Allantoin_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Allantoin perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Allantoin_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.153232
VIM vimentin 0.0826838
TXNRD1 thioredoxin reductase 1 0.0793423
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.077546
ERRFI1 ERBB receptor feedback inhibitor 1 0.0680423
EEF2 eukaryotic translation elongation factor 2 0.0633186
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0632627
TM4SF1 transmembrane 4 L six family member 1 0.0630994
UBC ubiquitin C 0.0559055
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0558861
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.054711
AHNAK AHNAK nucleoprotein 0.0538133
LOC112694756 uncharaterized LOC112694756 0.0483144
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0463568
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0458297
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.044504
FTH1 ferritin, heavy polypeptide 1 0.0441422
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0434554
WWTR1 WW domain containing transcription regulator 1 0.0393061
BCAR3 breast cancer anti-estrogen resistance 3 0.03869
EREG epiregulin 0.03731
JUN jun proto-oncogene 0.0372328
KMT2E lysine (K)-specific methyltransferase 2E 0.0364952
CMIP c-Maf inducing protein 0.0343341
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0342247
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0335443
MACF1 microtubule-actin crosslinking factor 1 0.0333266
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.033158
MT1X metallothionein 1X 0.0325021
RAI1 retinoic acid induced 1 0.0316068
CAPRIN2 caprin family member 2 0.0307805
EMP1 epithelial membrane protein 1 0.0307013
SPAG9 sperm associated antigen 9 0.0304352
PKM pyruvate kinase, muscle 0.0298303
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0297605
RTN4 reticulon 4 0.0297076
BIRC3 baculoviral IAP repeat containing 3 0.0295739
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0295142
TRIP12 thyroid hormone receptor interactor 12 0.0287014
H1-0 H1.0 linker histone 0.0286031
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0285993
HSPA8 heat shock 70kDa protein 8 0.0285985
MYH9 myosin, heavy chain 9, non-muscle 0.0279976
MKI67 marker of proliferation Ki-67 0.027785
PDIA6 protein disulfide isomerase family A, member 6 0.0274093
POTEF POTE ankyrin domain family, member F 0.0273292
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0270096
LDHA lactate dehydrogenase A 0.0265484
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0263408
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.026266
USP9X ubiquitin specific peptidase 9, X-linked 0.025766
CENPF centromere protein F, 350/400kDa 0.0255779
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0253293
POM121 POM121 transmembrane nucleoporin 0.0253194
CANX calnexin 0.0248793
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0242028
SDC4 syndecan 4 0.0240189
ARHGAP5 Rho GTPase activating protein 5 0.0233128
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0231543
APP amyloid beta (A4) precursor protein 0.0230886
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0229657
APLP2 amyloid beta (A4) precursor-like protein 2 0.0226226
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0224969
HDLBP high density lipoprotein binding protein 0.0223752
PCBP2 poly(rC) binding protein 2 0.0223567
SPRY4 sprouty homolog 4 (Drosophila) 0.0221095
CAPN2 calpain 2, (m/II) large subunit 0.0219389
SMC4 structural maintenance of chromosomes 4 0.0219199
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0218982
IQGAP1 IQ motif containing GTPase activating protein 1 0.0218912
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 0.0218327
ENO1 enolase 1, (alpha) 0.0217489
ZEB1 zinc finger E-box binding homeobox 1 0.0216643
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0215668
USP34 ubiquitin specific peptidase 34 0.0214228
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0213842
TMEM41B transmembrane protein 41B 0.0209743
VCL vinculin 0.0208156
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0208015
SMAD3 SMAD family member 3 0.0207463
CDCP1 CUB domain containing protein 1 0.0207463
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0206861
RCOR1 REST corepressor 1 0.0205569
TOP1 topoisomerase (DNA) I 0.0200348
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0200096
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0199988
SRPK2 SRSF protein kinase 2 0.0199491
PGK1 phosphoglycerate kinase 1 0.0199195
CSNK1A1 casein kinase 1, alpha 1 0.0198168
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0198166
SFPQ splicing factor proline/glutamine-rich 0.0197956
PRRC2B proline-rich coiled-coil 2B 0.0196605
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0195919
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.019555
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.0195353
EIF4A1 eukaryotic translation initiation factor 4A1 0.0192139
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0191453
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.018899
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0187856
PDIA4 protein disulfide isomerase family A, member 4 0.0185164

decreased expression

Symbol Name Standardized Value
TP63 tumor protein p63 -0.100186
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0760388
RPL35A ribosomal protein L35a -0.0726765
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0698424
DLG1 discs, large homolog 1 (Drosophila) -0.0696237
HLA-B major histocompatibility complex, class I, B -0.0685026
TPT1 tumor protein, translationally-controlled 1 -0.0652448
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.056895
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0516331
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0515867
EFNA5 ephrin-A5 -0.0496969
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0419004
RPL37A ribosomal protein L37a -0.0406417
WARS1 tryptophanyl-tRNA synthetase 1 -0.0406029
CADM2 cell adhesion molecule 2 -0.0402436
CD44 CD44 molecule (Indian blood group) -0.039637
RPL36 ribosomal protein L36 -0.0391941
TMSB10 thymosin beta 10 -0.0383618
SP100 SP100 nuclear antigen -0.0365636
RPL26 ribosomal protein L26 -0.034932
RPS8 ribosomal protein S8 -0.0345143
EPHA4 EPH receptor A4 -0.0343205
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0342408
RPL37 ribosomal protein L37 -0.033139
B2M beta-2-microglobulin -0.0330106
RPL12 ribosomal protein L12 -0.0324463
ESYT2 extended synaptotagmin-like protein 2 -0.0319903
RPS19 ribosomal protein S19 -0.0310057
WSB1 WD repeat and SOCS box containing 1 -0.0292358
RPL31 ribosomal protein L31 -0.0288434
RPL19 ribosomal protein L19 -0.0287271
RPS12 ribosomal protein S12 -0.0286214
RPL34 ribosomal protein L34 -0.0279848
RPS3 ribosomal protein S3 -0.0275377
RPS6 ribosomal protein S6 -0.0274936
EHBP1 EH domain binding protein 1 -0.0273214
RIGI RNA sensor RIG-I -0.0270061
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0268774
TMSB4X thymosin beta 4, X-linked -0.0263402
RPS10 ribosomal protein S10 -0.0263162
RPL27 ribosomal protein L27 -0.0262002
IFI6 interferon, alpha-inducible protein 6 -0.0261877
RNF213 ring finger protein 213 -0.0259919
RPS24 ribosomal protein S24 -0.0258424
IFIH1 interferon induced with helicase C domain 1 -0.0254864
RPL36A ribosomal protein L36a -0.0253181
RPL11 ribosomal protein L11 -0.024941
CSMD3 CUB and Sushi multiple domains 3 -0.0249141
TNS3 tensin 3 -0.0246934
RPL38 ribosomal protein L38 -0.0246686
RPS23 ribosomal protein S23 -0.0243713
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0239783
LOC102724023 ES1 protein homolog, mitochondrial -0.0238861
RPLP1 ribosomal protein, large, P1 -0.0238519
CFAP299 cilia and flagella associated protein 299 -0.022244
RPS28 ribosomal protein S28 -0.0213788
RPS21 ribosomal protein S21 -0.0213484
HDAC9 histone deacetylase 9 -0.0211714
RPL35 ribosomal protein L35 -0.0209157
PTMA prothymosin, alpha -0.0207882
RPS29 ribosomal protein S29 -0.0201222
ZDHHC14 zinc finger, DHHC-type containing 14 -0.019685
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.019505
RPS14 ribosomal protein S14 -0.0194917
VDAC1 voltage-dependent anion channel 1 -0.0185688
RPL9 ribosomal protein L9 -0.0184621
RPLP0 ribosomal protein, large, P0 -0.0175786
MEF2A myocyte enhancer factor 2A -0.0175441
ISG15 ISG15 ubiquitin-like modifier -0.0174233
RPL23 ribosomal protein L23 -0.0172729
ANKRD26 ankyrin repeat domain 26 -0.0172531
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0171872
MT2A metallothionein 2A -0.0168897
FTL ferritin, light polypeptide -0.0168747
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0168034
TRIM5 tripartite motif containing 5 -0.0167194
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0165131
DOCK11 dedicator of cytokinesis 11 -0.0161655
RPLP2 ribosomal protein, large, P2 -0.015776
DPH6 diphthamine biosynthesis 6 -0.0157107
IGF2 insulin-like growth factor 2 -0.0157073
PTPRF protein tyrosine phosphatase, receptor type, F -0.0153831
DPYD dihydropyrimidine dehydrogenase -0.0153811
LRRC49 leucine rich repeat containing 49 -0.0153568
RPS25 ribosomal protein S25 -0.0151729
IFITM1 interferon induced transmembrane protein 1 -0.0149946
FOXN3 forkhead box N3 -0.0148895
TSC22D1 TSC22 domain family, member 1 -0.0148443
MYOF myoferlin -0.0148407
RPL30 ribosomal protein L30 -0.0147209
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0147042
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0146804
RAD51B RAD51 paralog B -0.0146593
RPS27 ribosomal protein S27 -0.014646
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 -0.0141997
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0141983
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0141562
RPL18 ribosomal protein L18 -0.0141463
PMP22 peripheral myelin protein 22 -0.013984
IFITM3 interferon induced transmembrane protein 3 -0.0139364