Allantoin_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Allantoin perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Allantoin_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.21433
NRG1 neuregulin 1 0.146432
HMGA2 high mobility group AT-hook 2 0.125503
MT2A metallothionein 2A 0.119009
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.108805
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.107843
ASPH aspartate beta-hydroxylase 0.10359
EXT1 exostosin glycosyltransferase 1 0.0840678
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0759353
TMSB10 thymosin beta 10 0.0727364
NDRG1 N-myc downstream regulated 1 0.0720069
FTL ferritin, light polypeptide 0.0703735
ITGA1 integrin, alpha 1 0.0699643
VCL vinculin 0.0694238
FTH1 ferritin, heavy polypeptide 1 0.0633801
SOX4 SRY (sex determining region Y)-box 4 0.0613003
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0586697
HIPK2 homeodomain interacting protein kinase 2 0.0586227
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0583604
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0560903
GLIS3 GLIS family zinc finger 3 0.0541564
TMEM156 transmembrane protein 156 0.0511626
LOC102724023 ES1 protein homolog, mitochondrial 0.0506528
LOC112694756 uncharaterized LOC112694756 0.0478829
OSMR oncostatin M receptor 0.0454384
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0441827
GRB10 growth factor receptor-bound protein 10 0.0436821
LOXL2 lysyl oxidase-like 2 0.0409289
EFNA5 ephrin-A5 0.0404974
TPI1 triosephosphate isomerase 1 0.0402211
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0400821
STC2 stanniocalcin 2 0.0389107
ENO1 enolase 1, (alpha) 0.0380453
H1-0 H1.0 linker histone 0.0376649
ENO2 enolase 2 (gamma, neuronal) 0.0370138
MYH9 myosin, heavy chain 9, non-muscle 0.0368054
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0366174
IFI27 interferon, alpha-inducible protein 27 0.0360027
NRP1 neuropilin 1 0.035342
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0349675
NTN4 netrin 4 0.0344914
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0344165
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0343815
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0341541
LIMCH1 LIM and calponin homology domains 1 0.0338646
HLA-A major histocompatibility complex, class I, A 0.0334865
B2M beta-2-microglobulin 0.0331966
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0328287
PDE4D phosphodiesterase 4D, cAMP-specific 0.0323056
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.032055
EGR1 early growth response 1 0.0320111
HMGA1 high mobility group AT-hook 1 0.0319063
NPAS2 neuronal PAS domain protein 2 0.0317058
LTBP1 latent transforming growth factor beta binding protein 1 0.0314055
DUSP6 dual specificity phosphatase 6 0.0307865
LMNA lamin A/C 0.030146
RAI14 retinoic acid induced 14 0.0298562
TRIO trio Rho guanine nucleotide exchange factor 0.0294194
HLA-B major histocompatibility complex, class I, B 0.0288645
ERRFI1 ERBB receptor feedback inhibitor 1 0.0286805
TOP1 topoisomerase (DNA) I 0.0286178
RPS19 ribosomal protein S19 0.0285478
RASAL2 RAS protein activator like 2 0.0284285
SYT1 synaptotagmin I 0.0283019
S100A6 S100 calcium binding protein A6 0.0282564
ETV1 ets variant 1 0.0275482
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0270443
AKAP12 A kinase (PRKA) anchor protein 12 0.0270439
FNDC3B fibronectin type III domain containing 3B 0.0269211
IFI16 interferon, gamma-inducible protein 16 0.0268581
PKM pyruvate kinase, muscle 0.0266991
PGK1 phosphoglycerate kinase 1 0.0266184
FOXP1 forkhead box P1 0.0264138
YBX3 Y box binding protein 3 0.0262944
BASP1 brain abundant, membrane attached signal protein 1 0.0255029
CAPN2 calpain 2, (m/II) large subunit 0.0252669
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0250305
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0249365
TXNIP thioredoxin interacting protein 0.0247934
MRPS6 mitochondrial ribosomal protein S6 0.0244234
TMSB4X thymosin beta 4, X-linked 0.0244154
IFI6 interferon, alpha-inducible protein 6 0.0242345
PLIN2 perilipin 2 0.0241519
MAP1B microtubule-associated protein 1B 0.023851
PDLIM5 PDZ and LIM domain 5 0.0236446
MBD5 methyl-CpG binding domain protein 5 0.0234712
TTC28 tetratricopeptide repeat domain 28 0.0232667
GLUL glutamate-ammonia ligase 0.0228241
WSB1 WD repeat and SOCS box containing 1 0.0226885
TNNC1 troponin C type 1 (slow) 0.0226667
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0221779
SVIL supervillin 0.0221596
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0219499
ACTN4 actinin, alpha 4 0.0218949
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0217841
DOCK5 dedicator of cytokinesis 5 0.0216885
RPL36 ribosomal protein L36 0.0215198
ANGPTL4 angiopoietin-like 4 0.0213785
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0212121
BZW1 basic leucine zipper and W2 domains 1 0.0211137

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.090924
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0579152
PTMA prothymosin, alpha -0.0548275
GOLGA4 golgin A4 -0.0385213
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0284792
SUCO SUN domain containing ossification factor -0.0279767
HILPDA hypoxia inducible lipid droplet-associated -0.0278914
RPL35A ribosomal protein L35a -0.0274278
SOD2 superoxide dismutase 2, mitochondrial -0.0229804
PDIA3 protein disulfide isomerase family A, member 3 -0.0215956
RNF145 ring finger protein 145 -0.0214497
RPS25 ribosomal protein S25 -0.0212839
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0208647
COG5 component of oligomeric golgi complex 5 -0.0207567
LCORL ligand dependent nuclear receptor corepressor-like -0.0206901
CALR calreticulin -0.0198529
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0197275
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0190511
RPS6 ribosomal protein S6 -0.0170718
HELZ helicase with zinc finger -0.0165444
NEK7 NIMA-related kinase 7 -0.0163438
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0161502
PDIA6 protein disulfide isomerase family A, member 6 -0.0161286
RLF rearranged L-myc fusion -0.0158687
RPS23 ribosomal protein S23 -0.0157046
WDR45B WD repeat domain 45B -0.0155031
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0151698
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0149632
NUP58 nucleoporin 58 -0.0147933
IRAK3 interleukin-1 receptor-associated kinase 3 -0.0146194
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0144388
RPL38 ribosomal protein L38 -0.0143778
CEP350 centrosomal protein 350kDa -0.0143375
TPT1 tumor protein, translationally-controlled 1 -0.0142683
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0139598
PUM2 pumilio RNA-binding family member 2 -0.0138822
WAC WW domain containing adaptor with coiled-coil -0.0138059
NAP1L1 nucleosome assembly protein 1-like 1 -0.0136552
RHEB Ras homolog enriched in brain -0.0135657
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0134742
QKI QKI, KH domain containing, RNA binding -0.0134548
DNM1L dynamin 1-like -0.0133395
CD109 CD109 molecule -0.0131814
OTUD7B OTU deubiquitinase 7B -0.0131437
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0131284
NOP58 NOP58 ribonucleoprotein -0.0128909
XPO1 exportin 1 -0.0127433
CANX calnexin -0.0126893
RAB6A RAB6A, member RAS oncogene family -0.0126513
ADAM9 ADAM metallopeptidase domain 9 -0.012627
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0125014
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0124093
ARRDC3 arrestin domain containing 3 -0.0121818
FOXJ3 forkhead box J3 -0.0121659
RAB8B RAB8B, member RAS oncogene family -0.0120908
RPL36A ribosomal protein L36a -0.0120809
PICALM phosphatidylinositol binding clathrin assembly protein -0.0120549
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0120057
ETNK1 ethanolamine kinase 1 -0.0118482
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0118261
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0118117
USP53 ubiquitin specific peptidase 53 -0.0117442
EIF1 eukaryotic translation initiation factor 1 -0.0117405
RPS16 ribosomal protein S16 -0.0117091
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0115862
CENPF centromere protein F, 350/400kDa -0.0114316
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0112815
UHMK1 U2AF homology motif (UHM) kinase 1 -0.0112231
PNISR PNN-interacting serine/arginine-rich protein -0.0111353
TENT2 terminal nucleotidyltransferase 2 -0.0111154
RPS24 ribosomal protein S24 -0.0110033
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0109523
RPS11 ribosomal protein S11 -0.0108929
OGA O-GlcNAcase -0.010881
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.010862
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0108156
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0107771
AHCTF1 AT hook containing transcription factor 1 -0.0106204
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0106009
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0106009
RPL7A ribosomal protein L7a -0.0105168
IARS1 isoleucyl-tRNA synthetase 1 -0.0105113
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.0104563
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0104053
TFG TRK-fused gene -0.0103411
PTGES2 prostaglandin E synthase 2 -0.0103402
SRP54 signal recognition particle 54kDa -0.0103262
ZNF451 zinc finger protein 451 -0.0102646
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0101814
COPA coatomer protein complex, subunit alpha -0.0101766
TPD52 tumor protein D52 -0.0101648
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0100637
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.00989273
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha -0.00988515
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.00985321
RYBP RING1 and YY1 binding protein -0.00983271
UVRAG UV radiation resistance associated -0.00980437
GOLPH3L golgi phosphoprotein 3-like -0.00973097
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 -0.0097116
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.00970452