Allopurinol_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Allopurinol perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Allopurinol_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.23846
EEF2 eukaryotic translation elongation factor 2 0.183158
TXNRD1 thioredoxin reductase 1 0.178984
CSDE1 cold shock domain containing E1, RNA-binding 0.126022
TFPI2 tissue factor pathway inhibitor 2 0.096235
TRIO trio Rho guanine nucleotide exchange factor 0.0891037
TPM3 tropomyosin 3 0.0691646
KTN1 kinectin 1 (kinesin receptor) 0.0654566
RBM39 RNA binding motif protein 39 0.0650821
KDM2A lysine (K)-specific demethylase 2A 0.0650371
ERRFI1 ERBB receptor feedback inhibitor 1 0.0650147
PABPC1 poly(A) binding protein, cytoplasmic 1 0.062349
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0619197
GOLGB1 golgin B1 0.0591848
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0581203
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0576962
MORF4L2 mortality factor 4 like 2 0.0573001
PCBP2 poly(rC) binding protein 2 0.0554715
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0544381
USP34 ubiquitin specific peptidase 34 0.0526589
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0525596
COPA coatomer protein complex, subunit alpha 0.0522497
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0518925
NIPBL Nipped-B homolog (Drosophila) 0.0504666
IPO7 importin 7 0.0480866
KIF5B kinesin family member 5B 0.0480861
RAB7A RAB7A, member RAS oncogene family 0.0461069
JMJD1C jumonji domain containing 1C 0.0457959
ZBTB20 zinc finger and BTB domain containing 20 0.0451127
SPAG9 sperm associated antigen 9 0.0444329
SFPQ splicing factor proline/glutamine-rich 0.0442256
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0436914
GRAMD1B GRAM domain containing 1B 0.0436245
XPO1 exportin 1 0.0436007
ZNF638 zinc finger protein 638 0.0431469
ZFC3H1 zinc finger, C3H1-type containing 0.0416996
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0414858
KDM3A lysine (K)-specific demethylase 3A 0.0413326
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0411248
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0408954
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0402449
CCNL1 cyclin L1 0.0398333
OGA O-GlcNAcase 0.0398146
CRY1 cryptochrome circadian clock 1 0.0396269
MACF1 microtubule-actin crosslinking factor 1 0.0395618
EXOC6B exocyst complex component 6B 0.0394161
PRRC2C proline-rich coiled-coil 2C 0.0392624
MKI67 marker of proliferation Ki-67 0.0392506
MARCHF4 membrane associated ring-CH-type finger 4 0.0392251
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0391462
ANO6 anoctamin 6 0.0389089
MCL1 myeloid cell leukemia 1 0.0384907
GOLGA4 golgin A4 0.0384551
CSNK1A1 casein kinase 1, alpha 1 0.0382471
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0380196
APP amyloid beta (A4) precursor protein 0.0369943
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0368666
PTK2 protein tyrosine kinase 2 0.0364173
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0363452
CLTC clathrin, heavy chain (Hc) 0.03603
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0359986
ZFAND3 zinc finger, AN1-type domain 3 0.0357473
PGK1 phosphoglycerate kinase 1 0.0356984
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0354488
SMAD3 SMAD family member 3 0.0351693
RTN4 reticulon 4 0.0351233
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0350307
RB1CC1 RB1-inducible coiled-coil 1 0.0348393
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0347822
NCOR1 nuclear receptor corepressor 1 0.0347199
MYH9 myosin, heavy chain 9, non-muscle 0.034467
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0343832
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0340422
NCAPD2 non-SMC condensin I complex, subunit D2 0.0340103
UBAP2L ubiquitin associated protein 2-like 0.0339881
SRRM1 serine/arginine repetitive matrix 1 0.0335397
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0331968
STK4 serine/threonine kinase 4 0.0330947
MATR3 matrin 3 0.0328697
WNK1 WNK lysine deficient protein kinase 1 0.0323251
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.032245
HDLBP high density lipoprotein binding protein 0.032228
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0321656
SRPK1 SRSF protein kinase 1 0.0316574
EIF4B eukaryotic translation initiation factor 4B 0.0315666
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0315107
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0313226
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0312842
EXOC4 exocyst complex component 4 0.0312626
FER fer (fps/fes related) tyrosine kinase 0.0311909
RASAL2 RAS protein activator like 2 0.031154
CCDC47 coiled-coil domain containing 47 0.0309302
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0308333
RAD51B RAD51 paralog B 0.0307122
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0306881
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.030614
FLNA filamin A, alpha 0.0305103
ZCCHC7 zinc finger, CCHC domain containing 7 0.0303848
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0301807
ARHGAP5 Rho GTPase activating protein 5 0.0300747

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.27717
TMSB10 thymosin beta 10 -0.113528
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0688457
AKAP12 A kinase (PRKA) anchor protein 12 -0.0531662
HMGA2 high mobility group AT-hook 2 -0.0431512
PTMA prothymosin, alpha -0.0402984
RPS8 ribosomal protein S8 -0.0387882
ACTG1 actin gamma 1 -0.0363593
RPLP1 ribosomal protein, large, P1 -0.0358384
RPS19 ribosomal protein S19 -0.0350215
RPL35A ribosomal protein L35a -0.0348891
PFN1 profilin 1 -0.0336243
RPS21 ribosomal protein S21 -0.0322194
GNAS GNAS complex locus -0.0320581
RIMS2 regulating synaptic membrane exocytosis 2 -0.0316683
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0315214
POTEF POTE ankyrin domain family, member F -0.0310934
IFI6 interferon, alpha-inducible protein 6 -0.0300523
RPS27 ribosomal protein S27 -0.0299585
RPS10 ribosomal protein S10 -0.0290584
RPL36 ribosomal protein L36 -0.0290372
TPM2 tropomyosin 2 (beta) -0.0279961
RPL28 ribosomal protein L28 -0.0277717
PDE10A phosphodiesterase 10A -0.0262064
RPS29 ribosomal protein S29 -0.0260971
RPS15 ribosomal protein S15 -0.025641
VCL vinculin -0.025515
RPS6 ribosomal protein S6 -0.0254601
OSMR oncostatin M receptor -0.0240286
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0230646
HLA-B major histocompatibility complex, class I, B -0.0229371
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0225175
RPL35 ribosomal protein L35 -0.0212444
TPT1 tumor protein, translationally-controlled 1 -0.0212359
TPI1 triosephosphate isomerase 1 -0.0212207
MT2A metallothionein 2A -0.0211722
FTL ferritin, light polypeptide -0.021079
RPL34 ribosomal protein L34 -0.0203413
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0202589
RYR3 ryanodine receptor 3 -0.0201962
RPL37 ribosomal protein L37 -0.0199497
RPL11 ribosomal protein L11 -0.0193861
ENO1 enolase 1, (alpha) -0.0184221
RPL27 ribosomal protein L27 -0.0183221
TPM4 tropomyosin 4 -0.0176483
RPL38 ribosomal protein L38 -0.0174609
RPL31 ribosomal protein L31 -0.0174317
THSD4 thrombospondin, type I, domain containing 4 -0.0174213
TUBA1B tubulin, alpha 1b -0.0173784
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0166078
PKM pyruvate kinase, muscle -0.0164458
RPL23 ribosomal protein L23 -0.0164421
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0163694
GSTP1 glutathione S-transferase pi 1 -0.016104
NCOA7 nuclear receptor coactivator 7 -0.0160968
VIM vimentin -0.016043
RPL26 ribosomal protein L26 -0.0158383
COL5A2 collagen, type V, alpha 2 -0.0154118
RPL36A ribosomal protein L36a -0.0153254
RPLP2 ribosomal protein, large, P2 -0.0152663
PRH1 proline-rich protein HaeIII subfamily 1 -0.0151622
RPL9 ribosomal protein L9 -0.0151552
STC1 stanniocalcin 1 -0.0151456
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.015083
RPS25 ribosomal protein S25 -0.0148432
WWOX WW domain containing oxidoreductase -0.0147271
UGCG UDP-glucose ceramide glucosyltransferase -0.0143689
RPL19 ribosomal protein L19 -0.0142229
RPL39 ribosomal protein L39 -0.0142026
S100A11 S100 calcium binding protein A11 -0.0140384
ATP5F1E ATP synthase F1 subunit epsilon -0.0139414
TRIM9 tripartite motif containing 9 -0.0136397
RPS26 ribosomal protein S26 -0.0135967
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0134494
C15ORF48 chromosome 15 open reading frame 48 -0.0132798
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0132544
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0132425
BNC2 basonuclin 2 -0.0132313
PDIA3 protein disulfide isomerase family A, member 3 -0.013215
RPS5 ribosomal protein S5 -0.0131837
RPS14 ribosomal protein S14 -0.012975
RPLP0 ribosomal protein, large, P0 -0.0128872
PYGL phosphorylase, glycogen, liver -0.0128519
RPL10A ribosomal protein L10a -0.0127611
RPL12 ribosomal protein L12 -0.0127195
S100A10 S100 calcium binding protein A10 -0.0127145
EPAS1 endothelial PAS domain protein 1 -0.0126661
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0125418
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0123755
RPS20 ribosomal protein S20 -0.0123643
KIRREL1 kirre like nephrin family adhesion molecule 1 -0.0119978
TCIM transcriptional and immune response regulator -0.0119609
GLO1 glyoxalase I -0.0118719
ROMO1 reactive oxygen species modulator 1 -0.011856
RPS3 ribosomal protein S3 -0.0117373
PTMS parathymosin -0.0117236
RPL5 ribosomal protein L5 -0.0117066
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0116924
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0116125
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0116041