Allantoin_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Allantoin perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Allantoin_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin 0.117654
LAMA5 laminin, alpha 5 0.0810732
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0796632
MT2A metallothionein 2A 0.0775914
KRT6A keratin 6A, type II 0.0642162
FTL ferritin, light polypeptide 0.058772
POTEF POTE ankyrin domain family, member F 0.0572967
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0560143
FTH1 ferritin, heavy polypeptide 1 0.0559763
HSPG2 heparan sulfate proteoglycan 2 0.0556397
PLAT plasminogen activator, tissue 0.0523635
RPL11 ribosomal protein L11 0.0501456
TGM2 transglutaminase 2 0.0482075
IFITM1 interferon induced transmembrane protein 1 0.0462371
RPL37 ribosomal protein L37 0.0456311
PLXNA2 plexin A2 0.0439706
RPS8 ribosomal protein S8 0.0435155
EXT1 exostosin glycosyltransferase 1 0.0414348
RPS12 ribosomal protein S12 0.0413213
SMAD3 SMAD family member 3 0.0392151
RPL37A ribosomal protein L37a 0.0386591
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0383378
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0382126
HLA-B major histocompatibility complex, class I, B 0.0381401
SIK3 SIK family kinase 3 0.0379962
CYB5R3 cytochrome b5 reductase 3 0.0379371
RPL12 ribosomal protein L12 0.037646
RPL30 ribosomal protein L30 0.037214
IFI6 interferon, alpha-inducible protein 6 0.0370499
TMSB10 thymosin beta 10 0.0367614
RASAL2 RAS protein activator like 2 0.0366772
MT1E metallothionein 1E 0.0363221
IRS2 insulin receptor substrate 2 0.0351267
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0350118
AMOTL1 angiomotin like 1 0.0346077
MEIS2 Meis homeobox 2 0.0346048
LMO7 LIM domain 7 0.0345082
MN1 meningioma (disrupted in balanced translocation) 1 0.0340962
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0337578
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.033454
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0333303
ITGB4 integrin, beta 4 0.0326021
TTC28 tetratricopeptide repeat domain 28 0.0325821
RPL9 ribosomal protein L9 0.0324409
RPLP1 ribosomal protein, large, P1 0.0311453
RPL31 ribosomal protein L31 0.0306304
EPS8 epidermal growth factor receptor pathway substrate 8 0.0303752
HMGA1 high mobility group AT-hook 1 0.0302496
KLF5 Kruppel-like factor 5 (intestinal) 0.030002
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0294857
CMIP c-Maf inducing protein 0.0294259
FNDC3A fibronectin type III domain containing 3A 0.0293443
BCAR1 breast cancer anti-estrogen resistance 1 0.0289698
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0289236
IFITM3 interferon induced transmembrane protein 3 0.0286946
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0285474
MBNL1 muscleblind-like splicing regulator 1 0.0285368
RPL26 ribosomal protein L26 0.0283901
SULF2 sulfatase 2 0.0279021
EEF1G eukaryotic translation elongation factor 1 gamma 0.0277372
MCL1 myeloid cell leukemia 1 0.0276871
RPL36 ribosomal protein L36 0.0276632
TXNRD1 thioredoxin reductase 1 0.0272281
MACF1 microtubule-actin crosslinking factor 1 0.0269928
EGFR epidermal growth factor receptor 0.0269081
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0266013
NCOA3 nuclear receptor coactivator 3 0.0265905
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0264765
RPL27 ribosomal protein L27 0.0264332
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0263087
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0262123
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0259096
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0256118
ATP5F1E ATP synthase F1 subunit epsilon 0.0254392
TOP1 topoisomerase (DNA) I 0.0253783
SEPTIN9 septin 9 0.0251277
TNS4 tensin 4 0.025059
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0250315
ZSWIM6 zinc finger, SWIM-type containing 6 0.0249269
HSPH1 heat shock 105kDa/110kDa protein 1 0.0247991
UGCG UDP-glucose ceramide glucosyltransferase 0.0244018
MX2 MX dynamin-like GTPase 2 0.0243421
FOXN2 forkhead box N2 0.0240631
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0236697
IGF2 insulin-like growth factor 2 0.023534
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0232552
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0232542
PLPP6 phospholipid phosphatase 6 0.0232084
FAT1 FAT atypical cadherin 1 0.0226849
DOCK9 dedicator of cytokinesis 9 0.0226026
TMBIM1 transmembrane BAX inhibitor motif containing 1 0.0225066
SVIL supervillin 0.0224775
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0222756
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0221891
RPS21 ribosomal protein S21 0.0221618
EFNB2 ephrin-B2 0.0220948
MSN moesin 0.0220537
TAGLN2 transgelin 2 0.021971
TSC22D1 TSC22 domain family, member 1 0.0217446
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 0.0217403

decreased expression

Symbol Name Standardized Value
MTSS1 metastasis suppressor 1 -0.151604
NDRG1 N-myc downstream regulated 1 -0.111095
SULF1 sulfatase 1 -0.0977755
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0808356
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0800062
TRIO trio Rho guanine nucleotide exchange factor -0.076328
RAI14 retinoic acid induced 14 -0.0747928
H1-0 H1.0 linker histone -0.0708635
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0664708
ABI3BP ABI family, member 3 (NESH) binding protein -0.0634706
MEF2A myocyte enhancer factor 2A -0.0621855
EMP1 epithelial membrane protein 1 -0.0589169
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0586903
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0557692
MKI67 marker of proliferation Ki-67 -0.0555355
CALU calumenin -0.0518166
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -0.0477663
HM13 histocompatibility (minor) 13 -0.0475816
GOLGA4 golgin A4 -0.0461087
KIAA1217 KIAA1217 -0.0460231
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0455445
ANLN anillin, actin binding protein -0.0453177
TMSB4X thymosin beta 4, X-linked -0.0425125
JMJD1C jumonji domain containing 1C -0.0414906
TPM4 tropomyosin 4 -0.0409664
DPYD dihydropyrimidine dehydrogenase -0.0407926
AHNAK AHNAK nucleoprotein -0.0407544
BHLHE40 basic helix-loop-helix family, member e40 -0.040235
DOK5 docking protein 5 -0.039064
PRSS23 protease, serine, 23 -0.0380692
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0373534
SDCBP syndecan binding protein (syntenin) -0.0370994
BLCAP bladder cancer associated protein -0.0369392
ANXA1 annexin A1 -0.03573
TTC3 tetratricopeptide repeat domain 3 -0.0346795
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0345766
ARID4B AT rich interactive domain 4B (RBP1-like) -0.034465
RICTOR RPTOR independent companion of MTOR, complex 2 -0.034127
SBF2 SET binding factor 2 -0.033629
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0332293
UTRN utrophin -0.0330706
S100A10 S100 calcium binding protein A10 -0.0327051
GNAS GNAS complex locus -0.0325082
ANKRD11 ankyrin repeat domain 11 -0.0324823
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0321526
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0321063
STC1 stanniocalcin 1 -0.0316056
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.0313453
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0306903
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0306511
PPARG peroxisome proliferator-activated receptor gamma -0.0306012
DSCAM Down syndrome cell adhesion molecule -0.0303507
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0300619
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0297054
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.029402
SUCO SUN domain containing ossification factor -0.0293808
RAD51B RAD51 paralog B -0.029331
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0290428
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease -0.0285819
GOLGB1 golgin B1 -0.0285568
RLF rearranged L-myc fusion -0.0285521
CANX calnexin -0.0285195
RPL36A ribosomal protein L36a -0.0284084
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0282987
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0281988
ERAP2 endoplasmic reticulum aminopeptidase 2 -0.0281637
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0277327
NAV2 neuron navigator 2 -0.027637
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0272201
CYRIB CYFIP related Rac1 interactor B -0.0270685
RSF1 remodeling and spacing factor 1 -0.0269519
ALCAM activated leukocyte cell adhesion molecule -0.0268177
CAPN2 calpain 2, (m/II) large subunit -0.0267416
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0263647
CEP170 centrosomal protein 170kDa -0.0263502
PTMA prothymosin, alpha -0.0263324
LAMC2 laminin, gamma 2 -0.0262474
LNPEP leucyl/cystinyl aminopeptidase -0.0261746
RAB1A RAB1A, member RAS oncogene family -0.0260817
ANO6 anoctamin 6 -0.025801
PLS3 plastin 3 -0.0257222
COPB1 coatomer protein complex, subunit beta 1 -0.0253569
AKAP9 A kinase (PRKA) anchor protein 9 -0.0251953
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0251488
SPAG9 sperm associated antigen 9 -0.0251395
NBEAL1 neurobeachin-like 1 -0.0249915
ITCH itchy E3 ubiquitin protein ligase -0.0248895
RSL1D1 ribosomal L1 domain containing 1 -0.0247177
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -0.0245782
CDC27 cell division cycle 27 -0.0244255
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0244065
DYNC2I1 dynein 2 intermediate chain 1 -0.024396
SEC31A SEC31 homolog A (S. cerevisiae) -0.0243008
STAG2 stromal antigen 2 -0.0240177
ZMYND8 zinc finger, MYND-type containing 8 -0.0235244
IARS1 isoleucyl-tRNA synthetase 1 -0.0234614
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0233874
PDIA3 protein disulfide isomerase family A, member 3 -0.0231385
YBX3 Y box binding protein 3 -0.023064
ADAM17 ADAM metallopeptidase domain 17 -0.0230197