| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Allopurinol perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Allopurinol_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL11A1 | collagen, type XI, alpha 1 | 0.19968 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.168427 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.157943 |
| PGK1 | phosphoglycerate kinase 1 | 0.133073 |
| VIM | vimentin | 0.121826 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.11884 |
| PEG10 | paternally expressed 10 | 0.115102 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.103167 |
| COL3A1 | collagen, type III, alpha 1 | 0.102755 |
| CALR | calreticulin | 0.097071 |
| PTMA | prothymosin, alpha | 0.0856828 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.083166 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0768287 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0731651 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0715215 |
| LDHA | lactate dehydrogenase A | 0.0708001 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0664658 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0632314 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0624774 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0568419 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0562164 |
| FN1 | fibronectin 1 | 0.0557498 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0553698 |
| PRRC2C | proline-rich coiled-coil 2C | 0.054728 |
| COL1A2 | collagen, type I, alpha 2 | 0.053785 |
| BSG | basigin (Ok blood group) | 0.0524029 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0515559 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0491894 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | 0.0490839 |
| PCDH9 | protocadherin 9 | 0.0484275 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0480058 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0479214 |
| ENO1 | enolase 1, (alpha) | 0.0476055 |
| MKI67 | marker of proliferation Ki-67 | 0.047463 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.047247 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0471836 |
| DEK | DEK proto-oncogene | 0.0468897 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0468776 |
| CENPF | centromere protein F, 350/400kDa | 0.0465192 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0451603 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0448092 |
| CEP350 | centrosomal protein 350kDa | 0.0436083 |
| LYST | lysosomal trafficking regulator | 0.0434627 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0432334 |
| PHIP | pleckstrin homology domain interacting protein | 0.0425797 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0423698 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0415077 |
| RLF | rearranged L-myc fusion | 0.0402674 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.040179 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0395983 |
| CCNA2 | cyclin A2 | 0.0392225 |
| RCOR1 | REST corepressor 1 | 0.0391956 |
| ENAH | enabled homolog (Drosophila) | 0.0390084 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0388106 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0384517 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0384323 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0382358 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.03821 |
| PHF3 | PHD finger protein 3 | 0.0380312 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0373745 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0367909 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0357015 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0356238 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0355593 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.035472 |
| MED13L | mediator complex subunit 13-like | 0.0347693 |
| ACTN4 | actinin, alpha 4 | 0.0345341 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0341253 |
| ANXA2 | annexin A2 | 0.0335106 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0332797 |
| GSE1 | Gse1 coiled-coil protein | 0.0332574 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0332129 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0332005 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0330251 |
| TMSB10 | thymosin beta 10 | 0.0328746 |
| NDRG1 | N-myc downstream regulated 1 | 0.0328216 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.032598 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0325944 |
| RREB1 | ras responsive element binding protein 1 | 0.0325481 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0325426 |
| RASAL2 | RAS protein activator like 2 | 0.0322159 |
| B2M | beta-2-microglobulin | 0.0318882 |
| GNAS | GNAS complex locus | 0.0314784 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0312113 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0311285 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0308748 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0306205 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0305322 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0304659 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0300728 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | 0.02995 |
| CENPE | centromere protein E, 312kDa | 0.0299154 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0298999 |
| HMCN1 | hemicentin 1 | 0.0295542 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | 0.0294827 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0293849 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0290824 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | 0.0288898 |
| OAZ1 | ornithine decarboxylase antizyme 1 | 0.0287434 |
| PFN1 | profilin 1 | 0.0285637 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HDAC9 | histone deacetylase 9 | -0.0710988 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0696246 |
| H1-4 | H1.4 linker histone, cluster member | -0.0684916 |
| RPS2 | ribosomal protein S2 | -0.0654553 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0477226 |
| PDGFC | platelet derived growth factor C | -0.0472905 |
| ITGAV | integrin, alpha V | -0.0471624 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0446899 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0439534 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0438181 |
| POTEF | POTE ankyrin domain family, member F | -0.0419205 |
| NTM | neurotrimin | -0.0400032 |
| SRP54 | signal recognition particle 54kDa | -0.0399906 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.0399773 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0398563 |
| SFPQ | splicing factor proline/glutamine-rich | -0.038615 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0383232 |
| COL5A2 | collagen, type V, alpha 2 | -0.0368001 |
| ZNF292 | zinc finger protein 292 | -0.0346526 |
| CLASP2 | cytoplasmic linker associated protein 2 | -0.0341815 |
| TEX11 | testis expressed 11 | -0.0334968 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.032537 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0323001 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0314178 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0305868 |
| OLA1 | Obg-like ATPase 1 | -0.0303318 |
| PARD3 | par-3 family cell polarity regulator | -0.030208 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0299936 |
| ZBTB35 | zinc finger and BTB domain containing 35 | -0.0299699 |
| OGA | O-GlcNAcase | -0.0296477 |
| RPS16 | ribosomal protein S16 | -0.0290295 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0288455 |
| ATAD2 | ATPase family, AAA domain containing 2 | -0.0284959 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | -0.0281852 |
| SFRP4 | secreted frizzled-related protein 4 | -0.0281702 |
| USP3 | ubiquitin specific peptidase 3 | -0.0277916 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.027547 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | -0.0272277 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0264876 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0261316 |
| H1-5 | H1.5 linker histone, cluster member | -0.0261274 |
| TNPO3 | transportin 3 | -0.0260999 |
| RRM2 | ribonucleotide reductase M2 | -0.0260998 |
| NUP153 | nucleoporin 153kDa | -0.0256132 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0253511 |
| GOLT1B | golgi transport 1B | -0.0252978 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | -0.0252835 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | -0.0250923 |
| COG5 | component of oligomeric golgi complex 5 | -0.0247732 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | -0.024725 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0246023 |
| YAP1 | Yes-associated protein 1 | -0.0242399 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0242335 |
| PRTG | protogenin | -0.0240645 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0236145 |
| MEIS2 | Meis homeobox 2 | -0.0235678 |
| CLTC | clathrin, heavy chain (Hc) | -0.0234788 |
| MMS22L | MMS22-like, DNA repair protein | -0.0232635 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0231429 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0231098 |
| RC3H1 | ring finger and CCCH-type domains 1 | -0.0227837 |
| PSMB7 | proteasome (prosome, macropain) subunit, beta type, 7 | -0.0226535 |
| AFG2A | AFG2 AAA ATPase homolog A | -0.0224313 |
| CTPS1 | CTP synthase 1 | -0.0223169 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0219128 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0218379 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.021674 |
| VRK2 | vaccinia related kinase 2 | -0.0216685 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0216517 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0215828 |
| WDR70 | WD repeat domain 70 | -0.021382 |
| PUS7 | pseudouridylate synthase 7 (putative) | -0.0213814 |
| CEP192 | centrosomal protein 192kDa | -0.0213772 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0212062 |
| DNMBP | dynamin binding protein | -0.0211696 |
| URI1 | URI1, prefoldin-like chaperone | -0.0210969 |
| UPP1 | uridine phosphorylase 1 | -0.0210706 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0210366 |
| SRPK2 | SRSF protein kinase 2 | -0.0209861 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | -0.020638 |
| UBN1 | ubinuclein 1 | -0.0206349 |
| MEF2A | myocyte enhancer factor 2A | -0.0206037 |
| PDCD5 | programmed cell death 5 | -0.0204112 |
| LCOR | ligand dependent nuclear receptor corepressor | -0.0204025 |
| ZNF385D | zinc finger protein 385D | -0.0202709 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0202388 |
| UBE3D | ubiquitin protein ligase E3D | -0.0201312 |
| PRKAA1 | protein kinase, AMP-activated, alpha 1 catalytic subunit | -0.0201072 |
| NHSL1 | NHS-like 1 | -0.0200999 |
| UBAP2 | ubiquitin associated protein 2 | -0.0200915 |
| PSMC2 | proteasome (prosome, macropain) 26S subunit, ATPase, 2 | -0.0199977 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0199321 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0197442 |
| COMMD1 | copper metabolism (Murr1) domain containing 1 | -0.0195156 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0194705 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0194243 |
| IPO11 | importin 11 | -0.0193847 |
| COPZ1 | coatomer protein complex, subunit zeta 1 | -0.0192378 |
| RAB10 | RAB10, member RAS oncogene family | -0.0191296 |
| SLC37A3 | solute carrier family 37, member 3 | -0.0190953 |
