Allantoin_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Allantoin perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Allantoin_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 0.161916
NDRG1 N-myc downstream regulated 1 0.114901
FTL ferritin, light polypeptide 0.0945288
LAMB3 laminin, beta 3 0.0944459
PGK1 phosphoglycerate kinase 1 0.0828151
IGFBP3 insulin-like growth factor binding protein 3 0.0804894
CEMIP cell migration inducing protein, hyaluronan binding 0.0796816
PRRC2C proline-rich coiled-coil 2C 0.079373
RPL36 ribosomal protein L36 0.0792369
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0766316
LDHA lactate dehydrogenase A 0.0750527
H1-0 H1.0 linker histone 0.070805
CTBP2 C-terminal binding protein 2 0.0680264
RPS8 ribosomal protein S8 0.0671241
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0647762
MCL1 myeloid cell leukemia 1 0.059955
AKAP12 A kinase (PRKA) anchor protein 12 0.0589059
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0578386
B2M beta-2-microglobulin 0.0559579
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0548055
RICTOR RPTOR independent companion of MTOR, complex 2 0.0515115
HLA-A major histocompatibility complex, class I, A 0.0512913
NKD1 naked cuticle homolog 1 (Drosophila) 0.0504223
RPS3 ribosomal protein S3 0.050156
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0499475
EXT1 exostosin glycosyltransferase 1 0.0497833
MT2A metallothionein 2A 0.0490226
MBD5 methyl-CpG binding domain protein 5 0.0489729
LOC112694756 uncharaterized LOC112694756 0.0488915
COPA coatomer protein complex, subunit alpha 0.0488164
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0461405
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0438767
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0436773
PDE4D phosphodiesterase 4D, cAMP-specific 0.0411114
KMT2C lysine (K)-specific methyltransferase 2C 0.0409265
GRB10 growth factor receptor-bound protein 10 0.0403523
PKM pyruvate kinase, muscle 0.0399363
TCF12 transcription factor 12 0.0395418
LIMCH1 LIM and calponin homology domains 1 0.0387488
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0385305
PDLIM5 PDZ and LIM domain 5 0.0382009
RSF1 remodeling and spacing factor 1 0.0381214
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0379761
ATXN7 ataxin 7 0.0379016
NAMPT nicotinamide phosphoribosyltransferase 0.0375761
RNF213 ring finger protein 213 0.0375517
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0360699
PCNX4 pecanex 4 0.0359125
PTBP3 polypyrimidine tract binding protein 3 0.0357204
LAMC2 laminin, gamma 2 0.0356959
APP amyloid beta (A4) precursor protein 0.0352886
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.034831
FN1 fibronectin 1 0.0343952
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0326203
MAML2 mastermind-like 2 (Drosophila) 0.0323878
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0321828
GPBP1 GC-rich promoter binding protein 1 0.0321766
SAMD4A sterile alpha motif domain containing 4A 0.0312644
KTN1 kinectin 1 (kinesin receptor) 0.0305263
NALF1 NALCN channel auxiliary factor 1 0.030458
TBC1D5 TBC1 domain family, member 5 0.029927
DST dystonin 0.0296032
AKAP13 A kinase (PRKA) anchor protein 13 0.0288086
PTK2 protein tyrosine kinase 2 0.0270382
HDLBP high density lipoprotein binding protein 0.0269522
AHNAK AHNAK nucleoprotein 0.0268452
ELL2 elongation factor, RNA polymerase II, 2 0.0265493
AOPEP aminopeptidase O (putative) 0.025431
MYO10 myosin X 0.0249151
COL8A1 collagen, type VIII, alpha 1 0.0243506
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0238156
ALCAM activated leukocyte cell adhesion molecule 0.0231452
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.0230553
ELOVL5 ELOVL fatty acid elongase 5 0.0229612
LMO7 LIM domain 7 0.0228376
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0227887
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0225031
H3-3B H3.3 histone B 0.0219327
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0215839
VIM vimentin 0.0211903
RPL37A ribosomal protein L37a 0.0208794
COG5 component of oligomeric golgi complex 5 0.0208623
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0208305
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.0193433
ANKHD1 ankyrin repeat and KH domain containing 1 0.0179852
RPL26 ribosomal protein L26 0.0177859
TXNRD1 thioredoxin reductase 1 0.0176557
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.017515
UBR1 ubiquitin protein ligase E3 component n-recognin 1 0.0170941
USP34 ubiquitin specific peptidase 34 0.0170806
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0165891
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0157566
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0156033
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0152188
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0151257
RIGI RNA sensor RIG-I 0.0148479
MAP4 microtubule-associated protein 4 0.0140546
FTH1 ferritin, heavy polypeptide 1 0.013743
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0133779
TTC3 tetratricopeptide repeat domain 3 0.0133064

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.173323
LRP1B low density lipoprotein receptor-related protein 1B -0.140102
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.12767
MAML3 mastermind-like 3 (Drosophila) -0.121442
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.112466
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.108808
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0868134
WAC WW domain containing adaptor with coiled-coil -0.078652
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0773911
EGFR epidermal growth factor receptor -0.0767777
ANKRD12 ankyrin repeat domain 12 -0.074565
NIPBL Nipped-B homolog (Drosophila) -0.0742857
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0711735
VMP1 vacuole membrane protein 1 -0.0681476
VCL vinculin -0.0673709
RPLP0 ribosomal protein, large, P0 -0.0671773
BHLHE40 basic helix-loop-helix family, member e40 -0.0669774
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.064611
SEC31A SEC31 homolog A (S. cerevisiae) -0.0639141
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0630826
DSCAM Down syndrome cell adhesion molecule -0.0622699
PDE10A phosphodiesterase 10A -0.0608023
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0602213
BPTF bromodomain PHD finger transcription factor -0.059652
RPS27A ribosomal protein S27a -0.0594849
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0593185
NPEPPS aminopeptidase puromycin sensitive -0.0585234
PRKCA protein kinase C, alpha -0.0577498
RPL11 ribosomal protein L11 -0.0576781
RTN4 reticulon 4 -0.0567012
ZMYND8 zinc finger, MYND-type containing 8 -0.0554038
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0552069
RPLP2 ribosomal protein, large, P2 -0.0521304
TLK1 tousled-like kinase 1 -0.0507269
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0506813
EIF1 eukaryotic translation initiation factor 1 -0.0482962
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0452568
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0441347
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0431298
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0429447
ACTG1 actin gamma 1 -0.0411348
SND1 staphylococcal nuclease and tudor domain containing 1 -0.03895
MED13L mediator complex subunit 13-like -0.0379085
COL6A3 collagen, type VI, alpha 3 -0.0375703
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0359917
RACK1 receptor for activated C kinase 1 -0.0358054
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0347608
RPL35A ribosomal protein L35a -0.0340294
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0337197
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.0330974
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0330204
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0328443
KMT2E lysine (K)-specific methyltransferase 2E -0.0324568
ITGA6 integrin, alpha 6 -0.0324466
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0323954
ATXN1 ataxin 1 -0.0321704
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.031446
CANX calnexin -0.0304843
TPT1 tumor protein, translationally-controlled 1 -0.0291182
SLTM SAFB-like, transcription modulator -0.0283778
RORA RAR-related orphan receptor A -0.0269119
MYO1E myosin IE -0.0263046
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0251864
RPL12 ribosomal protein L12 -0.0251798
ENO1 enolase 1, (alpha) -0.025089
CUX1 cut-like homeobox 1 -0.0249938
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0247192
TBC1D22A TBC1 domain family, member 22A -0.0242966
HMGA2 high mobility group AT-hook 2 -0.0242111
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0239667
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0239372
KDM2A lysine (K)-specific demethylase 2A -0.0239204
GPC6 glypican 6 -0.0233449
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0232621
PCBP3 poly(rC) binding protein 3 -0.0226367
TRIO trio Rho guanine nucleotide exchange factor -0.022238
GMDS GDP-mannose 4,6-dehydratase -0.0220763
SPAG9 sperm associated antigen 9 -0.0219217
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0211918
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0209045
PUM2 pumilio RNA-binding family member 2 -0.0207783
DOCK5 dedicator of cytokinesis 5 -0.0207339
NBEAL1 neurobeachin-like 1 -0.0202141
EZR ezrin -0.0186958
FAT1 FAT atypical cadherin 1 -0.0174442
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0168353
PTPRM protein tyrosine phosphatase, receptor type, M -0.0168117
BBX bobby sox homolog (Drosophila) -0.0166317
PSD3 pleckstrin and Sec7 domain containing 3 -0.015729
FNDC3B fibronectin type III domain containing 3B -0.0156183
RPS6 ribosomal protein S6 -0.0153194
TOP1 topoisomerase (DNA) I -0.0152341
RPLP1 ribosomal protein, large, P1 -0.0145822
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0115581
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0115132
ZBTB20 zinc finger and BTB domain containing 20 -0.0110996
ERBIN erbb2 interacting protein -0.0109382
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0109254
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0106395
LAMA4 laminin, alpha 4 -0.0104191