225074 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0223913 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.022264 |
| DISC1 | disrupted in schizophrenia 1 | 0.0220925 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0219858 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0219666 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.021515 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0214969 |
| AFDN | afadin, adherens junction formation factor | 0.0213221 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | 0.0212437 |
| WDR70 | WD repeat domain 70 | 0.0212016 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0211154 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0210922 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0210786 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.020971 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.020954 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | 0.0208913 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0207749 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | 0.0207698 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.020743 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MUC16 | mucin 16, cell surface associated | -0.0893305 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0859578 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0853268 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.080471 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0734092 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0698865 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0695245 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0601524 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0573287 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0539799 |
| LMO7 | LIM domain 7 | -0.0532283 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0531844 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0520534 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0519342 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0495158 |
| SRPK2 | SRSF protein kinase 2 | -0.0486025 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0483265 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0462797 |
| B2M | beta-2-microglobulin | -0.0453372 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0442486 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0435482 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0422818 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0417247 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0415937 |
| MACC1 | metastasis associated in colon cancer 1 | -0.040588 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0402487 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0391799 |
| ATOSA | atos homolog A | -0.0378975 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0375506 |
| FOXO3 | forkhead box O3 | -0.0375126 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0374292 |
| SLMAP | sarcolemma associated protein | -0.0370596 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0367924 |
| LDLR | low density lipoprotein receptor | -0.0365908 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0361622 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0358851 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0352255 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0348286 |
| FDPS | farnesyl diphosphate synthase | -0.0343816 |
| RPS6 | ribosomal protein S6 | -0.0342885 |
| STC1 | stanniocalcin 1 | -0.0337397 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0332955 |
| USP6NL | USP6 N-terminal like | -0.0328074 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0324524 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0322136 |
| CUX1 | cut-like homeobox 1 | -0.0321103 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0319853 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | -0.0319654 |
| TMEM87A | transmembrane protein 87A | -0.0317286 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0317267 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0317107 |
| CEP350 | centrosomal protein 350kDa | -0.0316839 |
| JUP | junction plakoglobin | -0.031208 |
| ABHD17C | abhydrolase domain containing 17C | -0.0310557 |
| RCOR1 | REST corepressor 1 | -0.0296362 |
| USP3 | ubiquitin specific peptidase 3 | -0.0294592 |
| PTEN | phosphatase and tensin homolog | -0.0292135 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.028995 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | -0.0286831 |
| RREB1 | ras responsive element binding protein 1 | -0.0283926 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0280056 |
| MYOF | myoferlin | -0.0278543 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0278165 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0277451 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0277254 |
| STEAP4 | STEAP family member 4 | -0.027485 |
| PRRC2B | proline-rich coiled-coil 2B | -0.027348 |
| RAB8B | RAB8B, member RAS oncogene family | -0.0272553 |
| EVI5 | ecotropic viral integration site 5 | -0.0272 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0271973 |
| DUSP4 | dual specificity phosphatase 4 | -0.0268622 |
| RPL23 | ribosomal protein L23 | -0.0264632 |
| CXXC1 | CXXC finger protein 1 | -0.0264246 |
| CANX | calnexin | -0.026282 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0262591 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | -0.0262297 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0261992 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0260819 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0257493 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0257364 |
| UBC | ubiquitin C | -0.02565 |
| FAM13A | family with sequence similarity 13, member A | -0.0255515 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0253858 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0251726 |
| RTN4 | reticulon 4 | -0.0251011 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0250264 |
| ZNF609 | zinc finger protein 609 | -0.0247077 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.0246362 |
| TOR1AIP2 | torsin A interacting protein 2 | -0.0244463 |
| VCP | valosin containing protein | -0.0243867 |
| ATG14 | autophagy related 14 | -0.0241355 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0240299 |
| S100A8 | S100 calcium binding protein A8 | -0.0240038 |
| SHTN1 | shootin 1 | -0.023912 |
| FOXO1 | forkhead box O1 | -0.0236469 |
| ITPRID2 | ITPR interacting domain containing 2 | -0.023424 |
| GLG1 | golgi glycoprotein 1 | -0.0231417 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0230069 |
| DST | dystonin | -0.0229544 |
| PARD6B | par-6 family cell polarity regulator beta | -0.0229096 |
