| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Aliskiren perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Aliskiren_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.251606 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.139774 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0683182 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0652854 |
| AFF3 | AF4/FMR2 family, member 3 | 0.0628382 |
| MCL1 | myeloid cell leukemia 1 | 0.0595013 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0562264 |
| POTEF | POTE ankyrin domain family, member F | 0.0527402 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.048926 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0478291 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0468843 |
| YBX3 | Y box binding protein 3 | 0.0462528 |
| ATXN1 | ataxin 1 | 0.0437912 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0434743 |
| WWOX | WW domain containing oxidoreductase | 0.0410569 |
| PDE10A | phosphodiesterase 10A | 0.0402293 |
| PRELID2 | PRELI domain containing 2 | 0.0385207 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0379055 |
| HMGA2 | high mobility group AT-hook 2 | 0.0378423 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0376229 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0371263 |
| DOCK5 | dedicator of cytokinesis 5 | 0.036506 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0351915 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 0.0349436 |
| AEBP2 | AE binding protein 2 | 0.0343824 |
| RAD51B | RAD51 paralog B | 0.0339809 |
| FMNL2 | formin-like 2 | 0.0333024 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0328851 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0315618 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0304356 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.029286 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0292383 |
| TPM3 | tropomyosin 3 | 0.0285186 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0280267 |
| PRKCE | protein kinase C, epsilon | 0.0273963 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0273928 |
| EXOC4 | exocyst complex component 4 | 0.0260393 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0248692 |
| TRIM9 | tripartite motif containing 9 | 0.0241811 |
| INTS6 | integrator complex subunit 6 | 0.0239631 |
| NLGN1 | neuroligin 1 | 0.0234518 |
| RYR3 | ryanodine receptor 3 | 0.0223597 |
| HOMER1 | homer scaffolding protein 1 | 0.0215093 |
| BRD2 | bromodomain containing 2 | 0.0214129 |
| DST | dystonin | 0.0209272 |
| DIAPH2 | diaphanous-related formin 2 | 0.0208313 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0206352 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0204259 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0204155 |
| ATP11A | ATPase, class VI, type 11A | 0.0203828 |
| EGFR | epidermal growth factor receptor | 0.0201754 |
| EGR1 | early growth response 1 | 0.0195419 |
| NEK10 | NIMA-related kinase 10 | 0.0192718 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0191354 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0190736 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 0.0189204 |
| RPL3 | ribosomal protein L3 | 0.0187486 |
| SVIL | supervillin | 0.0186706 |
| TAPBP | TAP binding protein (tapasin) | 0.0185031 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0183485 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0180137 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0172975 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0172918 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0172553 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0172444 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.017223 |
| VCL | vinculin | 0.0172042 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0166354 |
| BNC2 | basonuclin 2 | 0.016574 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0165206 |
| TPM2 | tropomyosin 2 (beta) | 0.0162974 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0162557 |
| VMP1 | vacuole membrane protein 1 | 0.016254 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0159609 |
| GPATCH2L | G patch domain containing 2-like | 0.0159586 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | 0.0159349 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0158048 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0157834 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 0.0155933 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0153617 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0152751 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0152087 |
| ZNF407 | zinc finger protein 407 | 0.0152087 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0151005 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.014958 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0149531 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0148722 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0147441 |
| WDR27 | WD repeat domain 27 | 0.0147421 |
| GOLGB1 | golgin B1 | 0.014681 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.014639 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0146329 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0144006 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0142126 |
| RPS7 | ribosomal protein S7 | 0.0138091 |
| NTSR1 | neurotensin receptor 1 (high affinity) | 0.0137347 |
| FHIT | fragile histidine triad | 0.0136824 |
| HDAC4 | histone deacetylase 4 | 0.0136252 |
| OSMR | oncostatin M receptor | 0.0134716 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0134556 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.122145 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.102983 |
| PTMA | prothymosin, alpha | -0.0981706 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0940205 |
| VIM | vimentin | -0.0807583 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0650928 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0643064 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0630766 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0574404 |
| RTN4 | reticulon 4 | -0.0497363 |
| PHIP | pleckstrin homology domain interacting protein | -0.0474207 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.047209 |
| RPLP1 | ribosomal protein, large, P1 | -0.0413596 |
| OGA | O-GlcNAcase | -0.0411543 |
| ZFR | zinc finger RNA binding protein | -0.0407724 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0407078 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0395094 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0385316 |
| RPL35A | ribosomal protein L35a | -0.0373672 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0366748 |
| TMSB10 | thymosin beta 10 | -0.0364976 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0343171 |
| XPO1 | exportin 1 | -0.0341635 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0338308 |
| CAVIN1 | caveolae associated protein 1 | -0.0335827 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0316704 |
| MKI67 | marker of proliferation Ki-67 | -0.0315994 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0312173 |
| MORF4L2 | mortality factor 4 like 2 | -0.0310953 |
| PGK1 | phosphoglycerate kinase 1 | -0.0310398 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0309009 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0307575 |
| GOLGA4 | golgin A4 | -0.0302941 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0301622 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0298897 |
| RPL12 | ribosomal protein L12 | -0.0297914 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0296711 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.029478 |
| LDHB | lactate dehydrogenase B | -0.0289795 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0285553 |
| GNAS | GNAS complex locus | -0.0285338 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0284841 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0284014 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0281295 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0278177 |
| RPS8 | ribosomal protein S8 | -0.0277028 |
| RPL23 | ribosomal protein L23 | -0.0274657 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.027351 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0272792 |
| RPL19 | ribosomal protein L19 | -0.0269258 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0268382 |
| FBXO11 | F-box protein 11 | -0.0267334 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0264529 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0258368 |
| RPLP0 | ribosomal protein, large, P0 | -0.0257029 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0256707 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0256591 |
| SPAG9 | sperm associated antigen 9 | -0.0255072 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0255029 |
| SRP72 | signal recognition particle 72kDa | -0.0254637 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0252627 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0252504 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.02513 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0250431 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0248152 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0246145 |
| CTTNBP2NL | CTTNBP2 N-terminal like | -0.0245561 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0243077 |
| MATR3 | matrin 3 | -0.0242568 |
| RPS24 | ribosomal protein S24 | -0.024179 |
| H1-0 | H1.0 linker histone | -0.0239094 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0236788 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0236786 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0235353 |
| RAB1A | RAB1A, member RAS oncogene family | -0.023125 |
| FTL | ferritin, light polypeptide | -0.0227428 |
| CANX | calnexin | -0.0226329 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.022438 |
| BBX | bobby sox homolog (Drosophila) | -0.0223912 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0223864 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0223619 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0223324 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0222385 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0220088 |
| RPS6 | ribosomal protein S6 | -0.0219871 |
| RBM39 | RNA binding motif protein 39 | -0.0218946 |
| CDC27 | cell division cycle 27 | -0.0215639 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0214517 |
| ZNF292 | zinc finger protein 292 | -0.0214128 |
| RPS29 | ribosomal protein S29 | -0.0213334 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0211458 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0210811 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.020986 |
| RPL38 | ribosomal protein L38 | -0.0209788 |
| CCND2 | cyclin D2 | -0.0209195 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0208744 |
| RNF169 | ring finger protein 169 | -0.0207751 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | -0.0206431 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0206108 |
| WDR45B | WD repeat domain 45B | -0.0206009 |
