Aliskiren_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aliskiren perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Aliskiren_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0734054
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0673682
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0638267
ERBB4 erb-b2 receptor tyrosine kinase 4 0.053005
ANK2 ankyrin 2, neuronal 0.0526886
ITGAV integrin, alpha V 0.0519982
CNTN6 contactin 6 0.0502639
TSC22D2 TSC22 domain family, member 2 0.0453542
FNDC3B fibronectin type III domain containing 3B 0.0446317
TRPS1 trichorhinophalangeal syndrome I 0.038185
NHSL1 NHS-like 1 0.035955
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0359266
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 0.0355141
MATR3 matrin 3 0.0340563
PLPP1 phospholipid phosphatase 1 0.0314505
FER fer (fps/fes related) tyrosine kinase 0.0310288
THBS1 thrombospondin 1 0.0303104
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0290598
EXT1 exostosin glycosyltransferase 1 0.0289737
POTEF POTE ankyrin domain family, member F 0.0287822
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0271707
TCF12 transcription factor 12 0.0269581
FAM13B family with sequence similarity 13, member B 0.0268996
TOX thymocyte selection-associated high mobility group box 0.026512
CENPF centromere protein F, 350/400kDa 0.0264257
ADGRL3 adhesion G protein-coupled receptor L3 0.0260477
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0259756
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0251153
PDGFC platelet derived growth factor C 0.025099
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0250688
SHROOM3 shroom family member 3 0.024523
PSPC1 paraspeckle component 1 0.0242379
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0242363
ZFPM2 zinc finger protein, FOG family member 2 0.0238682
CALCR calcitonin receptor 0.0236222
EVI5 ecotropic viral integration site 5 0.0233047
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0232579
SYT1 synaptotagmin I 0.0232133
FUBP1 far upstream element (FUSE) binding protein 1 0.0227838
SLC44A5 solute carrier family 44, member 5 0.0227807
PFN1 profilin 1 0.0227536
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0225294
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0224875
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0222693
PTBP2 polypyrimidine tract binding protein 2 0.0220896
CDK6 cyclin-dependent kinase 6 0.022037
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0219517
TRIM33 tripartite motif containing 33 0.02193
ZFHX4 zinc finger homeobox 4 0.021818
CADM2 cell adhesion molecule 2 0.021641
NFIA nuclear factor I/A 0.0214812
ZNF292 zinc finger protein 292 0.0213361
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0209093
NCAM2 neural cell adhesion molecule 2 0.0207082
WDR43 WD repeat domain 43 0.0204723
WDFY3 WD repeat and FYVE domain containing 3 0.0202696
AMBRA1 autophagy/beclin-1 regulator 1 0.0202434
KIF1B kinesin family member 1B 0.0202034
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0201664
METAP2 methionyl aminopeptidase 2 0.020121
MYEF2 myelin expression factor 2 0.0199055
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0198506
FIGN fidgetin 0.0197307
YAP1 Yes-associated protein 1 0.0197256
PCBP2 poly(rC) binding protein 2 0.0196017
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0195303
PSD3 pleckstrin and Sec7 domain containing 3 0.0194226
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0193831
ZNF608 zinc finger protein 608 0.0193493
SPRED1 sprouty-related, EVH1 domain containing 1 0.0193138
CORO1C coronin, actin binding protein, 1C 0.0192379
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0191446
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0190651
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0190601
RIMS2 regulating synaptic membrane exocytosis 2 0.0188764
SLIT2 slit homolog 2 (Drosophila) 0.0186379
PTPRM protein tyrosine phosphatase, receptor type, M 0.0185003
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0184843
RPN1 ribophorin I 0.0184742
SMAD5 SMAD family member 5 0.0184448
ICE1 interactor of little elongation complex ELL subunit 1 0.0184195
EPHA5 EPH receptor A5 0.0183533
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0183196
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0177164
KIF18B kinesin family member 18B 0.0176536
RB1CC1 RB1-inducible coiled-coil 1 0.0175374
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0173908
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 0.0173449
RGS5 regulator of G-protein signaling 5 0.0171971
SNX2 sorting nexin 2 0.017197
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0170389
TULP4 tubby like protein 4 0.0170212
PRTG protogenin 0.0170209
RFC3 replication factor C (activator 1) 3, 38kDa 0.0169421
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0168224
CAMKMT calmodulin-lysine N-methyltransferase 0.0167303
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.0165911
NCAPG2 non-SMC condensin II complex, subunit G2 0.0165732
PTAR1 protein prenyltransferase alpha subunit repeat containing 1 0.0165433
NUSAP1 nucleolar and spindle associated protein 1 0.0165157

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.226691
VIM vimentin -0.15704
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.11329
RPS16 ribosomal protein S16 -0.107975
COL11A1 collagen, type XI, alpha 1 -0.105794
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.105658
WSB1 WD repeat and SOCS box containing 1 -0.102701
COL3A1 collagen, type III, alpha 1 -0.0982374
B2M beta-2-microglobulin -0.0896671
ISG15 ISG15 ubiquitin-like modifier -0.0820457
RPL35A ribosomal protein L35a -0.0710469
RPS8 ribosomal protein S8 -0.0700926
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.06516
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0651596
GNAS GNAS complex locus -0.0642013
RPS6 ribosomal protein S6 -0.0625678
TPT1 tumor protein, translationally-controlled 1 -0.0610581
RPL37 ribosomal protein L37 -0.0594668
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0577676
H1-0 H1.0 linker histone -0.0568148
CAVIN1 caveolae associated protein 1 -0.0564458
FGF13 fibroblast growth factor 13 -0.0544777
MDK midkine (neurite growth-promoting factor 2) -0.0527235
GSE1 Gse1 coiled-coil protein -0.0511357
RIGI RNA sensor RIG-I -0.0510251
COL1A2 collagen, type I, alpha 2 -0.0504437
GPC3 glypican 3 -0.0503973
MED13L mediator complex subunit 13-like -0.0492966
SPAG9 sperm associated antigen 9 -0.0484252
FNDC3A fibronectin type III domain containing 3A -0.0480401
RPL11 ribosomal protein L11 -0.0463508
TTC28 tetratricopeptide repeat domain 28 -0.0460969
PDIA3 protein disulfide isomerase family A, member 3 -0.0458073
PCDH9 protocadherin 9 -0.0453763
PGK1 phosphoglycerate kinase 1 -0.0451014
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0450407
ACTG1 actin gamma 1 -0.0438768
EIF1 eukaryotic translation initiation factor 1 -0.0435592
CEP350 centrosomal protein 350kDa -0.0428604
RPL37A ribosomal protein L37a -0.0426505
RPL31 ribosomal protein L31 -0.0420193
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0419527
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.041429
ZNF217 zinc finger protein 217 -0.0407132
RAD51B RAD51 paralog B -0.0406671
RPL23 ribosomal protein L23 -0.0404515
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0403848
AKAP12 A kinase (PRKA) anchor protein 12 -0.040285
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0401038
RPS13 ribosomal protein S13 -0.0400431
RPL7A ribosomal protein L7a -0.0398212
MEIS2 Meis homeobox 2 -0.0395624
BRD2 bromodomain containing 2 -0.0390171
FST follistatin -0.0387132
ATF4 activating transcription factor 4 -0.0382475
TNRC6B trinucleotide repeat containing 6B -0.0378738
CALR calreticulin -0.0378503
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0373221
KDM3A lysine (K)-specific demethylase 3A -0.0373199
MAP4 microtubule-associated protein 4 -0.0365251
IFIH1 interferon induced with helicase C domain 1 -0.0361425
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0360599
SRRM2 serine/arginine repetitive matrix 2 -0.0358601
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0352377
TMSB10 thymosin beta 10 -0.035115
KMT2C lysine (K)-specific methyltransferase 2C -0.0350938
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0347089
AHNAK AHNAK nucleoprotein -0.0346452
CALU calumenin -0.0343485
S100A10 S100 calcium binding protein A10 -0.0342883
IGF2 insulin-like growth factor 2 -0.0336216
SIK2 salt-inducible kinase 2 -0.0334369
RPL19 ribosomal protein L19 -0.0333567
SMIM44 small integral membrane protein 44 -0.0332773
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0332161
TRIM2 tripartite motif containing 2 -0.033206
CSNK1A1 casein kinase 1, alpha 1 -0.0329076
APOE apolipoprotein E -0.0317409
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0316139
LYST lysosomal trafficking regulator -0.0315377
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0314793
RPS24 ribosomal protein S24 -0.0313684
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0312018
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0309689
RPLP1 ribosomal protein, large, P1 -0.0309235
RAB10 RAB10, member RAS oncogene family -0.0308447
LDHA lactate dehydrogenase A -0.0304553
SETD5 SET domain containing 5 -0.0302515
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0302411
CNRIP1 cannabinoid receptor interacting protein 1 -0.0301294
RPS25 ribosomal protein S25 -0.0298525
RPL9 ribosomal protein L9 -0.0294426
COL5A2 collagen, type V, alpha 2 -0.0293611
UBE2H ubiquitin-conjugating enzyme E2H -0.0292965
KMT2A lysine (K)-specific methyltransferase 2A -0.0292174
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 -0.0289771
FOXK1 forkhead box K1 -0.0288837
TTC3 tetratricopeptide repeat domain 3 -0.0288771
VMP1 vacuole membrane protein 1 -0.0287668
UBE2K ubiquitin-conjugating enzyme E2K -0.0287262