Aliskiren_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aliskiren perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Aliskiren_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HDAC9 histone deacetylase 9 0.0476288
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0464536
KYNU kynureninase 0.0407551
NAV2 neuron navigator 2 0.0406449
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0365636
FNDC3B fibronectin type III domain containing 3B 0.0323062
INTS6 integrator complex subunit 6 0.0297557
ZSWIM6 zinc finger, SWIM-type containing 6 0.0271278
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0246272
PRELID2 PRELI domain containing 2 0.0244732
TRIO trio Rho guanine nucleotide exchange factor 0.0234597
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.023447
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0230805
DUSP10 dual specificity phosphatase 10 0.0213671
SOD2 superoxide dismutase 2, mitochondrial 0.0207056
FNIP1 folliculin interacting protein 1 0.0204519
NRIP1 nuclear receptor interacting protein 1 0.0195218
USP9X ubiquitin specific peptidase 9, X-linked 0.0194518
ZBTB38 zinc finger and BTB domain containing 38 0.018991
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0185705
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0178677
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0172995
DST dystonin 0.0168833
VMP1 vacuole membrane protein 1 0.0157139
EPAS1 endothelial PAS domain protein 1 0.0156863
ATXN1 ataxin 1 0.0151489
SPAG9 sperm associated antigen 9 0.0151455
EXT1 exostosin glycosyltransferase 1 0.0149796
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0149773
HSPA8 heat shock 70kDa protein 8 0.0147155
FHIT fragile histidine triad 0.0144291
MBNL2 muscleblind-like splicing regulator 2 0.0142315
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0140787
RIGI RNA sensor RIG-I 0.0139955
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0137642
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0137102
AHR aryl hydrocarbon receptor 0.0132399
MYH9 myosin, heavy chain 9, non-muscle 0.0132288
BICC1 BicC family RNA binding protein 1 0.0127842
PCLO piccolo presynaptic cytomatrix protein 0.0127285
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0126782
SMAD3 SMAD family member 3 0.0126104
RNF213 ring finger protein 213 0.0125342
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0124695
TGM2 transglutaminase 2 0.0122034
SVIL supervillin 0.0121296
DUSP5 dual specificity phosphatase 5 0.0118983
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0117102
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0115694
AKAP13 A kinase (PRKA) anchor protein 13 0.0115665
GLS2 glutaminase 2 (liver, mitochondrial) 0.0114516
EEF2 eukaryotic translation elongation factor 2 0.0113335
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0113307
FLNA filamin A, alpha 0.0113173
SMYD3 SET and MYND domain containing 3 0.0112849
HMGA2 high mobility group AT-hook 2 0.0109631
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0109274
DSCAM Down syndrome cell adhesion molecule 0.010817
MYOF myoferlin 0.0108005
ZHX2 zinc fingers and homeoboxes 2 0.0107972
TLE4 transducin-like enhancer of split 4 0.010795
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0105134
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0104818
SMAD2 SMAD family member 2 0.0104034
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0103462
PPARD peroxisome proliferator-activated receptor delta 0.0103069
TIAM2 T-cell lymphoma invasion and metastasis 2 0.0102624
PLSCR1 phospholipid scramblase 1 0.0102344
RAD51B RAD51 paralog B 0.010178
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0101684
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0101452
FNIP2 folliculin interacting protein 2 0.00997077
MLPH melanophilin 0.00988602
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.00988561
FBXO32 F-box protein 32 0.0098234
WWOX WW domain containing oxidoreductase 0.00977346
UTRN utrophin 0.00970652
WWTR1 WW domain containing transcription regulator 1 0.00957721
ANKRD28 ankyrin repeat domain 28 0.00949396
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.00948381
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.00947258
PTK2 protein tyrosine kinase 2 0.0093735
NOTCH2 notch 2 0.00934303
FAM120B family with sequence similarity 120B 0.00928707
PICALM phosphatidylinositol binding clathrin assembly protein 0.00927895
TRIP12 thyroid hormone receptor interactor 12 0.00920611
SOX9 SRY (sex determining region Y)-box 9 0.00917776
BCAR3 breast cancer anti-estrogen resistance 3 0.00903324
ASPH aspartate beta-hydroxylase 0.00900462
RUNX1 runt-related transcription factor 1 0.00898337
FBXL7 F-box and leucine-rich repeat protein 7 0.00896599
PARP14 poly (ADP-ribose) polymerase family, member 14 0.00895725
KLF12 Kruppel-like factor 12 0.00890483
EP300 E1A binding protein p300 0.00890465
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.00887528
ZNF608 zinc finger protein 608 0.008871
JAG1 jagged 1 0.00879517
JMJD1C jumonji domain containing 1C 0.00877372
PLPP4 phospholipid phosphatase 4 0.00877075
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0087369

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.262898
HLA-B major histocompatibility complex, class I, B -0.103782
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.102877
IGFBP3 insulin-like growth factor binding protein 3 -0.0798318
FTL ferritin, light polypeptide -0.0742066
TMSB10 thymosin beta 10 -0.0723861
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0709611
AKAP12 A kinase (PRKA) anchor protein 12 -0.0617747
TPT1 tumor protein, translationally-controlled 1 -0.0595329
IER3 immediate early response 3 -0.059382
NAMPT nicotinamide phosphoribosyltransferase -0.0500613
ZMYND8 zinc finger, MYND-type containing 8 -0.0499037
PGK1 phosphoglycerate kinase 1 -0.0485322
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0471346
HLA-A major histocompatibility complex, class I, A -0.0424523
B2M beta-2-microglobulin -0.0420799
PTMA prothymosin, alpha -0.0414922
NDRG1 N-myc downstream regulated 1 -0.0404164
FTH1 ferritin, heavy polypeptide 1 -0.03921
MT2A metallothionein 2A -0.0385117
ENO1 enolase 1, (alpha) -0.0381748
TMSB4X thymosin beta 4, X-linked -0.0371903
ADM adrenomedullin -0.0369872
HLA-E major histocompatibility complex, class I, E -0.0365338
EGR1 early growth response 1 -0.0365302
TPM4 tropomyosin 4 -0.033513
BASP1 brain abundant, membrane attached signal protein 1 -0.0326999
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0326672
RPS6 ribosomal protein S6 -0.0326335
LDHA lactate dehydrogenase A -0.0316816
SFRP1 secreted frizzled-related protein 1 -0.0313335
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.031251
CTSD cathepsin D -0.0309854
EIF1 eukaryotic translation initiation factor 1 -0.0305799
RPL35A ribosomal protein L35a -0.0304545
BTG1 B-cell translocation gene 1, anti-proliferative -0.0296877
FRMD4A FERM domain containing 4A -0.0293373
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0291852
RPS8 ribosomal protein S8 -0.0291071
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0290347
UGCG UDP-glucose ceramide glucosyltransferase -0.028813
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0276409
PLIN2 perilipin 2 -0.0269131
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0261868
GNAS GNAS complex locus -0.0259983
RPL23 ribosomal protein L23 -0.0258827
RPS24 ribosomal protein S24 -0.0250392
IFITM3 interferon induced transmembrane protein 3 -0.0248819
CD44 CD44 molecule (Indian blood group) -0.024186
COL1A2 collagen, type I, alpha 2 -0.0240106
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.023968
CALR calreticulin -0.0236658
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0234682
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0232448
RTN4 reticulon 4 -0.0231993
STC1 stanniocalcin 1 -0.0231536
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0229386
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0229135
SLC38A1 solute carrier family 38, member 1 -0.0229109
CADM1 cell adhesion molecule 1 -0.0228931
RPS13 ribosomal protein S13 -0.022893
KPNB1 karyopherin (importin) beta 1 -0.022833
PDE10A phosphodiesterase 10A -0.0226134
RPS12 ribosomal protein S12 -0.0224541
RAI14 retinoic acid induced 14 -0.0224468
KRT19 keratin 19, type I -0.0222935
CDH13 cadherin 13 -0.022277
UBC ubiquitin C -0.0220432
GLIS3 GLIS family zinc finger 3 -0.0218334
RPL37A ribosomal protein L37a -0.0216511
ANXA2 annexin A2 -0.0215806
RPLP2 ribosomal protein, large, P2 -0.0214599
C3 complement component 3 -0.021164
RPS3 ribosomal protein S3 -0.0208996
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0207299
RPL36A ribosomal protein L36a -0.0200474
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0198868
COL1A1 collagen, type I, alpha 1 -0.0198791
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0198236
HMGA1 high mobility group AT-hook 1 -0.0196955
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0195983
RPL19 ribosomal protein L19 -0.0193793
ACTG1 actin gamma 1 -0.0189752
TGFBI transforming growth factor, beta-induced, 68kDa -0.0189728
CD63 CD63 molecule -0.0188163
CANX calnexin -0.0187496
RPS21 ribosomal protein S21 -0.0187395
NRN1 neuritin 1 -0.0186962
JUN jun proto-oncogene -0.0186743
STC2 stanniocalcin 2 -0.0184473
ARL4C ADP-ribosylation factor-like 4C -0.018358
MXI1 MAX interactor 1, dimerization protein -0.0183428
LOX lysyl oxidase -0.0183091
LOC112694756 uncharaterized LOC112694756 -0.0182854
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0179825
S100A9 S100 calcium binding protein A9 -0.0179077
NPEPPS aminopeptidase puromycin sensitive -0.0177057
RPL12 ribosomal protein L12 -0.0176677
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0176489
SEPTIN7 septin 7 -0.0176118