Allopurinol_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Allopurinol perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Allopurinol_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HDLBP high density lipoprotein binding protein 0.0829143
NDRG1 N-myc downstream regulated 1 0.0808506
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0747443
ANXA2 annexin A2 0.065759
KRT18 keratin 18, type I 0.0651969
FN1 fibronectin 1 0.0550192
DSPP dentin sialophosphoprotein 0.0536117
WAC WW domain containing adaptor with coiled-coil 0.0503451
DSCAM Down syndrome cell adhesion molecule 0.048028
TTC3 tetratricopeptide repeat domain 3 0.0479366
RPS6 ribosomal protein S6 0.0475414
EEF2 eukaryotic translation elongation factor 2 0.0474939
MYO1E myosin IE 0.0461135
TRIO trio Rho guanine nucleotide exchange factor 0.0452875
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0449281
SLTM SAFB-like, transcription modulator 0.0436281
PDE4D phosphodiesterase 4D, cAMP-specific 0.0402418
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0402328
BIRC6 baculoviral IAP repeat containing 6 0.0398206
STC1 stanniocalcin 1 0.0376035
FLNB filamin B, beta 0.03705
RPL26 ribosomal protein L26 0.0365087
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0364368
MYOF myoferlin 0.0357933
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0356819
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.035233
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0352022
ATP13A3 ATPase type 13A3 0.0348288
PRRC2C proline-rich coiled-coil 2C 0.0343221
ANKHD1 ankyrin repeat and KH domain containing 1 0.0325509
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0323831
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0316673
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.031149
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0310473
MCL1 myeloid cell leukemia 1 0.0308758
PUM2 pumilio RNA-binding family member 2 0.0303284
RBM39 RNA binding motif protein 39 0.0297214
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0285635
JMJD1C jumonji domain containing 1C 0.0283596
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0280072
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0275285
HELZ helicase with zinc finger 0.0267839
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0265681
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0264731
ANKRD11 ankyrin repeat domain 11 0.0264126
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0253867
IGFBP3 insulin-like growth factor binding protein 3 0.0253733
USP34 ubiquitin specific peptidase 34 0.0236477
GOLGA4 golgin A4 0.0231059
ANKRD17 ankyrin repeat domain 17 0.0230302
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0228184
KDM3A lysine (K)-specific demethylase 3A 0.0227115
VIM vimentin 0.0226474
TM9SF3 transmembrane 9 superfamily member 3 0.0223849
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0213826
TRA2A transformer 2 alpha homolog (Drosophila) 0.0207398
ACTG1 actin gamma 1 0.0205745
EPS8 epidermal growth factor receptor pathway substrate 8 0.0204405
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.020418
THSD4 thrombospondin, type I, domain containing 4 0.0193571
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0190678
RPL37 ribosomal protein L37 0.0188595
TOP1 topoisomerase (DNA) I 0.0185773
CANX calnexin 0.017797
ITCH itchy E3 ubiquitin protein ligase 0.017709
RAD21 RAD21 homolog (S. pombe) 0.0174371
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0171135
APP amyloid beta (A4) precursor protein 0.0169551
VCL vinculin 0.0162732
RPS8 ribosomal protein S8 0.0162502
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0157999
SEPTIN2 septin 2 0.0147648
SQSTM1 sequestosome 1 0.0142778
SND1 staphylococcal nuclease and tudor domain containing 1 0.014232
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0130384
ENO1 enolase 1, (alpha) 0.0130329
ITGA6 integrin, alpha 6 0.0127706
ARHGAP5 Rho GTPase activating protein 5 0.0126112
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0122071
LAMB3 laminin, beta 3 0.0115414
AFF4 AF4/FMR2 family, member 4 0.0111204
RTN4 reticulon 4 0.011012
UBA6 ubiquitin-like modifier activating enzyme 6 0.0109863
RBM6 RNA binding motif protein 6 0.0105682
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0102022
YEATS2 YEATS domain containing 2 0.0100058
ARB2A ARB2 cotranscriptional regulator A 0.0097094
GPHN gephyrin 0.0089415
RPS16 ribosomal protein S16 0.00847481
UGCG UDP-glucose ceramide glucosyltransferase 0.00776223
VMP1 vacuole membrane protein 1 0.00769375
EXT1 exostosin glycosyltransferase 1 0.00769328
PTMA prothymosin, alpha 0.00737892
ZBTB20 zinc finger and BTB domain containing 20 0.0073692
HOOK2 hook microtubule-tethering protein 2 0.006587
WSB1 WD repeat and SOCS box containing 1 0.00647534
RPL19 ribosomal protein L19 0.0064113
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.00598341
TXNRD1 thioredoxin reductase 1 0.00596893
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.00585066

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.188776
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.162305
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.100259
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0830072
TENM3 teneurin transmembrane protein 3 -0.079234
NFIA nuclear factor I/A -0.0693557
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0675067
RAB10 RAB10, member RAS oncogene family -0.0650701
NALF1 NALCN channel auxiliary factor 1 -0.0638388
PSD3 pleckstrin and Sec7 domain containing 3 -0.0598163
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0561846
ANKRD12 ankyrin repeat domain 12 -0.0558197
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0552174
SMYD3 SET and MYND domain containing 3 -0.0534326
GPC6 glypican 6 -0.0521346
FMNL2 formin-like 2 -0.0520432
KDM4C lysine (K)-specific demethylase 4C -0.0498923
PRKCA protein kinase C, alpha -0.0461907
RAD51B RAD51 paralog B -0.0440182
WNK1 WNK lysine deficient protein kinase 1 -0.0391916
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0363273
ASPH aspartate beta-hydroxylase -0.0359756
RPLP1 ribosomal protein, large, P1 -0.0359173
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0354671
LPP LIM domain containing preferred translocation partner in lipoma -0.0351743
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0344976
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0341169
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0333248
EXOC6B exocyst complex component 6B -0.0312363
NAP1L1 nucleosome assembly protein 1-like 1 -0.030589
EFNA5 ephrin-A5 -0.0294903
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0290595
FNDC3B fibronectin type III domain containing 3B -0.0285016
FAM13A family with sequence similarity 13, member A -0.027457
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0259952
KMT2C lysine (K)-specific methyltransferase 2C -0.0259132
SLC38A1 solute carrier family 38, member 1 -0.0258142
MAML2 mastermind-like 2 (Drosophila) -0.0244677
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0243763
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0231147
GOLGB1 golgin B1 -0.0227669
PKM pyruvate kinase, muscle -0.0213987
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.020748
CTBP2 C-terminal binding protein 2 -0.0200743
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0194895
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0192055
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0191617
RPL37A ribosomal protein L37a -0.0181045
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0179106
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0174049
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0168246
RPL11 ribosomal protein L11 -0.0167572
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0164828
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.014948
RPS12 ribosomal protein S12 -0.0129349
AKAP9 A kinase (PRKA) anchor protein 9 -0.0128639
PUM1 pumilio RNA-binding family member 1 -0.012375
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0123232
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.012233
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.012137
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0121157
RPL34 ribosomal protein L34 -0.0117994
ACTN4 actinin, alpha 4 -0.0111378
DOCK5 dedicator of cytokinesis 5 -0.011099
PTK2 protein tyrosine kinase 2 -0.0107195
SBF2 SET binding factor 2 -0.0103655
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0101491
AKAP12 A kinase (PRKA) anchor protein 12 -0.00973262
ZFAND3 zinc finger, AN1-type domain 3 -0.0094815
ARHGAP26 Rho GTPase activating protein 26 -0.00930255
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.00917584
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0091401
EGFR epidermal growth factor receptor -0.00911438
FXR1 fragile X mental retardation, autosomal homolog 1 -0.00872097
RORA RAR-related orphan receptor A -0.00793272
TMSB10 thymosin beta 10 -0.00744966
DST dystonin -0.00732163
PICALM phosphatidylinositol binding clathrin assembly protein -0.00694232
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0066936
SPAG9 sperm associated antigen 9 -0.00654697
PGK1 phosphoglycerate kinase 1 -0.00654372
PARD3 par-3 family cell polarity regulator -0.00644813
CAMTA1 calmodulin binding transcription activator 1 -0.00643458
RPS24 ribosomal protein S24 -0.00584741
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.00534406
OGA O-GlcNAcase -0.00510352
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0048307
H3-3B H3.3 histone B -0.00403663
PDE10A phosphodiesterase 10A -0.00388395
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0034938
RAB1A RAB1A, member RAS oncogene family -0.00325067
MED13L mediator complex subunit 13-like -0.00322051
PDIA3 protein disulfide isomerase family A, member 3 -0.00321836
EIF1 eukaryotic translation initiation factor 1 -0.00317974
RPL23 ribosomal protein L23 -0.00286965
IGFBP5 insulin-like growth factor binding protein 5 -0.00281245
RPL35A ribosomal protein L35a -0.00271644
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.00269307
IQGAP1 IQ motif containing GTPase activating protein 1 -0.00245303
ZNF292 zinc finger protein 292 -0.0024455