Allopurinol_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Allopurinol perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Allopurinol_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.12853
EEF2 eukaryotic translation elongation factor 2 0.117481
FTH1 ferritin, heavy polypeptide 1 0.0865006
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0802425
TPM3 tropomyosin 3 0.0777603
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0759933
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.069873
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.066097
APP amyloid beta (A4) precursor protein 0.0637059
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0632602
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0617985
PCBP2 poly(rC) binding protein 2 0.0615199
POTEF POTE ankyrin domain family, member F 0.0609011
COPA coatomer protein complex, subunit alpha 0.058027
CMIP c-Maf inducing protein 0.057379
SAMD4A sterile alpha motif domain containing 4A 0.0571179
LPP LIM domain containing preferred translocation partner in lipoma 0.0570643
GLG1 golgi glycoprotein 1 0.0570011
MCL1 myeloid cell leukemia 1 0.0559983
FLNB filamin B, beta 0.0541714
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0524997
ANKRD11 ankyrin repeat domain 11 0.0516754
MACF1 microtubule-actin crosslinking factor 1 0.0508533
CALR calreticulin 0.0503255
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0500381
WAC WW domain containing adaptor with coiled-coil 0.0500097
RBM39 RNA binding motif protein 39 0.047759
ACTN1 actinin, alpha 1 0.0476568
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0474397
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0470282
BRD2 bromodomain containing 2 0.0466276
FMNL2 formin-like 2 0.046387
FLNA filamin A, alpha 0.0454658
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.045159
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0446616
RBM25 RNA binding motif protein 25 0.0445353
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0442298
SFPQ splicing factor proline/glutamine-rich 0.0437848
ZFAND3 zinc finger, AN1-type domain 3 0.0437287
PDIA6 protein disulfide isomerase family A, member 6 0.0434327
UBASH3B ubiquitin associated and SH3 domain containing B 0.0432281
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0430915
IGFBP3 insulin-like growth factor binding protein 3 0.0428495
RAB7A RAB7A, member RAS oncogene family 0.0424102
AKAP13 A kinase (PRKA) anchor protein 13 0.0424016
LDHA lactate dehydrogenase A 0.04216
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0421422
GOLGA4 golgin A4 0.0411869
MSN moesin 0.0407997
CCNL1 cyclin L1 0.0406864
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0399205
EXT1 exostosin glycosyltransferase 1 0.0395821
WDR43 WD repeat domain 43 0.0390171
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0390102
EGFR epidermal growth factor receptor 0.0386292
PUM1 pumilio RNA-binding family member 1 0.0383622
SMOC1 SPARC related modular calcium binding 1 0.0380172
ANXA1 annexin A1 0.0365051
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0362723
RICTOR RPTOR independent companion of MTOR, complex 2 0.0359811
KTN1 kinectin 1 (kinesin receptor) 0.0359057
BIRC6 baculoviral IAP repeat containing 6 0.0356395
PTK2 protein tyrosine kinase 2 0.0355979
TPD52 tumor protein D52 0.0352119
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.034333
MYH9 myosin, heavy chain 9, non-muscle 0.0340762
ASXL1 additional sex combs like transcriptional regulator 1 0.0332347
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0330356
HSPA8 heat shock 70kDa protein 8 0.0327998
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0327941
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0327486
SRSF5 serine/arginine-rich splicing factor 5 0.0312118
FTO fat mass and obesity associated 0.03114
MYOF myoferlin 0.0310214
FNDC3B fibronectin type III domain containing 3B 0.0305797
INO80 INO80 complex subunit 0.0305525
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0304316
FAM168A family with sequence similarity 168, member A 0.0304114
TRIO trio Rho guanine nucleotide exchange factor 0.0303185
YTHDC1 YTH domain containing 1 0.0302428
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0300141
CSDE1 cold shock domain containing E1, RNA-binding 0.0299583
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) 0.0297227
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0295117
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0291844
DOCK5 dedicator of cytokinesis 5 0.0290701
SRP54 signal recognition particle 54kDa 0.0289998
USP36 ubiquitin specific peptidase 36 0.0289752
WIPF2 WAS/WASL interacting protein family, member 2 0.0288558
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0288127
DENND4A DENN/MADD domain containing 4A 0.0285931
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0284903
RBM8A RNA binding motif protein 8A 0.0284166
FOS FBJ murine osteosarcoma viral oncogene homolog 0.028387
DSCAM Down syndrome cell adhesion molecule 0.0283804
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0282626
NOP58 NOP58 ribonucleoprotein 0.0280496
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0279929
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0275201
OAZ1 ornithine decarboxylase antizyme 1 0.0274718

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.259304
GRAMD1B GRAM domain containing 1B -0.220595
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.178265
PDE4D phosphodiesterase 4D, cAMP-specific -0.167218
PM20D1 peptidase M20 domain containing 1 -0.15793
TMSB10 thymosin beta 10 -0.152558
TFPI2 tissue factor pathway inhibitor 2 -0.0728891
FTL ferritin, light polypeptide -0.0692559
WWOX WW domain containing oxidoreductase -0.0667035
RPS21 ribosomal protein S21 -0.0631936
RPL19 ribosomal protein L19 -0.0623681
RPLP1 ribosomal protein, large, P1 -0.0583075
TXNRD1 thioredoxin reductase 1 -0.0570384
BIRC3 baculoviral IAP repeat containing 3 -0.0491546
NNMT nicotinamide N-methyltransferase -0.0463827
RPS19 ribosomal protein S19 -0.0433914
RPS8 ribosomal protein S8 -0.0408947
VIM vimentin -0.0401139
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0400993
RPL35A ribosomal protein L35a -0.0353156
RPL23 ribosomal protein L23 -0.0351104
RPL36 ribosomal protein L36 -0.0342964
BICC1 BicC family RNA binding protein 1 -0.0325741
RPS29 ribosomal protein S29 -0.0324929
RPS27A ribosomal protein S27a -0.0322381
TPT1 tumor protein, translationally-controlled 1 -0.0322014
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0321343
RPS24 ribosomal protein S24 -0.0320163
EFNA5 ephrin-A5 -0.0297681
RPL30 ribosomal protein L30 -0.0294892
HMGB1 high mobility group box 1 -0.029456
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0292651
RPS20 ribosomal protein S20 -0.0285313
RAD51B RAD51 paralog B -0.0277018
C15ORF48 chromosome 15 open reading frame 48 -0.0275659
OSMR oncostatin M receptor -0.0274589
ADGRG6 adhesion G protein-coupled receptor G6 -0.0274315
RPS5 ribosomal protein S5 -0.0268473
RPL26 ribosomal protein L26 -0.0264688
ATP5F1E ATP synthase F1 subunit epsilon -0.026247
RPS23 ribosomal protein S23 -0.0252293
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0249544
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0243625
RPL7 ribosomal protein L7 -0.0242244
HDAC9 histone deacetylase 9 -0.0240509
RPL8 ribosomal protein L8 -0.0239584
TUBB tubulin, beta class I -0.0238165
NCOA7 nuclear receptor coactivator 7 -0.0237799
MKI67 marker of proliferation Ki-67 -0.0236186
RPL34 ribosomal protein L34 -0.0232371
RPS25 ribosomal protein S25 -0.0229827
RPL4 ribosomal protein L4 -0.0227152
S100A6 S100 calcium binding protein A6 -0.0226474
MYL12B myosin, light chain 12B, regulatory -0.0226265
RPL38 ribosomal protein L38 -0.0225074
BMP5 bone morphogenetic protein 5 -0.0222185
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0217191
LGALS1 lectin, galactoside-binding, soluble, 1 -0.021402
ZNF804A zinc finger protein 804A -0.0213819
RFWD3 ring finger and WD repeat domain 3 -0.0213436
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0213124
RPL23A ribosomal protein L23a -0.0213116
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0213066
RPL9 ribosomal protein L9 -0.0210251
RPL12 ribosomal protein L12 -0.0208695
S100A10 S100 calcium binding protein A10 -0.0207845
RPL11 ribosomal protein L11 -0.020605
CENPF centromere protein F, 350/400kDa -0.0205474
RPL37 ribosomal protein L37 -0.0200964
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.020005
IGF1R insulin-like growth factor 1 receptor -0.0199022
RPS16 ribosomal protein S16 -0.0198245
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0197212
RPLP0 ribosomal protein, large, P0 -0.019317
SLC38A2 solute carrier family 38, member 2 -0.0192797
RPLP2 ribosomal protein, large, P2 -0.0191411
RPL28 ribosomal protein L28 -0.0191303
KNL1 kinetochore scaffold 1 -0.0190653
IER3 immediate early response 3 -0.0189206
GNAS GNAS complex locus -0.0189156
ZNF292 zinc finger protein 292 -0.018693
FSTL5 follistatin-like 5 -0.0186174
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0183181
RPL36AL ribosomal protein L36a-like -0.0182206
ROMO1 reactive oxygen species modulator 1 -0.0181715
RPS15 ribosomal protein S15 -0.0181681
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0181102
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0180206
PRKN parkin RBR E3 ubiquitin protein ligase -0.017701
RPL27 ribosomal protein L27 -0.0173622
TTC28 tetratricopeptide repeat domain 28 -0.0170333
RPS14 ribosomal protein S14 -0.0169542
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0168945
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0168648
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -0.016646
RSPO3 R-spondin 3 -0.0163251
RTN4 reticulon 4 -0.0162388
SERF2 small EDRK-rich factor 2 -0.0160606
RACK1 receptor for activated C kinase 1 -0.0158778
FGG fibrinogen gamma chain -0.0158508