Allopurinol_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Allopurinol perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Allopurinol_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.189417
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.157678
COL6A3 collagen, type VI, alpha 3 0.137258
FTH1 ferritin, heavy polypeptide 1 0.115185
PTMA prothymosin, alpha 0.0997482
NDRG1 N-myc downstream regulated 1 0.0993579
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0968545
RND3 Rho family GTPase 3 0.0720443
ZSWIM6 zinc finger, SWIM-type containing 6 0.0704772
VIM vimentin 0.0704394
HILPDA hypoxia inducible lipid droplet-associated 0.0635379
GPBP1 GC-rich promoter binding protein 1 0.0622503
ADM adrenomedullin 0.0621299
KMT2E lysine (K)-specific methyltransferase 2E 0.0618007
GOLGB1 golgin B1 0.0608105
VEGFA vascular endothelial growth factor A 0.0607397
PKM pyruvate kinase, muscle 0.0606414
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0594936
STC1 stanniocalcin 1 0.0588925
LOC112694756 uncharaterized LOC112694756 0.0583088
ARRDC3 arrestin domain containing 3 0.0573617
MT2A metallothionein 2A 0.0565659
COG5 component of oligomeric golgi complex 5 0.0563268
CXCL8 chemokine (C-X-C motif) ligand 8 0.0534417
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0525753
B2M beta-2-microglobulin 0.0510589
RAB1A RAB1A, member RAS oncogene family 0.0503382
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0498387
BSG basigin (Ok blood group) 0.048683
CALR calreticulin 0.0482181
ANXA1 annexin A1 0.0471989
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0465142
TTC3 tetratricopeptide repeat domain 3 0.0464118
HDLBP high density lipoprotein binding protein 0.045044
MYH9 myosin, heavy chain 9, non-muscle 0.0449193
PDIA6 protein disulfide isomerase family A, member 6 0.0447176
AKAP12 A kinase (PRKA) anchor protein 12 0.0441724
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0432262
PCBP2 poly(rC) binding protein 2 0.043211
COPA coatomer protein complex, subunit alpha 0.0432109
TMED9 transmembrane emp24 protein transport domain containing 9 0.0428262
SEC31A SEC31 homolog A (S. cerevisiae) 0.0419227
LOX lysyl oxidase 0.0412816
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0411584
HOOK2 hook microtubule-tethering protein 2 0.0406994
UBA6 ubiquitin-like modifier activating enzyme 6 0.0406806
ERRFI1 ERBB receptor feedback inhibitor 1 0.0402044
LIMS1 LIM and senescent cell antigen-like domains 1 0.0399961
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0399802
POTEF POTE ankyrin domain family, member F 0.0394973
F3 coagulation factor III (thromboplastin, tissue factor) 0.0385373
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.038141
PRRC2C proline-rich coiled-coil 2C 0.0379811
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0377777
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.037491
CCNL1 cyclin L1 0.0370868
HLA-A major histocompatibility complex, class I, A 0.0368746
DSCAM Down syndrome cell adhesion molecule 0.0364463
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0363244
EGFR epidermal growth factor receptor 0.0362841
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0362075
CDH13 cadherin 13 0.0356231
CCDC14 coiled-coil domain containing 14 0.0353946
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0352974
CCNI cyclin I 0.0351493
WDFY2 WD repeat and FYVE domain containing 2 0.0347569
TPM3 tropomyosin 3 0.0343623
EXT1 exostosin glycosyltransferase 1 0.0335564
XPO6 exportin 6 0.0335324
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0332868
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0331336
COL7A1 collagen, type VII, alpha 1 0.0328245
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0328104
PTGES2 prostaglandin E synthase 2 0.0327781
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0327468
CD99 CD99 molecule 0.0327307
MACF1 microtubule-actin crosslinking factor 1 0.0326334
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0325894
PMM2 phosphomannomutase 2 0.0323869
HIP1 huntingtin interacting protein 1 0.0319122
CD44 CD44 molecule (Indian blood group) 0.031905
ESYT2 extended synaptotagmin-like protein 2 0.031303
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0311273
BASP1 brain abundant, membrane attached signal protein 1 0.0308489
FN1 fibronectin 1 0.03084
PTN pleiotrophin 0.0306058
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0304031
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0303186
TLN1 talin 1 0.0302956
TRAM1 translocation associated membrane protein 1 0.0297524
BCLAF1 BCL2-associated transcription factor 1 0.0297283
ACBD3 acyl-CoA binding domain containing 3 0.0297049
UGCG UDP-glucose ceramide glucosyltransferase 0.0295636
VDAC1 voltage-dependent anion channel 1 0.0293664
MRPS6 mitochondrial ribosomal protein S6 0.0292905
GLG1 golgi glycoprotein 1 0.0291872
MYLK myosin light chain kinase 0.029177
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.0291482
PDIA3 protein disulfide isomerase family A, member 3 0.0280733
NRXN3 neurexin 3 0.0280474

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.153249
PRELID2 PRELI domain containing 2 -0.0715502
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0678205
COL1A2 collagen, type I, alpha 2 -0.0582142
SOD2 superoxide dismutase 2, mitochondrial -0.0529869
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.051664
VCL vinculin -0.0490016
TENT5A terminal nucleotidyltransferase 5A -0.0444427
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0427349
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0406531
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0391302
WTAP Wilms tumor 1 associated protein -0.0386697
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0380222
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0372007
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0369285
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0356867
ATP13A3 ATPase type 13A3 -0.0350471
TAS2R14 taste receptor, type 2, member 14 -0.0350152
EZR ezrin -0.0342667
COL1A1 collagen, type I, alpha 1 -0.0337389
NIPBL Nipped-B homolog (Drosophila) -0.0335654
DNAH11 dynein, axonemal, heavy chain 11 -0.0330458
SCLT1 sodium channel and clathrin linker 1 -0.0314737
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0311753
DPYD dihydropyrimidine dehydrogenase -0.0302217
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0299814
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0285961
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0283734
SSBP2 single-stranded DNA binding protein 2 -0.0281214
AHNAK AHNAK nucleoprotein -0.0279216
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0278509
CPNE8 copine VIII -0.0271793
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0270009
MED13L mediator complex subunit 13-like -0.0269661
LCOR ligand dependent nuclear receptor corepressor -0.0269453
FGGY FGGY carbohydrate kinase domain containing -0.0268736
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0266404
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0265845
SDK1 sidekick cell adhesion molecule 1 -0.0264978
TPD52 tumor protein D52 -0.0263604
MX2 MX dynamin-like GTPase 2 -0.0261291
GRB10 growth factor receptor-bound protein 10 -0.0260255
ZBTB20 zinc finger and BTB domain containing 20 -0.0259984
ZNF644 zinc finger protein 644 -0.0258378
JAG1 jagged 1 -0.0258349
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0258195
SMYD3 SET and MYND domain containing 3 -0.0257344
TXNIP thioredoxin interacting protein -0.0252882
CEP350 centrosomal protein 350kDa -0.0251635
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0251406
PAIP2 poly(A) binding protein interacting protein 2 -0.0250497
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 -0.0249537
KIAA1217 KIAA1217 -0.0248413
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0246834
MARCHF6 membrane associated ring-CH-type finger 6 -0.0244101
ZMYM4 zinc finger, MYM-type 4 -0.0244023
TRAM2 translocation associated membrane protein 2 -0.0241535
AFDN afadin, adherens junction formation factor -0.0241129
NRG1 neuregulin 1 -0.0240583
TBC1D23 TBC1 domain family, member 23 -0.024029
TRAK2 trafficking protein, kinesin binding 2 -0.0239893
RUNX1 runt-related transcription factor 1 -0.0239217
SSH2 slingshot protein phosphatase 2 -0.023718
RAI1 retinoic acid induced 1 -0.0236953
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0236085
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0234045
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0233546
TPM4 tropomyosin 4 -0.0231459
BABAM2 BRISC and BRCA1 A complex member 2 -0.0230186
CRYBG3 beta-gamma crystallin domain containing 3 -0.0229974
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) -0.0228704
NCAM1 neural cell adhesion molecule 1 -0.0228077
EXOC1 exocyst complex component 1 -0.0227729
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0225565
ATXN1 ataxin 1 -0.0224625
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.0224402
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0223647
PCDH7 protocadherin 7 -0.0223441
LTN1 listerin E3 ubiquitin protein ligase 1 -0.0223048
TULP4 tubby like protein 4 -0.0222506
PDZD2 PDZ domain containing 2 -0.0222319
IFRD1 interferon-related developmental regulator 1 -0.0222248
RLIM ring finger protein, LIM domain interacting -0.022179
MAPK8 mitogen-activated protein kinase 8 -0.022154
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0219242
MEF2A myocyte enhancer factor 2A -0.0219113
RPS12 ribosomal protein S12 -0.0218773
RPS24 ribosomal protein S24 -0.0218428
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 -0.0217695
ANO6 anoctamin 6 -0.0214809
KLF10 Kruppel-like factor 10 -0.0214632
ABI2 abl-interactor 2 -0.0214496
WARS1 tryptophanyl-tRNA synthetase 1 -0.0213859
MEIS1 Meis homeobox 1 -0.0213421
NECTIN3 nectin cell adhesion molecule 3 -0.0212694
MAML2 mastermind-like 2 (Drosophila) -0.0211498
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.021137
TANK TRAF family member-associated NFKB activator -0.0210023
ATP11B ATPase, class VI, type 11B -0.0208927
CAMTA1 calmodulin binding transcription activator 1 -0.0207408