| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Allopurinol perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Allopurinol_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.141639 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.120393 |
| NDRG1 | N-myc downstream regulated 1 | 0.11656 |
| MKI67 | marker of proliferation Ki-67 | 0.108108 |
| TXNRD1 | thioredoxin reductase 1 | 0.0999585 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0921978 |
| ARRDC3 | arrestin domain containing 3 | 0.0798065 |
| PCBP2 | poly(rC) binding protein 2 | 0.0787797 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0715622 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0707324 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0706158 |
| MCL1 | myeloid cell leukemia 1 | 0.0694909 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0684655 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.064386 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0638748 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0637553 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0608988 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0608056 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0536648 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0535664 |
| USP34 | ubiquitin specific peptidase 34 | 0.0518419 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0514991 |
| PLEC | plectin | 0.0503848 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0490445 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0484975 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0474044 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0458147 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0453221 |
| CES1 | carboxylesterase 1 | 0.0450298 |
| LAMC2 | laminin, gamma 2 | 0.0448922 |
| LAMB3 | laminin, beta 3 | 0.044343 |
| GPATCH2L | G patch domain containing 2-like | 0.0437442 |
| ZNF638 | zinc finger protein 638 | 0.0433863 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0427088 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0420207 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0417948 |
| SPAG9 | sperm associated antigen 9 | 0.0409698 |
| RUNX1 | runt-related transcription factor 1 | 0.0402968 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0399104 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0388961 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0388666 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0387983 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0387649 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0381674 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0378367 |
| FNIP1 | folliculin interacting protein 1 | 0.0368717 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0365813 |
| FAM13A | family with sequence similarity 13, member A | 0.0364627 |
| RBM39 | RNA binding motif protein 39 | 0.0364386 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0358007 |
| NGLY1 | N-glycanase 1 | 0.0354635 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0353292 |
| BRD2 | bromodomain containing 2 | 0.0349093 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0347659 |
| ABLIM1 | actin binding LIM protein 1 | 0.0346521 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0341994 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0338779 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0337262 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0336722 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0336596 |
| ANXA1 | annexin A1 | 0.0330838 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0329525 |
| DENND4A | DENN/MADD domain containing 4A | 0.0322857 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0320565 |
| SLTM | SAFB-like, transcription modulator | 0.0316751 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.0314775 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0313371 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0311304 |
| EMP1 | epithelial membrane protein 1 | 0.0310455 |
| SMAD3 | SMAD family member 3 | 0.0302722 |
| EGFR | epidermal growth factor receptor | 0.0300274 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0300051 |
| EP300 | E1A binding protein p300 | 0.029563 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0295112 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.029492 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0294205 |
| CCNL1 | cyclin L1 | 0.0293959 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0292501 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0291389 |
| GOLGB1 | golgin B1 | 0.0291051 |
| HBP1 | HMG-box transcription factor 1 | 0.0289972 |
| HDLBP | high density lipoprotein binding protein | 0.0288596 |
| MSMO1 | methylsterol monooxygenase 1 | 0.028725 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0286143 |
| FAM193A | family with sequence similarity 193, member A | 0.0284345 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0283875 |
| EZR | ezrin | 0.0281441 |
| CUL4A | cullin 4A | 0.0280899 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0278352 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0277298 |
| SON | SON DNA binding protein | 0.0276676 |
| WASF2 | WAS protein family, member 2 | 0.0275625 |
| MLF1 | myeloid leukemia factor 1 | 0.0274732 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0273719 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.027271 |
| ATP11A | ATPase, class VI, type 11A | 0.02715 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0271025 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0269931 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0269475 |
| RLF | rearranged L-myc fusion | 0.0268917 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.144254 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.126981 |
| TMSB10 | thymosin beta 10 | -0.0975542 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0944193 |
| LMO7 | LIM domain 7 | -0.0916744 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0642273 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0633927 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0599829 |
| S100A10 | S100 calcium binding protein A10 | -0.0535713 |
| ASPH | aspartate beta-hydroxylase | -0.0530637 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0520573 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0504735 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.048906 |
| OSMR | oncostatin M receptor | -0.0488427 |
| ACTG1 | actin gamma 1 | -0.0487063 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0466259 |
| SEC61G | Sec61 gamma subunit | -0.0454969 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0443988 |
| PDE8A | phosphodiesterase 8A | -0.0422568 |
| GRAMD1B | GRAM domain containing 1B | -0.0409149 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0408075 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0403156 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0394488 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0386078 |
| FNDC3B | fibronectin type III domain containing 3B | -0.037692 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0360199 |
| VCL | vinculin | -0.0345368 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0335375 |
| SCEL | sciellin | -0.0328491 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0323013 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0319492 |
| RAB10 | RAB10, member RAS oncogene family | -0.0319253 |
| NTN4 | netrin 4 | -0.0317308 |
| AHNAK | AHNAK nucleoprotein | -0.0311707 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0309941 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0300581 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0300087 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0297105 |
| MYOF | myoferlin | -0.0291024 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0291006 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0279827 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0276385 |
| LAMA4 | laminin, alpha 4 | -0.0271983 |
| RNF145 | ring finger protein 145 | -0.0270089 |
| KRT7 | keratin 7, type II | -0.0267147 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0255917 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0248831 |
| CCND1 | cyclin D1 | -0.0248657 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0246002 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0240723 |
| FOXP1 | forkhead box P1 | -0.0238465 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0234706 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0232606 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0232425 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0228383 |
| CUX1 | cut-like homeobox 1 | -0.0224804 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0221837 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0220656 |
| RIN2 | Ras and Rab interactor 2 | -0.0220369 |
| S100A6 | S100 calcium binding protein A6 | -0.0218822 |
| PRKCA | protein kinase C, alpha | -0.0215732 |
| KRT18 | keratin 18, type I | -0.0210893 |
| CST3 | cystatin C | -0.0204308 |
| KYNU | kynureninase | -0.0198933 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0198335 |
| ZNF609 | zinc finger protein 609 | -0.0197964 |
| PARD3 | par-3 family cell polarity regulator | -0.0193883 |
| KRT19 | keratin 19, type I | -0.0190629 |
| PLS3 | plastin 3 | -0.018897 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | -0.0188116 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0187674 |
| MYO1D | myosin ID | -0.0186777 |
| CHML | choroideremia-like (Rab escort protein 2) | -0.0184868 |
| PCED1B | PC-esterase domain containing 1B | -0.018344 |
| TPM4 | tropomyosin 4 | -0.0182467 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0177726 |
| IER3 | immediate early response 3 | -0.0177626 |
| AREG | amphiregulin | -0.0176289 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0175658 |
| TOP1 | topoisomerase (DNA) I | -0.0171438 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0170978 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0170797 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0168987 |
| TNS3 | tensin 3 | -0.0167936 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0167366 |
| ENOSF1 | enolase superfamily member 1 | -0.0167038 |
| SMYD3 | SET and MYND domain containing 3 | -0.0166986 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0165461 |
| AGR2 | anterior gradient 2 | -0.016325 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0162359 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0160851 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.01581 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0157438 |
| EFNA5 | ephrin-A5 | -0.015602 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0156018 |
| KRT8 | keratin 8, type II | -0.0155506 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0154855 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0154153 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0151567 |
| ETV6 | ets variant 6 | -0.0151135 |
