Aliskiren_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Aliskiren perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Aliskiren_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.191879
CXCL8 chemokine (C-X-C motif) ligand 8 0.0764775
VEGFC vascular endothelial growth factor C 0.0681098
EGFR epidermal growth factor receptor 0.0615648
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.055715
ATP13A3 ATPase type 13A3 0.0510315
KYNU kynureninase 0.0489732
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0484602
PRELID2 PRELI domain containing 2 0.0484565
CDH13 cadherin 13 0.047219
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0463562
STC1 stanniocalcin 1 0.0460729
GLIS3 GLIS family zinc finger 3 0.0423025
IL6 interleukin 6 0.040936
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0407415
FNDC3A fibronectin type III domain containing 3A 0.0396844
PDE4D phosphodiesterase 4D, cAMP-specific 0.0393087
NRXN3 neurexin 3 0.0392361
ZSWIM6 zinc finger, SWIM-type containing 6 0.0362946
SON SON DNA binding protein 0.0334391
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0330789
EXOC4 exocyst complex component 4 0.032668
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0325169
RNF145 ring finger protein 145 0.0323803
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0323023
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0317309
SAMD4A sterile alpha motif domain containing 4A 0.0314048
CDK6 cyclin-dependent kinase 6 0.0306476
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0305538
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0303035
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0302803
FNDC3B fibronectin type III domain containing 3B 0.030138
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.029487
N4BP2L2 NEDD4 binding protein 2-like 2 0.0290236
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.028646
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0285226
SETD5 SET domain containing 5 0.0281531
FRMD6 FERM domain containing 6 0.0274715
USP47 ubiquitin specific peptidase 47 0.0271182
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0268017
DST dystonin 0.0266117
CCDC14 coiled-coil domain containing 14 0.0261587
SDK1 sidekick cell adhesion molecule 1 0.0260273
MT1X metallothionein 1X 0.0259149
HIP1 huntingtin interacting protein 1 0.0259059
TBC1D5 TBC1 domain family, member 5 0.0256952
ARHGAP24 Rho GTPase activating protein 24 0.0255187
ZFP36L1 ZFP36 ring finger protein-like 1 0.0255162
RUNX1 runt-related transcription factor 1 0.0254456
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0252625
SEPTIN9 septin 9 0.0252443
EFNA5 ephrin-A5 0.0251988
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0250741
DNAH11 dynein, axonemal, heavy chain 11 0.0250115
OSMR oncostatin M receptor 0.0250056
MYH9 myosin, heavy chain 9, non-muscle 0.0249625
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0248163
SPAG9 sperm associated antigen 9 0.0246527
DENND1A DENN/MADD domain containing 1A 0.0244885
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0241126
GPBP1 GC-rich promoter binding protein 1 0.0237296
SEC24A SEC24 family member A 0.0235768
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0235563
ETV6 ets variant 6 0.0234509
C1D C1D nuclear receptor corepressor 0.0233189
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0231561
HIPK2 homeodomain interacting protein kinase 2 0.0231384
GLS2 glutaminase 2 (liver, mitochondrial) 0.0230733
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0229208
COPB1 coatomer protein complex, subunit beta 1 0.0226269
STARD13 StAR-related lipid transfer (START) domain containing 13 0.022564
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.0225571
RNF216 ring finger protein 216 0.0223858
FAM107B family with sequence similarity 107, member B 0.022307
TTC17 tetratricopeptide repeat domain 17 0.0217844
SOD2 superoxide dismutase 2, mitochondrial 0.0215976
SNX9 sorting nexin 9 0.0215597
SYNPO synaptopodin 0.0213015
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0210808
ANKRD28 ankyrin repeat domain 28 0.0210021
TNIP1 TNFAIP3 interacting protein 1 0.020975
JAZF1 JAZF zinc finger 1 0.0208973
EHBP1 EH domain binding protein 1 0.0208699
UBN2 ubinuclein 2 0.0208616
AHR aryl hydrocarbon receptor 0.0208493
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.020818
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.0208092
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0207506
AKAP13 A kinase (PRKA) anchor protein 13 0.0204898
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0204637
ASPH aspartate beta-hydroxylase 0.0203427
IGFBP7 insulin-like growth factor binding protein 7 0.0202404
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.020182
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0201687
GRB10 growth factor receptor-bound protein 10 0.0200415
ZEB2 zinc finger E-box binding homeobox 2 0.0200093
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0198231
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 0.0198022
DIAPH3 diaphanous-related formin 3 0.0197165
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.019715

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.239711
IGFBP3 insulin-like growth factor binding protein 3 -0.168434
VIM vimentin -0.150507
FTL ferritin, light polypeptide -0.0933794
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0890913
FN1 fibronectin 1 -0.0889287
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.084862
PTMA prothymosin, alpha -0.072358
TGFBI transforming growth factor, beta-induced, 68kDa -0.0654392
HLA-B major histocompatibility complex, class I, B -0.0645002
TMSB10 thymosin beta 10 -0.0614282
ACTG1 actin gamma 1 -0.0599385
CALR calreticulin -0.0550721
ZNF395 zinc finger protein 395 -0.0482513
RPLP1 ribosomal protein, large, P1 -0.0474375
LOC112694756 uncharaterized LOC112694756 -0.0454286
PKM pyruvate kinase, muscle -0.0439762
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0431289
TENT5A terminal nucleotidyltransferase 5A -0.0418212
COL1A1 collagen, type I, alpha 1 -0.0412712
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0398893
TPM4 tropomyosin 4 -0.0391913
CANX calnexin -0.0384236
F3 coagulation factor III (thromboplastin, tissue factor) -0.0374429
TMSB4X thymosin beta 4, X-linked -0.0367968
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0344314
MEF2A myocyte enhancer factor 2A -0.0342889
RPL35A ribosomal protein L35a -0.0338861
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0330442
MAP1B microtubule-associated protein 1B -0.0326294
PGK1 phosphoglycerate kinase 1 -0.0320748
RPL5 ribosomal protein L5 -0.0318131
ELL2 elongation factor, RNA polymerase II, 2 -0.0317942
HM13 histocompatibility (minor) 13 -0.0317577
RPL34 ribosomal protein L34 -0.0313686
CCNI cyclin I -0.0311063
PRSS23 protease, serine, 23 -0.0307892
DLG1 discs, large homolog 1 (Drosophila) -0.0304132
CALD1 caldesmon 1 -0.0296683
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0296519
RPS6 ribosomal protein S6 -0.0294646
COL1A2 collagen, type I, alpha 2 -0.0290816
S100A6 S100 calcium binding protein A6 -0.0287653
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0286161
HMGB1 high mobility group box 1 -0.0285435
RPS14 ribosomal protein S14 -0.0284035
CAVIN1 caveolae associated protein 1 -0.02839
EGR1 early growth response 1 -0.0283718
TRA2A transformer 2 alpha homolog (Drosophila) -0.0268828
CST3 cystatin C -0.0261451
TNNC1 troponin C type 1 (slow) -0.0259243
RAB1A RAB1A, member RAS oncogene family -0.0257636
UBE2B ubiquitin-conjugating enzyme E2B -0.0254766
WDR45B WD repeat domain 45B -0.0251435
RPLP2 ribosomal protein, large, P2 -0.0247537
SEPTIN7 septin 7 -0.0245468
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0244269
B2M beta-2-microglobulin -0.0243453
RPL11 ribosomal protein L11 -0.0241766
RPL9 ribosomal protein L9 -0.0232794
GNAS GNAS complex locus -0.0231847
FXR1 fragile X mental retardation, autosomal homolog 1 -0.023002
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0228605
ADM adrenomedullin -0.0225739
COL6A1 collagen, type VI, alpha 1 -0.0223337
RSF1 remodeling and spacing factor 1 -0.0222999
SEC31A SEC31 homolog A (S. cerevisiae) -0.0219497
ENO1 enolase 1, (alpha) -0.0219415
ACBD3 acyl-CoA binding domain containing 3 -0.0219267
NACA nascent polypeptide-associated complex alpha subunit -0.0216499
ELP4 elongator acetyltransferase complex subunit 4 -0.0214371
RAD21 RAD21 homolog (S. pombe) -0.0213784
MARCHF6 membrane associated ring-CH-type finger 6 -0.0212644
PSD3 pleckstrin and Sec7 domain containing 3 -0.0212018
TRIO trio Rho guanine nucleotide exchange factor -0.0211922
S100A10 S100 calcium binding protein A10 -0.0211782
CADM1 cell adhesion molecule 1 -0.0211279
SREBF2 sterol regulatory element binding transcription factor 2 -0.0209419
PALLD palladin, cytoskeletal associated protein -0.0208768
MT2A metallothionein 2A -0.0208054
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0205258
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0203199
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.020208
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0201916
EMP1 epithelial membrane protein 1 -0.0200959
VCL vinculin -0.0200708
RTN4 reticulon 4 -0.0199063
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0198211
RAI14 retinoic acid induced 14 -0.0197546
TUBB tubulin, beta class I -0.0196886
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0194129
EIF3D eukaryotic translation initiation factor 3, subunit D -0.0193378
RPS16 ribosomal protein S16 -0.0190491
HLA-C major histocompatibility complex, class I, C -0.0190418
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0187236
PIAS1 protein inhibitor of activated STAT, 1 -0.0187052
TANK TRAF family member-associated NFKB activator -0.0185681
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0185308
BZW1 basic leucine zipper and W2 domains 1 -0.0184564
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0184561