| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Aliskiren perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Aliskiren_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ASPH | aspartate beta-hydroxylase | 0.101701 |
| NDRG1 | N-myc downstream regulated 1 | 0.0998627 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0910247 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0767049 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0766853 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0753295 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0636309 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0580501 |
| NTN4 | netrin 4 | 0.0554593 |
| POTEF | POTE ankyrin domain family, member F | 0.0535458 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0534259 |
| PTK2 | protein tyrosine kinase 2 | 0.0521147 |
| FN1 | fibronectin 1 | 0.0517737 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0517532 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0517473 |
| VEGFC | vascular endothelial growth factor C | 0.0514583 |
| CD109 | CD109 molecule | 0.0494568 |
| NRP1 | neuropilin 1 | 0.0492305 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0487356 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.048249 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0479882 |
| VEGFA | vascular endothelial growth factor A | 0.0458189 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0454639 |
| MYOF | myoferlin | 0.0454343 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0452623 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0438745 |
| DST | dystonin | 0.0433045 |
| RNF145 | ring finger protein 145 | 0.0428428 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0427649 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0425195 |
| TPM3 | tropomyosin 3 | 0.0424775 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0415335 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.04117 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0403263 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0393227 |
| ITGA1 | integrin, alpha 1 | 0.0386521 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0376839 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0376219 |
| NPAS2 | neuronal PAS domain protein 2 | 0.03689 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0366225 |
| STC2 | stanniocalcin 2 | 0.0360076 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0358465 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0351756 |
| FAM13A | family with sequence similarity 13, member A | 0.0347574 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.034433 |
| SIRT1 | sirtuin 1 | 0.0334184 |
| SMAD3 | SMAD family member 3 | 0.0332726 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0330889 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0320397 |
| RASAL2 | RAS protein activator like 2 | 0.031743 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0313829 |
| AFDN | afadin, adherens junction formation factor | 0.0312523 |
| PLIN2 | perilipin 2 | 0.0311903 |
| SYT1 | synaptotagmin I | 0.0310748 |
| RAI14 | retinoic acid induced 14 | 0.0310045 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0310028 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0304213 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0300252 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0296267 |
| COPA | coatomer protein complex, subunit alpha | 0.029607 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0290438 |
| RNF213 | ring finger protein 213 | 0.0290267 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0289374 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0288802 |
| TMEM156 | transmembrane protein 156 | 0.0288366 |
| TXNIP | thioredoxin interacting protein | 0.0288232 |
| ATXN1 | ataxin 1 | 0.0288107 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0286873 |
| ZNF638 | zinc finger protein 638 | 0.028204 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0280337 |
| SVIL | supervillin | 0.0278937 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0277665 |
| PKM | pyruvate kinase, muscle | 0.0277084 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0265088 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0264428 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.026326 |
| NAV2 | neuron navigator 2 | 0.026224 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0262148 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0261213 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0259922 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0259578 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 0.0258207 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0257888 |
| FLNB | filamin B, beta | 0.0255315 |
| MLPH | melanophilin | 0.0252842 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0252285 |
| SPAG9 | sperm associated antigen 9 | 0.0251946 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0251751 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0249847 |
| GPC6 | glypican 6 | 0.0248121 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0247437 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0245015 |
| RUNX1 | runt-related transcription factor 1 | 0.0241181 |
| FOSL1 | FOS-like antigen 1 | 0.0240102 |
| RAD51B | RAD51 paralog B | 0.0238678 |
| EZR | ezrin | 0.0232859 |
| FHIT | fragile histidine triad | 0.023242 |
| HMGA2 | high mobility group AT-hook 2 | 0.0230834 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0230806 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0230691 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.42714 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.236841 |
| SQSTM1 | sequestosome 1 | -0.131375 |
| NRG1 | neuregulin 1 | -0.126519 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.10584 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.103569 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.087882 |
| CANX | calnexin | -0.0877725 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0715922 |
| HLA-B | major histocompatibility complex, class I, B | -0.0701843 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0528867 |
| RPS24 | ribosomal protein S24 | -0.0518653 |
| VCL | vinculin | -0.0504418 |
| PTMA | prothymosin, alpha | -0.0504245 |
| ARF1 | ADP-ribosylation factor 1 | -0.0485274 |
| TMSB4X | thymosin beta 4, X-linked | -0.0454703 |
| LRRC23 | leucine rich repeat containing 23 | -0.0451845 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0449292 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0408638 |
| CALU | calumenin | -0.0371967 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0371893 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0364559 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0361254 |
| RPL26 | ribosomal protein L26 | -0.0357496 |
| RACK1 | receptor for activated C kinase 1 | -0.0354728 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0339089 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0338232 |
| AEBP2 | AE binding protein 2 | -0.0336768 |
| AHR | aryl hydrocarbon receptor | -0.0328832 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0327046 |
| S100A6 | S100 calcium binding protein A6 | -0.0323824 |
| GOLT1B | golgi transport 1B | -0.0313619 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0305249 |
| RPL31 | ribosomal protein L31 | -0.0302669 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0293259 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0291116 |
| RPL12 | ribosomal protein L12 | -0.0288548 |
| EREG | epiregulin | -0.0286279 |
| FAM20C | family with sequence similarity 20, member C | -0.028191 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0278169 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0276855 |
| INTS6 | integrator complex subunit 6 | -0.0274705 |
| HDLBP | high density lipoprotein binding protein | -0.0274482 |
| TMEM263 | transmembrane protein 263 | -0.027365 |
| PHF3 | PHD finger protein 3 | -0.0272826 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0272214 |
| LOX | lysyl oxidase | -0.0268965 |
| GNAS | GNAS complex locus | -0.026558 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0264701 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0264479 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0259062 |
| TMSB10 | thymosin beta 10 | -0.0254014 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.025333 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0247899 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0247179 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0245592 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.02437 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0243338 |
| RPL37 | ribosomal protein L37 | -0.0241112 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0238811 |
| RPL34 | ribosomal protein L34 | -0.0235705 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.0235408 |
| MMP13 | matrix metallopeptidase 13 | -0.0232663 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0231659 |
| RPS20 | ribosomal protein S20 | -0.0231546 |
| SFTPA2 | surfactant protein A2 | -0.0229711 |
| COG5 | component of oligomeric golgi complex 5 | -0.0228365 |
| AHRR | aryl-hydrocarbon receptor repressor | -0.0228053 |
| OSMR | oncostatin M receptor | -0.0227463 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0226235 |
| IER3 | immediate early response 3 | -0.0222336 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0219554 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0218802 |
| RPLP0 | ribosomal protein, large, P0 | -0.0218336 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0215838 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0214637 |
| TFRC | transferrin receptor | -0.0212495 |
| CDK13 | cyclin-dependent kinase 13 | -0.0211992 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0211914 |
| RPS21 | ribosomal protein S21 | -0.0211401 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0209553 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0207889 |
| RPS25 | ribosomal protein S25 | -0.0207673 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.0207462 |
| RRBP1 | ribosome binding protein 1 | -0.0206717 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0205865 |
| CLINT1 | clathrin interactor 1 | -0.0205654 |
| RPLP1 | ribosomal protein, large, P1 | -0.0203894 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0203632 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0201899 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0201402 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0199611 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | -0.0197822 |
| RTN3 | reticulon 3 | -0.0197203 |
| CCDC138 | coiled-coil domain containing 138 | -0.0197136 |
| RPS5 | ribosomal protein S5 | -0.0194474 |
| RPL38 | ribosomal protein L38 | -0.0194008 |
| ZNF217 | zinc finger protein 217 | -0.0193034 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0192768 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0192677 |
