Allantoin_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Allantoin perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Allantoin_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.181245
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.135405
FMN1 formin 1 0.107117
VCL vinculin 0.104062
TLE4 transducin-like enhancer of split 4 0.0958581
VIM vimentin 0.0754011
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0718478
EGR1 early growth response 1 0.0713197
PTMA prothymosin, alpha 0.0683694
PLAT plasminogen activator, tissue 0.0618784
ZSWIM6 zinc finger, SWIM-type containing 6 0.0602841
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0578793
ACTG1 actin gamma 1 0.0575133
RPS6 ribosomal protein S6 0.0569343
PRRC2C proline-rich coiled-coil 2C 0.0564317
RPL35A ribosomal protein L35a 0.0556068
EIF1 eukaryotic translation initiation factor 1 0.0554353
MEIS2 Meis homeobox 2 0.0552489
EEF2 eukaryotic translation elongation factor 2 0.0495375
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.048746
RPL23 ribosomal protein L23 0.0467689
B2M beta-2-microglobulin 0.04657
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.045337
RPLP1 ribosomal protein, large, P1 0.0451679
COL1A1 collagen, type I, alpha 1 0.0448668
MED13 mediator complex subunit 13 0.0445237
SCG2 secretogranin II 0.0441612
RPL34 ribosomal protein L34 0.0440285
RPL26 ribosomal protein L26 0.0438799
TMSB10 thymosin beta 10 0.0432078
RNF213 ring finger protein 213 0.0430962
EXT1 exostosin glycosyltransferase 1 0.0419987
CRH corticotropin releasing hormone 0.0417717
AMOTL1 angiomotin like 1 0.0417021
RPL19 ribosomal protein L19 0.0409446
TPST1 tyrosylprotein sulfotransferase 1 0.0403632
GLCCI1 glucocorticoid induced 1 0.0401747
THSD4 thrombospondin, type I, domain containing 4 0.0400847
PKM pyruvate kinase, muscle 0.039987
PSD3 pleckstrin and Sec7 domain containing 3 0.0393691
TBX2 T-box 2 0.0392431
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.038995
RPLP0 ribosomal protein, large, P0 0.0388403
ANGPT1 angiopoietin 1 0.0386833
MYO6 myosin VI 0.0382854
S100A9 S100 calcium binding protein A9 0.0381425
RPS24 ribosomal protein S24 0.038102
GNAS GNAS complex locus 0.037211
TPT1 tumor protein, translationally-controlled 1 0.0367538
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0367148
NRG1 neuregulin 1 0.0364385
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0361284
RIGI RNA sensor RIG-I 0.0359272
RPL37A ribosomal protein L37a 0.0358751
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0355234
TIMP3 TIMP metallopeptidase inhibitor 3 0.0346981
FTL ferritin, light polypeptide 0.0339793
LIMCH1 LIM and calponin homology domains 1 0.0337597
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0336917
SEPTIN9 septin 9 0.0331772
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0331544
PTPRD protein tyrosine phosphatase, receptor type, D 0.0331212
THBS1 thrombospondin 1 0.0324232
RPS19 ribosomal protein S19 0.032197
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0319778
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0311669
SIK2 salt-inducible kinase 2 0.0311576
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0309952
RPS12 ribosomal protein S12 0.0308824
COL4A1 collagen, type IV, alpha 1 0.0308434
ZFP36L1 ZFP36 ring finger protein-like 1 0.0306532
MX2 MX dynamin-like GTPase 2 0.0305949
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.030585
RNASEH2A ribonuclease H2, subunit A 0.0305761
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0300854
POTEF POTE ankyrin domain family, member F 0.0299945
ACTN1 actinin, alpha 1 0.0299543
RPL12 ribosomal protein L12 0.0295959
JUP junction plakoglobin 0.0295465
CENPF centromere protein F, 350/400kDa 0.0294451
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0289044
RPS27A ribosomal protein S27a 0.028903
RPS8 ribosomal protein S8 0.0287121
RPS14 ribosomal protein S14 0.0284634
PGK1 phosphoglycerate kinase 1 0.0282493
RPL32 ribosomal protein L32 0.028024
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0277147
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0273004
CLTC clathrin, heavy chain (Hc) 0.0272883
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0271452
SET SET nuclear proto-oncogene 0.0271301
ITGA1 integrin, alpha 1 0.0267929
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0266511
LOC112694756 uncharaterized LOC112694756 0.0266356
CUL3 cullin 3 0.0262859
ZMIZ1 zinc finger, MIZ-type containing 1 0.0259186
RPL9 ribosomal protein L9 0.0257595
FHIT fragile histidine triad 0.0257091
IER3 immediate early response 3 0.0256519
FAM107B family with sequence similarity 107, member B 0.0255982

decreased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0546546
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0457344
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0452079
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.043235
SMYD3 SET and MYND domain containing 3 -0.0424023
NREP neuronal regeneration related protein -0.0405259
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0386593
FAM13A family with sequence similarity 13, member A -0.0372391
MBD5 methyl-CpG binding domain protein 5 -0.0334236
GMDS GDP-mannose 4,6-dehydratase -0.0333775
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0331327
GPC5 glypican 5 -0.0321588
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0300471
MAML2 mastermind-like 2 (Drosophila) -0.0299988
OGA O-GlcNAcase -0.0298472
ZC3H11A zinc finger CCCH-type containing 11A -0.0290185
RPTOR regulatory associated protein of MTOR, complex 1 -0.0285724
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0267579
SBF2 SET binding factor 2 -0.026413
KCTD16 potassium channel tetramerization domain containing 16 -0.026103
UNC5C unc-5 homolog C (C. elegans) -0.02565
TET2 tet methylcytosine dioxygenase 2 -0.0251124
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0248514
DACH2 dachshund family transcription factor 2 -0.0244541
CEMIP cell migration inducing protein, hyaluronan binding -0.0244024
MTUS1 microtubule associated tumor suppressor 1 -0.0231753
KIF26B kinesin family member 26B -0.022683
GSE1 Gse1 coiled-coil protein -0.022596
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0225789
C1ORF21 chromosome 1 open reading frame 21 -0.0225492
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0222852
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0221436
LCORL ligand dependent nuclear receptor corepressor-like -0.0219836
CADM1 cell adhesion molecule 1 -0.0219041
CCNY cyclin Y -0.0216095
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0215017
NPEPPS aminopeptidase puromycin sensitive -0.0214922
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0210975
PRTG protogenin -0.0206926
DNAH14 dynein, axonemal, heavy chain 14 -0.0206372
KMT2E lysine (K)-specific methyltransferase 2E -0.020413
NGLY1 N-glycanase 1 -0.0201557
FNIP1 folliculin interacting protein 1 -0.0199321
MAPK10 mitogen-activated protein kinase 10 -0.019782
PLCB4 phospholipase C, beta 4 -0.0194658
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0193756
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0191704
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0188649
GATAD2B GATA zinc finger domain containing 2B -0.0188525
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0187005
XPO1 exportin 1 -0.0186198
NDRG1 N-myc downstream regulated 1 -0.0184962
AHCTF1 AT hook containing transcription factor 1 -0.0184748
TMEM131 transmembrane protein 131 -0.0184439
NPAS3 neuronal PAS domain protein 3 -0.0183981
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0183922
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0183207
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.018284
MSI2 musashi RNA-binding protein 2 -0.0182233
TOX thymocyte selection-associated high mobility group box -0.018087
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0180623
MBNL2 muscleblind-like splicing regulator 2 -0.0180578
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.01805
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.01802
PICALM phosphatidylinositol binding clathrin assembly protein -0.0180158
TBC1D19 TBC1 domain family, member 19 -0.017889
VCAN versican -0.0178809
MXI1 MAX interactor 1, dimerization protein -0.0178322
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 -0.0176636
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0175245
ANKRD28 ankyrin repeat domain 28 -0.0174963
GPR75-ASB3 GPR75-ASB3 readthrough -0.0174455
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0173692
APTX aprataxin -0.017355
ZNF654 zinc finger protein 654 -0.0171555
PANK3 pantothenate kinase 3 -0.0170776
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma -0.0170295
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -0.0168412
NEK7 NIMA-related kinase 7 -0.0168047
ACACA acetyl-CoA carboxylase alpha -0.0166689
BRWD1 bromodomain and WD repeat domain containing 1 -0.0166541
WDR45B WD repeat domain 45B -0.0165815
KIF21A kinesin family member 21A -0.0164568
PYGL phosphorylase, glycogen, liver -0.016351
PRR16 proline rich 16 -0.0163375
ZNF652 zinc finger protein 652 -0.0162823
ZNF292 zinc finger protein 292 -0.0162039
PDE8A phosphodiesterase 8A -0.0162039
IGFBP3 insulin-like growth factor binding protein 3 -0.0159769
MBTD1 mbt domain containing 1 -0.0157508
CEP95 centrosomal protein 95kDa -0.0157465
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0157442
ARHGAP32 Rho GTPase activating protein 32 -0.0157415
FOXK2 forkhead box K2 -0.0156632
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0155481
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0155275
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0153502
CUX2 cut-like homeobox 2 -0.0152538
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0151871
SLC39A11 solute carrier family 39, member 11 -0.0151113