Allantoin_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Allantoin perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Allantoin_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.392494
MT2A metallothionein 2A 0.132601
FTH1 ferritin, heavy polypeptide 1 0.129364
TMSB10 thymosin beta 10 0.118579
LOC112694756 uncharaterized LOC112694756 0.0806225
NDRG1 N-myc downstream regulated 1 0.0774742
SEC61G Sec61 gamma subunit 0.0758567
FTL ferritin, light polypeptide 0.0723683
EGR1 early growth response 1 0.0685201
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0673922
RPS3 ribosomal protein S3 0.066985
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0658421
RPLP1 ribosomal protein, large, P1 0.0635785
PKM pyruvate kinase, muscle 0.0630672
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0586637
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0536126
RPL37A ribosomal protein L37a 0.051494
TPT1 tumor protein, translationally-controlled 1 0.0507717
STC1 stanniocalcin 1 0.049473
B2M beta-2-microglobulin 0.0480077
CST3 cystatin C 0.0448351
MCL1 myeloid cell leukemia 1 0.043121
AREG amphiregulin 0.0424105
RPS12 ribosomal protein S12 0.0405771
CXCL8 chemokine (C-X-C motif) ligand 8 0.0405663
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.040519
ENO1 enolase 1, (alpha) 0.0401469
RPS8 ribosomal protein S8 0.0395263
PTMA prothymosin, alpha 0.0386243
IFI6 interferon, alpha-inducible protein 6 0.0366222
S100A10 S100 calcium binding protein A10 0.0363244
RPL31 ribosomal protein L31 0.0354349
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0337616
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0328881
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0318517
RPL34 ribosomal protein L34 0.0312597
RPL37 ribosomal protein L37 0.0312236
SLC38A1 solute carrier family 38, member 1 0.0305476
RPS6 ribosomal protein S6 0.0304921
RPL30 ribosomal protein L30 0.0303773
RPS19 ribosomal protein S19 0.0303222
EIF1 eukaryotic translation initiation factor 1 0.0301475
RPL35A ribosomal protein L35a 0.0301066
RPL23 ribosomal protein L23 0.0291911
MT1X metallothionein 1X 0.0290389
RPS17 ribosomal protein S17 0.0283395
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0283205
S100A11 S100 calcium binding protein A11 0.0282786
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0281139
RPS27 ribosomal protein S27 0.0280773
NAMPT nicotinamide phosphoribosyltransferase 0.0279871
CIB1 calcium and integrin binding 1 (calmyrin) 0.0278415
YBX3 Y box binding protein 3 0.0277137
RPL11 ribosomal protein L11 0.0275727
S100P S100 calcium binding protein P 0.0275307
CPE carboxypeptidase E 0.0272472
ANKRD12 ankyrin repeat domain 12 0.0264875
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0263534
RPL12 ribosomal protein L12 0.0256508
BTG1 B-cell translocation gene 1, anti-proliferative 0.0255699
PGK1 phosphoglycerate kinase 1 0.0254729
RPL36 ribosomal protein L36 0.0250027
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0248809
RPLP0 ribosomal protein, large, P0 0.0243515
RPS29 ribosomal protein S29 0.0242251
NSUN6 NOP2/Sun domain family, member 6 0.0236077
RPS27A ribosomal protein S27a 0.0233459
CEMIP cell migration inducing protein, hyaluronan binding 0.0232006
RPL19 ribosomal protein L19 0.0224269
BLZF1 basic leucine zipper nuclear factor 1 0.0224096
RPS14 ribosomal protein S14 0.021579
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0215236
RACK1 receptor for activated C kinase 1 0.0214496
RPS25 ribosomal protein S25 0.0213157
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0210234
RPL9 ribosomal protein L9 0.0208481
TPI1 triosephosphate isomerase 1 0.0207895
LDHA lactate dehydrogenase A 0.0206834
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0205782
LOC102724023 ES1 protein homolog, mitochondrial 0.0200707
RHOV ras homolog family member V 0.0199673
RPS21 ribosomal protein S21 0.0198327
RPS23 ribosomal protein S23 0.0195031
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0192623
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0192093
WSB1 WD repeat and SOCS box containing 1 0.0190965
PLAUR plasminogen activator, urokinase receptor 0.0186531
HLA-B major histocompatibility complex, class I, B 0.0184427
S100A9 S100 calcium binding protein A9 0.0183564
RPS24 ribosomal protein S24 0.0181828
UBC ubiquitin C 0.0181331
LAMB3 laminin, beta 3 0.0179748
IER3 immediate early response 3 0.0179496
RPL5 ribosomal protein L5 0.0179297
RPLP2 ribosomal protein, large, P2 0.0175342
ATF4 activating transcription factor 4 0.0175326
HLA-A major histocompatibility complex, class I, A 0.0172541
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.0170101
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0167139
RPL26 ribosomal protein L26 0.0167038

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.130209
ASPH aspartate beta-hydroxylase -0.0383695
LMO7 LIM domain 7 -0.0382947
PTPRM protein tyrosine phosphatase, receptor type, M -0.0374569
THSD4 thrombospondin, type I, domain containing 4 -0.0349369
PATJ PATJ crumbs cell polarity complex component -0.0259191
AHNAK AHNAK nucleoprotein -0.0219903
HDLBP high density lipoprotein binding protein -0.0208241
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0206898
ZC3H11A zinc finger CCCH-type containing 11A -0.0205651
ARHGAP32 Rho GTPase activating protein 32 -0.0205359
BRWD1 bromodomain and WD repeat domain containing 1 -0.0203449
DSPP dentin sialophosphoprotein -0.0198297
SCEL sciellin -0.0196967
PDLIM5 PDZ and LIM domain 5 -0.017714
TAS2R14 taste receptor, type 2, member 14 -0.0174779
CAMTA1 calmodulin binding transcription activator 1 -0.0171522
MKI67 marker of proliferation Ki-67 -0.0166938
TXNRD1 thioredoxin reductase 1 -0.016388
MYOF myoferlin -0.0163315
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0161083
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0153019
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0152323
FER fer (fps/fes related) tyrosine kinase -0.0133023
SOD2 superoxide dismutase 2, mitochondrial -0.0130087
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0129968
LRP12 low density lipoprotein receptor-related protein 12 -0.0127854
MAML3 mastermind-like 3 (Drosophila) -0.0126732
MON2 MON2 homolog (S. cerevisiae) -0.0126504
PDE4D phosphodiesterase 4D, cAMP-specific -0.0122578
ZNF638 zinc finger protein 638 -0.0120377
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0119011
RIMS2 regulating synaptic membrane exocytosis 2 -0.0118283
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0116202
ECT2 epithelial cell transforming 2 -0.0116162
ZBTB20 zinc finger and BTB domain containing 20 -0.0115242
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0114333
TAOK1 TAO kinase 1 -0.0114071
EHBP1 EH domain binding protein 1 -0.0112403
NCOA2 nuclear receptor coactivator 2 -0.0111277
SEC31A SEC31 homolog A (S. cerevisiae) -0.0111265
USP9X ubiquitin specific peptidase 9, X-linked -0.0111257
GCLC glutamate-cysteine ligase, catalytic subunit -0.0110867
GOLGB1 golgin B1 -0.0109773
BIRC6 baculoviral IAP repeat containing 6 -0.0108634
BRWD3 bromodomain and WD repeat domain containing 3 -0.0108276
CES1 carboxylesterase 1 -0.0108097
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0107776
MGAT4C MGAT4 family, member C -0.010753
SPIRE1 spire-type actin nucleation factor 1 -0.0107405
USP53 ubiquitin specific peptidase 53 -0.0105732
USP34 ubiquitin specific peptidase 34 -0.0105134
FNIP1 folliculin interacting protein 1 -0.0105026
FRYL FRY-like -0.0103073
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0103036
PDIA3 protein disulfide isomerase family A, member 3 -0.010234
ANKRD17 ankyrin repeat domain 17 -0.0102006
LIMCH1 LIM and calponin homology domains 1 -0.0100848
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0100242
PAPOLA poly(A) polymerase alpha -0.00992541
MCU mitochondrial calcium uniporter -0.00990051
INTS6 integrator complex subunit 6 -0.00980728
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.00974638
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.00970947
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.00969778
TRAPPC9 trafficking protein particle complex 9 -0.0096737
ZFC3H1 zinc finger, C3H1-type containing -0.00966673
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0096288
NBEAL1 neurobeachin-like 1 -0.00956134
ADGRV1 adhesion G protein-coupled receptor V1 -0.00951421
STRN3 striatin, calmodulin binding protein 3 -0.00949809
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.00929473
PUM2 pumilio RNA-binding family member 2 -0.0092095
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.00910091
LPP LIM domain containing preferred translocation partner in lipoma -0.00907976
LGALS12 lectin, galactoside-binding, soluble, 12 -0.00895034
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0089049
GSK3B glycogen synthase kinase 3 beta -0.00874032
PTPRJ protein tyrosine phosphatase, receptor type, J -0.00871189
SBF2 SET binding factor 2 -0.00864101
KMT2A lysine (K)-specific methyltransferase 2A -0.0086337
CANX calnexin -0.00863123
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.00859378
SUCO SUN domain containing ossification factor -0.00853801
TNS3 tensin 3 -0.00850697
MARF1 meiosis regulator and mRNA stability factor 1 -0.00850426
MBD5 methyl-CpG binding domain protein 5 -0.00841227
LHFPL2 lipoma HMGIC fusion partner-like 2 -0.00835207
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.00829092
TBC1D5 TBC1 domain family, member 5 -0.0082701
WDFY3 WD repeat and FYVE domain containing 3 -0.00825497
RAB10 RAB10, member RAS oncogene family -0.00824887
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.00819549
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.00819336
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.00818934
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.00816805
MRTFB myocardin related transcription factor B -0.0081438
SP3 Sp3 transcription factor -0.00808958
ARCN1 archain 1 -0.00804085
ZBTB1 zinc finger and BTB domain containing 1 -0.00803756