Allantoin_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Allantoin perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Allantoin_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.226292
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.209054
LAMB3 laminin, beta 3 0.159053
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.138492
NDRG1 N-myc downstream regulated 1 0.111629
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.100245
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0978578
AHNAK AHNAK nucleoprotein 0.0971018
ERRFI1 ERBB receptor feedback inhibitor 1 0.08955
LAMC2 laminin, gamma 2 0.0865332
TRIO trio Rho guanine nucleotide exchange factor 0.0864916
DSPP dentin sialophosphoprotein 0.0849209
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0842258
SDC4 syndecan 4 0.0830517
ALCAM activated leukocyte cell adhesion molecule 0.0794586
KRT7 keratin 7, type II 0.073972
POTEF POTE ankyrin domain family, member F 0.0731653
LMO7 LIM domain 7 0.0722147
LOC112694756 uncharaterized LOC112694756 0.0709329
ACTG1 actin gamma 1 0.0629143
TACSTD2 tumor-associated calcium signal transducer 2 0.0624531
EGFR epidermal growth factor receptor 0.0602138
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0583556
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0573159
HMGA1 high mobility group AT-hook 1 0.0570681
TM4SF1 transmembrane 4 L six family member 1 0.0544156
PLEC plectin 0.0541151
FLNA filamin A, alpha 0.0525119
FTH1 ferritin, heavy polypeptide 1 0.0511814
ANXA2 annexin A2 0.0509685
HSPA8 heat shock 70kDa protein 8 0.0506344
CTSB cathepsin B 0.0504748
CAPN2 calpain 2, (m/II) large subunit 0.047925
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0478854
SMAD3 SMAD family member 3 0.047108
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0469639
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0463701
BHLHE40 basic helix-loop-helix family, member e40 0.0457174
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0456422
ZBTB38 zinc finger and BTB domain containing 38 0.0447126
ENO1 enolase 1, (alpha) 0.0446621
PKM pyruvate kinase, muscle 0.044502
VGLL3 vestigial-like family member 3 0.0444373
SQSTM1 sequestosome 1 0.0438817
ELL2 elongation factor, RNA polymerase II, 2 0.0437358
S100A10 S100 calcium binding protein A10 0.0433619
EEF2 eukaryotic translation elongation factor 2 0.042909
SGMS2 sphingomyelin synthase 2 0.0425158
DSG2 desmoglein 2 0.0423273
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0419736
MYH9 myosin, heavy chain 9, non-muscle 0.0417626
CCND1 cyclin D1 0.041181
LDHA lactate dehydrogenase A 0.0409273
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0401516
ASPH aspartate beta-hydroxylase 0.0398999
H1-0 H1.0 linker histone 0.0395439
ZBTB20 zinc finger and BTB domain containing 20 0.0389071
JUP junction plakoglobin 0.0379465
MT2A metallothionein 2A 0.0375047
NTN4 netrin 4 0.037168
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0369778
UBC ubiquitin C 0.0365332
FLNB filamin B, beta 0.0364228
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0363253
S100A6 S100 calcium binding protein A6 0.0360609
AREG amphiregulin 0.0346559
SACK1A scaffolding CK1 anchoring protein A 0.0338587
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0337317
RPL4 ribosomal protein L4 0.0336844
KRT18 keratin 18, type I 0.0335968
KLF6 Kruppel-like factor 6 0.0334547
DOCK5 dedicator of cytokinesis 5 0.0333269
EZR ezrin 0.0332672
TXNRD1 thioredoxin reductase 1 0.0331102
ARF1 ADP-ribosylation factor 1 0.0326337
CD44 CD44 molecule (Indian blood group) 0.0322597
MSN moesin 0.0322349
RUNX1 runt-related transcription factor 1 0.0320014
SEPTIN9 septin 9 0.0319156
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0318234
STEAP4 STEAP family member 4 0.0318212
PPARG peroxisome proliferator-activated receptor gamma 0.0318016
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0314501
SGPP2 sphingosine-1-phosphate phosphatase 2 0.0302902
BIRC3 baculoviral IAP repeat containing 3 0.0302584
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0298552
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0297422
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0295029
IL6ST interleukin 6 signal transducer 0.0294874
GRAMD2B GRAM domain containing 2B 0.029374
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0293156
KRT8 keratin 8, type II 0.0292501
ICAM1 intercellular adhesion molecule 1 0.029123
ANO6 anoctamin 6 0.0289869
BZW1 basic leucine zipper and W2 domains 1 0.0287995
MAP1B microtubule-associated protein 1B 0.0286398
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0286242
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0283427
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0281821
HOMER2 homer scaffolding protein 2 0.0277399

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.126379
TSC22D2 TSC22 domain family, member 2 -0.0916152
GRB10 growth factor receptor-bound protein 10 -0.0748555
FTL ferritin, light polypeptide -0.0674012
PTMA prothymosin, alpha -0.065505
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0606713
KMT2E lysine (K)-specific methyltransferase 2E -0.0588388
LIMCH1 LIM and calponin homology domains 1 -0.0577625
GOLGA4 golgin A4 -0.05022
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0480116
FAM13A family with sequence similarity 13, member A -0.0464724
PRRC2C proline-rich coiled-coil 2C -0.045328
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0447594
GPBP1 GC-rich promoter binding protein 1 -0.0439318
ZNF292 zinc finger protein 292 -0.0422639
CCNL1 cyclin L1 -0.0409514
STRN3 striatin, calmodulin binding protein 3 -0.0389602
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0373491
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0372283
FNDC3B fibronectin type III domain containing 3B -0.0366251
RBM25 RNA binding motif protein 25 -0.0365029
MSI2 musashi RNA-binding protein 2 -0.0347294
LPP LIM domain containing preferred translocation partner in lipoma -0.034537
ZNF207 zinc finger protein 207 -0.034476
KDM5B lysine (K)-specific demethylase 5B -0.033425
TMF1 TATA element modulatory factor 1 -0.0333046
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0332746
ARF4 ADP-ribosylation factor 4 -0.0329521
ITCH itchy E3 ubiquitin protein ligase -0.0328462
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0327817
TMEM165 transmembrane protein 165 -0.0326467
CDC73 cell division cycle 73 -0.0319779
CERT1 ceramide transporter 1 -0.031466
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0311794
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0309473
ZFAND3 zinc finger, AN1-type domain 3 -0.0307789
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0305718
COPA coatomer protein complex, subunit alpha -0.0301537
SEC31A SEC31 homolog A (S. cerevisiae) -0.0297777
PUM2 pumilio RNA-binding family member 2 -0.0293618
ANKRD11 ankyrin repeat domain 11 -0.0292472
SEC23A Sec23 homolog A (S. cerevisiae) -0.0288082
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0287806
RBM39 RNA binding motif protein 39 -0.0286243
AKAP9 A kinase (PRKA) anchor protein 9 -0.0283446
SPAG9 sperm associated antigen 9 -0.0282625
FBXO11 F-box protein 11 -0.0276687
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0276254
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0274631
UBE2H ubiquitin-conjugating enzyme E2H -0.0268595
ATOSA atos homolog A -0.0267827
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0266728
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.0266596
MON2 MON2 homolog (S. cerevisiae) -0.0266245
ZNF148 zinc finger protein 148 -0.026409
GOLGB1 golgin B1 -0.0263111
MCU mitochondrial calcium uniporter -0.0258985
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0257271
DTNA dystrobrevin, alpha -0.0254683
RPL37A ribosomal protein L37a -0.0253269
PDLIM5 PDZ and LIM domain 5 -0.0251925
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.025007
BBX bobby sox homolog (Drosophila) -0.0246012
BRWD1 bromodomain and WD repeat domain containing 1 -0.0245198
OGA O-GlcNAcase -0.0244609
BLZF1 basic leucine zipper nuclear factor 1 -0.0244386
ENO2 enolase 2 (gamma, neuronal) -0.0243284
COPB1 coatomer protein complex, subunit beta 1 -0.0243041
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0242488
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0240009
IFRD1 interferon-related developmental regulator 1 -0.0237393
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0237374
YTHDC1 YTH domain containing 1 -0.0236187
LYN LYN proto-oncogene, Src family tyrosine kinase -0.0234702
HELZ helicase with zinc finger -0.0233729
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0232933
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0232523
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0231815
KMT2C lysine (K)-specific methyltransferase 2C -0.023059
CD109 CD109 molecule -0.0229794
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0228201
CCNY cyclin Y -0.0228162
PICALM phosphatidylinositol binding clathrin assembly protein -0.0228081
FNIP1 folliculin interacting protein 1 -0.0227478
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0226448
SIK3 SIK family kinase 3 -0.0223045
CHD1 chromodomain helicase DNA binding protein 1 -0.0222481
WAC WW domain containing adaptor with coiled-coil -0.0220116
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0218847
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0218603
WASF2 WAS protein family, member 2 -0.0217447
TMSB10 thymosin beta 10 -0.0217289
USP53 ubiquitin specific peptidase 53 -0.0216609
ARID4A AT rich interactive domain 4A (RBP1-like) -0.0215262
WARS1 tryptophanyl-tRNA synthetase 1 -0.0211738
FAM3C family with sequence similarity 3, member C -0.0210905
KLHL24 kelch-like family member 24 -0.021018
RPL9 ribosomal protein L9 -0.0207358
JMJD1C jumonji domain containing 1C -0.0205395
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0204452