Allantoin_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Allantoin perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Allantoin_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PEG10 paternally expressed 10 0.153066
COL11A1 collagen, type XI, alpha 1 0.120072
H1-0 H1.0 linker histone 0.112827
VIM vimentin 0.106521
COL5A2 collagen, type V, alpha 2 0.0958962
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0923251
PCLO piccolo presynaptic cytomatrix protein 0.0889592
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0792375
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0764811
GPC3 glypican 3 0.0713163
SMYD3 SET and MYND domain containing 3 0.0701173
TMSB10 thymosin beta 10 0.0659504
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0654291
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0624833
CADM2 cell adhesion molecule 2 0.060608
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0592401
FOXP2 forkhead box P2 0.0564277
COL1A2 collagen, type I, alpha 2 0.0560002
DST dystonin 0.0536293
SNX6 sorting nexin 6 0.050479
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) 0.0493366
RPL23 ribosomal protein L23 0.0487419
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0481829
LOC112694756 uncharaterized LOC112694756 0.0475616
ENO1 enolase 1, (alpha) 0.0469188
MEIS2 Meis homeobox 2 0.0463777
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.0452479
CNRIP1 cannabinoid receptor interacting protein 1 0.0450043
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0406248
SOX2 SRY (sex determining region Y)-box 2 0.0404201
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0404049
NFIA nuclear factor I/A 0.0394977
FST follistatin 0.0390454
GARS1 glycyl-tRNA synthetase 1 0.0389285
RPS6 ribosomal protein S6 0.0388631
SPTSSA serine palmitoyltransferase, small subunit A 0.0374139
SAMD4B sterile alpha motif domain containing 4B 0.0371096
SGO2 shugoshin 2 0.036521
SSB Sjogren syndrome antigen B (autoantigen La) 0.036171
RAI1 retinoic acid induced 1 0.0354842
PBX3 pre-B-cell leukemia homeobox 3 0.035399
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0349436
TPX2 TPX2, microtubule-associated 0.0349432
CLTC clathrin, heavy chain (Hc) 0.0349234
METAP2 methionyl aminopeptidase 2 0.0349093
FOXG1 forkhead box G1 0.0343167
RPS3 ribosomal protein S3 0.033411
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0329899
RPS19 ribosomal protein S19 0.0328703
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0320757
RPL18 ribosomal protein L18 0.0320666
SHROOM3 shroom family member 3 0.0313105
RBM39 RNA binding motif protein 39 0.0307999
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0301326
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0300553
PABPN1 poly(A) binding protein, nuclear 1 0.0294971
FAM177A1 family with sequence similarity 177, member A1 0.0294493
EEF2 eukaryotic translation elongation factor 2 0.0290479
PCDH9 protocadherin 9 0.0288034
CKAP2 cytoskeleton associated protein 2 0.0287289
CDH19 cadherin 19, type 2 0.0286996
PLS3 plastin 3 0.0286484
ANK2 ankyrin 2, neuronal 0.0285351
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0284065
SLC38A2 solute carrier family 38, member 2 0.0283437
MYL12B myosin, light chain 12B, regulatory 0.0283403
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.028056
HMGB2 high mobility group box 2 0.0280476
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0279048
NCAM2 neural cell adhesion molecule 2 0.0278921
RPLP1 ribosomal protein, large, P1 0.0278861
TRPS1 trichorhinophalangeal syndrome I 0.0277701
ADD3 adducin 3 (gamma) 0.027606
TENM3 teneurin transmembrane protein 3 0.0275803
CENPE centromere protein E, 312kDa 0.0275534
SLC2A4RG SLC2A4 regulator 0.0275321
RPS2 ribosomal protein S2 0.0275196
TTC3 tetratricopeptide repeat domain 3 0.0273459
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0270411
PDCD5 programmed cell death 5 0.0268128
UBE2K ubiquitin-conjugating enzyme E2K 0.0268071
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0266533
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0263422
THBS1 thrombospondin 1 0.0261699
RAD21 RAD21 homolog (S. pombe) 0.0261386
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.0261132
PRELID2 PRELI domain containing 2 0.0259607
RPL4 ribosomal protein L4 0.025884
SEC62 SEC62 homolog (S. cerevisiae) 0.0257487
FBXO17 F-box protein 17 0.0256915
PPP1R14A protein phosphatase 1, regulatory (inhibitor) subunit 14A 0.0256862
ZFR zinc finger RNA binding protein 0.0256844
TRIM2 tripartite motif containing 2 0.0256263
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0255336
RAB31 RAB31, member RAS oncogene family 0.0248001
CENPF centromere protein F, 350/400kDa 0.024754
PRRC2C proline-rich coiled-coil 2C 0.0247205
CSMD3 CUB and Sushi multiple domains 3 0.0247196
GNAS GNAS complex locus 0.024566
ARB2A ARB2 cotranscriptional regulator A 0.0245599

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.0720868
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.070991
TPT1 tumor protein, translationally-controlled 1 -0.0564311
RPS27A ribosomal protein S27a -0.0562786
PDIA3 protein disulfide isomerase family A, member 3 -0.0529625
FNDC3B fibronectin type III domain containing 3B -0.0488325
RPS16 ribosomal protein S16 -0.0482999
RPS25 ribosomal protein S25 -0.045743
SPAG9 sperm associated antigen 9 -0.0457341
RPL36A ribosomal protein L36a -0.0453348
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0414656
RPL35A ribosomal protein L35a -0.0408788
BIRC6 baculoviral IAP repeat containing 6 -0.03925
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.038646
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0378739
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0365736
BRWD1 bromodomain and WD repeat domain containing 1 -0.0355183
TSC22D2 TSC22 domain family, member 2 -0.0349068
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0344193
PGAP1 post-GPI attachment to proteins 1 -0.033759
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.033239
RPS13 ribosomal protein S13 -0.0332123
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0331508
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0330987
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.032874
NTM neurotrimin -0.0324291
VDAC1 voltage-dependent anion channel 1 -0.0314586
DCAF7 DDB1 and CUL4 associated factor 7 -0.0311543
ASPH aspartate beta-hydroxylase -0.031099
AFF1 AF4/FMR2 family, member 1 -0.0309701
UPP1 uridine phosphorylase 1 -0.0307848
ATP5F1B ATP synthase F1 subunit beta -0.030327
KDM3A lysine (K)-specific demethylase 3A -0.0301819
RPS24 ribosomal protein S24 -0.0296906
RAB1A RAB1A, member RAS oncogene family -0.0296166
RPS8 ribosomal protein S8 -0.0295006
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.028895
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.028666
RPL31 ribosomal protein L31 -0.0283577
S100A10 S100 calcium binding protein A10 -0.0280274
PLPP1 phospholipid phosphatase 1 -0.0280105
CCDC102B coiled-coil domain containing 102B -0.0276869
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.0274252
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -0.0272046
FOXO1 forkhead box O1 -0.0268958
RPL8 ribosomal protein L8 -0.0267685
RPS15 ribosomal protein S15 -0.0266566
CANX calnexin -0.0264553
ANKRD11 ankyrin repeat domain 11 -0.0260786
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0259504
CHD1 chromodomain helicase DNA binding protein 1 -0.0258728
TRA2A transformer 2 alpha homolog (Drosophila) -0.0255096
UBC ubiquitin C -0.0251647
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0250607
HM13 histocompatibility (minor) 13 -0.024904
RHEB Ras homolog enriched in brain -0.0245602
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0243956
RPS29 ribosomal protein S29 -0.0243464
CCDC138 coiled-coil domain containing 138 -0.0239331
DEK DEK proto-oncogene -0.0236887
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0236741
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0236085
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0235519
ZNF207 zinc finger protein 207 -0.0235459
MTF2 metal response element binding transcription factor 2 -0.0233557
CSNK1A1 casein kinase 1, alpha 1 -0.023189
FAF1 Fas (TNFRSF6) associated factor 1 -0.0230822
MCL1 myeloid cell leukemia 1 -0.0230086
SREBF2 sterol regulatory element binding transcription factor 2 -0.0227588
TOP1 topoisomerase (DNA) I -0.0225585
CAMTA1 calmodulin binding transcription activator 1 -0.0224386
HMGB1 high mobility group box 1 -0.0222261
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 -0.0222199
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0219868
GLS2 glutaminase 2 (liver, mitochondrial) -0.0219573
POTEF POTE ankyrin domain family, member F -0.0217367
RPS11 ribosomal protein S11 -0.0216929
TUBA1B tubulin, alpha 1b -0.0215629
SQSTM1 sequestosome 1 -0.0212599
TTC28 tetratricopeptide repeat domain 28 -0.0212195
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0212146
MARCHF6 membrane associated ring-CH-type finger 6 -0.0211692
RPLP2 ribosomal protein, large, P2 -0.0210598
NRG1 neuregulin 1 -0.0209077
PRR16 proline rich 16 -0.0208187
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0206646
ACACA acetyl-CoA carboxylase alpha -0.0206399
KTN1 kinectin 1 (kinesin receptor) -0.0205878
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0205289
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0204156
FNBP1L formin binding protein 1-like -0.020215
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0199242
USP34 ubiquitin specific peptidase 34 -0.0198468
APLP2 amyloid beta (A4) precursor-like protein 2 -0.019753
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.019749
FOXC1 forkhead box C1 -0.0195042
LGMN legumain -0.0194129
ERLEC1 endoplasmic reticulum lectin 1 -0.0190849
MRPS6 mitochondrial ribosomal protein S6 -0.0189486
ATXN2 ataxin 2 -0.018927