Allantoin_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Allantoin perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Allantoin_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.14287
MT2A metallothionein 2A 0.119242
FTH1 ferritin, heavy polypeptide 1 0.106948
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0678832
TGFBI transforming growth factor, beta-induced, 68kDa 0.0557101
FN1 fibronectin 1 0.0516243
MYH9 myosin, heavy chain 9, non-muscle 0.0483706
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0481706
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0448084
PTMA prothymosin, alpha 0.0439772
POTEF POTE ankyrin domain family, member F 0.0432202
HIPK2 homeodomain interacting protein kinase 2 0.0406509
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0405999
NCOR2 nuclear receptor corepressor 2 0.0401504
GSE1 Gse1 coiled-coil protein 0.0381861
RPS8 ribosomal protein S8 0.0373892
EXT1 exostosin glycosyltransferase 1 0.0372144
MT1X metallothionein 1X 0.0359447
HLA-A major histocompatibility complex, class I, A 0.0351744
CCNI cyclin I 0.0345044
ZSWIM6 zinc finger, SWIM-type containing 6 0.0333663
LOC112694756 uncharaterized LOC112694756 0.0333061
RPLP1 ribosomal protein, large, P1 0.0311767
STC1 stanniocalcin 1 0.0311658
PKM pyruvate kinase, muscle 0.0311569
PTN pleiotrophin 0.0303761
TNS3 tensin 3 0.0296976
RACK1 receptor for activated C kinase 1 0.0294776
EEF2 eukaryotic translation elongation factor 2 0.0286647
RFC3 replication factor C (activator 1) 3, 38kDa 0.0282622
BASP1 brain abundant, membrane attached signal protein 1 0.0277359
RPL12 ribosomal protein L12 0.0274923
RAD51B RAD51 paralog B 0.0263063
TOP1 topoisomerase (DNA) I 0.0255026
FLNA filamin A, alpha 0.0254637
PDE10A phosphodiesterase 10A 0.0252781
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.024852
PTGES2 prostaglandin E synthase 2 0.0245094
DPYSL2 dihydropyrimidinase-like 2 0.0244056
MAP1B microtubule-associated protein 1B 0.0239086
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0236307
RPS24 ribosomal protein S24 0.0235472
NCAPG2 non-SMC condensin II complex, subunit G2 0.0230414
RPLP2 ribosomal protein, large, P2 0.0227339
RPL26 ribosomal protein L26 0.0227183
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0226341
YBX1 Y box binding protein 1 0.0224903
PDIA4 protein disulfide isomerase family A, member 4 0.0223083
ACTN4 actinin, alpha 4 0.0221043
WNK1 WNK lysine deficient protein kinase 1 0.0219767
PFN1 profilin 1 0.0218961
RPL32 ribosomal protein L32 0.0218011
RPL37A ribosomal protein L37a 0.02156
RPS5 ribosomal protein S5 0.0215016
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0213201
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.021185
PDLIM5 PDZ and LIM domain 5 0.0209016
NFE2L2 nuclear factor, erythroid 2-like 2 0.02067
JMJD1C jumonji domain containing 1C 0.020618
FAM13B family with sequence similarity 13, member B 0.0204857
POM121C POM121 transmembrane nucleoporin C 0.020442
GPBP1 GC-rich promoter binding protein 1 0.020415
JAK1 Janus kinase 1 0.0203387
RPL28 ribosomal protein L28 0.0201168
INTS6 integrator complex subunit 6 0.0200869
HMGB1 high mobility group box 1 0.020067
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.019862
ECE1 endothelin converting enzyme 1 0.0197608
MED13 mediator complex subunit 13 0.0197187
ANLN anillin, actin binding protein 0.0196814
RPS2 ribosomal protein S2 0.0196451
FTL ferritin, light polypeptide 0.0195938
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0195876
MPRIP myosin phosphatase Rho interacting protein 0.0194784
BTBD9 BTB (POZ) domain containing 9 0.0194289
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0192634
CLSTN1 calsyntenin 1 0.0192542
SLC38A1 solute carrier family 38, member 1 0.0192458
RPL7 ribosomal protein L7 0.0191722
RPL19 ribosomal protein L19 0.0190054
ITFG1 integrin alpha FG-GAP repeat containing 1 0.0189629
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0187309
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0185417
JPH2 junctophilin 2 0.0181779
TBC1D32 TBC1 domain family, member 32 0.0181396
FBXL7 F-box and leucine-rich repeat protein 7 0.0181149
ITGAV integrin, alpha V 0.018088
RPL23 ribosomal protein L23 0.0179241
RNF216 ring finger protein 216 0.0178957
RPL37 ribosomal protein L37 0.0177974
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0177379
CUX1 cut-like homeobox 1 0.017683
MPG N-methylpurine-DNA glycosylase 0.0174394
HMGA1 high mobility group AT-hook 1 0.0173603
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0172286
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0172285
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0170868
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0170478
ACIN1 apoptotic chromatin condensation inducer 1 0.0169643
PCOLCE procollagen C-endopeptidase enhancer 0.0168512

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.124972
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0704766
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0607363
TMSB10 thymosin beta 10 -0.0583808
COL1A2 collagen, type I, alpha 2 -0.0557246
VIM vimentin -0.0547075
AKAP9 A kinase (PRKA) anchor protein 9 -0.0542577
COL6A3 collagen, type VI, alpha 3 -0.0518142
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0495498
HLA-B major histocompatibility complex, class I, B -0.0467943
TENT5A terminal nucleotidyltransferase 5A -0.0441167
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0439639
ELL2 elongation factor, RNA polymerase II, 2 -0.0421188
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0408779
IGFBP3 insulin-like growth factor binding protein 3 -0.0397292
KDM5B lysine (K)-specific demethylase 5B -0.0392025
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0382496
CADM1 cell adhesion molecule 1 -0.0369045
OGA O-GlcNAcase -0.0367886
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0367626
FAM13A family with sequence similarity 13, member A -0.0366155
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0364512
ZNF292 zinc finger protein 292 -0.0363763
ZEB2 zinc finger E-box binding homeobox 2 -0.0344393
ATP13A3 ATPase type 13A3 -0.0341358
KAZN kazrin, periplakin interacting protein -0.0321793
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0321369
CDH13 cadherin 13 -0.0314989
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0310303
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0309787
KMT2C lysine (K)-specific methyltransferase 2C -0.0306505
NKTR natural killer cell triggering receptor -0.03055
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0305346
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0298604
UBE2H ubiquitin-conjugating enzyme E2H -0.0297916
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0296051
LOXL2 lysyl oxidase-like 2 -0.029583
RTN4 reticulon 4 -0.0295581
HOOK2 hook microtubule-tethering protein 2 -0.0290873
GCC2 GRIP and coiled-coil domain containing 2 -0.028859
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0286124
MON2 MON2 homolog (S. cerevisiae) -0.0284097
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0283312
ANKRD28 ankyrin repeat domain 28 -0.0274574
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0270557
NAMPT nicotinamide phosphoribosyltransferase -0.0267098
USP34 ubiquitin specific peptidase 34 -0.0266108
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0264216
RAI14 retinoic acid induced 14 -0.0261848
PRELID2 PRELI domain containing 2 -0.0261355
ANXA5 annexin A5 -0.0259527
TAGLN2 transgelin 2 -0.0256896
TRA2A transformer 2 alpha homolog (Drosophila) -0.0254914
WTAP Wilms tumor 1 associated protein -0.0254503
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0251631
AFTPH aftiphilin -0.0250722
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0248548
TRIO trio Rho guanine nucleotide exchange factor -0.0248507
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0247835
NRXN3 neurexin 3 -0.0247447
RASAL2 RAS protein activator like 2 -0.0244987
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.024458
DENND4A DENN/MADD domain containing 4A -0.0243606
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0238674
JARID2 jumonji, AT rich interactive domain 2 -0.0234846
ARF4 ADP-ribosylation factor 4 -0.0233719
CHD1 chromodomain helicase DNA binding protein 1 -0.0232866
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0232626
PGK1 phosphoglycerate kinase 1 -0.0231973
HELZ helicase with zinc finger -0.0231318
TFPI2 tissue factor pathway inhibitor 2 -0.0230886
GLS2 glutaminase 2 (liver, mitochondrial) -0.0230349
MARCHF6 membrane associated ring-CH-type finger 6 -0.0230304
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0229991
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0229167
TBC1D23 TBC1 domain family, member 23 -0.0228797
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0225866
S100A10 S100 calcium binding protein A10 -0.0223169
MORC3 MORC family CW-type zinc finger 3 -0.022184
AHNAK AHNAK nucleoprotein -0.0220825
PDIA5 protein disulfide isomerase family A, member 5 -0.0220128
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0218929
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0217484
RAP1B RAP1B, member of RAS oncogene family -0.021335
CALD1 caldesmon 1 -0.0212913
CUL3 cullin 3 -0.021176
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0210022
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0209641
RLF rearranged L-myc fusion -0.0209282
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0208826
GARS1 glycyl-tRNA synthetase 1 -0.0208022
ZFC3H1 zinc finger, C3H1-type containing -0.0207791
SKAP2 src kinase associated phosphoprotein 2 -0.0207386
ZNF644 zinc finger protein 644 -0.0206719
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0203995
MAPK8 mitogen-activated protein kinase 8 -0.0202676
IFRD1 interferon-related developmental regulator 1 -0.0201
CD2AP CD2-associated protein -0.0200965
LMAN1 lectin, mannose-binding, 1 -0.0200382
SEPTIN2 septin 2 -0.0200015