Allantoin_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Allantoin perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Allantoin_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.227541
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.179372
MT2A metallothionein 2A 0.17371
COL6A3 collagen, type VI, alpha 3 0.109813
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.10646
FTH1 ferritin, heavy polypeptide 1 0.0938504
TGFBI transforming growth factor, beta-induced, 68kDa 0.083072
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.077038
TMSB10 thymosin beta 10 0.0682199
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0681516
WWTR1 WW domain containing transcription regulator 1 0.0672419
CD44 CD44 molecule (Indian blood group) 0.0598701
VIM vimentin 0.0598633
EXT1 exostosin glycosyltransferase 1 0.0586192
COL1A1 collagen, type I, alpha 1 0.0585341
STC1 stanniocalcin 1 0.0560277
HMGA2 high mobility group AT-hook 2 0.052729
NAV1 neuron navigator 1 0.0500903
FTL ferritin, light polypeptide 0.0486495
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0477306
INHBA inhibin, beta A 0.0462559
GLIS3 GLIS family zinc finger 3 0.0462162
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0461464
VEGFA vascular endothelial growth factor A 0.0441483
TIMP1 TIMP metallopeptidase inhibitor 1 0.0406479
LTBP1 latent transforming growth factor beta binding protein 1 0.0401252
EGR1 early growth response 1 0.0395373
COL5A1 collagen, type V, alpha 1 0.0393775
ECE1 endothelin converting enzyme 1 0.0393702
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0388268
PDLIM5 PDZ and LIM domain 5 0.037977
LDHA lactate dehydrogenase A 0.037426
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0367673
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0366242
PKM pyruvate kinase, muscle 0.0362387
ZBTB38 zinc finger and BTB domain containing 38 0.0361673
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.035927
IGFBP7 insulin-like growth factor binding protein 7 0.0354082
VCL vinculin 0.0349185
IL6 interleukin 6 0.0343178
F3 coagulation factor III (thromboplastin, tissue factor) 0.0329075
LOC112694756 uncharaterized LOC112694756 0.0328449
POTEF POTE ankyrin domain family, member F 0.032807
LOX lysyl oxidase 0.0327091
MT1X metallothionein 1X 0.032137
TAPBP TAP binding protein (tapasin) 0.032116
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0319742
COL7A1 collagen, type VII, alpha 1 0.0317654
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0310383
MYH9 myosin, heavy chain 9, non-muscle 0.0304962
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0304599
FLNA filamin A, alpha 0.0297007
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0291259
ENO1 enolase 1, (alpha) 0.0286134
ADAM12 ADAM metallopeptidase domain 12 0.0279771
ERRFI1 ERBB receptor feedback inhibitor 1 0.0271738
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.026809
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0264204
CYB5R3 cytochrome b5 reductase 3 0.0263822
CALD1 caldesmon 1 0.0262953
HIPK2 homeodomain interacting protein kinase 2 0.0261921
PLEC plectin 0.0260502
HLA-A major histocompatibility complex, class I, A 0.0254495
JAG1 jagged 1 0.0254378
MAML2 mastermind-like 2 (Drosophila) 0.0247555
RPS19 ribosomal protein S19 0.0247488
EEF2 eukaryotic translation elongation factor 2 0.024446
CNTN5 contactin 5 0.0244235
HAS2 hyaluronan synthase 2 0.0244076
LGALS1 lectin, galactoside-binding, soluble, 1 0.0242272
NRP1 neuropilin 1 0.0230317
ANGPTL4 angiopoietin-like 4 0.0225982
LAMA5 laminin, alpha 5 0.0221239
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0220295
IFI6 interferon, alpha-inducible protein 6 0.022002
COL1A2 collagen, type I, alpha 2 0.0219063
ASPH aspartate beta-hydroxylase 0.0208995
CTSB cathepsin B 0.0208448
MBNL1 muscleblind-like splicing regulator 1 0.020568
CD59 CD59 molecule, complement regulatory protein 0.0205065
FAT1 FAT atypical cadherin 1 0.0204305
AXL AXL receptor tyrosine kinase 0.0199614
ZBTB20 zinc finger and BTB domain containing 20 0.019926
COL6A2 collagen, type VI, alpha 2 0.0198666
ALCAM activated leukocyte cell adhesion molecule 0.0197025
HSPA8 heat shock 70kDa protein 8 0.0191984
OSMR oncostatin M receptor 0.0191182
RPS8 ribosomal protein S8 0.019092
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0189698
RUNX1 runt-related transcription factor 1 0.0189587
ACTG1 actin gamma 1 0.0187927
MYO10 myosin X 0.0186297
SDC2 syndecan 2 0.0181569
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.018002
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0179105
MSN moesin 0.0176439
PDLIM7 PDZ and LIM domain 7 (enigma) 0.0173923
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0172825
HDAC9 histone deacetylase 9 0.0172638
STARD13 StAR-related lipid transfer (START) domain containing 13 0.0171042

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.201311
CADM1 cell adhesion molecule 1 -0.144907
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.135857
NDRG1 N-myc downstream regulated 1 -0.118177
IGFBP3 insulin-like growth factor binding protein 3 -0.0878857
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0778428
GOLGA4 golgin A4 -0.0674476
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.06537
NAMPT nicotinamide phosphoribosyltransferase -0.06384
PDE10A phosphodiesterase 10A -0.0614121
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0554927
SPAG9 sperm associated antigen 9 -0.0533424
TRIO trio Rho guanine nucleotide exchange factor -0.0524788
ZNF292 zinc finger protein 292 -0.0493948
ATP13A3 ATPase type 13A3 -0.046762
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.046307
JARID2 jumonji, AT rich interactive domain 2 -0.0457684
QKI QKI, KH domain containing, RNA binding -0.039477
ZFAND3 zinc finger, AN1-type domain 3 -0.0391943
USP3 ubiquitin specific peptidase 3 -0.0383259
CAMTA1 calmodulin binding transcription activator 1 -0.0375937
CANX calnexin -0.03747
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0367961
KDM3A lysine (K)-specific demethylase 3A -0.0366114
RLF rearranged L-myc fusion -0.0345658
KMT2C lysine (K)-specific methyltransferase 2C -0.0344745
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0343392
ELL2 elongation factor, RNA polymerase II, 2 -0.0336199
RAB1A RAB1A, member RAS oncogene family -0.0333371
CLINT1 clathrin interactor 1 -0.0327733
TRAM1 translocation associated membrane protein 1 -0.032484
FNDC3B fibronectin type III domain containing 3B -0.0319568
OGA O-GlcNAcase -0.0318463
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0317262
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0313186
HOOK2 hook microtubule-tethering protein 2 -0.0312659
MARCHF6 membrane associated ring-CH-type finger 6 -0.0306552
FMNL2 formin-like 2 -0.0306215
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0302396
HELZ helicase with zinc finger -0.0299706
KIF13A kinesin family member 13A -0.0299671
MTDH metadherin -0.0297559
TMEM165 transmembrane protein 165 -0.0296591
SOD2 superoxide dismutase 2, mitochondrial -0.0296144
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0289948
COPA coatomer protein complex, subunit alpha -0.0289498
AFF4 AF4/FMR2 family, member 4 -0.0284335
NPEPPS aminopeptidase puromycin sensitive -0.0283834
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0282511
ARRDC3 arrestin domain containing 3 -0.0280753
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0280537
PTMA prothymosin, alpha -0.0280498
WSB1 WD repeat and SOCS box containing 1 -0.0280236
RAB6A RAB6A, member RAS oncogene family -0.0279095
CD109 CD109 molecule -0.0277428
TFG TRK-fused gene -0.0273068
TBC1D23 TBC1 domain family, member 23 -0.0271865
BBX bobby sox homolog (Drosophila) -0.0271561
FGFR1 fibroblast growth factor receptor 1 -0.0268472
RHEB Ras homolog enriched in brain -0.0265644
SEC24A SEC24 family member A -0.0263236
HILPDA hypoxia inducible lipid droplet-associated -0.0260629
KIF1B kinesin family member 1B -0.0260116
TSC22D2 TSC22 domain family, member 2 -0.0259963
PDIA3 protein disulfide isomerase family A, member 3 -0.025855
CCNY cyclin Y -0.0256281
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0250136
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.0249732
RBM39 RNA binding motif protein 39 -0.0245421
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme -0.0245383
ADAM17 ADAM metallopeptidase domain 17 -0.0245293
PSD3 pleckstrin and Sec7 domain containing 3 -0.024511
RYBP RING1 and YY1 binding protein -0.0244756
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0242686
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.023811
SUCO SUN domain containing ossification factor -0.0236475
PTK2 protein tyrosine kinase 2 -0.0235977
SEC63 SEC63 homolog (S. cerevisiae) -0.0234817
IARS1 isoleucyl-tRNA synthetase 1 -0.0233929
KCTD9 potassium channel tetramerization domain containing 9 -0.0233776
ANKRD11 ankyrin repeat domain 11 -0.0233718
ESYT2 extended synaptotagmin-like protein 2 -0.0233575
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0232899
MATR3 matrin 3 -0.0231431
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0229353
ITCH itchy E3 ubiquitin protein ligase -0.0226317
PRRC1 proline-rich coiled-coil 1 -0.0225018
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0223039
IER3 immediate early response 3 -0.0222789
TRA2A transformer 2 alpha homolog (Drosophila) -0.0222496
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0221759
CDC73 cell division cycle 73 -0.0220618
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.021986
CALR calreticulin -0.0216076
PDE8A phosphodiesterase 8A -0.0215596
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0214903
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.021294
KMT2E lysine (K)-specific methyltransferase 2E -0.0211318
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0211203
RASA2 RAS p21 protein activator 2 -0.0210711