Allantoin_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Allantoin perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Allantoin_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.175951
PKM pyruvate kinase, muscle 0.157153
AHNAK AHNAK nucleoprotein 0.125222
VCL vinculin 0.106142
BMP10 bone morphogenetic protein 10 0.0837642
EGFR epidermal growth factor receptor 0.0771295
PYGB phosphorylase, glycogen; brain 0.0737393
ARL4C ADP-ribosylation factor-like 4C 0.0720426
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0708966
GLI2 GLI family zinc finger 2 0.0704403
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0701041
GSE1 Gse1 coiled-coil protein 0.0694084
FLNB filamin B, beta 0.0664864
PRELID2 PRELI domain containing 2 0.0604547
SOX6 SRY (sex determining region Y)-box 6 0.0593062
GLI3 GLI family zinc finger 3 0.0566469
HJURP Holliday junction recognition protein 0.0535935
NPAS2 neuronal PAS domain protein 2 0.0513678
MKI67 marker of proliferation Ki-67 0.0502351
LOC112694756 uncharaterized LOC112694756 0.0495976
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0476673
ENO1 enolase 1, (alpha) 0.045888
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0446897
SDK1 sidekick cell adhesion molecule 1 0.0434302
PDGFC platelet derived growth factor C 0.0430852
BMP2K BMP2 inducible kinase 0.0430003
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0408103
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0401946
EFNA5 ephrin-A5 0.0394692
TXNRD1 thioredoxin reductase 1 0.0386877
LOXL3 lysyl oxidase-like 3 0.0385463
CCND1 cyclin D1 0.0384114
SPRY4 sprouty homolog 4 (Drosophila) 0.0383894
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0382238
MYO5C myosin VC 0.0368034
DUSP4 dual specificity phosphatase 4 0.036684
RPLP1 ribosomal protein, large, P1 0.0366813
SMYD3 SET and MYND domain containing 3 0.035238
RPS8 ribosomal protein S8 0.03522
MACROD2 MACRO domain containing 2 0.0349255
EEF1G eukaryotic translation elongation factor 1 gamma 0.0348212
NBEA neurobeachin 0.0336713
TTC28 tetratricopeptide repeat domain 28 0.0324501
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0322931
TMEM65 transmembrane protein 65 0.0313151
TUBB4B tubulin, beta 4B class IVb 0.0311048
ENO2 enolase 2 (gamma, neuronal) 0.0301534
S100A11 S100 calcium binding protein A11 0.0301228
TM4SF1 transmembrane 4 L six family member 1 0.0299764
ATP9B ATPase, class II, type 9B 0.0299348
NAV2 neuron navigator 2 0.029836
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 0.0295227
RPS12 ribosomal protein S12 0.0289489
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0284737
RPL4 ribosomal protein L4 0.0282421
AMOTL2 angiomotin like 2 0.0279115
TPM4 tropomyosin 4 0.0275255
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) 0.0274937
RPL36 ribosomal protein L36 0.0272277
RPL37A ribosomal protein L37a 0.0269686
SEPTIN9 septin 9 0.0268891
RPL18 ribosomal protein L18 0.0265283
SOX9 SRY (sex determining region Y)-box 9 0.026423
FBLN2 fibulin 2 0.0263095
EEF2 eukaryotic translation elongation factor 2 0.0259679
ARHGAP25 Rho GTPase activating protein 25 0.0259577
HSPB1 heat shock 27kDa protein 1 0.0258589
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.0252994
YEATS2 YEATS domain containing 2 0.0252215
TPI1 triosephosphate isomerase 1 0.0248581
S100A4 S100 calcium binding protein A4 0.0248446
FOXP1 forkhead box P1 0.0248162
RAB27B RAB27B, member RAS oncogene family 0.0246344
ANKRD12 ankyrin repeat domain 12 0.0241555
EZR ezrin 0.023834
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0238317
TRIOBP TRIO and F-actin binding protein 0.0233516
CENPF centromere protein F, 350/400kDa 0.0226267
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0226206
KLF2 Kruppel-like factor 2 0.022603
FOXK1 forkhead box K1 0.02254
UNC13A unc-13 homolog A (C. elegans) 0.0225354
TMSB10 thymosin beta 10 0.0218908
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0217613
RACK1 receptor for activated C kinase 1 0.0217188
TPX2 TPX2, microtubule-associated 0.0215781
SMAD6 SMAD family member 6 0.0215353
IRS1 insulin receptor substrate 1 0.0210849
ZNF608 zinc finger protein 608 0.0210159
RPS2 ribosomal protein S2 0.0209601
TGFBR3 transforming growth factor, beta receptor III 0.0209499
TSC22D1 TSC22 domain family, member 1 0.0209433
DIAPH3 diaphanous-related formin 3 0.019904
ZMYND8 zinc finger, MYND-type containing 8 0.0198037
KLF3 Kruppel-like factor 3 (basic) 0.0195406
GYS1 glycogen synthase 1 (muscle) 0.0194649
NCOR2 nuclear receptor corepressor 2 0.0194251
NFE2L2 nuclear factor, erythroid 2-like 2 0.0194242
CLIP1 CAP-GLY domain containing linker protein 1 0.0193984
SCAPER S-phase cyclin A-associated protein in the ER 0.0193337

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.199948
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.191294
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.145202
SSBP2 single-stranded DNA binding protein 2 -0.118101
PTMA prothymosin, alpha -0.104623
GOLGA4 golgin A4 -0.101184
QKI QKI, KH domain containing, RNA binding -0.0861847
NAMPT nicotinamide phosphoribosyltransferase -0.0829829
ZNF292 zinc finger protein 292 -0.0825653
RBM39 RNA binding motif protein 39 -0.0740226
KDM3A lysine (K)-specific demethylase 3A -0.0705173
KMT2E lysine (K)-specific methyltransferase 2E -0.069915
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0681589
TFG TRK-fused gene -0.0643067
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0639834
GARS1 glycyl-tRNA synthetase 1 -0.0626944
ZFAND3 zinc finger, AN1-type domain 3 -0.0619626
ECT2 epithelial cell transforming 2 -0.0617162
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0597659
TMSB4X thymosin beta 4, X-linked -0.0564619
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0562164
ELOVL5 ELOVL fatty acid elongase 5 -0.055789
RNF145 ring finger protein 145 -0.0539268
WAC WW domain containing adaptor with coiled-coil -0.0538999
EML4 echinoderm microtubule associated protein like 4 -0.0534325
CDC73 cell division cycle 73 -0.0518428
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.049814
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0493355
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0493221
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0490939
ACTG1 actin gamma 1 -0.0479901
IARS1 isoleucyl-tRNA synthetase 1 -0.0470842
RPL35A ribosomal protein L35a -0.0465939
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.045945
NUP58 nucleoporin 58 -0.0459377
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0458869
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0446707
CCNL1 cyclin L1 -0.0446702
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0439839
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0435662
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0432946
USP3 ubiquitin specific peptidase 3 -0.0429231
RLF rearranged L-myc fusion -0.042875
RAB1A RAB1A, member RAS oncogene family -0.0428611
SETD5 SET domain containing 5 -0.0428544
RTN4 reticulon 4 -0.042457
CNOT6L CCR4-NOT transcription complex, subunit 6-like -0.0422031
FBXO11 F-box protein 11 -0.0421307
DSCAM Down syndrome cell adhesion molecule -0.0419718
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0417783
FNDC3B fibronectin type III domain containing 3B -0.0415188
COPA coatomer protein complex, subunit alpha -0.0413684
TPT1 tumor protein, translationally-controlled 1 -0.041055
COG5 component of oligomeric golgi complex 5 -0.0409124
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0408081
PDIA3 protein disulfide isomerase family A, member 3 -0.0395558
RNMT RNA (guanine-7-) methyltransferase -0.0394961
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0389704
CALR calreticulin -0.0389436
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0383225
RHEB Ras homolog enriched in brain -0.0379283
TRA2A transformer 2 alpha homolog (Drosophila) -0.0376222
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0375239
WDR43 WD repeat domain 43 -0.0373968
MON2 MON2 homolog (S. cerevisiae) -0.037232
ADAM9 ADAM metallopeptidase domain 9 -0.0370092
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0356959
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0355205
NBAS neuroblastoma amplified sequence -0.0353125
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0349953
DSTN destrin (actin depolymerizing factor) -0.0348306
MSI2 musashi RNA-binding protein 2 -0.0337648
S100A6 S100 calcium binding protein A6 -0.0335041
MATR3 matrin 3 -0.033358
PUM2 pumilio RNA-binding family member 2 -0.0332492
SEC31A SEC31 homolog A (S. cerevisiae) -0.0331921
NFIA nuclear factor I/A -0.0331677
TMEM41B transmembrane protein 41B -0.0330947
PTBP2 polypyrimidine tract binding protein 2 -0.0329618
LMAN1 lectin, mannose-binding, 1 -0.0327144
ANKRD11 ankyrin repeat domain 11 -0.0325951
COPB1 coatomer protein complex, subunit beta 1 -0.0325547
LCORL ligand dependent nuclear receptor corepressor-like -0.0323783
PDIA6 protein disulfide isomerase family A, member 6 -0.0323726
CHD1 chromodomain helicase DNA binding protein 1 -0.0322374
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -0.0318766
ZNF207 zinc finger protein 207 -0.0317251
TTC3 tetratricopeptide repeat domain 3 -0.0317145
NOP58 NOP58 ribonucleoprotein -0.0313714
SLMAP sarcolemma associated protein -0.031292
NCOR1 nuclear receptor corepressor 1 -0.0312665
PRRC1 proline-rich coiled-coil 1 -0.0309454
NAP1L1 nucleosome assembly protein 1-like 1 -0.0307059
MARCHF6 membrane associated ring-CH-type finger 6 -0.0303918
XPO1 exportin 1 -0.0302291
CRY1 cryptochrome circadian clock 1 -0.0301823
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.030122
JMJD1C jumonji domain containing 1C -0.0300755
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0295773
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0294802