Allopurinol_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Allopurinol perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Allopurinol_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPTBN1 spectrin, beta, non-erythrocytic 1 0.12166
IGF2 insulin-like growth factor 2 0.111858
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.102939
APOB apolipoprotein B 0.0575267
EEF2 eukaryotic translation elongation factor 2 0.0573807
DSPP dentin sialophosphoprotein 0.0502836
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0461094
ELL2 elongation factor, RNA polymerase II, 2 0.0439885
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0438584
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0410979
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0394119
ERRFI1 ERBB receptor feedback inhibitor 1 0.0387411
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.03809
FNDC3B fibronectin type III domain containing 3B 0.0349442
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0321248
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0313236
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0309188
TBC1D22A TBC1 domain family, member 22A 0.0307486
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0296149
ZMIZ1 zinc finger, MIZ-type containing 1 0.0264172
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0255461
FN1 fibronectin 1 0.0249534
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0245802
HSPH1 heat shock 105kDa/110kDa protein 1 0.0244684
CANX calnexin 0.0242635
BHLHE40 basic helix-loop-helix family, member e40 0.0239984
ESYT2 extended synaptotagmin-like protein 2 0.0220704
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0220521
SOD2 superoxide dismutase 2, mitochondrial 0.0219336
CRY1 cryptochrome circadian clock 1 0.0213366
TF transferrin 0.0212433
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.02119
FTH1 ferritin, heavy polypeptide 1 0.0207664
VEGFA vascular endothelial growth factor A 0.0205646
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0202287
C3 complement component 3 0.0200431
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0198157
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0198053
PCBP2 poly(rC) binding protein 2 0.0197202
KDM7A lysine (K)-specific demethylase 7A 0.0191916
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0190854
PTPRM protein tyrosine phosphatase, receptor type, M 0.0189764
EPS8 epidermal growth factor receptor pathway substrate 8 0.0187712
FAM13A family with sequence similarity 13, member A 0.0185459
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0184948
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0184026
SKI SKI proto-oncogene 0.0180939
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0180856
NKD1 naked cuticle homolog 1 (Drosophila) 0.0179439
EIF4B eukaryotic translation initiation factor 4B 0.0177988
AFDN afadin, adherens junction formation factor 0.0176453
PEG3 paternally expressed 3 0.0176401
NFE2L1 nuclear factor, erythroid 2-like 1 0.0176255
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0174991
SPAG9 sperm associated antigen 9 0.0174628
GDF15 growth differentiation factor 15 0.0172014
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0171337
DDIT4 DNA-damage-inducible transcript 4 0.0169271
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0168307
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0165786
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0164736
RAI14 retinoic acid induced 14 0.0163813
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0162753
TMEM51 transmembrane protein 51 0.0162064
IL1RAP interleukin 1 receptor accessory protein 0.0160719
TNS1 tensin 1 0.0159675
MTSS1 metastasis suppressor 1 0.0159156
CAMTA1 calmodulin binding transcription activator 1 0.0157813
MACF1 microtubule-actin crosslinking factor 1 0.0156808
SMAD3 SMAD family member 3 0.0155181
YTHDC1 YTH domain containing 1 0.015286
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0149837
IQSEC1 IQ motif and Sec7 domain 1 0.0149586
CHD6 chromodomain helicase DNA binding protein 6 0.0149
TPST1 tyrosylprotein sulfotransferase 1 0.0147461
SCAF8 SR-related CTD-associated factor 8 0.0146474
IGFBP1 insulin-like growth factor binding protein 1 0.0145939
MTUS1 microtubule associated tumor suppressor 1 0.0145291
OPTN optineurin 0.0145027
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0143778
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 0.0143073
AFF1 AF4/FMR2 family, member 1 0.0142244
TOP1 topoisomerase (DNA) I 0.0141428
ZC3H13 zinc finger CCCH-type containing 13 0.0138368
COBL cordon-bleu WH2 repeat protein 0.0138322
TRAK1 trafficking protein, kinesin binding 1 0.0137621
ZFP36L2 ZFP36 ring finger protein-like 2 0.0137187
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0135114
MYH9 myosin, heavy chain 9, non-muscle 0.0133794
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0131453
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0129837
FAF1 Fas (TNFRSF6) associated factor 1 0.0128098
KCMF1 potassium channel modulatory factor 1 0.0125798
RICTOR RPTOR independent companion of MTOR, complex 2 0.0125661
OGA O-GlcNAcase 0.0125524
RUNX1 runt-related transcription factor 1 0.0124779
HP1BP3 heterochromatin protein 1, binding protein 3 0.0124141
PTK2 protein tyrosine kinase 2 0.0124073
HSPA1A heat shock 70kDa protein 1A 0.012387
GLG1 golgi glycoprotein 1 0.0122937

decreased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.170402
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.131666
MT2A metallothionein 2A -0.113077
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0970258
TMSB10 thymosin beta 10 -0.0926416
APOA2 apolipoprotein A-II -0.09097
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0839088
AKAP12 A kinase (PRKA) anchor protein 12 -0.0838499
GPC6 glypican 6 -0.0807012
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0693798
VCL vinculin -0.0606198
SLC38A2 solute carrier family 38, member 2 -0.0508135
HMGA1 high mobility group AT-hook 1 -0.0499488
RPS24 ribosomal protein S24 -0.0459746
STAT1 signal transducer and activator of transcription 1, 91kDa -0.045427
TPT1 tumor protein, translationally-controlled 1 -0.0454101
RPS8 ribosomal protein S8 -0.0404178
ZBTB20 zinc finger and BTB domain containing 20 -0.0379082
MARCKS myristoylated alanine-rich protein kinase C substrate -0.037399
RPL23 ribosomal protein L23 -0.0373804
LRMDA leucine rich melanocyte differentiation associated -0.0365098
RPL11 ribosomal protein L11 -0.0351867
ENO1 enolase 1, (alpha) -0.0346771
RPS21 ribosomal protein S21 -0.034493
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0333056
RPL35A ribosomal protein L35a -0.0327892
NPAS2 neuronal PAS domain protein 2 -0.031742
SAMD4A sterile alpha motif domain containing 4A -0.0313665
RPS6 ribosomal protein S6 -0.0311511
EHBP1 EH domain binding protein 1 -0.0307332
IFI6 interferon, alpha-inducible protein 6 -0.0304473
S100A9 S100 calcium binding protein A9 -0.030124
EGR1 early growth response 1 -0.0296047
FTL ferritin, light polypeptide -0.0279248
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0271764
IFITM1 interferon induced transmembrane protein 1 -0.026751
DST dystonin -0.0267056
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.026462
PTCHD4 patched domain containing 4 -0.0263314
RPS19 ribosomal protein S19 -0.0262982
ISG15 ISG15 ubiquitin-like modifier -0.0262642
RPS23 ribosomal protein S23 -0.0261069
FRMD5 FERM domain containing 5 -0.0256533
GPC3 glypican 3 -0.0250979
PKM pyruvate kinase, muscle -0.0249367
POTEF POTE ankyrin domain family, member F -0.024898
TPM4 tropomyosin 4 -0.0246782
DLC1 DLC1 Rho GTPase activating protein -0.0245474
RNF213 ring finger protein 213 -0.0242078
GMDS GDP-mannose 4,6-dehydratase -0.0239107
RPLP1 ribosomal protein, large, P1 -0.0234825
TXNIP thioredoxin interacting protein -0.0231412
RPL37A ribosomal protein L37a -0.0230242
RPL9 ribosomal protein L9 -0.0228849
MT1X metallothionein 1X -0.0226708
GNAS GNAS complex locus -0.0224115
RPL28 ribosomal protein L28 -0.0224079
B2M beta-2-microglobulin -0.0218624
RPS29 ribosomal protein S29 -0.0217294
HLA-A major histocompatibility complex, class I, A -0.0212074
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0210081
RPL37 ribosomal protein L37 -0.0208686
RPL34 ribosomal protein L34 -0.0208132
IFI27 interferon, alpha-inducible protein 27 -0.0207908
ITGAV integrin, alpha V -0.0206066
RPL27 ribosomal protein L27 -0.0205643
LOC112694756 uncharaterized LOC112694756 -0.0200451
RPS14 ribosomal protein S14 -0.0200111
RPS27A ribosomal protein S27a -0.0196203
RPLP2 ribosomal protein, large, P2 -0.0194962
IFITM3 interferon induced transmembrane protein 3 -0.0194625
TMEM123 transmembrane protein 123 -0.0194429
RPL19 ribosomal protein L19 -0.0192729
RPS12 ribosomal protein S12 -0.0192588
RPL31 ribosomal protein L31 -0.0192555
CCL20 chemokine (C-C motif) ligand 20 -0.0191386
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0184322
AMBP alpha-1-microglobulin/bikunin precursor -0.0183777
RIGI RNA sensor RIG-I -0.018346
RPS17 ribosomal protein S17 -0.0180578
ADAR adenosine deaminase, RNA-specific -0.0179527
ANKRD17 ankyrin repeat domain 17 -0.0178741
SOX5 SRY (sex determining region Y)-box 5 -0.0178094
RAB1A RAB1A, member RAS oncogene family -0.0177851
RPL35 ribosomal protein L35 -0.0177337
TM4SF1 transmembrane 4 L six family member 1 -0.0172976
RPL5 ribosomal protein L5 -0.0172847
KLF6 Kruppel-like factor 6 -0.0169949
RPS16 ribosomal protein S16 -0.0168373
CKAP4 cytoskeleton-associated protein 4 -0.0166824
ASPH aspartate beta-hydroxylase -0.0166619
ITGA1 integrin, alpha 1 -0.0164823
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0164337
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0164262
CST3 cystatin C -0.0164218
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0162743
RPS10 ribosomal protein S10 -0.0162445
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0162414
ETFB electron-transfer-flavoprotein, beta polypeptide -0.0161143
GLRX glutaredoxin (thioltransferase) -0.0161057