Allantoin_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Allantoin perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Allantoin_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 0.183831
MT2A metallothionein 2A 0.126231
MYO1E myosin IE 0.121693
EGFR epidermal growth factor receptor 0.110255
FTL ferritin, light polypeptide 0.107682
FTH1 ferritin, heavy polypeptide 1 0.107166
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.10008
PLAUR plasminogen activator, urokinase receptor 0.0957172
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0947852
NDRG1 N-myc downstream regulated 1 0.0924837
LAMC2 laminin, gamma 2 0.0907303
TXNRD1 thioredoxin reductase 1 0.0904534
AKAP12 A kinase (PRKA) anchor protein 12 0.0843205
B2M beta-2-microglobulin 0.0767323
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0730626
SDC4 syndecan 4 0.0709158
LOC112694756 uncharaterized LOC112694756 0.0704946
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.06857
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0683799
GRB10 growth factor receptor-bound protein 10 0.0658626
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0624259
SPAG9 sperm associated antigen 9 0.061472
RAB7A RAB7A, member RAS oncogene family 0.0606534
TMSB10 thymosin beta 10 0.056691
IGF1R insulin-like growth factor 1 receptor 0.0554483
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0540215
OSMR oncostatin M receptor 0.0537391
HLA-B major histocompatibility complex, class I, B 0.0522882
TJP1 tight junction protein 1 0.0516142
SAMD4A sterile alpha motif domain containing 4A 0.0490993
EGR1 early growth response 1 0.049053
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0476614
WSB1 WD repeat and SOCS box containing 1 0.0475151
GPC6 glypican 6 0.0458639
SOX4 SRY (sex determining region Y)-box 4 0.0453051
VCL vinculin 0.0446237
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0443032
CCL5 chemokine (C-C motif) ligand 5 0.0440755
EZR ezrin 0.0437053
RSAD2 radical S-adenosyl methionine domain containing 2 0.0435551
PKM pyruvate kinase, muscle 0.0427295
VIM vimentin 0.042077
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0420468
S100P S100 calcium binding protein P 0.0419456
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0413415
OASL 2'-5'-oligoadenylate synthetase-like 0.0403588
HLA-C major histocompatibility complex, class I, C 0.0401171
CSTB cystatin B (stefin B) 0.0392731
CLDN4 claudin 4 0.0391947
SACK1A scaffolding CK1 anchoring protein A 0.0385143
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0381524
KLF6 Kruppel-like factor 6 0.0372986
GPBP1 GC-rich promoter binding protein 1 0.0370852
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0368011
CAPN2 calpain 2, (m/II) large subunit 0.0356298
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.035046
PPARD peroxisome proliferator-activated receptor delta 0.03502
RTN4 reticulon 4 0.0347634
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0343991
TPI1 triosephosphate isomerase 1 0.0336218
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0334791
ARRDC4 arrestin domain containing 4 0.0334616
VMP1 vacuole membrane protein 1 0.0329511
RIGI RNA sensor RIG-I 0.0327556
ACTN4 actinin, alpha 4 0.0327439
RAD51B RAD51 paralog B 0.0325422
KDM6A lysine (K)-specific demethylase 6A 0.0325286
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.032453
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.03245
RCOR1 REST corepressor 1 0.0324311
TPT1 tumor protein, translationally-controlled 1 0.0323082
SQSTM1 sequestosome 1 0.0322543
NCEH1 neutral cholesterol ester hydrolase 1 0.0321836
ISG15 ISG15 ubiquitin-like modifier 0.0321669
TUFT1 tuftelin 1 0.0318002
DUSP5 dual specificity phosphatase 5 0.0315685
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0313309
EFNA5 ephrin-A5 0.0313228
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0312614
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0310282
NPC1 Niemann-Pick disease, type C1 0.0309812
CD44 CD44 molecule (Indian blood group) 0.0308738
ABHD17C abhydrolase domain containing 17C 0.0308161
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0306912
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.030691
MYO5B myosin VB 0.0304381
NECTIN2 nectin cell adhesion molecule 2 0.0303889
F3 coagulation factor III (thromboplastin, tissue factor) 0.0301531
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0300675
GOLM1 golgi membrane protein 1 0.0300562
RBM25 RNA binding motif protein 25 0.0291891
FGFR2 fibroblast growth factor receptor 2 0.0291523
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0290181
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0288494
SNX9 sorting nexin 9 0.0280521
PELI1 pellino E3 ubiquitin protein ligase 1 0.028002
MYO10 myosin X 0.0278135
ETV6 ets variant 6 0.0277712
GPHN gephyrin 0.0274652
ABI1 abl-interactor 1 0.0273838

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.10924
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0985483
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0775296
AKAP13 A kinase (PRKA) anchor protein 13 -0.0699588
KRT17 keratin 17, type I -0.0667713
ACTG1 actin gamma 1 -0.0601523
ATOSA atos homolog A -0.0562251
ASPH aspartate beta-hydroxylase -0.0561187
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.055167
ZNF638 zinc finger protein 638 -0.0538955
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0526847
PDIA3 protein disulfide isomerase family A, member 3 -0.0512415
MUC16 mucin 16, cell surface associated -0.0503305
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0500438
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0497774
DST dystonin -0.0494788
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.0486901
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0485776
CDH13 cadherin 13 -0.0452811
CANX calnexin -0.0437388
CHD1 chromodomain helicase DNA binding protein 1 -0.0432335
MBD5 methyl-CpG binding domain protein 5 -0.0431016
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0422778
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0411705
MARCHF3 membrane associated ring-CH-type finger 3 -0.0403236
LPP LIM domain containing preferred translocation partner in lipoma -0.0402983
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0400738
SLMAP sarcolemma associated protein -0.0400497
RUNX1 runt-related transcription factor 1 -0.0396893
ARRDC3 arrestin domain containing 3 -0.0394198
COPA coatomer protein complex, subunit alpha -0.0390582
TCP11L2 t-complex 11, testis-specific-like 2 -0.0390469
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0389245
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0388344
RPL9 ribosomal protein L9 -0.038328
PDE10A phosphodiesterase 10A -0.0376267
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0373768
TMEM165 transmembrane protein 165 -0.0366911
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0360513
WAC WW domain containing adaptor with coiled-coil -0.0349523
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0349461
DSG2 desmoglein 2 -0.0346829
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0341047
MRPS6 mitochondrial ribosomal protein S6 -0.0336444
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0335534
SLC38A1 solute carrier family 38, member 1 -0.0334582
SOS2 son of sevenless homolog 2 (Drosophila) -0.033439
USP53 ubiquitin specific peptidase 53 -0.0330303
FBXL17 F-box and leucine-rich repeat protein 17 -0.0329832
PTPRK protein tyrosine phosphatase, receptor type, K -0.03285
ANXA3 annexin A3 -0.0327675
CEMIP cell migration inducing protein, hyaluronan binding -0.0325698
SVIL supervillin -0.0324762
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.032473
MON2 MON2 homolog (S. cerevisiae) -0.0324396
RAB1A RAB1A, member RAS oncogene family -0.0322936
MAP7 microtubule-associated protein 7 -0.032258
PHF14 PHD finger protein 14 -0.032212
QKI QKI, KH domain containing, RNA binding -0.0320805
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0319411
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha -0.031848
RPL31 ribosomal protein L31 -0.0318273
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0315615
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0315355
TBC1D5 TBC1 domain family, member 5 -0.0313262
FAM107B family with sequence similarity 107, member B -0.0312718
ZMYND8 zinc finger, MYND-type containing 8 -0.0311789
MSI2 musashi RNA-binding protein 2 -0.0310795
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0309508
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0308592
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 -0.0308541
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0307956
FNIP1 folliculin interacting protein 1 -0.0307221
ARB2A ARB2 cotranscriptional regulator A -0.0306141
MYO9A myosin IXA -0.0305535
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0303972
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0302471
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0299284
ARPP19 cAMP-regulated phosphoprotein, 19kDa -0.0298351
DOCK5 dedicator of cytokinesis 5 -0.0297541
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0297482
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0294123
DGKD diacylglycerol kinase, delta 130kDa -0.0292935
ANKRD17 ankyrin repeat domain 17 -0.0291494
PCM1 pericentriolar material 1 -0.0290684
RPL32 ribosomal protein L32 -0.0289094
GOLGB1 golgin B1 -0.0288079
TVP23C-CDRT4 TVP23C-CDRT4 readthrough -0.0286905
ARFGEF3 ARFGEF family member 3 -0.0286551
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0286228
FNBP1L formin binding protein 1-like -0.0284625
RPL28 ribosomal protein L28 -0.0281663
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0281643
RPS24 ribosomal protein S24 -0.0280902
PARD6B par-6 family cell polarity regulator beta -0.0280796
PRKCSH protein kinase C substrate 80K-H -0.0279318
KDM3A lysine (K)-specific demethylase 3A -0.0279305
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0279141
KLF3 Kruppel-like factor 3 (basic) -0.027793
RAD9A RAD9 homolog A (S. pombe) -0.0277656