| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Aliskiren perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Aliskiren_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.113827 |
| DST | dystonin | 0.075913 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0631311 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0595258 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0557077 |
| KYNU | kynureninase | 0.0494093 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.048677 |
| EFNA5 | ephrin-A5 | 0.0471583 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0453268 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0441277 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0421387 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0392721 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.035586 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0349595 |
| PDE10A | phosphodiesterase 10A | 0.0318199 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0308762 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0304933 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0292638 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.027879 |
| RPS6 | ribosomal protein S6 | 0.026376 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0261417 |
| PTEN | phosphatase and tensin homolog | 0.0251302 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0245772 |
| PDE7B | phosphodiesterase 7B | 0.0239987 |
| KIAA0825 | KIAA0825 | 0.0227741 |
| RPS23 | ribosomal protein S23 | 0.0226615 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | 0.0223308 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0219885 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0219736 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0216712 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0206619 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0204603 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0200699 |
| VCL | vinculin | 0.0196417 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0192308 |
| MSN | moesin | 0.0191909 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0188135 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0187143 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0186466 |
| RPS2 | ribosomal protein S2 | 0.0181282 |
| RPS17 | ribosomal protein S17 | 0.0181044 |
| RAD51B | RAD51 paralog B | 0.0180289 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.017986 |
| EPHA4 | EPH receptor A4 | 0.0176691 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0175391 |
| ASTN2 | astrotactin 2 | 0.0172748 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0171877 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0171239 |
| RPL21 | ribosomal protein L21 | 0.0170937 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0170456 |
| COL4A6 | collagen, type IV, alpha 6 | 0.0167462 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0165147 |
| RPL3 | ribosomal protein L3 | 0.0163921 |
| GPC6 | glypican 6 | 0.016268 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0162021 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0160049 |
| RPS19 | ribosomal protein S19 | 0.0155661 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0154872 |
| BPTF | bromodomain PHD finger transcription factor | 0.0152821 |
| GRAMD1B | GRAM domain containing 1B | 0.0148856 |
| PFN1 | profilin 1 | 0.0146558 |
| GREM2 | gremlin 2, DAN family BMP antagonist | 0.0146526 |
| TXNIP | thioredoxin interacting protein | 0.0145018 |
| SLF1 | SMC5-SMC6 complex localization factor 1 | 0.0140642 |
| CADM2 | cell adhesion molecule 2 | 0.01404 |
| SCARA5 | scavenger receptor class A, member 5 | 0.0139985 |
| NCAM2 | neural cell adhesion molecule 2 | 0.0138043 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0136847 |
| POTEF | POTE ankyrin domain family, member F | 0.013605 |
| GLRX | glutaredoxin (thioltransferase) | 0.0135844 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0133735 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0133641 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0132216 |
| ATP5F1E | ATP synthase F1 subunit epsilon | 0.0132133 |
| SORBS2 | sorbin and SH3 domain containing 2 | 0.0131844 |
| DNER | delta/notch-like EGF repeat containing | 0.0129601 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0129266 |
| CLU | clusterin | 0.0129225 |
| EXOC4 | exocyst complex component 4 | 0.0127315 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0126414 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.0125825 |
| MYPN | myopalladin | 0.0123406 |
| RPL36 | ribosomal protein L36 | 0.0123339 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0122857 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0122548 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0121256 |
| MARCHF1 | membrane associated ring-CH-type finger 1 | 0.0121231 |
| FLRT2 | fibronectin leucine rich transmembrane protein 2 | 0.0121181 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | 0.0120202 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0118624 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0117382 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0116978 |
| PCDH15 | protocadherin-related 15 | 0.0114993 |
| MPP2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | 0.0114993 |
| METTL15 | methyltransferase like 15 | 0.0114891 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0114478 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0114325 |
| RNF145 | ring finger protein 145 | 0.0113318 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | 0.0112332 |
| RPS13 | ribosomal protein S13 | 0.0111941 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.259157 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.148898 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.118211 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.094596 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0944582 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0915678 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0755441 |
| VIM | vimentin | -0.0693345 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0654184 |
| UBC | ubiquitin C | -0.0649553 |
| CANX | calnexin | -0.0572469 |
| PTMA | prothymosin, alpha | -0.0556224 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0542473 |
| PCBP3 | poly(rC) binding protein 3 | -0.0518861 |
| ENO1 | enolase 1, (alpha) | -0.0464161 |
| RPS27A | ribosomal protein S27a | -0.0457086 |
| ASPH | aspartate beta-hydroxylase | -0.042751 |
| CDH13 | cadherin 13 | -0.0405972 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0394895 |
| PGK1 | phosphoglycerate kinase 1 | -0.0389819 |
| SPAG9 | sperm associated antigen 9 | -0.0389766 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0388976 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0385723 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0366911 |
| MYOF | myoferlin | -0.0363517 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0362664 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0360516 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0350555 |
| RPLP1 | ribosomal protein, large, P1 | -0.034934 |
| RPS24 | ribosomal protein S24 | -0.034894 |
| CTSL | cathepsin L | -0.0347719 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0342907 |
| SQSTM1 | sequestosome 1 | -0.0339609 |
| LDHA | lactate dehydrogenase A | -0.0338877 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0338745 |
| INHBA | inhibin, beta A | -0.0338592 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.033043 |
| ANXA2 | annexin A2 | -0.0326265 |
| BMERB1 | bMERB domain containing 1 | -0.0324702 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0312069 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0306127 |
| OGA | O-GlcNAcase | -0.0305477 |
| GNAS | GNAS complex locus | -0.0303935 |
| TMSB4X | thymosin beta 4, X-linked | -0.0303689 |
| RPL38 | ribosomal protein L38 | -0.029827 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0295672 |
| IER3 | immediate early response 3 | -0.0294272 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0283783 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0283071 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0282192 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0281739 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0276268 |
| RHOB | ras homolog family member B | -0.0269394 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0266951 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0264809 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0256091 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0254927 |
| TENM3 | teneurin transmembrane protein 3 | -0.0254489 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0253172 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0247837 |
| CALU | calumenin | -0.0243957 |
| CCDC68 | coiled-coil domain containing 68 | -0.0242621 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0242163 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0239596 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0238769 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0236697 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0236696 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0235081 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0233092 |
| FLNB | filamin B, beta | -0.0232984 |
| AHNAK | AHNAK nucleoprotein | -0.0229791 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0229059 |
| TMSB10 | thymosin beta 10 | -0.0227809 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0227216 |
| RPLP0 | ribosomal protein, large, P0 | -0.0225389 |
| RPL26 | ribosomal protein L26 | -0.0224164 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.02231 |
| ACTG1 | actin gamma 1 | -0.0220687 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0217266 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | -0.0217254 |
| OSMR | oncostatin M receptor | -0.0217126 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0217013 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0216813 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0215946 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0212602 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0212372 |
| FTL | ferritin, light polypeptide | -0.0212366 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0209777 |
| TXNRD1 | thioredoxin reductase 1 | -0.020955 |
| CD44 | CD44 molecule (Indian blood group) | -0.0207412 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.020728 |
| AOPEP | aminopeptidase O (putative) | -0.0207163 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0206408 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0206045 |
| LMNA | lamin A/C | -0.0205828 |
| STC1 | stanniocalcin 1 | -0.0205539 |
| APP | amyloid beta (A4) precursor protein | -0.0202166 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0202116 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | -0.0197651 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0197248 |
