| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Aliskiren perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Aliskiren_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.175722 |
| FOXP1 | forkhead box P1 | 0.11813 |
| PTMA | prothymosin, alpha | 0.0911141 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0880854 |
| TJP1 | tight junction protein 1 | 0.0734772 |
| EGFR | epidermal growth factor receptor | 0.0729642 |
| HDAC9 | histone deacetylase 9 | 0.0651229 |
| EZR | ezrin | 0.0617658 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0601586 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0551128 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0525626 |
| RHOA | ras homolog family member A | 0.0478742 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0472129 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0457285 |
| PARD3 | par-3 family cell polarity regulator | 0.0442562 |
| EFNA5 | ephrin-A5 | 0.0441467 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0441303 |
| RPL35A | ribosomal protein L35a | 0.0441291 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0431806 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0426235 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.042256 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0405084 |
| PDGFC | platelet derived growth factor C | 0.0402829 |
| POTEF | POTE ankyrin domain family, member F | 0.0398896 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0388714 |
| CRPPA | CDP-L-ribitol pyrophosphorylase A | 0.038647 |
| UBE3C | ubiquitin protein ligase E3C | 0.0386463 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0383846 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.0373672 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0372172 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0366026 |
| YAP1 | Yes-associated protein 1 | 0.0364333 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0358854 |
| PKM | pyruvate kinase, muscle | 0.0355913 |
| FMN1 | formin 1 | 0.0346864 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0337703 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0336291 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.0335511 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0333666 |
| VMP1 | vacuole membrane protein 1 | 0.033262 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0331112 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | 0.0327126 |
| MED13L | mediator complex subunit 13-like | 0.0324709 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0324587 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0320584 |
| MED13 | mediator complex subunit 13 | 0.0319298 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0317259 |
| SRPK2 | SRSF protein kinase 2 | 0.0315245 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0314562 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0312851 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0309973 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0307731 |
| SEPTIN9 | septin 9 | 0.0305319 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0305031 |
| ATAD2B | ATPase family, AAA domain containing 2B | 0.0300307 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.03001 |
| LATS2 | large tumor suppressor kinase 2 | 0.0298552 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | 0.0298239 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0295668 |
| OLA1 | Obg-like ATPase 1 | 0.0295509 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | 0.0293369 |
| SOX6 | SRY (sex determining region Y)-box 6 | 0.0292401 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0291518 |
| RCOR1 | REST corepressor 1 | 0.0287885 |
| ZNF644 | zinc finger protein 644 | 0.0285752 |
| LRP6 | low density lipoprotein receptor-related protein 6 | 0.0284177 |
| ZNF609 | zinc finger protein 609 | 0.0284082 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0283987 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0282963 |
| CUL3 | cullin 3 | 0.0281392 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0281012 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0280501 |
| CTBP2 | C-terminal binding protein 2 | 0.0280072 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0277648 |
| JMJD1C | jumonji domain containing 1C | 0.0275601 |
| PDS5B | PDS5 cohesin associated factor B | 0.0275111 |
| SFSWAP | splicing factor, suppressor of white-apricot family | 0.0271796 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0270802 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0267368 |
| NCKAP1 | NCK-associated protein 1 | 0.0262811 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0262792 |
| RFX7 | regulatory factor X, 7 | 0.0262497 |
| RNF13 | ring finger protein 13 | 0.026221 |
| RHEB | Ras homolog enriched in brain | 0.0262132 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0262073 |
| USP34 | ubiquitin specific peptidase 34 | 0.0259911 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0259893 |
| NUP153 | nucleoporin 153kDa | 0.02582 |
| GLI3 | GLI family zinc finger 3 | 0.0256232 |
| MKI67 | marker of proliferation Ki-67 | 0.0254022 |
| EMP3 | epithelial membrane protein 3 | 0.0253452 |
| SMYD3 | SET and MYND domain containing 3 | 0.0253015 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0251588 |
| EVI5 | ecotropic viral integration site 5 | 0.0250009 |
| S100A4 | S100 calcium binding protein A4 | 0.0249612 |
| WDR43 | WD repeat domain 43 | 0.024922 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0248998 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0247863 |
| OSMR | oncostatin M receptor | 0.0246675 |
| GTF2I | general transcription factor IIi | 0.0246034 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.220001 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.144492 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.088051 |
| AHNAK | AHNAK nucleoprotein | -0.0802578 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.0764631 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.076375 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0729213 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0599811 |
| ENO1 | enolase 1, (alpha) | -0.0577492 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0573374 |
| TMSB4X | thymosin beta 4, X-linked | -0.0573026 |
| RRBP1 | ribosome binding protein 1 | -0.0568637 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0551292 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0544526 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | -0.0535792 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0494033 |
| PGK1 | phosphoglycerate kinase 1 | -0.046443 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0456476 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0444639 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0444527 |
| FHIT | fragile histidine triad | -0.044427 |
| LDHA | lactate dehydrogenase A | -0.0420296 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0410478 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0389763 |
| NFIA | nuclear factor I/A | -0.0386511 |
| GOLGA4 | golgin A4 | -0.0384695 |
| UBC | ubiquitin C | -0.0372867 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0367186 |
| ZNF217 | zinc finger protein 217 | -0.0363703 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0360686 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0358132 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0355448 |
| TGFBR3 | transforming growth factor, beta receptor III | -0.0345015 |
| MEIS2 | Meis homeobox 2 | -0.0343877 |
| APP | amyloid beta (A4) precursor protein | -0.0339098 |
| CD47 | CD47 molecule | -0.0332611 |
| SEC24D | SEC24 family member D | -0.0327561 |
| HELZ | helicase with zinc finger | -0.0323134 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0315791 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0312268 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0310218 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0309464 |
| HDLBP | high density lipoprotein binding protein | -0.0303823 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0302533 |
| BMP10 | bone morphogenetic protein 10 | -0.0290174 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0287525 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.028749 |
| RPL3 | ribosomal protein L3 | -0.0286406 |
| YEATS2 | YEATS domain containing 2 | -0.0278367 |
| TMEM263 | transmembrane protein 263 | -0.0277494 |
| TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b | -0.0276891 |
| ZNF106 | zinc finger protein 106 | -0.0271697 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0270255 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.026296 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0261116 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0258168 |
| RPS3 | ribosomal protein S3 | -0.0257687 |
| WDR45B | WD repeat domain 45B | -0.0254211 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0253476 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -0.0249809 |
| WDR33 | WD repeat domain 33 | -0.0249557 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0246785 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0246678 |
| MT2A | metallothionein 2A | -0.0240899 |
| KIZ | kizuna centrosomal protein | -0.0239258 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | -0.0238679 |
| BCOR | BCL6 corepressor | -0.0238167 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0236583 |
| RPLP0 | ribosomal protein, large, P0 | -0.0233266 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | -0.0233237 |
| CCND1 | cyclin D1 | -0.0229927 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0229656 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0227559 |
| ARL5A | ADP-ribosylation factor-like 5A | -0.022731 |
| RPS27A | ribosomal protein S27a | -0.0225169 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0224192 |
| CENPE | centromere protein E, 312kDa | -0.0216971 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0215838 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0214054 |
| ACTG1 | actin gamma 1 | -0.0213314 |
| CDV3 | CDV3 homolog (mouse) | -0.0212783 |
| KIAA1958 | KIAA1958 | -0.0211729 |
| PRELID2 | PRELI domain containing 2 | -0.0210533 |
| SHOC2 | soc-2 suppressor of clear homolog (C. elegans) | -0.0208273 |
| PPP2CB | protein phosphatase 2, catalytic subunit, beta isozyme | -0.0206129 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0205444 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0205064 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | -0.0204727 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0204499 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0203032 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0200474 |
| FAM162A | family with sequence similarity 162, member A | -0.0200162 |
| PHF3 | PHD finger protein 3 | -0.0198282 |
| RPS2 | ribosomal protein S2 | -0.0197512 |
| TRAM1 | translocation associated membrane protein 1 | -0.0196667 |
| MYH10 | myosin, heavy chain 10, non-muscle | -0.0196569 |
| PREPL | prolyl endopeptidase-like | -0.0196287 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0196096 |
| RSF1 | remodeling and spacing factor 1 | -0.0193432 |
| TRAF3 | TNF receptor-associated factor 3 | -0.0191448 |
