| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Allopurinol perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Allopurinol_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.222282 |
| NDRG1 | N-myc downstream regulated 1 | 0.168539 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.138706 |
| TSC22D2 | TSC22 domain family, member 2 | 0.12967 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.123582 |
| FNDC3B | fibronectin type III domain containing 3B | 0.117616 |
| ASPH | aspartate beta-hydroxylase | 0.11706 |
| FN1 | fibronectin 1 | 0.0983078 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0888204 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.084103 |
| FAM13A | family with sequence similarity 13, member A | 0.0807358 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0785831 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0738218 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.073128 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0698173 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0669817 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0643328 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.062221 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0621207 |
| LAMC2 | laminin, gamma 2 | 0.0610186 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0601148 |
| PCBP2 | poly(rC) binding protein 2 | 0.0588942 |
| ARRDC3 | arrestin domain containing 3 | 0.0552143 |
| VEGFA | vascular endothelial growth factor A | 0.0525758 |
| RNF145 | ring finger protein 145 | 0.0524834 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0516813 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0515819 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0511949 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0502695 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0496716 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.049665 |
| RLF | rearranged L-myc fusion | 0.0489064 |
| GOLGA4 | golgin A4 | 0.0485707 |
| TFG | TRK-fused gene | 0.0472736 |
| CCNL1 | cyclin L1 | 0.0471427 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0467789 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0467683 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.046713 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0463573 |
| CALR | calreticulin | 0.0463437 |
| QKI | QKI, KH domain containing, RNA binding | 0.0461058 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0451551 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0442702 |
| EZR | ezrin | 0.043874 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.04373 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0428047 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0427569 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0424863 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0411596 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0410928 |
| COPA | coatomer protein complex, subunit alpha | 0.0410248 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0408684 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0401 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.039821 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0397763 |
| YTHDC1 | YTH domain containing 1 | 0.0389671 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0388614 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0378027 |
| CCNY | cyclin Y | 0.0371136 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0368147 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0359541 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0358146 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0357305 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0348588 |
| SUCO | SUN domain containing ossification factor | 0.0346653 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.034465 |
| ZNF292 | zinc finger protein 292 | 0.0340753 |
| NUP58 | nucleoporin 58 | 0.0340616 |
| RTN4 | reticulon 4 | 0.0339833 |
| LDHA | lactate dehydrogenase A | 0.0339454 |
| FLNB | filamin B, beta | 0.0336745 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0335215 |
| CD109 | CD109 molecule | 0.0334279 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0333957 |
| ANXA2 | annexin A2 | 0.0333462 |
| PTK2 | protein tyrosine kinase 2 | 0.0332751 |
| RBM39 | RNA binding motif protein 39 | 0.0328057 |
| SLMAP | sarcolemma associated protein | 0.0327949 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0326762 |
| MXD1 | MAX dimerization protein 1 | 0.0326658 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0326033 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0324673 |
| RYK | receptor-like tyrosine kinase | 0.0323631 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0320087 |
| AZIN1 | antizyme inhibitor 1 | 0.0318836 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0318564 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0317299 |
| NPTN | neuroplastin | 0.0315562 |
| YBX1 | Y box binding protein 1 | 0.0315426 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0310887 |
| MATR3 | matrin 3 | 0.030936 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0308041 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0305561 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.030218 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0298699 |
| DIAPH1 | diaphanous-related formin 1 | 0.0298649 |
| HELZ | helicase with zinc finger | 0.0295745 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0289011 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0288538 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.028551 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.150771 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.113071 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.112806 |
| ACTG1 | actin gamma 1 | -0.11141 |
| FBXO32 | F-box protein 32 | -0.0884066 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0785998 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0750222 |
| FTL | ferritin, light polypeptide | -0.0728426 |
| LAMB3 | laminin, beta 3 | -0.0708473 |
| RPL35A | ribosomal protein L35a | -0.0690328 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0682233 |
| PTMA | prothymosin, alpha | -0.0640656 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.063422 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0631024 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0595497 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0585396 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0579186 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0554665 |
| RNF213 | ring finger protein 213 | -0.0534716 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0499757 |
| CSTB | cystatin B (stefin B) | -0.0496505 |
| RPL34 | ribosomal protein L34 | -0.0461532 |
| HLA-B | major histocompatibility complex, class I, B | -0.0452351 |
| MX2 | MX dynamin-like GTPase 2 | -0.044668 |
| CCND1 | cyclin D1 | -0.0443103 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0429617 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0423655 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0393312 |
| CD2AP | CD2-associated protein | -0.0375077 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0363968 |
| FBXO34 | F-box protein 34 | -0.0351492 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0337116 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.032478 |
| HSPB1 | heat shock 27kDa protein 1 | -0.032403 |
| VCL | vinculin | -0.0323669 |
| PGBD5 | piggyBac transposable element derived 5 | -0.0319962 |
| S100A10 | S100 calcium binding protein A10 | -0.0318241 |
| ETV6 | ets variant 6 | -0.0311376 |
| RPLP1 | ribosomal protein, large, P1 | -0.0310159 |
| H1-0 | H1.0 linker histone | -0.0309455 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0295987 |
| RPS24 | ribosomal protein S24 | -0.0291285 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0284018 |
| RAI14 | retinoic acid induced 14 | -0.027675 |
| RPS21 | ribosomal protein S21 | -0.027561 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0272482 |
| GNAS | GNAS complex locus | -0.0271364 |
| RPS29 | ribosomal protein S29 | -0.027068 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0268041 |
| PPP2R3A | protein phosphatase 2, regulatory subunit B'', alpha | -0.0263193 |
| ARHGAP20 | Rho GTPase activating protein 20 | -0.0250776 |
| HLA-A | major histocompatibility complex, class I, A | -0.0250675 |
| RPS25 | ribosomal protein S25 | -0.0250193 |
| PALLD | palladin, cytoskeletal associated protein | -0.0247838 |
| MAP3K13 | mitogen-activated protein kinase kinase kinase 13 | -0.0245584 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0245016 |
| LMO7 | LIM domain 7 | -0.0239792 |
| RPL23 | ribosomal protein L23 | -0.0238765 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0238208 |
| CD63 | CD63 molecule | -0.0234864 |
| SP100 | SP100 nuclear antigen | -0.0231955 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0231429 |
| RIGI | RNA sensor RIG-I | -0.022664 |
| RBM47 | RNA binding motif protein 47 | -0.0223072 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0222721 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0220675 |
| CAVIN1 | caveolae associated protein 1 | -0.0216683 |
| ZNF217 | zinc finger protein 217 | -0.0216234 |
| RPL38 | ribosomal protein L38 | -0.0213141 |
| PSME2 | proteasome (prosome, macropain) activator subunit 2 (PA28 beta) | -0.0210608 |
| RRBP1 | ribosome binding protein 1 | -0.0210365 |
| FNIP1 | folliculin interacting protein 1 | -0.0207558 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0207524 |
| GOLGB1 | golgin B1 | -0.020699 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0204645 |
| RPLP2 | ribosomal protein, large, P2 | -0.020429 |
| CDKL5 | cyclin-dependent kinase-like 5 | -0.0204155 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0201593 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.020149 |
| MACC1 | metastasis associated in colon cancer 1 | -0.020115 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0200689 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0200207 |
| AHNAK | AHNAK nucleoprotein | -0.0199791 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0199738 |
| RAD51B | RAD51 paralog B | -0.0198278 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0197547 |
| RPS13 | ribosomal protein S13 | -0.0197216 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0195521 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.0192303 |
| S100A6 | S100 calcium binding protein A6 | -0.0191083 |
| NAV2 | neuron navigator 2 | -0.0190856 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0190732 |
| RPS15 | ribosomal protein S15 | -0.0190396 |
| F11R | F11 receptor | -0.0189532 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0186441 |
| MKI67 | marker of proliferation Ki-67 | -0.0182787 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0182168 |
| H3-3B | H3.3 histone B | -0.0181968 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0181102 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0180732 |
