Allergic Asthma Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description An asthma that is characterized by symptoms that are triggered by an allergic reaction caused by inhaled allergens such as dust mite allergen, pet dander, pollen and mold. Allergic asthma is airway obstruction and inflammation that is partially reversible with medication. The disease has_symptom coughing, has_symptom wheezing, has_symptom shortness of breath or has_symptom rapid breathing, and has_symptom chest tightness. (Human Disease Ontology, DOID_9415)
External Link https://www.disgenet.org/browser/0/1/0/C0155877
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Genes

355 genes associated with the disease Allergic Asthma in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ACAA1 acetyl-CoA acyltransferase 1
ADA adenosine deaminase
ADAM33 ADAM metallopeptidase domain 33
ADORA2A adenosine A2a receptor
ADRB2 adrenoceptor beta 2, surface
AGER advanced glycosylation end product-specific receptor
AGXT alanine-glyoxylate aminotransferase
AHR aryl hydrocarbon receptor
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AICDA activation-induced cytidine deaminase
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALCAM activated leukocyte cell adhesion molecule
ALOX5 arachidonate 5-lipoxygenase
AOAH acyloxyacyl hydrolase (neutrophil)
APOE apolipoprotein E
AREG amphiregulin
ARG1 arginase 1
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ATP5F1A ATP synthase F1 subunit alpha
BATF basic leucine zipper transcription factor, ATF-like
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2 B-cell CLL/lymphoma 2
BCL6 B-cell CLL/lymphoma 6
BDKRB2 bradykinin receptor B2
BDNF brain-derived neurotrophic factor
C1ORF228 chromosome 1 open reading frame 228
C3 complement component 3
C5 complement component 5
C5AR1 complement component 5a receptor 1
C5ORF42 chromosome 5 open reading frame 42
CALCA calcitonin-related polypeptide alpha
CAMK2N2 calcium/calmodulin-dependent protein kinase II inhibitor 2
CAMP cathelicidin antimicrobial peptide
CCL11 chemokine (C-C motif) ligand 11
CCL17 chemokine (C-C motif) ligand 17
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL2 chemokine (C-C motif) ligand 2
CCL25 chemokine (C-C motif) ligand 25
CCL5 chemokine (C-C motif) ligand 5
CCL7 chemokine (C-C motif) ligand 7
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR3 chemokine (C-C motif) receptor 3
CCR4 chemokine (C-C motif) receptor 4
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR7 chemokine (C-C motif) receptor 7
CCR8 chemokine (C-C motif) receptor 8
CCR9 chemokine (C-C motif) receptor 9
CD14 CD14 molecule
CD27 CD27 molecule
CD276 CD276 molecule
CD28 CD28 molecule
CD34 CD34 molecule
CD4 CD4 molecule
CD86 CD86 molecule
CDHR3 cadherin-related family member 3
CEL carboxyl ester lipase
CETN1 centrin, EF-hand protein, 1
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIA chitinase, acidic
CHIT1 chitinase 1 (chitotriosidase)
CHML choroideremia-like (Rab escort protein 2)
CHRM2 cholinergic receptor, muscarinic 2
CMA1 chymase 1, mast cell
CREB1 cAMP responsive element binding protein 1
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRLF2 cytokine receptor-like factor 2
CSF1R colony stimulating factor 1 receptor
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)
CTH cystathionine gamma-lyase
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTNNBL1 catenin, beta like 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYSLTR2 cysteinyl leukotriene receptor 2
DAD1 defender against cell death 1
DCLK3 doublecortin-like kinase 3
DDIT3 DNA-damage-inducible transcript 3
DDO D-aspartate oxidase
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DLL1 delta-like 1 (Drosophila)
DOCK8 dedicator of cytokinesis 8
DPP4 dipeptidyl-peptidase 4
DUOX1 dual oxidase 1
EBNA1BP2 EBNA1 binding protein 2
EDIL3 EGF-like repeats and discoidin I-like domains 3
EDN1 endothelin 1
EDNRB endothelin receptor type B
EGLN2 egl-9 family hypoxia-inducible factor 2
EGLN3 egl-9 family hypoxia-inducible factor 3
ELN elastin
ELP1 elongator acetyltransferase complex subunit 1
ENO2 enolase 2 (gamma, neuronal)
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPX eosinophil peroxidase
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FCAR Fc fragment of IgA receptor
FLG filaggrin
FOXP3 forkhead box P3
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB1 GRB2-associated binding protein 1
GATA3 GATA binding protein 3
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GRAP2 GRB2-related adaptor protein 2
GSDMB gasdermin B
GSTK1 glutathione S-transferase kappa 1
GSTM1 glutathione S-transferase mu 1
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
HAS2 hyaluronan synthase 2
HAVCR1 hepatitis A virus cellular receptor 1
HAVCR2 hepatitis A virus cellular receptor 2
HDAC9 histone deacetylase 9
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-B major histocompatibility complex, class I, B
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGB1 high mobility group box 1
HNMT histamine N-methyltransferase
HPGDS hematopoietic prostaglandin D synthase
HRH1 histamine receptor H1
HSPA4 heat shock 70kDa protein 4
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IDO1 indoleamine 2,3-dioxygenase 1
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IFNG interferon, gamma
IFNGR1 interferon gamma receptor 1
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1)
IFNL1 interferon, lambda 1
IFNL3 interferon, lambda 3
IL10 interleukin 10
IL12B interleukin 12B
IL13 interleukin 13
IL13RA1 interleukin 13 receptor, alpha 1
IL13RA2 interleukin 13 receptor, alpha 2
IL16 interleukin 16
IL17A interleukin 17A
IL17D interleukin 17D
IL17F interleukin 17F
IL17RA interleukin 17 receptor A
IL18 interleukin 18
IL18R1 interleukin 18 receptor 1
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1F10 interleukin 1 family, member 10 (theta)
IL1RN interleukin 1 receptor antagonist
IL21 interleukin 21
IL22 interleukin 22
IL23A interleukin 23, alpha subunit p19
IL25 interleukin 25
IL27 interleukin 27
IL2RA interleukin 2 receptor, alpha
IL3 interleukin 3
IL31 interleukin 31
IL32 interleukin 32
IL33 interleukin 33
IL33R interleukin 33 receptor
IL37 interleukin 37
IL3RA interleukin 3 receptor, alpha (low affinity)
IL4 interleukin 4
IL4R interleukin 4 receptor
IL5 interleukin 5
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
IL9 interleukin 9
IL9R interleukin 9 receptor
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IRF1 interferon regulatory factor 1
IRF4 interferon regulatory factor 4
IRF7 interferon regulatory factor 7
ISG20 interferon stimulated exonuclease gene 20kDa
ITGB4 integrin, beta 4
JAG1 jagged 1
KAT5 K(lysine) acetyltransferase 5
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KNG1 kininogen 1
LAG3 lymphocyte-activation gene 3
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LAT linker for activation of T cells
LEP leptin
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LIPG lipase, endothelial
LPAR2 lysophosphatidic acid receptor 2
LTA lymphotoxin alpha
LTB4R2 leukotriene B4 receptor 2
LTC4S leukotriene C4 synthase
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MARCHF1 membrane associated ring-CH-type finger 1
MCC mutated in colorectal cancers
METTL24 methyltransferase like 24
MEX3B mex-3 RNA binding family member B
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYB v-myb avian myeloblastosis viral oncogene homolog
MYDGF myeloid-derived growth factor
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRP3 NLR family, pyrin domain containing 3
NOD1 nucleotide-binding oligomerization domain containing 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NPR1 natriuretic peptide receptor 1
NPSR1 neuropeptide S receptor 1
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NT5E 5'-nucleotidase, ecto (CD73)
NTS neurotensin
NTSR1 neurotensin receptor 1 (high affinity)
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2
OPN3 opsin 3
ORM1 orosomucoid 1
ORMDL3 ORMDL sphingolipid biosynthesis regulator 3
OXA1L oxidase (cytochrome c) assembly 1-like
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PARP9 poly (ADP-ribose) polymerase family, member 9
PCDH1 protocadherin 1
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PDCD5 programmed cell death 5
PDE4A phosphodiesterase 4A, cAMP-specific
PDE4B phosphodiesterase 4B, cAMP-specific
PDIA3 protein disulfide isomerase family A, member 3
PHC1 polyhomeotic homolog 1 (Drosophila)
PHF11 PHD finger protein 11
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G1B phospholipase A2, group IB (pancreas)
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLA2R1 phospholipase A2 receptor 1, 180kDa
PLB1 phospholipase B1
PLK1 polo-like kinase 1
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POSTN periostin, osteoblast specific factor
PPARG peroxisome proliferator-activated receptor gamma
PRRC2A proline-rich coiled-coil 2A
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PTAFR platelet-activating factor receptor
PTEN phosphatase and tensin homolog
PTGDR prostaglandin D2 receptor (DP)
PTGDR2 prostaglandin D2 receptor 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRE protein tyrosine phosphatase, receptor type, E
PXN paxillin
RABEPK Rab9 effector protein with kelch motifs
RAD50 RAD50 homolog (S. cerevisiae)
RBM45 RNA binding motif protein 45
RHEB Ras homolog enriched in brain
RHOA ras homolog family member A
RIOX2 ribosomal oxygenase 2
RIPK2 receptor-interacting serine-threonine kinase 2
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RORA RAR-related orphan receptor A
RPL17 ribosomal protein L17
RPL17-C18ORF32 RPL17-C18orf32 readthrough
RPSA ribosomal protein SA
S100A12 S100 calcium binding protein A12
S1PR2 sphingosine-1-phosphate receptor 2
SAA1 serum amyloid A1
SAA2 serum amyloid A2
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCGB3A2 secretoglobin, family 3A, member 2
SDF4 stromal cell derived factor 4
SEC14L3 SEC14-like 3 (S. cerevisiae)
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP4 secreted frizzled-related protein 4
SFTPD surfactant protein D
SIGLEC8 sialic acid binding Ig-like lectin 8
SIRT1 sirtuin 1
SIT1 signaling threshold regulating transmembrane adaptor 1
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
SLCO6A1 solute carrier organic anion transporter family, member 6A1
SMAD3 SMAD family member 3
SMC3 structural maintenance of chromosomes 3
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD3 superoxide dismutase 3, extracellular
SPATA2 spermatogenesis associated 2
SPINK5 serine peptidase inhibitor, Kazal type 5
SPP1 secreted phosphoprotein 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBX21 T-box 21
TBXA2R thromboxane A2 receptor
TES testin LIM domain protein
TFF2 trefoil factor 2
TFIP11 tuftelin interacting protein 11
TGFB1 transforming growth factor, beta 1
TGFB2 transforming growth factor, beta 2
TGFBR3 transforming growth factor, beta receptor III
THBS1 thrombospondin 1
TIMELESS timeless circadian clock
TIMP1 TIMP metallopeptidase inhibitor 1
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TLR7 toll-like receptor 7
TLR9 toll-like receptor 9
TNF tumor necrosis factor
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TP63 tumor protein p63
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV4 transient receptor potential cation channel, subfamily V, member 4
TSLP thymic stromal lymphopoietin
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VSIR V-set immunoregulatory receptor
WDR20 WD repeat domain 20
WDR36 WD repeat domain 36
WDR83OS WD repeat domain 83 opposite strand
XCL1 chemokine (C motif) ligand 1
XCR1 chemokine (C motif) receptor 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZFPM1 zinc finger protein, FOG family member 1
ZNF266 zinc finger protein 266
ZNF645 zinc finger protein 645