Allantoin_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Allantoin perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Allantoin_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.155525
FTH1 ferritin, heavy polypeptide 1 0.136467
FAT1 FAT atypical cadherin 1 0.121581
ONECUT3 one cut homeobox 3 0.112985
MYO1E myosin IE 0.112758
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.110184
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.104047
CEMIP cell migration inducing protein, hyaluronan binding 0.10285
RPS6 ribosomal protein S6 0.0924723
PKM pyruvate kinase, muscle 0.0911946
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0821958
LOC112694756 uncharaterized LOC112694756 0.0815946
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.0736596
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0717561
HSPA8 heat shock 70kDa protein 8 0.0707976
H1-0 H1.0 linker histone 0.0697792
PTMA prothymosin, alpha 0.0590559
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0586156
MUC13 mucin 13, cell surface associated 0.0563212
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0533082
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0532739
LOC102724023 ES1 protein homolog, mitochondrial 0.0529352
AHNAK AHNAK nucleoprotein 0.0499953
EXT1 exostosin glycosyltransferase 1 0.0497791
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0497602
EGFR epidermal growth factor receptor 0.0488956
MYH9 myosin, heavy chain 9, non-muscle 0.0484657
SOX9 SRY (sex determining region Y)-box 9 0.0482364
TNS4 tensin 4 0.0477029
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0438468
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0422171
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0410239
VEGFA vascular endothelial growth factor A 0.0396169
EEF1G eukaryotic translation elongation factor 1 gamma 0.0390658
ACTN4 actinin, alpha 4 0.0385271
MT2A metallothionein 2A 0.0378745
RPLP1 ribosomal protein, large, P1 0.0377716
LMO7 LIM domain 7 0.0367961
KLF5 Kruppel-like factor 5 (intestinal) 0.0367868
MBNL1 muscleblind-like splicing regulator 1 0.036715
TSC22D1 TSC22 domain family, member 1 0.0366433
ACTG1 actin gamma 1 0.0365625
VCL vinculin 0.0365494
RPS12 ribosomal protein S12 0.0362178
MED13 mediator complex subunit 13 0.0359509
RPS2 ribosomal protein S2 0.0355415
CENPF centromere protein F, 350/400kDa 0.0354937
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.034219
MPRIP myosin phosphatase Rho interacting protein 0.033591
KRT8 keratin 8, type II 0.0332309
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0321102
FLNA filamin A, alpha 0.0315868
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0312862
EEF2 eukaryotic translation elongation factor 2 0.0307244
ITGB4 integrin, beta 4 0.0306662
APLP2 amyloid beta (A4) precursor-like protein 2 0.0305316
HSPG2 heparan sulfate proteoglycan 2 0.0304087
LDHA lactate dehydrogenase A 0.029778
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0291065
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0288406
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0286544
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0282517
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.028072
TXNIP thioredoxin interacting protein 0.027874
CEMIP2 cell migration inducing hyaluronidase 2 0.0275853
TPM4 tropomyosin 4 0.0274479
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 0.0271263
CMIP c-Maf inducing protein 0.027057
S100A10 S100 calcium binding protein A10 0.0269266
MT1E metallothionein 1E 0.0265423
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0261348
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0258146
EPHA2 EPH receptor A2 0.0256335
TUBB4B tubulin, beta 4B class IVb 0.0254513
MYH14 myosin, heavy chain 14, non-muscle 0.0251586
NKD1 naked cuticle homolog 1 (Drosophila) 0.0251501
POTEF POTE ankyrin domain family, member F 0.0250192
DSPP dentin sialophosphoprotein 0.0250009
SQSTM1 sequestosome 1 0.0243041
SVIL supervillin 0.0242767
SEPTIN9 septin 9 0.0240967
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0240757
PPARD peroxisome proliferator-activated receptor delta 0.0239949
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0238543
AREG amphiregulin 0.0237569
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.023392
PDLIM5 PDZ and LIM domain 5 0.0233192
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0231222
EZR ezrin 0.0228971
ENO1 enolase 1, (alpha) 0.0228533
FHIT fragile histidine triad 0.0227813
ERRFI1 ERBB receptor feedback inhibitor 1 0.0227524
RAB10 RAB10, member RAS oncogene family 0.0226629
EGR1 early growth response 1 0.0225703
PDZD8 PDZ domain containing 8 0.0225354
RPS27 ribosomal protein S27 0.0224944
APP amyloid beta (A4) precursor protein 0.022289
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0221003
WNK1 WNK lysine deficient protein kinase 1 0.021861
RPS26 ribosomal protein S26 0.0217188

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.132192
GPHN gephyrin -0.105737
NALF1 NALCN channel auxiliary factor 1 -0.103518
GOLGA4 golgin A4 -0.10162
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0944654
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0883328
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0792672
GCC2 GRIP and coiled-coil domain containing 2 -0.0773016
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0756132
MON2 MON2 homolog (S. cerevisiae) -0.0716854
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0664023
BIRC6 baculoviral IAP repeat containing 6 -0.0631307
ZFAND3 zinc finger, AN1-type domain 3 -0.0612224
MBNL2 muscleblind-like splicing regulator 2 -0.0603816
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0592856
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0559371
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0547893
PPARG peroxisome proliferator-activated receptor gamma -0.0537283
BTBD9 BTB (POZ) domain containing 9 -0.0518136
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.050756
NCOR1 nuclear receptor corepressor 1 -0.0506172
SEC31A SEC31 homolog A (S. cerevisiae) -0.0505406
SBF2 SET binding factor 2 -0.0483211
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0471316
CANX calnexin -0.0468467
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.045853
PIGR polymeric immunoglobulin receptor -0.0456455
ESYT2 extended synaptotagmin-like protein 2 -0.0444871
AKAP9 A kinase (PRKA) anchor protein 9 -0.043767
RNF145 ring finger protein 145 -0.0431818
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0428306
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0421185
NFIA nuclear factor I/A -0.0420625
IARS1 isoleucyl-tRNA synthetase 1 -0.0419989
MED13L mediator complex subunit 13-like -0.0411933
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0407463
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0402089
FAM13A family with sequence similarity 13, member A -0.03985
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0394821
TTC3 tetratricopeptide repeat domain 3 -0.0393835
CCNY cyclin Y -0.0388283
EPCAM epithelial cell adhesion molecule -0.0380855
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0380391
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -0.0379931
ZMYM2 zinc finger, MYM-type 2 -0.0378944
CD46 CD46 molecule, complement regulatory protein -0.0378361
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0376745
ITGA6 integrin, alpha 6 -0.0375643
INSIG1 insulin induced gene 1 -0.0372392
DERA deoxyribose-phosphate aldolase (putative) -0.0371255
FNDC3A fibronectin type III domain containing 3A -0.0363332
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0362201
PCDHB16 protocadherin beta 16 -0.0360603
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0359174
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0355492
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0352564
NBAS neuroblastoma amplified sequence -0.0349025
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta -0.0346857
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0344607
AGR2 anterior gradient 2 -0.0340761
DLG1 discs, large homolog 1 (Drosophila) -0.0336131
OGA O-GlcNAcase -0.0333961
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0330643
SCFD1 sec1 family domain containing 1 -0.0329678
FNBP1L formin binding protein 1-like -0.0327831
SEC24D SEC24 family member D -0.0327177
COG5 component of oligomeric golgi complex 5 -0.0325756
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0320762
RAB1A RAB1A, member RAS oncogene family -0.0318789
EHBP1 EH domain binding protein 1 -0.0312225
USP34 ubiquitin specific peptidase 34 -0.0311377
MLEC malectin -0.0310995
KLF3 Kruppel-like factor 3 (basic) -0.0309153
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0307017
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0306075
GREB1L growth regulation by estrogen in breast cancer-like -0.0306073
EXOC1 exocyst complex component 1 -0.0305558
CSDE1 cold shock domain containing E1, RNA-binding -0.0303727
TMSB10 thymosin beta 10 -0.0300387
BRWD1 bromodomain and WD repeat domain containing 1 -0.0299545
TMF1 TATA element modulatory factor 1 -0.0297721
ANKRD17 ankyrin repeat domain 17 -0.029667
GSK3B glycogen synthase kinase 3 beta -0.0291085
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0290194
RAB6A RAB6A, member RAS oncogene family -0.0289846
DSCAM Down syndrome cell adhesion molecule -0.0289184
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0287323
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0287004
SETD5 SET domain containing 5 -0.0286451
CDK13 cyclin-dependent kinase 13 -0.0286418
S100A6 S100 calcium binding protein A6 -0.0286091
CD2AP CD2-associated protein -0.0283815
TMEM131 transmembrane protein 131 -0.0283654
EPB41 erythrocyte membrane protein band 4.1 -0.0279696
PTPRK protein tyrosine phosphatase, receptor type, K -0.0276719
SENP6 SUMO1/sentrin specific peptidase 6 -0.0275953
MMP12 matrix metallopeptidase 12 -0.0275857
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0275079
XPOT exportin, tRNA -0.0269338
FNDC3B fibronectin type III domain containing 3B -0.0269108