Aliskiren_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aliskiren perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

149 genes differentially expressed following the Aliskiren_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYO1E myosin IE 0.178593
EGFR epidermal growth factor receptor 0.17144
EPS8 epidermal growth factor receptor pathway substrate 8 0.142335
GLS2 glutaminase 2 (liver, mitochondrial) 0.11452
RERE arginine-glutamic acid dipeptide (RE) repeats 0.107942
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.09825
UBE2H ubiquitin-conjugating enzyme E2H 0.0980401
FAT1 FAT atypical cadherin 1 0.0930059
GSK3B glycogen synthase kinase 3 beta 0.081372
ERRFI1 ERBB receptor feedback inhibitor 1 0.0711815
NF1 neurofibromin 1 0.0696258
JMJD1C jumonji domain containing 1C 0.0693964
NDRG1 N-myc downstream regulated 1 0.0683978
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0681788
CHD9 chromodomain helicase DNA binding protein 9 0.067381
SGMS2 sphingomyelin synthase 2 0.0652064
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0646709
NCOR1 nuclear receptor corepressor 1 0.0640127
ANXA2 annexin A2 0.0628039
MPRIP myosin phosphatase Rho interacting protein 0.0627653
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.061212
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0579723
VCL vinculin 0.0578491
PRELID2 PRELI domain containing 2 0.0556011
PDE10A phosphodiesterase 10A 0.0548351
FLNB filamin B, beta 0.0521597
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0513117
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0501777
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.050074
CD44 CD44 molecule (Indian blood group) 0.0461582
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0456229
SLC38A2 solute carrier family 38, member 2 0.0455711
NKD1 naked cuticle homolog 1 (Drosophila) 0.0450004
MAML3 mastermind-like 3 (Drosophila) 0.0444942
ZSWIM6 zinc finger, SWIM-type containing 6 0.043899
TXNRD1 thioredoxin reductase 1 0.0398805
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0391195
MMP1 matrix metallopeptidase 1 0.0383598
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0380625
EFNA5 ephrin-A5 0.0371712
CHD1 chromodomain helicase DNA binding protein 1 0.0366267
RPL11 ribosomal protein L11 0.0363584
RAD51B RAD51 paralog B 0.036328
DSCAM Down syndrome cell adhesion molecule 0.0350793
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0341375
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0339758
ANKRD11 ankyrin repeat domain 11 0.0335794
GPC6 glypican 6 0.0301427
MED13 mediator complex subunit 13 0.0270904
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0245858
ZFAND3 zinc finger, AN1-type domain 3 0.0237915
ANKRD12 ankyrin repeat domain 12 0.0234501
RPS4X ribosomal protein S4, X-linked 0.0233109
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0198468
MON2 MON2 homolog (S. cerevisiae) 0.0177782
RORA RAR-related orphan receptor A 0.014886
OGA O-GlcNAcase 0.014802
TRIO trio Rho guanine nucleotide exchange factor 0.0136724
LMO7 LIM domain 7 0.0135632
IGFBP3 insulin-like growth factor binding protein 3 0.0126203
DOCK5 dedicator of cytokinesis 5 0.0117098
MT2A metallothionein 2A 0.0115737
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0112376
NALF1 NALCN channel auxiliary factor 1 0.0105349
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0092737
NAV2 neuron navigator 2 0.00798897
MYOF myoferlin 0.00735651
ZBTB20 zinc finger and BTB domain containing 20 0.00651367
PDE4D phosphodiesterase 4D, cAMP-specific 0.00626824
MACF1 microtubule-actin crosslinking factor 1 0.00532066
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.00297207
NPAS2 neuronal PAS domain protein 2 0.00276672
PTK2 protein tyrosine kinase 2 0.00208677
RAP1B RAP1B, member of RAS oncogene family 0.00191168
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.00125248

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.225778
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.172246
FN1 fibronectin 1 -0.168923
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.162999
ASPH aspartate beta-hydroxylase -0.106473
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.105933
PTMA prothymosin, alpha -0.0985301
ZNF292 zinc finger protein 292 -0.0907953
TMSB10 thymosin beta 10 -0.0822314
CANX calnexin -0.0817937
TPT1 tumor protein, translationally-controlled 1 -0.0726311
SBF2 SET binding factor 2 -0.0700183
RPL35A ribosomal protein L35a -0.0692637
RBM25 RNA binding motif protein 25 -0.0670536
EXT1 exostosin glycosyltransferase 1 -0.0663844
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0633903
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0615236
GOLGA4 golgin A4 -0.061451
STC1 stanniocalcin 1 -0.0573057
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.050749
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0498819
MEF2A myocyte enhancer factor 2A -0.0491045
B2M beta-2-microglobulin -0.0480927
AKAP13 A kinase (PRKA) anchor protein 13 -0.0465952
PGK1 phosphoglycerate kinase 1 -0.0456322
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0439433
CALR calreticulin -0.0437401
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0436114
KTN1 kinectin 1 (kinesin receptor) -0.0429057
COG5 component of oligomeric golgi complex 5 -0.0404492
LRP1B low density lipoprotein receptor-related protein 1B -0.0401323
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0367685
SPAG9 sperm associated antigen 9 -0.0367565
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0356997
AKAP12 A kinase (PRKA) anchor protein 12 -0.0354698
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0340992
KDM5B lysine (K)-specific demethylase 5B -0.0329791
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0327024
ACTG1 actin gamma 1 -0.0312747
FNDC3B fibronectin type III domain containing 3B -0.0309224
EZR ezrin -0.0302928
RASA3 RAS p21 protein activator 3 -0.0282599
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0281868
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0281408
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0270525
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0250993
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0250495
RPL26 ribosomal protein L26 -0.0238749
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.020308
AHNAK AHNAK nucleoprotein -0.0195641
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0184272
HDLBP high density lipoprotein binding protein -0.0173966
PSD3 pleckstrin and Sec7 domain containing 3 -0.0170457
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0144372
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0135695
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0126678
IGFBP5 insulin-like growth factor binding protein 5 -0.0126089
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0125653
SRPK2 SRSF protein kinase 2 -0.0119093
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0117529
PRRC2C proline-rich coiled-coil 2C -0.0113592
GOLGB1 golgin B1 -0.0107798
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.00937189
RPS6 ribosomal protein S6 -0.00924219
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.00899017
PDLIM5 PDZ and LIM domain 5 -0.00829821
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.00825369
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.00784343
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.00607174
NAMPT nicotinamide phosphoribosyltransferase -0.00536499
PARD3 par-3 family cell polarity regulator -0.00276556
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.00226241
KMT2E lysine (K)-specific methyltransferase 2E -0.00220663
LDHA lactate dehydrogenase A -0.00203011