| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Aliskiren perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Aliskiren_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| POTEF | POTE ankyrin domain family, member F | 0.106742 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0542624 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0520634 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0519889 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0465246 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0433637 |
| BRD2 | bromodomain containing 2 | 0.0407979 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.039979 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0357065 |
| DTNA | dystrobrevin, alpha | 0.0341816 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0337543 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0324889 |
| TPM3 | tropomyosin 3 | 0.0320734 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.031865 |
| VEGFA | vascular endothelial growth factor A | 0.0303323 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0300165 |
| MCL1 | myeloid cell leukemia 1 | 0.0296946 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0293529 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0291617 |
| GOLGB1 | golgin B1 | 0.0286667 |
| MSN | moesin | 0.0278725 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0268523 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0261253 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0255912 |
| RPL3 | ribosomal protein L3 | 0.0247646 |
| EGR1 | early growth response 1 | 0.0247243 |
| RPS2 | ribosomal protein S2 | 0.0244506 |
| BLZF1 | basic leucine zipper nuclear factor 1 | 0.0224119 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.021729 |
| VMP1 | vacuole membrane protein 1 | 0.0212437 |
| DSPP | dentin sialophosphoprotein | 0.0209286 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0205806 |
| RCOR1 | REST corepressor 1 | 0.0202067 |
| PGBD5 | piggyBac transposable element derived 5 | 0.020157 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0200923 |
| HDAC9 | histone deacetylase 9 | 0.0196829 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0192481 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0189792 |
| INTS6 | integrator complex subunit 6 | 0.0189125 |
| PRKCA | protein kinase C, alpha | 0.0184359 |
| RAD51B | RAD51 paralog B | 0.0181321 |
| OCLN | occludin | 0.0180485 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0179809 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0177234 |
| MYO1E | myosin IE | 0.017607 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0170851 |
| RAI14 | retinoic acid induced 14 | 0.0168377 |
| USP53 | ubiquitin specific peptidase 53 | 0.0167625 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0166744 |
| PHACTR4 | phosphatase and actin regulator 4 | 0.0165481 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0164613 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0160718 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0160161 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0156513 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0155763 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0154607 |
| ARHGAP20 | Rho GTPase activating protein 20 | 0.015371 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0150112 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.015011 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0147092 |
| RIGI | RNA sensor RIG-I | 0.0146853 |
| PALLD | palladin, cytoskeletal associated protein | 0.014595 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0145941 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0144323 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.0143732 |
| VGLL3 | vestigial-like family member 3 | 0.0137074 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0137006 |
| SKIL | SKI-like proto-oncogene | 0.0133732 |
| TAPBP | TAP binding protein (tapasin) | 0.0132437 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0131249 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0130595 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0127326 |
| ABHD3 | abhydrolase domain containing 3 | 0.0126379 |
| GLRX | glutaredoxin (thioltransferase) | 0.0125426 |
| ATF3 | activating transcription factor 3 | 0.012373 |
| PCBP2 | poly(rC) binding protein 2 | 0.0122651 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.012214 |
| FNIP1 | folliculin interacting protein 1 | 0.0121919 |
| JUP | junction plakoglobin | 0.0120026 |
| CNNM4 | cyclin and CBS domain divalent metal cation transport mediator 4 | 0.0119553 |
| SERINC5 | serine incorporator 5 | 0.0119152 |
| SHISA5 | shisa family member 5 | 0.0117481 |
| PTK2B | protein tyrosine kinase 2 beta | 0.0117317 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0116981 |
| ATP6V1C1 | ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 | 0.0116701 |
| FHIT | fragile histidine triad | 0.011646 |
| MX1 | MX dynamin-like GTPase 1 | 0.0116179 |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | 0.0116139 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0115767 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0115684 |
| KDM4B | lysine (K)-specific demethylase 4B | 0.0114539 |
| RPS12 | ribosomal protein S12 | 0.0114129 |
| TUFT1 | tuftelin 1 | 0.0113765 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.0112894 |
| NOTCH2 | notch 2 | 0.0112837 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0112753 |
| TMF1 | TATA element modulatory factor 1 | 0.0111946 |
| ARF4 | ADP-ribosylation factor 4 | 0.0111896 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0111521 |
| PPP1R13B | protein phosphatase 1, regulatory subunit 13B | 0.0111402 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.153696 |
| PTMA | prothymosin, alpha | -0.145697 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.137301 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.125168 |
| FN1 | fibronectin 1 | -0.116788 |
| S100A6 | S100 calcium binding protein A6 | -0.112495 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.098308 |
| LMO7 | LIM domain 7 | -0.0930871 |
| ASPH | aspartate beta-hydroxylase | -0.0832314 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0801616 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0796141 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0763425 |
| TOP1 | topoisomerase (DNA) I | -0.0755222 |
| PGK1 | phosphoglycerate kinase 1 | -0.072902 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0648912 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0637987 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.06362 |
| TMSB4X | thymosin beta 4, X-linked | -0.0608232 |
| CD2AP | CD2-associated protein | -0.0599719 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0587996 |
| UBC | ubiquitin C | -0.0578812 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0570763 |
| FTL | ferritin, light polypeptide | -0.05591 |
| RPL35A | ribosomal protein L35a | -0.054663 |
| S100A10 | S100 calcium binding protein A10 | -0.0526828 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0521759 |
| RPL34 | ribosomal protein L34 | -0.0507328 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0501963 |
| RNF145 | ring finger protein 145 | -0.0500414 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0495599 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0493128 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0492147 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0479004 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0473339 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0470523 |
| ACTG1 | actin gamma 1 | -0.0468678 |
| TFG | TRK-fused gene | -0.0465187 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0463009 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0458503 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0455043 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0451458 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0449293 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0446089 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0442252 |
| RPLP1 | ribosomal protein, large, P1 | -0.0437958 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.043228 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0430993 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0421121 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0416989 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0414157 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0411035 |
| HMGB2 | high mobility group box 2 | -0.0399315 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0397238 |
| ARF1 | ADP-ribosylation factor 1 | -0.0396563 |
| GNAS | GNAS complex locus | -0.0393994 |
| PLAU | plasminogen activator, urokinase | -0.0382482 |
| HMGA1 | high mobility group AT-hook 1 | -0.038212 |
| RPL32 | ribosomal protein L32 | -0.0381864 |
| RBM39 | RNA binding motif protein 39 | -0.0377959 |
| ANXA2 | annexin A2 | -0.0376728 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0373314 |
| TMEM123 | transmembrane protein 123 | -0.0372818 |
| RPS24 | ribosomal protein S24 | -0.0367939 |
| KRT7 | keratin 7, type II | -0.0363468 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0360125 |
| RPL8 | ribosomal protein L8 | -0.0358044 |
| TMEM263 | transmembrane protein 263 | -0.0356779 |
| QKI | QKI, KH domain containing, RNA binding | -0.035352 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0352442 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0352392 |
| RPLP2 | ribosomal protein, large, P2 | -0.0349722 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0346982 |
| RPS19 | ribosomal protein S19 | -0.0345489 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0344261 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | -0.0341821 |
| FAM3C | family with sequence similarity 3, member C | -0.0340617 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.033839 |
| RPLP0 | ribosomal protein, large, P0 | -0.033565 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0334287 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0333715 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0323796 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.031955 |
| FAM162A | family with sequence similarity 162, member A | -0.0319115 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.0315124 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0313483 |
| RPL23 | ribosomal protein L23 | -0.0310189 |
| CDK17 | cyclin-dependent kinase 17 | -0.0309763 |
| USP3 | ubiquitin specific peptidase 3 | -0.0306811 |
| CALU | calumenin | -0.0306783 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0305065 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0304926 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.0304178 |
| AREG | amphiregulin | -0.0304083 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | -0.0302914 |
| RASA2 | RAS p21 protein activator 2 | -0.0301898 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | -0.0301551 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0297435 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0297314 |
| RPL12 | ribosomal protein L12 | -0.0294617 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0293308 |
